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1. 发明授权

US07091018B2 Enzyme gene and its expression product 有权
标题翻译：酶基因及其表达产物
公开(公告)号：US07091018B2
公开(公告)日：2006-08-15
申请号：US10297599
申请日：2001-06-12
申请人： Tsutomu Fujiwara , Takashi Okamoto , Masashi Niimi , Hiroyuki Kyushiki , Yasuchika Yamamoto , Atsunori Ueyama
发明人： Tsutomu Fujiwara , Takashi Okamoto , Masashi Niimi , Hiroyuki Kyushiki , Yasuchika Yamamoto , Atsunori Ueyama
IPC分类号： C12N9/10 , C12N1/12 , C12N15/00 , C07H21/04
CPC分类号： C12N9/1096 , A61K48/00
摘要： The present invention is drawn to a gene comprising a polynucleotide encoding a polypeptide composed of an amino acid sequence represented by SEQ ID NO: 1; a gene expression product produced through expression of the gene; a recombinant expression vector including the gene; a host cell (transformant) harboring the recombinant expression vector; a protein composed of an amino acid having an amino acid sequence represented by SEQ ID NO: 1; a therapeutic or preventive composition for hypoglycemia containing as an active ingredient the above-mentioned gene or protein; and an antibody capable of binding to the protein. Through use of the gene or an expression product thereof of the present invention, it is possible to elucidate the pathology of diabetes and develop drugs for treatment and prevention of diabetes via a new action mechanism.
摘要翻译：本发明涉及包含编码由SEQ ID NO：1所示的氨基酸序列构成的多肽的多核苷酸的基因; 通过表达基因产生的基因表达产物; 包含该基因的重组表达载体; 携带重组表达载体的宿主细胞（转化体）由具有SEQ ID NO：1所示的氨基酸序列的氨基酸组成的蛋白质; 含有作为上述基因或蛋白质的活性成分的低血糖的治疗或预防组合物; 和能够结合蛋白质的抗体。通过使用本发明的基因或其表达产物，可以通过新的作用机制阐明糖尿病的病理学并开发用于治疗和预防糖尿病的药物。

2. 发明申请

US20110105718A1 NEL-RELATED PROTEIN TYPE 1 ANTIBODY 失效
标题翻译： NEL相关蛋白1型抗体
公开(公告)号：US20110105718A1
公开(公告)日：2011-05-05
申请号：US12977497
申请日：2010-12-23
申请人： Tsutomu Fujiwara , Takeshi Watanabe , Masato Horie
发明人： Tsutomu Fujiwara , Takeshi Watanabe , Masato Horie
IPC分类号： C07K2/00
CPC分类号： C07K14/47 , C07K14/4702 , C07K14/4705 , C12N9/1205 , C12N9/6421 , C12N9/93
摘要： The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.
摘要翻译：本发明提供新的人基因，例如包含编码SEQ ID NO：1所示氨基酸序列的核苷酸序列的新型人基因。基因的使用使得可以在各种组织中检测其表达，分析其结构和功能，并通过基因工程技术产生由基因编码的人类蛋白质。通过这些，可以分析相应的表达产物，阐明与基因有关的疾病的病理学，例如遗传性疾病和癌症，以及诊断和治疗这些疾病。

3. 发明授权

US07858754B2 Nel-related protein type 1 antibody 失效
标题翻译： Nel相关蛋白1型抗体
公开(公告)号：US07858754B2
公开(公告)日：2010-12-28
申请号：US12510074
申请日：2009-07-27
申请人： Tsutomu Fujiwara , Takeshi Watanabe , Masato Horie
发明人： Tsutomu Fujiwara , Takeshi Watanabe , Masato Horie
IPC分类号： C07K16/18
CPC分类号： C07K14/47 , C07K14/4702 , C07K14/4705 , C12N9/1205 , C12N9/6421 , C12N9/93
摘要： The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.
摘要翻译：本发明提供新的人基因，例如包含编码SEQ ID NO：1所示氨基酸序列的核苷酸序列的新型人基因。基因的使用使得可以在各种组织中检测其表达，分析其结构和功能，并通过基因工程技术产生由该基因编码的人类蛋白质。通过这些，可以分析相应的表达产物，阐明与基因有关的疾病的病理学，例如遗传性疾病和癌症，以及诊断和治疗这些疾病。

