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1. 发明授权

US5696232A Listeria monocytogenes specific proteins, and uses thereof 失效
标题翻译：单核细胞增生利斯特氏菌特异性蛋白质及其用途
公开(公告)号：US5696232A
公开(公告)日：1997-12-09
申请号：US456656
申请日：1995-06-02
申请人： Trinad Chakraborty , Werner Goebel , Servatius Hubertus Wilhelmus Notermans
发明人： Trinad Chakraborty , Werner Goebel , Servatius Hubertus Wilhelmus Notermans
IPC分类号： C07K14/195 , C07K16/12 , C12Q1/68 , C07K14/00 , A61K39/00 , C07K1/00 , C07K17/00
CPC分类号： C07K16/1296 , C07K14/195 , C12Q1/689 , Y10S530/806 , Y10S530/82 , Y10S530/825
摘要： The present invention is directed to Listeria monocytogenes specific protein that is encoded by nucleotide sequence of FIG. 1, the complementary sequence of which hybridizes to the nucleotide sequence of FIG. 1 at 5-6x SSC and 42.degree.-60.degree. C. A Listeria monocytogenes specific protein is also described having an amino aicd sequence as set forth in FIGS. 1A-1D. The proteins are suitable for the production of antibodies against Listeria monocytogenes.
摘要翻译：本发明涉及由图1的核苷酸序列编码的单核细胞增多利斯特氏菌特异性蛋白质。 1，其互补序列与图1的核苷酸序列杂交。 1在5-6x SSC和42 -60℃。单核细胞增生利斯特氏菌特异性蛋白质也被描述为具有如图1和2所示的氨基酸序列。 1A-1D。蛋白质适用于生产针对单核细胞增生利斯特氏菌的抗体。

2. 发明授权

US5550022A Method for the determination of pathogenic listeria bacteria 失效
标题翻译：测定致病性李斯特菌的方法
公开(公告)号：US5550022A
公开(公告)日：1996-08-27
申请号：US303577
申请日：1994-09-08
申请人： Trinad Chakraborty , Werner Goebel , Servatius H. W. Notermans
发明人： Trinad Chakraborty , Werner Goebel , Servatius H. W. Notermans
IPC分类号： C07K14/195 , C07K16/12 , C12Q1/68 , C07H21/04
CPC分类号： C07K16/1296 , C07K14/195 , C12Q1/689 , Y10S530/806 , Y10S530/82 , Y10S530/825
摘要： Nucleic acids which preferably hybridize under the hybridization conditions 5-6.times. SSC and 42.degree. C. to 60.degree. C. with a 2.5 kb large KpnI-BamHI fragment from pLM63, preferably with a nucleic acid according to FIG. 1. Such nucleic acids are suitable for hybridization tests for Listeria bacteria if they contain reporter groups. Proteins are also described which are suitable for the production of antibodies against Listeria bacteria.
摘要翻译：优选与来自pLM63的2.5kb大KpnI-BamHI片段，优选用根据图1的核酸在杂交条件5-6xSSC和42℃至60℃下杂交的核酸。如果这些核酸含有报告基团，则这种核酸适用于利斯特氏菌的杂交检测。还描述了适用于生产抗李斯特氏菌的抗体的蛋白质。

