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1. 发明申请

US20070286842A1 Organic Compounds and Their Uses 有权
公开(公告)号：US20070286842A1
公开(公告)日：2007-12-13
申请号：US11697894
申请日：2007-04-09
申请人： Trixi Brandl , Jiping Fu , Francois Lenoir , David Parker , Michael Patane , Branko Redetich , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Aregahegn Yifru , Rui Zheng
发明人： Trixi Brandl , Jiping Fu , Francois Lenoir , David Parker , Michael Patane , Branko Redetich , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Aregahegn Yifru , Rui Zheng
IPC分类号： A61K38/21 , A61K31/40 , A61K31/421 , A61K31/44 , A61P31/12 , C07D207/00 , C07D239/02 , C07D251/02 , C07D295/00 , C12N9/99 , C12N7/06 , C07D263/52 , C07D241/02 , C07D213/02 , A61P7/00 , A61K31/495 , A61K31/53 , A61K31/5377
CPC分类号： A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/04 , C07D498/10 , C07K5/06034 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C07K5/101 , C07K5/1016
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.

2. 发明授权

US08445527B2 Organic compounds and their uses 有权
标题翻译：有机化合物及其用途
公开(公告)号：US08445527B2
公开(公告)日：2013-05-21
申请号：US13477866
申请日：2012-05-22
申请人： Michael Patane , Prakash Raman , David Thomas Parker , Jiping Fu , Branko Radetich , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng , Trixi Brandl , Francois Lenoir , Pascal Rigollier , Oliver Simic
发明人： Michael Patane , Prakash Raman , David Thomas Parker , Jiping Fu , Branko Radetich , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng , Trixi Brandl , Francois Lenoir , Pascal Rigollier , Oliver Simic
IPC分类号： A61K31/5377 , A61K31/506 , A61K31/497 , A61K31/4439 , A61K31/454 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/4155 , A61K31/403
CPC分类号： A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/04 , C07D498/10 , C07K5/06034 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C07K5/101 , C07K5/1016
摘要： The present invention provides a method of treating a HCV infection in a subject in need thereof by administering a compound of Formula I: or pharmaceutically acceptable salts thereof or stereoisomers thereof.
摘要翻译：本发明提供了通过给予式I化合物或其药学上可接受的盐或其立体异构体来治疗有需要的受试者的HCV感染的方法。

3. 发明申请

US20120231998A1 ORGANIC COMPOUNDS AND THEIR USES 有权
标题翻译：有机化合物及其用途
公开(公告)号：US20120231998A1
公开(公告)日：2012-09-13
申请号：US13477866
申请日：2012-05-22
申请人： Trixi Brandl , Jiping Fu , Francois Lenoir , David Thomas Parker , Michael Patane , Branko Radetich , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Aregahegn Yifru , Rui Zheng
发明人： Trixi Brandl , Jiping Fu , Francois Lenoir , David Thomas Parker , Michael Patane , Branko Radetich , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Aregahegn Yifru , Rui Zheng
IPC分类号： A61K38/07 , A61P31/14
CPC分类号： A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/04 , C07D498/10 , C07K5/06034 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C07K5/101 , C07K5/1016
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
摘要翻译：本申请描述了可用于治疗，预防和/或改善人类疾病的有机化合物。

4. 发明授权

US07825152B2 Organic compounds and their uses 有权
标题翻译：有机化合物及其用途
公开(公告)号：US07825152B2
公开(公告)日：2010-11-02
申请号：US11697894
申请日：2007-04-09
申请人： Trixi Brandl , Jiping Fu , Francois Lenoir , David Thomas Parker , Michael Patane , Branko Radetich , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Aregahegn Yifru , Rui Zheng
发明人： Trixi Brandl , Jiping Fu , Francois Lenoir , David Thomas Parker , Michael Patane , Branko Radetich , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Aregahegn Yifru , Rui Zheng
IPC分类号： C07D417/12 , C07D403/12 , C07D401/12 , C07D409/12 , C07D417/14 , C07D405/12 , C07D413/12 , C07D405/04 , C07D403/04 , C07D413/14 , C07D409/14 , C07D405/14 , C07D207/00 , C07D209/96 , A61K31/5377 , A61K31/506 , A61K31/497 , A61K31/4439 , A61K31/454 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/4155 , A61K31/403
CPC分类号： A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/04 , C07D498/10 , C07K5/06034 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C07K5/101 , C07K5/1016
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
摘要翻译：本申请描述了可用于治疗，预防和/或改善人类疾病的有机化合物。

