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1. 发明授权

US06025467A Parathyroid hormone derivatives and their use 失效
标题翻译：甲状旁腺激素衍生物及其用途
公开(公告)号：US06025467A
公开(公告)日：2000-02-15
申请号：US44536
申请日：1998-03-19
申请人： Tsunehiko Fukuda , Shizue Nakagawa , Junko Habashita , Shigehisa Taketomi
发明人： Tsunehiko Fukuda , Shizue Nakagawa , Junko Habashita , Shigehisa Taketomi
IPC分类号： A61K38/00 , C07K14/635 , C12N15/16 , C07K7/06 , A61K38/16
CPC分类号： C07K14/635 , A61K38/00
摘要： Disclosed is a parathyroid hormone (PTH) (1-34) derivative in which at least the amino acid residue at the 10-position is substituted by an acidic amino acid residue. The derivatives of the present invention showing potent cAMP-producing activity and bone formation activity, and thus are useful as therapeutic agents for bone diseases, etc.
摘要翻译：披露了至少10位的氨基酸残基被酸性氨基酸残基取代的甲状旁腺激素（PTH）（1-34）衍生物。本发明的衍生物显示出有效的cAMP生产活性和骨形成活性，因此可用作骨疾病等的治疗剂。

2. 发明授权

US5434246A Parathyroid hormone derivatives 失效
标题翻译：甲状旁腺激素衍生物
公开(公告)号：US5434246A
公开(公告)日：1995-07-18
申请号：US033099
申请日：1993-03-16
申请人： Tsunehiko Fukuda , Shizue Nakagawa , Shigehisa Taketomi
发明人： Tsunehiko Fukuda , Shizue Nakagawa , Shigehisa Taketomi
IPC分类号： A61K38/00 , C07K14/635 , C07K14/00 , A61K38/23 , C07K4/00
CPC分类号： C07K14/635 , A61K38/00
摘要： Parathyroid hormone (PTH) derivatives represented by the general formula: ##STR1## or a salt thereof, wherein R.sub.1 represents Ser or a D-.alpha.-amino acid residue of 4 or less carbon atoms;R.sub.2 represents a tetrapeptide chain which contains at least one water-soluble .alpha.-amino acid residue;R.sub.3 represents a tripeptide chain which contains at least one water-soluble .alpha.-amino acid residue; andR.sub.4 represents an aromatic amino acid residue or an amide thereof,except that R.sub.1 is Ser when R.sub.2 is His-Leu-Asn-Ser, R.sub.3 is E-F-Gwherein E is Arg or His, F is Lys or His, G is Lys, Leu or Gln, are disclosed.The parathyroid hormone derivatives of the present invention are stable and have high biological activity, therefore they are useful as drugs for bone diseases and the like.
摘要翻译：由以下通式表示的甲状旁腺激素（PTH）衍生物或其盐，其中R1表示Ser或4个或更少碳原子的D-α-氨基酸残基; R2表示含有至少一个水溶性α-氨基酸残基的四肽链; R3表示含有至少一个水溶性α-氨基酸残基的三肽链; R4代表芳族氨基酸残基或酰胺，当R 2为His-Leu-Asn-Ser时，R1为Ser，R3为EFG，其中E为Arg或His，F为Lys或His，G为Lys，Leu 或Gln。本发明的甲状旁腺激素衍生物是稳定的并且具有高的生物活性，因此它们可用作骨疾病等药物。