3. 发明申请

US20120248333A1 Device For Fluorescence Diagnosis 审中-公开
标题翻译：荧光诊断装置
公开(公告)号：US20120248333A1
公开(公告)日：2012-10-04
申请号：US13430174
申请日：2012-03-26
申请人： Johannes Fallert , Peter Schwarz , Werner Goebel , Andre Ehrhardt , Klaus-Martin Irion
发明人： Johannes Fallert , Peter Schwarz , Werner Goebel , Andre Ehrhardt , Klaus-Martin Irion
IPC分类号： G01N21/64
CPC分类号： G01N21/6456 , A61B1/00186 , A61B1/0638 , A61B1/0646 , G01N2021/6471
摘要： A diagnosis device having an illumination system configured to produce white light along an illumination path, an observation system for observing the target region in a white-light and fluorescence mode, the observation system having an observation path having at least one first image sensor for receiving a white-light image and at least one second image sensor for receiving a fluorescence image, an observation spectral filter in the observation path are configured such that light in the spectral range of the fluorescence can be fed to the second image sensor while light in the spectral ranges outside of the fluorescence is blocked. An illumination spectral filter is arranged in the illumination path and having a characteristic of the observation spectral filter such that the target region is illuminated with the whole spectral range of the white light with the exception of the spectral range of the fluorescence to be observed.
摘要翻译：一种具有照明系统的诊断装置，被配置为沿着照明路径产生白光，观察系统用于以白光和荧光模式观察所述目标区域，所述观察系统具有观察路径，所述观察路径具有至少一个用于接收的第一图像传感器白光图像和用于接收荧光图像的至少一个第二图像传感器，观察路径中的观察光谱滤波器被配置为使得荧光的光谱范围内的光可以被馈送到第二图像传感器，同时在荧光外的光谱范围被阻断。照明光谱滤光器布置在照明路径中，并且具有观察光谱滤波器的特性，使得除了要观察的荧光的光谱范围之外，白色光的整个光谱范围被照射目标区域。

4. 发明申请

US20110235324A1 LIGHT SOURCE DEVICE FOR ENDOSCOPIC OR EXOSCOPIC APPLICATIONS 有权
标题翻译：用于内窥镜或外用应用的光源装置
公开(公告)号：US20110235324A1
公开(公告)日：2011-09-29
申请号：US13074975
申请日：2011-03-29
申请人： Klaus-Martin Irion , Thomas Hinding , Werner Goebel
发明人： Klaus-Martin Irion , Thomas Hinding , Werner Goebel
IPC分类号： F21V5/00 , F21S4/00
CPC分类号： A61B1/07 , A61B1/043 , A61B1/063 , A61B1/0638 , A61B1/0653 , A61B1/0661 , A61B1/0669 , A61B1/0676 , A61B1/0684
摘要： A light source device for endoscopic or exoscopic applications includes a flat first light source, a second light source, an illuminating beam path that is configured to provide a first light beam emanating from the first light source for an endoscopic or exoscopic application, and a coupling device to couple a second light beam from the second light source into the illuminating beam path, whereby the coupling device is configured in such a way that at the coupling site the cross-section surface of the second light beam is smaller than the cross-section surface of the first light beam.
摘要翻译：用于内窥镜或外窥镜应用的光源装置包括平坦的第一光源，第二光源，照明光束路径，其被配置为提供从第一光源发出的用于内窥镜或外窥镜应用的第一光束，以及耦合将第二光束从第二光源耦合到照明光束路径中的装置，由此耦合装置被配置成使得在耦合位置处，第二光束的横截面小于横截面第一光束的表面。

5. 发明申请

US20060240038A1 Cells used as carriers for bacteria 审中-公开
标题翻译：细胞用作细菌的载体
公开(公告)号：US20060240038A1
公开(公告)日：2006-10-26
申请号：US10559663
申请日：2004-06-07
申请人： Joachim Fensterle , Werner Goebel , Ulf Rapp , Jochen Stritzker , Andreas Schmidt , Ivatlo Gentschev , Tamara Potapenko
发明人： Joachim Fensterle , Werner Goebel , Ulf Rapp , Jochen Stritzker , Andreas Schmidt , Ivatlo Gentschev , Tamara Potapenko
IPC分类号： A61K39/12
CPC分类号： A61K35/17 , A61K35/12 , A61K35/13 , A61K35/15 , A61K35/74 , A61K2035/11 , A61K2039/5152 , A61K2039/5154 , A61K2039/521 , A61K2039/522 , A61K2039/523 , Y02A50/478 , Y02A50/484
摘要： The invention relates to the use of a cell, which is charged with a micro-organism that contains foreign DNA, in particular a bacterial micro-organism, to produce a pharmaceutical composition. Preferably, the foreign DNA codes for a defined active agent and the pharmaceutical composition is designed for use in the prophylaxis or treatment of a disease that can be treated with said active agent.
摘要翻译：本发明涉及细胞的使用，其中装有含有外来DNA的微生物，特别是细菌微生物，以产生药物组合物。优选地，将限定的活性剂和药物组合物的外源DNA编码设计用于预防或治疗可用所述活性剂治疗的疾病。