4. 发明授权

US5808030A hTFIIIA gene 失效
标题翻译： hTFIIIA基因
公开(公告)号：US5808030A
公开(公告)日：1998-09-15
申请号：US523376
申请日：1995-09-05
申请人： Tsutomu Fujiwara , Satoshi Takeda , Yoshikazu Shimada , Kouichi Ozaki , Sadahito Shin, deceased
发明人： Tsutomu Fujiwara , Satoshi Takeda , Yoshikazu Shimada , Kouichi Ozaki , Sadahito Shin, deceased
IPC分类号： C12N15/09 , A61K31/70 , A61K38/00 , A61K48/00 , A61P35/00 , C07H21/04 , C07K14/46
CPC分类号： C07K14/46 , A61K38/00
摘要： An isolated hTFIIIA gene having a nucleotide sequence coding for the amino acid sequence of SEQ ID NO:1, as disclosed, and in particular the hTFIIIA gene having the nucleotide sequence of SEQ ID NO:2. The gene can be used to express a corresponding hTFIIIA protein. The gene and protein serve as transcription regulating factors, and are useful in the diagnosis or identification of hereditary disease, such as cancer or other diseases resulting from abnormal transcriptional control and, further, in analyzing the mechanisms of action thereof.
摘要翻译：具有编码SEQ ID NO：1的氨基酸序列的核苷酸序列的分离的hTFIIIA基因，特别是具有SEQ ID NO：2的核苷酸序列的hTFIIIA基因。该基因可用于表达相应的hTFIIIA蛋白。该基因和蛋白质用作转录调节因子，并且可用于诊断或鉴定遗传性疾病，例如癌症或由异常转录控制引起的其它疾病，以及进一步分析其作用机制。

5. 发明授权

US08066278B2 Printer 有权
标题翻译：打印机
公开(公告)号：US08066278B2
公开(公告)日：2011-11-29
申请号：US12556902
申请日：2009-09-10
申请人： Tsuyoshi Sanada , Kiyoshi Morino , Tsutomu Fujiwara , Toshiharu Sekino
发明人： Tsuyoshi Sanada , Kiyoshi Morino , Tsutomu Fujiwara , Toshiharu Sekino
IPC分类号： B65H29/00 , B65H5/00
CPC分类号： B65H29/125 , B65H31/3027 , B65H2301/42122 , B65H2301/42262 , B65H2511/51 , B65H2513/412 , Y10S271/902 , B65H2220/01 , B65H2220/02
摘要： In the state that a preceding sheet awaits at an awaiting position, a pair of conveying rollers are separated from each other, and the front end of a subsequent sheet sent out from a main conveying path passes the gap between the pair of conveying rollers. Based on a configuration that the distance from the trailing end of the subsequent sheet in the conveying direction to the pair of conveying rollers becomes equal to that from the front end of the preceding sheet to the pair of conveying rollers, the preceding sheet and subsequent sheet are sandwiched by the pair of conveying rollers so as to be conveyed in a first direction, thereby making the sheets into a state that the sheets are put on each other. Thereafter, the sheets are conveyed in a second direction by the pair of conveying rollers, so as to be discharged into discharging unit.
摘要翻译：在前一片材等待在等待位置的状态下，一对输送辊彼此分离，并且从主输送路径发出的后续片材的前端穿过一对输送辊之间的间隙。基于从后续片材的后端到输送辊的距离与从前一片材的前端到一对输送辊的距离相等的构造，前述片材和随后的片材被一对输送辊夹持以便沿第一方向输送，从而使纸张成为彼此放置的状态。此后，通过一对输送辊在第二方向上输送纸张，以便排出到排出单元中。

6. 发明授权

US08048995B2 Human skeletal muscle-specific ubiquitin-conjugating enzyme 失效
标题翻译：人骨骼肌特异性泛素缀合酶
公开(公告)号：US08048995B2
公开(公告)日：2011-11-01
申请号：US12689917
申请日：2010-01-19
申请人： Tsutomu Fujiwara , Takeshi Watanabe , Masato Horie
发明人： Tsutomu Fujiwara , Takeshi Watanabe , Masato Horie
IPC分类号： C07K16/40 , C07K16/00
CPC分类号： C07K14/47 , C07K14/4702 , C07K14/4705 , C12N9/1205 , C12N9/6421 , C12N9/93
摘要： The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.
摘要翻译：本发明提供新的人基因，例如包含编码SEQ ID NO：1所示氨基酸序列的核苷酸序列的新型人基因。基因的使用使得可以在各种组织中检测其表达，分析其结构和功能，并通过基因工程技术产生由基因编码的人类蛋白质。通过这些，可以分析相应的表达产物，阐明与基因有关的疾病的病理学，例如遗传性疾病和癌症，以及诊断和治疗这些疾病。

7. 发明申请

US20100048878A1 HUMAN GENE 失效
标题翻译：人类基因
公开(公告)号：US20100048878A1
公开(公告)日：2010-02-25
申请号：US12510074
申请日：2009-07-27
申请人： Tsutomu Fujiwara , Takeshi Watanabe , Masato Horie
发明人： Tsutomu Fujiwara , Takeshi Watanabe , Masato Horie
IPC分类号： C07K16/00 , C07K14/435
CPC分类号： C07K14/47 , C07K14/4702 , C07K14/4705 , C12N9/1205 , C12N9/6421 , C12N9/93
摘要： The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.
摘要翻译：本发明提供新的人基因，例如包含编码SEQ ID NO：1所示氨基酸序列的核苷酸序列的新型人基因。基因的使用使得可以在各种组织中检测其表达，分析其结构和功能，并通过基因工程技术产生由该基因编码的人类蛋白质。通过这些，可以分析相应的表达产物，阐明与基因有关的疾病的病理学，例如遗传性疾病和癌症，以及诊断和治疗这些疾病。