3. 发明授权

US5393869A Parathyroid hormone derivatives 失效
标题翻译：甲状旁腺激素衍生物
公开(公告)号：US5393869A
公开(公告)日：1995-02-28
申请号：US765373
申请日：1991-09-25
申请人： Shizue Nakagawa , Tsunehiko Fukuda , Masahiro Kawase , Iwao Yamazaki
发明人： Shizue Nakagawa , Tsunehiko Fukuda , Masahiro Kawase , Iwao Yamazaki
IPC分类号： A61K38/22 , A61K38/00 , A61P3/02 , A61P5/12 , A61P9/12 , A61P19/10 , A61P43/00 , C07K7/00 , C07K14/575 , C07K14/635 , A61K37/00 , C07K5/00 , A61K37/02
CPC分类号： C07K14/635 , A61K38/00 , Y02P20/55
摘要： Disclosed are peptides and salts thereof represented by general formul ##STR1## wherein R.sub.1 represents Ser or Aib; R.sub.2 represents Met or a naturally occurring hydrophobic amino acid; R.sub.3 represents Leu, Ser, Lys or an aromatic amino acid; R.sub.4 represents Gly or a D-.alpha.-amino acid; R.sub.5 represents Lys or Leu; R.sub.6 represents Met or a naturally occurring hydrophobic amino acid; R.sub.7 represents Glu or a basic amino acid; R.sub.8 represents Val or basic amino acid; R.sub.9 represents Trp or 2-(1,3-dithiolane-2-yl)Trp; R.sub.10 represents Arg or His; R.sub.11 represents Lys or His; R.sub.12 represents Lys, Gln or Leu; and R.sub.13 represents Phe or Phe-NH.sub.2 ; except that simultaneously R.sub.1 consists of Ser, R.sub.2 consists of Met, R.sub.3 consists of Leu, R.sub.4 consists of Gly, D-Ala or D-Pro, R.sub.5 consists of Lys, R.sub.6 consists of Met, R.sub.7 consists of Glu, R.sub.8 consists of Val, R.sub.9 consists of Trp, R.sub.10 consists of Arg, R.sub.11 consists of Lys and R.sub.12 consists of Lys.The parathyroid hormone (1-34) analogs are useful in hormone therapy.
摘要翻译：公开了由通式R1-Val-Ser-Glu-Ile-Gln-Leu-R2-His-Asn-R3-R4-R5-His-Leu-Asn-Ser-R6-R7-Arg- R8-Glu-R9-Leu- R10-R11-R12-Leu-Gln-Asp-Val-His-Asn-R13，其中R1表示Ser或Aib; R2表示Met或天然存在的疏水性氨基酸; R3表示Leu，Ser，Lys或芳香族氨基酸; R4表示Gly或D-α-氨基酸; R5表示Lys或Leu; R6表示Met或天然存在的疏水性氨基酸; R7代表Glu或碱性氨基酸; R8代表Val或碱性氨基酸; R 9表示Trp或2-（1,3-二硫戊环-2-基）Trp; R10表示Arg或His; R11表示Lys或His; R12表示Lys，Gln或Leu; R13表示Phe或Phe-NH2; 除了同时R1由Ser组成，R2由Met组成，R3由Leu组成，R4由Gly，D-Ala或D-Pro组成，R5由Lys组成，R6由Met组成，R7由Glu组成，R8由Val组成 R9由Trp组成，R10由Arg组成，R11由Lys组成，R12由Lys组成。甲状旁腺激素（1-34）类似物可用于激素治疗。

4. 发明授权

US07064141B1 Method for preventing, treating or inhibiting development of simple retinopathy and preproliferative retinopathy 失效
标题翻译：预防，治疗或抑制简单视网膜病变和增生性视网膜病变发展的方法
公开(公告)号：US07064141B1
公开(公告)日：2006-06-20
申请号：US09958740
申请日：2000-04-27
申请人： Shizue Nakagawa , Yasutaka Nagisa , Hitoshi Ikeda
发明人： Shizue Nakagawa , Yasutaka Nagisa , Hitoshi Ikeda
IPC分类号： A61K31/41
CPC分类号： A61K31/519 , A61K31/00 , A61K31/41 , A61K31/4178 , A61K31/4184 , Y10S514/912
摘要： To provide a pharmaceutical composition for preventing, treating or development-inhibiting simple retinopathy or preproliferative retinopathy, comprising a compound having angiotensin II antagonistic activity, or a salt thereof.
摘要翻译：提供包含具有血管紧张素II拮抗活性的化合物或其盐的预防，治疗或显影抑制性简单视网膜病变或预增生性视网膜病变的药物组合物。

5. 发明申请

US20060189669A1 Pharmaceutical composition for preventing, treating or development-inhibiting simple retinopathy and preproliferative retinopathy 审中-公开
标题翻译：用于预防，治疗或发展抑制简单视网膜病变和预增生性视网膜病变的药物组合物
公开(公告)号：US20060189669A1
公开(公告)日：2006-08-24
申请号：US11406345
申请日：2006-04-19
申请人： Shizue Nakagawa , Yasutaka Nagisa , Hitoshi Ikeda
发明人： Shizue Nakagawa , Yasutaka Nagisa , Hitoshi Ikeda
IPC分类号： A61K31/4184
CPC分类号： A61K31/519 , A61K31/00 , A61K31/41 , A61K31/4178 , A61K31/4184 , Y10S514/912
摘要： To provide a pharmaceutical composition for preventing, treating or development-inhibiting simple retinopathy or preproliferative retinopathy, comprising a compound having angiotensin II antagonistic activity, or a salt thereof.
摘要翻译：提供包含具有血管紧张素II拮抗活性的化合物或其盐的预防，治疗或显影抑制性简单视网膜病变或预增生性视网膜病变的药物组合物。

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