6. 发明授权

US5987777A Dry end 有权
标题翻译：干端
公开(公告)号：US5987777A
公开(公告)日：1999-11-23
申请号：US091715
申请日：1998-09-09
申请人： Werner Goebel , Karlheinz Straub
发明人： Werner Goebel , Karlheinz Straub
IPC分类号： D21F5/04 , D21G9/00 , F26B3/00 , D21F5/00
CPC分类号： D21G9/0063 , D21F5/042
摘要： The invention relates to a dry end for drying a material web, in particular a paper or cardboard web, having at least one drying group with a plurality of drying cylinders and web guiding rollers and at least one nozzle device for transporting the threading part of the material web along a winding path by means of at least one conveyor band. The dry end is characterised in that groups of at least two nozzle devices (17, 19, 21) located at the same side of the material web (11) follow each other in the direction of transport of the material web (11).
摘要翻译： PCT No.PCT / EP96 / 05798 371 1998年9月9日第 102（e）1998年9月9日PCT PCT 1996年12月21日PCT公布。公开号WO97 / 23690 日期1997年7月3日本发明涉及用于干燥材料纤维网，特别是纸或纸板幅材的干燥端，其具有至少一个具有多个干燥筒和幅材引导辊的干燥组和至少一个用于输送的喷嘴装置通过至少一个传送带，沿着卷绕路径的材料卷材的穿线部分。干端的特征在于，位于材料纤维网（11）的同一侧的至少两个喷嘴装置（17,19,21）的组在材料纤维网（11）的输送方向上彼此相邻。

7. 发明授权

US5733724A Oligonucleotides for the detection of enterobacteriaceae selected from salmolysin 失效
标题翻译：用于检测选自溶血素的肠杆菌科的寡核苷酸
公开(公告)号：US5733724A
公开(公告)日：1998-03-31
申请号：US332747
申请日：1994-11-01
申请人： Andreas Bubert , Werner Goebel , Monika Goetz , Albrecht Ludwig , Peter Schubert , Siegfried Neumann
发明人： Andreas Bubert , Werner Goebel , Monika Goetz , Albrecht Ludwig , Peter Schubert , Siegfried Neumann
IPC分类号： C12N15/09 , C07H21/04 , C12Q1/68 , C12R1/42 , C07H21/02 , C12P19/34
CPC分类号： C12Q1/689
摘要： The invention relates to oligonucleotides which are suitable for use as nucleic acid probes or as primers for the detection of Enterobacteriaceae, in particular of pathogenic Enterobacteriaceae, such as, for example, Salmonella sp. The oligonucieotides according to the invention are selected from the salmolysin-like DNA region and possess a sequence according to one of the formulae IIIa to IIIh, or a corresponding complementary sequence: ______________________________________ GAA TAT ATT GCG TTA GAT TAA T IIIa (SEQ ID NO:19) AAA CTG AAG CTA CAG GTG CC IIIb (SEQ ID NO:20) CTT AGC AAG CTA ATT ATA AGG IIIc (SEQ ID NO:21) GGC ACG GTT GGT GCG CAT TTG G IIId (SEQ ID NO:22) GCC ATA CGT GTG GCC ATG TGA IIIe (SEQ ID NO:23) GGC GTG TGG TCA GTA ACC TGA IIIf (SEQ ID NO:24) TTG CTG GCC AGC ACG ACA CG IIIg (SEQ ID NO:25) and GAA TCA TCA CCG CCC TGA AT IIIh (SEQ ID NO:25). ______________________________________
摘要翻译：本发明涉及适合用作核酸探针或用作检测肠杆菌科，特别是病原肠杆菌科的引物的寡核苷酸，例如沙门氏菌属。根据本发明的寡核苷酸选自溶血素样DNA区域，并且具有根据式IIIa至IIIh之一的序列或相应的互补序列：-GAA TAT ATT GCG TTA GAT TAA T IIIa（SEQ ID NO： 19） - AAA CTG AAG CTA CAG GTG CC IIIb（SEQ ID NO：20） - CTT AGC AAG CTA ATT ATA AGG IIIc（SEQ ID NO：21）-GGC ACG GTT GGT GCG CAT TTG G IIId（SEQ ID NO：22 ） - GCC ATA CGT GTG GCC ATG TGA IIIe（SEQ ID NO：23）-GGC GTG TGG TCA GTA ACC TGA IIIf（SEQ ID NO：24）-TTG CTG GCC AGC ACG ACA CG IIIg（SEQ ID NO：25）和 - GAA TCA TCA CCG CCC TGA AT IIIh（SEQ ID NO：25）。 -

