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1. 发明授权

US5460814A Fermentation broth and microorganisms which produce them 失效
标题翻译：发酵肉汤和生产它们的微生物
公开(公告)号：US5460814A
公开(公告)日：1995-10-24
申请号：US228712
申请日：1994-04-18
申请人： Tsuneo Watanabe , Takeshi Yasumoto , Michio Murata , Michito Tagawa , Hiroyuki Narushima , Takashi Furusato , Masao Kuwahara , Masami Hanaue , Tatsuya Seki
发明人： Tsuneo Watanabe , Takeshi Yasumoto , Michio Murata , Michito Tagawa , Hiroyuki Narushima , Takashi Furusato , Masao Kuwahara , Masami Hanaue , Tatsuya Seki
IPC分类号： C07D493/04 , C12P17/18 , C12N1/16 , C12P1/02
CPC分类号： C07D493/04 , C12P17/181 , C12R1/645
摘要： The present invention relates to the compound A of the formula (A), the related compound B, carboxylic acid derived from acid anhydride group of these compounds and esters and salts thereof, microorganisms for producing the compounds, methods for producing the compounds A and/or B by using the microorganisms, and a treated or untreated fermentation broth obtained by culturing strains belonging to genus Zopfiella or Zopfiella curvata No. 37-3 strain. ##STR1## The present invention provides the compounds A and B, derivatives thereof, and treated or untreated fermentation broth obtained by culturing the strains belonging to genus Zopfiella or Zopfiella curvata No. 37-3 strain, which show an excellent activities as antifungal agent and anti-thrombotic agent.
摘要翻译：本发明涉及式（A）化合物A，相关化合物B，衍生自这些化合物的酸酐基团的羧酸及其酯和盐，用于制备化合物的微生物，化合物A和/ 或B，以及通过培养属于Zopfiella属或No.37-3菌株的菌株获得的处理或未处理的发酵肉汤。（A）本发明提供了化合物A和B及其衍生物，以及通过培养属于Zopfiella属或曲霉菌株37-3株的菌株获得的处理或未处理的发酵液，其显示出优异的活性抗真菌剂和抗血栓形成剂。

2. 发明授权

US5346919A Anti-bacterial substances and microorganisms which produce them 失效
标题翻译：产生它们的抗菌物质和微生物
公开(公告)号：US5346919A
公开(公告)日：1994-09-13
申请号：US100171
申请日：1993-08-02
申请人： Tsuneo Watanabe , Takeshi Yasumoto , Michio Murata , Michito Tagawa , Hiroyuki Narushima , Takashi Furusato , Masao Kuwahara , Masami Hanaue , Tatsuya Seki
发明人： Tsuneo Watanabe , Takeshi Yasumoto , Michio Murata , Michito Tagawa , Hiroyuki Narushima , Takashi Furusato , Masao Kuwahara , Masami Hanaue , Tatsuya Seki
IPC分类号： C07D493/04 , C12P17/18 , A61K31/34 , C07D307/93 , C12P7/40
CPC分类号： C07D493/04 , C12P17/181 , C12R1/645
摘要： The present invention relates to the compound A of the formula (A), the related compound B, carboxylic acid derived from acid anhydride group of these compounds and esters and salts thereof, microorganisms for producing the compounds, methods for producing the compounds A and/or B by using the microorganisms, and a treated or untreated fermentation broth obtained by culturing strains belonging to genus Zopfiella or Zopfiella curvata No. 37-3 strain. ##STR1## The present invention provides the compounds A and B, derivatives thereof, and treated or untreated fermentation broth obtained by culturing the strains belonging to genus Zopfiella or Zopfiella curvata No. 37-3 strain, which show an excellent activities as antifungal agent and anti-thrombotic agent.
摘要翻译：本发明涉及式（A）化合物A，相关化合物B，衍生自这些化合物的酸酐基团的羧酸及其酯和盐，用于制备化合物的微生物，化合物A和/ 或B，以及通过培养属于Zopfiella属或No.37-3菌株的菌株获得的处理或未处理的发酵肉汤。（A）本发明提供了化合物A和B及其衍生物，以及通过培养属于Zopfiella属或曲霉菌株37-3株的菌株获得的处理或未处理的发酵液，其显示出优异的活性抗真菌剂和抗血栓形成剂。

