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1. 发明申请

US20080039465A1 TRIAZOLYL PHENYL BENZENESULFONAMIDES 有权
标题翻译：三唑基苯并噻二唑
公开(公告)号：US20080039465A1
公开(公告)日：2008-02-14
申请号：US11775585
申请日：2007-07-10
申请人： Trevor Charvat , Cheng Hu , Anita Melikian , Aaron Novack , Andrew Pennell , Sreenivas Punna , Edward Sullivan , Xuefei Tan , William Thomas , Solomon Ungashe , Yibin Zeng
发明人： Trevor Charvat , Cheng Hu , Anita Melikian , Aaron Novack , Andrew Pennell , Sreenivas Punna , Edward Sullivan , Xuefei Tan , William Thomas , Solomon Ungashe , Yibin Zeng
IPC分类号： A61K31/4196 , A61K31/422 , A61K31/454 , A61K31/496 , A61K31/5377 , A61P29/00 , A61P3/00 , A61P37/00 , A61P9/00 , A61P9/10 , C07D249/08 , C07D403/04 , C07D403/06 , C07D405/04 , C07D413/04 , C07D413/06
CPC分类号： C07D249/08 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
摘要： Compounds are provided that act as potent antagonists of the CCR2 or CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2 and CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2-mediated diseases, CCR9-mediated diseases, as controls in assays for the identification of CCR2 antagonists and as controls in assays for the identification of CCR9 antagonists.
摘要翻译：提供了作为CCR2或CCR9受体的有效拮抗剂的化合物。动物试验表明，这些化合物可用于治疗炎症，CCR2和CCR9的标志性疾病。化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR2介导的疾病，CCR9介导的疾病的方法，作为用于鉴定CCR2拮抗剂的测定中的对照和用于鉴定CCR9拮抗剂的测定中的对照。

2. 发明申请

US20070254915A1 CXCR4 MODULATORS 有权
标题翻译： CXCR4调制器
公开(公告)号：US20070254915A1
公开(公告)日：2007-11-01
申请号：US11694935
申请日：2007-03-30
申请人： Manmohan Leleti , William Thomas , Penglie Zhang , Andrew Pennell
发明人： Manmohan Leleti , William Thomas , Penglie Zhang , Andrew Pennell
IPC分类号： A61K31/4709 , A61K31/454 , A61K31/4162 , C07D491/02
CPC分类号： C07D491/052 , C07D231/54 , C07D471/04 , C07D491/04
摘要： The present invention is directed to novel compounds and pharmaceutical compositions that inhibit the binding of the SDF-1 chemokine to the chemokine receptor CXCR4 and/or the binding of the SDF-1 or I-TAC chemokines to the chemokine receptor CCXCKR2 (CXCR7). These compounds are useful in preventing tumor cell proliferation, tumor formation, metastasis, inflammatory diseases, treatment of HIV infectivity, treatment of stem cell differentiation and mobilization disorders, and ocular disorders.
摘要翻译：本发明涉及抑制SDF-1趋化因子与趋化因子受体CXCR4的结合和/或SDF-1或I-TAC趋化因子与趋化因子受体CCXCKR2（CXCR7）的结合的新化合物和药物组合物。这些化合物可用于预防肿瘤细胞增殖，肿瘤形成，转移，炎性疾病，HIV感染的治疗，治疗干细胞分化和动员障碍以及眼部疾病。