8. 发明申请

US20060105423A1 Microorganisms as carriers of nucleotide sequences coding for cell antigens used for the treatment of tumors 审中-公开
标题翻译：微生物作为编码用于治疗肿瘤的细胞抗原的核苷酸序列的载体
公开(公告)号：US20060105423A1
公开(公告)日：2006-05-18
申请号：US10506096
申请日：2003-02-13
申请人： Ulf Rapp , Werner Goebel , Ivaylo Gentschev , Joachim Fensterle
发明人： Ulf Rapp , Werner Goebel , Ivaylo Gentschev , Joachim Fensterle
IPC分类号： C07K14/195 , C07K14/245 , C07H21/04 , C12P21/06 , C12N15/74 , C12N1/21
CPC分类号： C12N9/1205 , A61K39/00 , A61K39/0011 , A61K2039/523 , A61K2039/53 , C07K14/255 , C07K14/4748 , C07K2319/02 , C12R1/42
摘要： The invention relates to a microorganism with a nucleotide sequence coding for a cell antigen in which the following components are inserted and are expressible: I) a nucleotide sequence coding for at least one epitope of an antigen of a tumor cell and/or a nucleotide sequence for at least one epitope of an antigen that is specific for a tissue cell from which the tumor originates; II) an optional nucleotide sequence coding for a protein that stimulates cells of the immune system; IIIA) a nucleotide sequence for a transport system which makes it possible to express the expression product of components I) and, optionally, II) on the outer surface of the bacterium and/or secrete the expression product of component I) and, optionally, of component II); and/or IIIB) a nucleotide sequence for a protein used for lysing the microorganisms in the cytosol of mammalian cells and for intracellularly releasing plasmids which are contained in the lysed microorganisms; and IV) an activation sequence for expressing one or several of components I) to IIIB), said activation sequence being selected among the group consisting of an activation sequence which is capable of being activated in the microorganism, is tissue-cell-specific but not cell-specific. Each of components I) to IV) can be identically or differently arranged in an individual or multiple manner. Also disclosed are uses of such a microorganism for the production of a medicament.
摘要翻译：本发明涉及具有编码细胞抗原的核苷酸序列的微生物，其中插入以下组分并且是可表达的：I）编码肿瘤细胞抗原和/或核苷酸序列的至少一个表位的核苷酸序列对于来自肿瘤的组织细胞特异性的抗原的至少一个表位; II）编码刺激免疫系统细胞的蛋白质的任选的核苷酸序列; IIIA）用于运输系统的核苷酸序列，其使得可以在细菌的外表面上表达组分I）和任选的II）的表达产物和/或分泌组分I）的表达产物，并且任选地，的组分II）; 和/或IIIB）用于裂解哺乳动物细胞的细胞质中的微生物和细胞内释放裂解微生物中所含质粒的蛋白质的核苷酸序列; 和IV）用于表达组分I）至IIIB）中的一种或几种的活化序列，所述活化序列选自能够在微生物中活化的活化序列是组织细胞特异性但不是组织细胞特异性细胞特异性组件I）至IV中的每一个）可以以单独或多种方式相同或不同地布置。还公开了这种微生物用于制备药物的用途。