5. 发明授权

US08211932B2 Organic compounds and their uses 有权
标题翻译：有机化合物及其用途
公开(公告)号：US08211932B2
公开(公告)日：2012-07-03
申请号：US12879644
申请日：2010-09-10
申请人： Michael Patane , Prakash Raman , David Thomas Parker , Jiping Fu , Branko Radetich , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng , Trixi Brandl , Francois Lenoir , Pascal Rigollier , Oliver Simic
发明人： Michael Patane , Prakash Raman , David Thomas Parker , Jiping Fu , Branko Radetich , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng , Trixi Brandl , Francois Lenoir , Pascal Rigollier , Oliver Simic
IPC分类号： C07D417/12 , C07D403/12 , C07D401/12 , C07D409/12 , C07D417/14 , C07D405/12 , C07D413/12 , C07D405/04 , C07D403/04 , C07D413/14 , C07D409/14 , C07D405/14 , C07D207/00 , C07D209/96 , A61K31/5377 , A61K31/506 , A61K31/497 , A61K31/4439 , A61K31/454 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/4155 , A61K31/403
CPC分类号： A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/04 , C07D498/10 , C07K5/06034 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C07K5/101 , C07K5/1016
摘要： The present application describes organic compounds of the Formula I that are useful for the treatment, prevention and/or amelioration of human diseases.
摘要翻译：本申请描述了可用于治疗，预防和/或改善人类疾病的式I的有机化合物。

6. 发明申请

US20100331243A1 ORGANIC COMPOUNDS AND THEIR USES 有权
标题翻译：有机化合物及其用途
公开(公告)号：US20100331243A1
公开(公告)日：2010-12-30
申请号：US12879644
申请日：2010-09-10
申请人： Trixi Brandl , Jiping Fu , Francois Lenoir , David Thomas Parker , Michael Patane , Branko Radetich , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Aregahegn Yifru , Rui Zheng
发明人： Trixi Brandl , Jiping Fu , Francois Lenoir , David Thomas Parker , Michael Patane , Branko Radetich , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Aregahegn Yifru , Rui Zheng
IPC分类号： A61K38/07 , C07K5/087 , A61K38/06 , A61P35/00 , C07K5/103
CPC分类号： A61K38/07 , A61K38/00 , A61K38/06 , A61K45/06 , C07D209/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/10 , C07D491/20 , C07D495/10 , C07D498/04 , C07D498/10 , C07K5/06034 , C07K5/06078 , C07K5/06165 , C07K5/0808 , C07K5/0812 , C07K5/101 , C07K5/1016
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
摘要翻译：本申请描述了可用于治疗，预防和/或改善人类疾病的有机化合物。

7. 发明授权

US08957068B2 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH 有权
标题翻译： 3-嘧啶-4-基 - 恶唑烷-2-酮作为突变体IDH的抑制剂
公开(公告)号：US08957068B2
公开(公告)日：2015-02-17
申请号：US14347481
申请日：2012-09-26
申请人： Thomas Raymond Caferro , Young Shin Cho , Abran Q. Costales , Huangshu Lei , Francois Lenoir , Julian Roy Levell , Gang Liu , Mark G. Palermo , Keith Bruce Pfister , Martin Sendzik , Cynthia Shafer , Michael David Shultz , Troy Smith , James Clifford Sutton , Bakary-Barry Toure , Fan Yang , Qian Zhao
发明人： Thomas Raymond Caferro , Young Shin Cho , Abran Q. Costales , Huangshu Lei , Francois Lenoir , Julian Roy Levell , Gang Liu , Mark G. Palermo , Keith Bruce Pfister , Martin Sendzik , Cynthia Shafer , Michael David Shultz , Troy Smith , James Clifford Sutton , Bakary-Barry Toure , Fan Yang , Qian Zhao
IPC分类号： C07D413/04 , C07D413/14 , A61K31/506 , C07D487/04 , C07D471/04 , C07D487/08 , C07D417/14 , C07D498/10
CPC分类号： C07D413/14 , C07D413/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D498/10 , C07D513/04
摘要： The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中R 1 -R 6在本文中定义。本发明还涉及含有式（I）化合物的组合物以及这些化合物在抑制具有新形态活性的突变体IDH蛋白质中的用途。本发明还涉及式（I）化合物在治疗与这种突变体IDH蛋白相关的疾病或病症中的用途，包括但不限于细胞增殖病症如癌症。