3. 发明申请

US20070275965A1 CXCR4 modulators 有权
标题翻译： CXCR4调节剂
公开(公告)号：US20070275965A1
公开(公告)日：2007-11-29
申请号：US11731695
申请日：2007-03-30
申请人： William Thomas , Manmohan Leleti , Andrew Pennell
发明人： William Thomas , Manmohan Leleti , Andrew Pennell
IPC分类号： A61K31/403 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/421 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/5377 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , C07D209/02 , C07D209/10 , C07D209/56 , C07D209/82 , C07D215/06 , C07D231/56 , C07D235/08 , C07D249/04 , C07D263/58 , C07D295/02 , C07D401/02 , C07D471/04
CPC分类号： C07D209/08 , C07D209/10 , C07D209/18 , C07D209/30 , C07D209/42 , C07D231/56 , C07D235/08 , C07D235/10 , C07D235/18 , C07D235/24 , C07D263/58 , C07D401/04 , C07D403/04 , C07D471/04
摘要： The present invention is directed to novel compounds and pharmaceutical compositions that inhibit the binding of the SDF-1 chemokine to the chemokine receptor CXCR4 and/or the binding of the SDF-1 or I-TAC chemokines to the chemokine receptor CCXCKR2 (CXCR7). These compounds are useful in preventing tumor cell proliferation, tumor formation, metastasis, inflammatory diseases, treatment of HIV infectivity, treatment of stem cell differentiation and mobilization disorders, and ocular disorders.
摘要翻译：本发明涉及抑制SDF-1趋化因子与趋化因子受体CXCR4的结合和/或SDF-1或I-TAC趋化因子与趋化因子受体CCXCKR2（CXCR7）的结合的新化合物和药物组合物。这些化合物可用于预防肿瘤细胞增殖，肿瘤形成，转移，炎性疾病，HIV感染的治疗，治疗干细胞分化和动员障碍以及眼部疾病。

4. 发明申请

US20070112015A1 Substituted dihydropyridines and methods of use 审中-公开
标题翻译：取代的二氢吡啶类及其使用方法
公开(公告)号：US20070112015A1
公开(公告)日：2007-05-17
申请号：US11590658
申请日：2006-10-30
申请人： Clarence Hurt , Andrew Pennell , John Wright , Manmohan Leleti , Qiang Wang , William Thomas , Yandong Li , Dean Dragoli
发明人： Clarence Hurt , Andrew Pennell , John Wright , Manmohan Leleti , Qiang Wang , William Thomas , Yandong Li , Dean Dragoli
IPC分类号： A61K31/519 , A61K31/4745 , A61K31/4741 , C07D491/02 , C07D487/02 , C07D471/02
CPC分类号： C07D217/22 , C07D217/26 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/04 , C07D417/04 , C07D471/04 , C07D491/04
摘要： Compounds are provided that are modulators of the C5a receptor. The compounds are substituted dihydropyridines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of C5a receptors.
摘要翻译：提供了作为C5a受体调节剂的化合物。化合物是取代的二氢吡啶并且可用于药物组合物，用于治疗涉及C5a受体的病理活化的疾病和病症的方法。

5. 发明授权

US11406886B1 Punching bag having two sections 有权
公开(公告)号：US11406886B1
公开(公告)日：2022-08-09
申请号：US16995949
申请日：2020-08-18
申请人： William Thomas
发明人： William Thomas
IPC分类号： A63B69/20 , A63B69/24 , A63B69/00 , A63B69/34 , A63B71/14
摘要： The punching bag having two sections is a physical training apparatus. The punching bag having two sections is adapted for use in training participants in combat sports. The punching bag having two sections presents a plurality of targets that are struck during training activities. The punching bag having two sections incorporates a plurality of punching bags, an internal fastener, and a harness. The internal fastener interconnect the plurality of punching bags. The harness limits the motion of a first punching bag selected from the plurality of punching bags relative to a second punching bag selected from the plurality of punching bags. Each of the plurality of punching bags forms a target selected from the plurality of targets.

6. 发明授权

US08613020B2 Program guide system with flip and browse advertisements 有权
公开(公告)号：US08613020B2
公开(公告)日：2013-12-17
申请号：US11371490
申请日：2006-03-08
申请人： Edward Knudson , Joel Hassell , Connie Marshall , Thomas Lemmons , Steven Reynolds , Robert Knee , Kenneth Carpenter, Jr. , William Thomas , W. Benjamin Herrington , Steven Williamson , Michael Ellis , Donald Allison
发明人： Edward Knudson , Joel Hassell , Connie Marshall , Thomas Lemmons , Steven Reynolds , Robert Knee , Kenneth Carpenter, Jr. , William Thomas , W. Benjamin Herrington , Steven Williamson , Michael Ellis , Donald Allison
IPC分类号： H04N5/445
CPC分类号： H04N21/482 , G06F3/0482 , H04N5/44543 , H04N5/45 , H04N21/4312 , H04N21/4316 , H04N21/435 , H04N21/478 , H04N21/812
摘要： An interactive television program guide is provided in which advertisements may be displayed in program listings display regions on program guide screens. The program listings display regions may be browse displays or flip displays. The program guide screens contain video for the current channel to which the user is tuned. The program listings display regions containing the advertisements may be overlaid on top of the current channel. Alternatively, the video for the current channel may be provided in a reduced-size video window. The advertisements may contain video. The advertisements may be used to promote television programs and conventional goods and services. Advertisements may be selectable. When a user selects an advertisement, the program guide provides the user with an opportunity to order products or services, request information, set reminders for upcoming programs, view program descriptions, record programs, or take other such actions.