3. 发明申请

US20130137163A1 MICROTOME AND CRYOSTAT 有权
标题翻译： MICROTOME和CRYOSTAT
公开(公告)号：US20130137163A1
公开(公告)日：2013-05-30
申请号：US13816458
申请日：2011-07-29
申请人： Hiroyuki Minemura , Tatsuya Seki
发明人： Hiroyuki Minemura , Tatsuya Seki
IPC分类号： A01N1/02
CPC分类号： A01N1/0257 , G01N1/06 , Y10S83/9155 , Y10T83/283 , Y10T83/293
摘要： Provided is a microtome in which refrigerant piping and electrical wiring are not impeditive so that cleaning and other works can be surely conducted.The microtome includes a head 32 which holds a sample, an alignment mechanism 50 which aligns a head 32, a body portion 42 which is provided on the back face side of the alignment mechanism 50, a cylindrical coupling portion 41 which couples the body portion 42 with the head 32, a temperature controller 34 in the head 32, and refrigerant piping 40 and electrical wiring 46 for the temperature controller 34, and the alignment mechanism 50 includes a spherical member 68 coupled with the back face side of the head and having a spherical outer periphery and includes retainer portions 70 and 71 retaining the outer periphery of the spherical member 68 slidably along a spherical surface, the spherical member 68 has a through hole 74 formed communicating with the hollow portion 43 of the coupling portion 41, and the refrigerant piping 40 and the electrical wiring 46 are connected with the temperature controller 34 in the head 32 through the through hole 74 of the spherical member 68 and the hollow portion 43 of the coupling portion 41.
摘要翻译：提供了一种切片机，其中制冷剂管道和电线不阻碍，从而可以可靠地进行清洁和其他工作。切片机包括保持样品的头部32，对准机构50，其对准头部32，设置在对准机构50的背面侧的主体部分42，连接主体部分42的圆柱形联接部分41 头32，头32中的温度控制器34和用于温度控制器34的制冷剂管道40和电线46，并且对准机构50包括与头部的背面侧联接的球形部件68，球形外周并且包括保持部分70和71，球形部件68沿着球形表面可滑动地保持外圆周，球形部件68具有与连接部分41的中空部分43连通的通孔74，并且制冷剂管道40和电线46通过球形构件68的通孔74和头部32中的温度控制器34连接在头部32中联接部41的低部43。

4. 发明授权

US08997615B2 Microtome and cryostat 有权
标题翻译：切片机和低温恒温器
公开(公告)号：US08997615B2
公开(公告)日：2015-04-07
申请号：US13816458
申请日：2011-07-29
申请人： Hiroyuki Minemura , Tatsuya Seki
发明人： Hiroyuki Minemura , Tatsuya Seki
IPC分类号： B26D7/10 , A01N1/02 , G01N1/06
CPC分类号： A01N1/0257 , G01N1/06 , Y10S83/9155 , Y10T83/283 , Y10T83/293
摘要： A microtome comprising a head 32 which holds a sample, an alignment mechanism 50 which aligns the head 32, a body portion 42 which is provided on a back face side of the alignment mechanism 50, a cylindrical coupling portion 41 which couples the body portion 42 with the head 32, a temperature controller 34 in the head 32, and refrigerant piping 40 and electrical wiring 46 for the temperature controller 34, and the alignment mechanism 50 includes a spherical member 68 coupled with the back face side of the head and having a spherical outer periphery and includes retainer portions 70 and 71 retaining the outer periphery of the spherical member 68 slidably along a spherical surface, the spherical member 68 has a through hole 74 which communicates with the hollow portion 43 of the coupling portion 41, the refrigerant piping 40 and the electrical wiring 46 are connected with the temperature controller 34 in the head 32 through the through hole 74 of the spherical member 68 and the hollow portion 43 of the coupling portion 41.
摘要翻译：切片机包括保持样品的头部32，对准头部32的对准机构50，设置在对准机构50的背面侧的主体部分42，连接主体部分42的圆柱形联接部分41 头32，头32中的温度控制器34和用于温度控制器34的制冷剂管道40和电线46，并且对准机构50包括与头部的背面侧联接的球形部件68，球形外周，并且包括保持部70和71，球形部件68沿着球面滑动地保持外周，球形部件68具有与联接部41的中空部43连通的通孔74，制冷剂配管 40并且电线46通过球形构件68的通孔74和中空po连接到头部32中的温度控制器34 连接部41的连接部43。

5. 发明授权

US07141389B1 Chromosome DNA coding for human hepatocyte growth factor 失效
标题翻译：编码人类肝细胞生长因子的染色体DNA
公开(公告)号：US07141389B1
公开(公告)日：2006-11-28
申请号：US08292160
申请日：1994-08-17
申请人： Toshikazu Nakamura , Tatsuya Seki , Michio Hagiya , Manabu Shimonishi , Shin Shimizu
发明人： Toshikazu Nakamura , Tatsuya Seki , Michio Hagiya , Manabu Shimonishi , Shin Shimizu
IPC分类号： C12N1/16 , C12N5/16 , C12N15/18 , C12N15/63 , C12N1/21
CPC分类号： C07K14/4753
摘要： A chromosome DNA which codes for human hepatocyte growth factor, a recombinant expression vector capable of expressing the DNA, a transformant transformed with the expression vector and a method of producing recombinant human hepatocyte growth factor. The DNA and polypeptide of the present invention are expected to serve well for hepatocyte cultivation reagents, liver regeneration promoters, various researches, clinical diagnostic reagents and therapeutic drugs for liver diseases.
摘要翻译：编码人肝细胞生长因子的染色体DNA，能够表达DNA的重组表达载体，用表达载体转化的转化体和产生重组人肝细胞生长因子的方法。本发明的DNA和多肽预期对于肝细胞培养试剂，肝脏再生促进剂，各种研究，临床诊断试剂和用于肝脏疾病的治疗药物起很好的作用。

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