8. 发明授权

US07420048B2 Human skeletal muscle-specific ubiquitin-conjugating enzyme 失效
标题翻译：人骨骼肌特异性泛素缀合酶
公开(公告)号：US07420048B2
公开(公告)日：2008-09-02
申请号：US10342276
申请日：2003-01-15
申请人： Tsutomu Fujiwara , Takeshi Watanabe , Masato Horie
发明人： Tsutomu Fujiwara , Takeshi Watanabe , Masato Horie
IPC分类号： C07H21/04
CPC分类号： C12N9/93 , C07K14/47 , C07K14/4705 , C12N9/1205 , C12N9/6421
摘要： An isolated and purified human skeletal muscle-specific ubiquitin-conjugating enzyme comprising the amino acid sequence shown in SEQ ID NO: 22 is disclosed. The use of the genes make it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.
摘要翻译：公开了包含SEQ ID NO：22所示的氨基酸序列的分离和纯化的人骨骼肌特异性泛素缀合酶。基因的使用使得可以在各种组织中检测到其表达，分析其结构和功能，并通过基因工程技术产生由基因编码的人类蛋白质。通过这些，可以分析相应的表达产物，阐明与基因有关的疾病的病理学，例如遗传性疾病和癌症，以及诊断和治疗这些疾病。

9. 发明授权

US5831058A Human GDP dissociation stimulating protein gene 失效
标题翻译：人类GDP解离刺激蛋白基因
公开(公告)号：US5831058A
公开(公告)日：1998-11-03
申请号：US820170
申请日：1997-03-19
申请人： Tsutomu Fujiwara , Takeshi Watanabe , Masato Horie
发明人： Tsutomu Fujiwara , Takeshi Watanabe , Masato Horie
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , C07H21/04 , C07K14/47 , C12N9/00 , C12N9/12 , C12N9/64 , C12N15/12 , C12N15/54 , C12N15/55 , C12P21/02 , C12Q1/68 , C12R1/19
CPC分类号： C07K14/47 , C07K14/4702 , C07K14/4705 , C12N9/1205 , C12N9/6421 , C12N9/93
摘要： The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.
摘要翻译：本发明提供新的人基因，例如包含编码SEQ ID NO：1所示氨基酸序列的核苷酸序列的新型人基因。基因的使用使得可以在各种组织中检测其表达，分析其结构和功能，并通过基因工程技术产生由基因编码的人类蛋白质。通过这些，可以分析相应的表达产物，阐明与基因有关的疾病的病理学，例如遗传性疾病和癌症，以及诊断和治疗这些疾病。

10. 发明授权

US5594487A Thermal head supporting device 失效
标题翻译：热头支撑装置
公开(公告)号：US5594487A
公开(公告)日：1997-01-14
申请号：US322338
申请日：1994-10-13
申请人： Akira Nuita , Tsutomu Fujiwara , Hisao Suzuki , Tsugio Narushima , Akira Suzuki , Mamoru Tago , Eiichi Furuya
发明人： Akira Nuita , Tsutomu Fujiwara , Hisao Suzuki , Tsugio Narushima , Akira Suzuki , Mamoru Tago , Eiichi Furuya
IPC分类号： B41J25/312 , B41J25/304
CPC分类号： B41J25/312
摘要： The thermal head supporting device of the invention comprises a pair of positioning members disposed at both sides of a platen, a head press/release mechanism movable toward and away from the platen, and a head unit coupled with the head press/release mechanism. The positioning members are disposed coaxially with the platen. The head unit is formed of a head supporting member removably coupled to the head press/release mechanism with a predetermined play, a thermal head supported on the head supporting member and having a plurality of heating elements arranged in a straight line thereon and in confronting relationship with the platen, and a pair of engagement members attached to both sides of the thermal head adjustably for position, and each of the engagement members has a cutting formed therein allowing each positioning member to be removably fitted therein.
摘要翻译：本发明的热头支撑装置包括设置在压板两侧的一对定位构件，可朝向和远离压板移动的头部按压/释放机构，以及与头部按压/释放机构联接的头部单元。定位构件与压板同轴设置。头单元由头部支撑构件形成，头部支撑构件以预定游隙可拆卸地联接到头部按压/释放机构，热头支撑在头部支撑构件上，并且具有多个沿着直线排列的加热元件，并且面对关系以及一对接合构件，其可调节地安装在热敏头的两侧用于位置，并且每个接合构件具有形成在其中的切割，允许每个定位构件可移除地装配在其中。

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