7. 发明授权

US08250970B2 Substance holder with removable insert 有权
标题翻译：具有可移除插入物的物质支架
公开(公告)号：US08250970B2
公开(公告)日：2012-08-28
申请号：US11140673
申请日：2005-05-27
申请人： William Thomas
发明人： William Thomas
IPC分类号： A47J31/24
CPC分类号： A47J31/0663 , A47J31/4467
摘要： A substance holder and an insert for use in the substance holder. The insert elevates a brewing substance, filter or pod above a floor of the substance holder. The substance holder and insert allow water to infuse the brewing substance and allow beverage to drain through a portion of the insert for draining into a container. The insert is retained in the holder and is selectively removable from the holder to facilitate actions, for example but not limited to cleaning of the holder and insert as well as replacing the insert with other structures which may be used with the holder.
摘要翻译：物质支架和用于物质支架的插入物。插入物将物质支架的地板上的冲泡物质，过滤器或荚提升。物质保持器和插入物允许水注入冲泡物质并允许饮料通过插入物的一部分排出以排入容器。插入件被保持在保持器中并且可选择性地从保持器移除，以促进动作，例如但不限于清洁保持器和插入件，以及用可能与保持器一起使用的其它结构来替换插入件。

8. 发明申请

US20070288958A1 Interactive program guide system and method 审中-公开
标题翻译：互动节目指南系统及方法
公开(公告)号：US20070288958A1
公开(公告)日：2007-12-13
申请号：US11788002
申请日：2007-04-17
申请人： Edward Knudson , Michael Ellis , W. Herrington , Steven Williamson , Pamela McKissick , William Thomas , David Berezowski , Kenneth Carpenter , Jeffrey Ross , Daniel Hagenbuch , Steven Reynolds , David Rudnick
发明人： Edward Knudson , Michael Ellis , W. Herrington , Steven Williamson , Pamela McKissick , William Thomas , David Berezowski , Kenneth Carpenter , Jeffrey Ross , Daniel Hagenbuch , Steven Reynolds , David Rudnick
IPC分类号： G06F3/00
CPC分类号： H04N21/488 , G06F3/0482 , H04N5/44543 , H04N7/17318 , H04N7/17327 , H04N21/23614 , H04N21/4135 , H04N21/42204 , H04N21/4316 , H04N21/4348 , H04N21/4532 , H04N21/4542 , H04N21/4622 , H04N21/47 , H04N21/472 , H04N21/47211 , H04N21/47214 , H04N21/4755 , H04N21/478 , H04N21/4782 , H04N21/4828 , H04N21/6547 , H04N21/812 , H04N21/8586
摘要： An interactive television program guide system and method is provided. Time separators are displayed within lists of program listings to allow users to more easily view the program listings. On-screen arrows have their display characteristics changed according to user actions. Similar program listings are displayed only once when using search program listings. Users are provided with an opportunity to view channel information before setting channels as favorites. Information from local information services is provided in program guide display screens that are configurable by a main facility. Users are provided with an opportunity to centrally lock and unlock programs, and to bypass locks when desired.
摘要翻译：提供了交互式电视节目指南系统和方法。时间分隔符显示在程序列表的列表中，以允许用户更轻松地查看程序列表。屏幕上的箭头显示特征根据用户操作而改变。使用搜索程序列表时，类似的程序列表只显示一次。在将频道设为收藏夹之前，向用户提供了查看频道信息的机会。来自本地信息服务的信息在可由主要设施配置的节目指南显示屏幕中提供。为用户提供了集中锁定和解锁程序的机会，并在需要时绕过锁定。

