专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080090222A1 Virus-Inactivated Hemoglobin And Method Of Producing The Same 审中-公开
标题翻译：病毒灭活血红蛋白及其生产方法
公开(公告)号：US20080090222A1
公开(公告)日：2008-04-17
申请号：US11631347
申请日：2005-06-29
申请人： Tsutomu Ueda , Tetsuhiro Kimura , Junya Kojima
发明人： Tsutomu Ueda , Tetsuhiro Kimura , Junya Kojima
IPC分类号： A01N1/00 , C07K14/805
CPC分类号： A61K38/42 , A61L2/0017 , A61L2/0088 , C07K14/805
摘要： [PROBLEMS] To provide a method of efficiently producing virus-inactivated hemoglobin from erythrocytes without affecting physical and chemical properties of hemoglobin while allowing to conduct an erythrocyte hemolysis treatment and viral inactivation treatment at the same time and also to perform a post-hemolysis purification step and a post-virus-inactivation purification step in a single step, and especially, a method of efficiently obtaining highly virus-inactivated and sterile hemoglobin assured of the inactivation of any virus regardless of the presence or absence of envelopes. [SOLVING MEANS] A method of producing virus-inactivated hemoglobin, which includes: an SD treatment step of bringing erythrocytes and a mixture of a solvent and a detergent into contact with each other to simultaneously conduct an erythrocyte hemolysis treatment and viral inactivation treatment of said erythrocytes and a purification step of collecting virus-inactivated hemoglobin from the resulting SD-treated solution. A final filtration step can be efficiently performed when the purification step is performed in the order of an adsorption treatment and ultrafiltration.
摘要翻译： [问题]提供从红细胞有效产生病毒灭活血红蛋白的方法，而不影响血红蛋白的物理和化学性质，同时允许同时进行红细胞溶血治疗和病毒灭活处理，并且还进行溶血后纯化步骤和病毒灭活纯化步骤，特别是有效获得高度病毒灭活和无菌血红蛋白的方法，其确保任何病毒灭活而不管存在或不存在信封。 [解决方案]一种生产病毒灭活血红蛋白的方法，其包括：将治疗红细胞和溶剂与洗涤剂的混合物相互接触的SD处理步骤同时进行所述红细胞溶血治疗和病毒灭活处理红细胞和从所得SD处理的溶液中收集病毒灭活的血红蛋白的纯化步骤。当以吸附处理和超滤的顺序进行纯化步骤时，可以有效地进行最终的过滤步骤。

2. 发明授权

US06303375B1 Cell supporting matrix, cell culture device, and fluid treating device 有权
标题翻译：细胞支持基质，细胞培养装置和流体处理装置
公开(公告)号：US06303375B1
公开(公告)日：2001-10-16
申请号：US09338382
申请日：1999-06-23
申请人： Tetsuhiro Kimura , Norifumi Tokunaga , Yoshitaka Omura
发明人： Tetsuhiro Kimura , Norifumi Tokunaga , Yoshitaka Omura
IPC分类号： C12N500
CPC分类号： C12M25/14 , A61K35/12 , C12N5/0068 , C12N5/0671 , C12N2533/30 , C12N2533/78
摘要： A matrix for supporting cells such as animal cells is provided that enables cells to be supported at high efficiency and density in a short period. The matrix contains a plurality of cone shaped pores having an average diameter opening in an upstream surface of the matrix of from 500 to 1500 &mgr;m. The diameter decreases from the upstream surface to a downstream surface, and the average diameter of the cone shaped pores in the whole matrix is from 100 to 1000 &mgr;m. The matrix also contains a plurality of communicating pores that communicate with the cone shaped pores and with each other. These pores have an average diameter of from 5 to 100 &mgr;m, and the diameter decreases from a pore opening positioned near one surface of the matrix or near an interior surface of the cone shaped pores to a pore opening positioned remote from the surfaces. The matrix may also contain a plurality of column shaped pores having an average diameter of 100 to 1000 &mgr;m. A porous skin layer having an average pore size smaller than the average pore size of the communicating pores may be on the downstream surface, and the matrix may be made of polyurethane.
摘要翻译：提供了用于支持诸如动物细胞的细胞的基质，其使细胞在短时间内以高效率和密度被支持。该基质含有多个锥形孔，该孔具有在500至1500μm的基质的上游表面中的平均直径开口。直径从上游表面下降到下游表面，整个基体中锥形孔的平均直径为100-1000μm。该基质还包含与锥形孔和彼此连通的多个连通孔。这些孔的平均直径为5至100μm，并且直径从位于基体的一个表面附近的孔隙或锥形孔的内表面附近的孔隙减小到远离表面的孔隙。基质还可以含有平均直径为100-1000μm的多个柱状孔。平均孔径小于连通孔的平均孔径的多孔表层可以在下游表面上，并且基质可以由聚氨酯制成。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式