8. 发明申请

US20100120872A1 ORGANIC COMPOUNDS AND THEIR USES 有权
公开(公告)号：US20100120872A1
公开(公告)日：2010-05-13
申请号：US12557654
申请日：2009-09-11
申请人： Markus Rolf Dobler , Francois Lenoir , David Thomas Parker , Yunshan Peng , Grazia Piizzi , Sompong Wattanasin
发明人： Markus Rolf Dobler , Francois Lenoir , David Thomas Parker , Yunshan Peng , Grazia Piizzi , Sompong Wattanasin
IPC分类号： A61K31/44 , C07C233/16 , C12N1/20 , A61K31/16 , A61P31/04 , C07D213/00
CPC分类号： C07D309/22 , C07B2200/05 , C07C259/06 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07D211/70 , C07D213/30 , C07D307/42 , C07D307/80
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.

9. 发明授权

US08372885B2 Organic compounds and their uses 有权
标题翻译：有机化合物及其用途
公开(公告)号：US08372885B2
公开(公告)日：2013-02-12
申请号：US12557654
申请日：2009-09-11
申请人： Markus Rolf Dobler , Francois Lenoir , David Thomas Parker , Yunshan Peng , Grazia Piizzi , Sompong Wattanasin
发明人： Markus Rolf Dobler , Francois Lenoir , David Thomas Parker , Yunshan Peng , Grazia Piizzi , Sompong Wattanasin
IPC分类号： A61K31/19 , C07C229/00 , C07C259/04
CPC分类号： C07D309/22 , C07B2200/05 , C07C259/06 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07D211/70 , C07D213/30 , C07D307/42 , C07D307/80
摘要： The present application describes organic compounds of a general formula: and salts, and isomers thereof, wherein R, R2 and R3 are defined in the specification. The compounds are useful for treating a gram-negative bacterial infection.
摘要翻译：本申请描述了通式为的有机化合物及其盐及其异构体，其中R 1，R 2和R 3在本说明书中定义。该化合物可用于治疗革兰氏阴性细菌感染。

10. 发明授权

US4839648A Method of determining the trajectory of a body suitable for moving along a portion of a path, and apparatus for implementing the method 失效
标题翻译：确定适于沿着路径的一部分移动的主体的轨迹的方法以及用于实现该方法的装置
公开(公告)号：US4839648A
公开(公告)日：1989-06-13
申请号：US143875
申请日：1988-01-14
申请人： Serge Beucher , Jean-Marc Blosseville , Francois Lenoir
发明人： Serge Beucher , Jean-Marc Blosseville , Francois Lenoir
IPC分类号： G08G1/04
CPC分类号： G08G1/04
摘要： A method of determining the trajectory of a body (1) such as a vehicle body on a relatively plane path portion (2), the method being characterized in that it consists: in forming a main real image (4) of the path portion in a plane (19) at a non-zero angle (5) with the path portion; in decomposing said main image as formed into a plurality of points (21); in determining the relationship between the size of a unit length (30) taken substantially at the level of the path portion and the size of its image formed in the main image the size being a function of the number of points covered by the image and of the location of the unit length on said path portion; in determining a secondary image (32) in the main image, the secondary image corresponding to a longitudinal reference mark (31) related to the vehicle on the path portion; and in determining the various successive positions (32, 33, 34) of the secondary image by correlation of the number of points covered by the secondary image, given that the secondary image corresponds, according to the relationship, to a length which is constant on the path portion.
摘要翻译：一种在相对平面路径部分（2）上确定车体（1）诸如车体的轨迹的方法，其特征在于，它包括：形成路径部分的主实际图像（4）与路径部分成非零角度（5）的平面（19）; 在将所述主图像分解成多个点（21）时; 在确定基本上在路径部分的水平上拍摄的单位长度（30）的尺寸与在主图像中形成的图像的尺寸之间的关系中，该尺寸是图像所覆盖的点数的函数，以及所述路径部分上的单位长度的位置; 在确定主图像中的次要图像（32）时，与在路径部分上与车辆相关的纵向参考标记（31）对应的次要图像; 以及在通过所述次级图像覆盖的点的数量的相关性来确定所述次级图像的各个连续位置（32,33,34），根据所述关系，所述辅助图像根据所述关系对应于长度，所述长度对于路径部分。

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