9. 发明申请

US20050222080A1 Cycloglycans suitable to inhibit mammalian infection 审中-公开
标题翻译：适合抑制哺乳动物感染的抗生素
公开(公告)号：US20050222080A1
公开(公告)日：2005-10-06
申请号：US10502059
申请日：2003-01-20
申请人： Bernd Stahl , Berndt Finke , Joachim Schmitt , Werner Goebel , Jorg Slaghuis , Gunther Boehm
发明人： Bernd Stahl , Berndt Finke , Joachim Schmitt , Werner Goebel , Jorg Slaghuis , Gunther Boehm
IPC分类号： A61K31/715 , A61K31/724
CPC分类号： A61K31/715 , Y02A50/473
摘要： Described is the use of in particular homopolymer cycloglycans having a ring-shaped base structure of 2 to 40 monosaccharides in the ring, for preventing the invasion and infection of mammal cells by pathogens, and for combating diseases caused by such pathogens, and food compositions, dietetic compositions and pharmaceutical compositions containing these cycloglycans.
摘要翻译：描述了特别是在环中具有2至40个单糖的环状基本结构的均聚物环糊精的用途，用于防止病原体侵染和感染哺乳动物细胞，以及用于防治由这种病原体引起的疾病，以及食物组合物，饮食组合物和含有这些循环体的药物组合物。

10. 发明申请

US20050004070A1 Anti-infectious carbohydrates 失效
标题翻译：抗感染性碳水化合物
公开(公告)号：US20050004070A1
公开(公告)日：2005-01-06
申请号：US10490102
申请日：2002-09-25
申请人： Bernd Stahl , Berndt Finke , Joachim Schmitt , Werner Goebel , Jorg Slaghuis
发明人： Bernd Stahl , Berndt Finke , Joachim Schmitt , Werner Goebel , Jorg Slaghuis
IPC分类号： A61K31/702 , A61K31/715 , A61P31/00 , A61K31/739 , C08B37/00
CPC分类号： A61K31/702 , A61K31/715
摘要： Neutral straight-chain or branched oligosaccharides for preventing the invasion and infection of mammal cells by pathogens and for fighting diseases caused by such pathogens are disclosed. Food, dietetic products and pharmaceutical agents containing oligosaccharides consist of a base unit of formula (I), and between 0 and 19 other units of formula (II), which are linked directly or indirectly to the base unit. Gal represents a galactose monosaccharide unit; Glc represents a glucose monosaccharide unit; HexNAc rpresents an N-acetylated galactosamine or glucosamine monosaccharide unit (GalNAc or GlcNAc); R independently represent a β 1-3 or β 1-6 glycosidic link to HexNAc monosaccharide of the next [Gal-HexNAc] unit (II), and on a terminal [Gal-HexNAc] unit, or R are not present; and a terminal [Gal-HexNAc] unit, wherein R represent a deoxyhexose radical, can have another deoxyhexose radical on the HexNAc monosaccharide unit.
摘要翻译：公开了用于防止病原体侵染和感染哺乳动物细胞并用于与这种病原体引起的疾病的中性直链或支链寡糖。含有寡糖的食品，饮食产品和药剂由式（I）的基本单元和0至19个式（II）的其它单元直接或间接连接到基础单元组成。 Gal代表半乳糖单糖单位; Glc表示葡萄糖单糖单元; HexNAc表示N-乙酰化的半乳糖胺或葡糖胺单糖单元（GalNAc或GlcNAc）; R独立地表示与下一个[Gal-HexNAc]单元（II）的HexNAc单糖的β1-3或β1-6糖基连接，并且在末端[Gal-HexNAc]单元上，或R不存在; 和末端[Gal-HexNAc]单元，其中R表示脱氧己糖基团，可以在HexNAc单糖单元上具有另一脱氧己糖基团。

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