9. 发明申请

US20060029608A1 Immunization against clostridium difficile disease 审中-公开
标题翻译：针对艰难梭菌病的免疫
公开(公告)号：US20060029608A1
公开(公告)日：2006-02-09
申请号：US11235609
申请日：2005-09-26
申请人： William Thomas , Paul Giannasca , Zhenxi Zhang , Wende Lei , Thomas Monath
发明人： William Thomas , Paul Giannasca , Zhenxi Zhang , Wende Lei , Thomas Monath
IPC分类号： A61K39/40 , A61K39/08 , C07K14/33
CPC分类号： A61K39/08 , A61K39/00 , A61K39/39 , A61K2039/505 , A61K2039/521 , A61K2039/54 , A61K2039/55505 , A61K2039/55511 , C07K14/33 , C07K16/1282 , C07K2317/76 , C12N9/1051 , G01N33/56911 , G01N2333/33 , G01N2469/20
摘要： The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
摘要翻译：本发明提供了用于预防和治疗艰难梭菌感染的主动和被动免疫方法，其涉及经皮给予艰难梭菌毒素中和多克隆免疫球蛋白，艰难梭菌类毒素或其组合。本发明还提供了艰难梭菌类毒素，艰难梭菌毒素中和多克隆免疫球蛋白，以及鉴定产生艰难梭菌毒素中和多克隆免疫球蛋白的受试者的方法。

10. 发明申请

US20050262542A1 Television chat system 审中-公开
标题翻译：电视聊天系统
公开(公告)号：US20050262542A1
公开(公告)日：2005-11-24
申请号：US10918753
申请日：2004-08-12
申请人： Toby DeWeese , Pamela McKissick , William Thomas , Michael Ellis
发明人： Toby DeWeese , Pamela McKissick , William Thomas , Michael Ellis
IPC分类号： G06F13/00 , H04N7/14 , H04N7/15 , H04N7/16 , H04N7/173 , G06F9/00
CPC分类号： H04N21/4788 , H04L12/1818 , H04N7/147 , H04N7/17318 , H04N21/2408 , H04N21/254 , H04N21/2665 , H04N21/4223 , H04N21/431 , H04N21/4316 , H04N21/454 , H04N21/4622 , H04N21/4751 , H04N21/4755 , H04N21/4756 , H04N21/4758 , H04N21/4782 , H04N21/4786 , H04N21/632 , H04N21/6581 , H04N21/812 , H04N21/8173 , H04N21/84 , H04N21/8545
摘要： A television chat system is provided that allows television viewers to engage in real-time communications in chat groups with other television viewers while watching television. Users of the television chat system may engage in real-time communications with other users who are currently watching the same television program or channel. The system allows real-time communications in a chat group to be transmitted between users at user television equipment devices via a television distribution facility. The television chat system of the present invention permits users to join chat groups related to television programs, channels, or categories of programs that the user may be interested in. Real-time communications may be textual messages, audio communications, or video communications. The television chat system may also allow users to send chat requests to ask other users to enter a chat group. The system also permits users to establish chat groups that television viewers are permitted to join. The television chat system may be based on an interactive television program guide or set-top box application implemented on a set-top box.
摘要翻译：提供电视聊天系统，其允许电视观众在观看电视的同时与其他电视观众进行聊天组中的实时通信。电视聊天系统的用户可以与正在观看同一电视节目或频道的其他用户进行实时通信。该系统允许通过电视分配设施在用户电视设备设备的用户之间传输聊天组中的实时通信。本发明的电视聊天系统允许用户加入与电视节目，频道或用户可能感兴趣的节目类别相关的聊天组。实时通信可以是文本消息，音频通信或视频通信。电视聊天系统还可以允许用户发送聊天请求以请求其他用户进入聊天组。该系统还允许用户建立电视观众允许加入的聊天组。电视聊天系统可以基于在机顶盒上实现的交互式电视节目指南或机顶盒应用程序。

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