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1. 发明授权

US10765731B2 Fusion of heterooligomeric mycobacterial antigens 有权
公开(公告)号：US10765731B2
公开(公告)日：2020-09-08
申请号：US15110514
申请日：2015-01-09
申请人： TRANSGENE SA
发明人： Jean-Baptiste Marchand , Nathalie Silvestre , François Penin
IPC分类号： A61K39/00 , A61K39/02 , A61K39/04 , C07H21/00 , C07K14/35 , C07K16/12 , A61K45/06
摘要： The present invention relates generally to novel immunogenic combinations comprising or encoding at least two heterooligomeric mycobacterial antigens and preferably a fusion polypeptide comprising said two heterooligomeric mycobacterial antigens, where the mycobacterial antigens are selected from the group of Esx, PE and PPE antigens of a Mycobacterium species, particularly a Mycobacterium of the tuberculosis complex such as Mycobacterium tuberculosis (Mtb). The present invention also relates to vectors, host cells and compositions comprising or encoding said immunogenic combination as well as to methods for expressing and producing it. The present invention also relates to methods of using said immunogenic combination, fusion polypeptide, vector, host cell, composition particularly for inducing or stimulating an immune response with the goal of providing a protective response against a Mycobacterium infection or any disease caused by or associated with a Mycobacterium infection.

2. 发明授权

US10357555B2 Mycobacterial antigen vaccine 有权
公开(公告)号：US10357555B2
公开(公告)日：2019-07-23
申请号：US14413565
申请日：2013-07-10
申请人： TRANSGENE SA
发明人： Emmanuel Tupin , Romain Micol , Charles Antoine Coupet , Geneviève Inchaupse , Marie Gouanvic , Nathalie Silvestre , Jean-Baptiste Marchand , Cécile Beny
IPC分类号： A61K39/00 , A61K39/04 , C07K14/35 , C07K16/12
摘要： The present invention relates generally to immunogenic combinations comprising at least five antigens of a Mycobacterium species as well as fusion thereof and nucleic acid molecules encoding such combined antigens and fusion. The present invention also relates to nucleic acid molecules, vectors, host cells and compositions comprising or encoding said combinations of mycobacterial antigens and fusion polypeptides as well as to methods for recombinantly producing them. The present invention also relates to methods of using said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions particularly for inducing or stimulating an immune response against a Mycobacterium infection or any disease caused by or associated with a Mycobacterium infection. The present invention also concerns antibodies directed to such mycobacterial antigens and fusion polypeptides that can be used in the diagnosis of a Mycobacterium infection and method of detection as well as kits of reagent comprising said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions or antibodies.

3. 发明申请

US20150165014A1 Mycobacterial Antigen Vaccine 审中-公开
标题翻译：分枝杆菌抗原疫苗
公开(公告)号：US20150165014A1
公开(公告)日：2015-06-18
申请号：US14413565
申请日：2013-07-10
申请人： TRANSGENE SA
发明人： Emmanuel Tupin , Romain Micol , Charles Antoine Coupet , Geneviève Inchaupse , Marie Gouanvic , Nathalie Silvestre , Jean-Baptiste Marchand , Cécile Beny
IPC分类号： A61K39/04 , C07K16/12 , C07K14/35
CPC分类号： A61K39/04 , A61K2039/51 , A61K2039/53 , C07K14/35 , C07K16/1289 , C07K2319/00 , C07K2319/40
摘要： The present invention relates generally to immunogenic combinations comprising at least five antigens of a Mycobacterium species as well as fusion thereof and nucleic acid molecules encoding such combined antigens and fusion. The present invention also relates to nucleic acid molecules, vectors, host cells and compositions comprising or encoding said combinations of mycobacterial antigens and fusion polypeptides as well as to methods for recombinantly producing them. The present invention also relates to methods of using said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions particularly for inducing or stimulating an immune response against a Mycobacterium infection or any disease caused by or associated with a Mycobacterium infection. The present invention also concerns antibodies directed to such mycobacterial antigens and fusion polypeptides that can be used in the diagnosis of a Mycobacterium infection and method of detection as well as kits of reagent comprising said combinations of mycobacterial antigens, fusion polypeptides, vectors, host cells, compositions or antibodies.
摘要翻译：本发明一般涉及包含分枝杆菌属物种的至少五种抗原及其融合物和编码这种组合抗原和融合物的核酸分子的免疫原性组合。本发明还涉及包含或编码分枝杆菌抗原和融合多肽的所述组合的核酸分子，载体，宿主细胞和组合物以及重组产生它们的方法。本发明还涉及使用分枝杆菌抗原，融合多肽，载体，宿主细胞，特别用于诱导或刺激针对分枝杆菌感染的免疫应答或由分枝杆菌感染引起或与分枝杆菌感染相关的任何疾病的组合的组合的方法。本发明还涉及可用于诊断分枝杆菌感染的这种分枝杆菌抗原和融合多肽的抗体以及检测方法以及包含分枝杆菌抗原，融合多肽，载体，宿主细胞的所述组合的试剂盒，组合物或抗体。

4. 发明授权

US11779619B2 Oncolytic virus for expression of immune checkpoint modulators 有权
公开(公告)号：US11779619B2
公开(公告)日：2023-10-10
申请号：US16725485
申请日：2019-12-23
申请人： Transgene SA
发明人： Nathalie Silvestre , Michel Geist , Karola Rittner , Jean-Baptiste Marchand , Christine Thioudellet
IPC分类号： A61K35/768 , C07K16/28 , C12N15/863 , A61K9/00 , C07K14/535 , A61K39/00 , A61K35/763 , A61K35/761 , A61K47/02 , A61K9/08 , C12N7/00 , C12N9/10 , C12N9/80
CPC分类号： A61K35/768 , A61K9/0019 , C07K14/535 , C07K16/2818 , C07K16/2896 , C12N15/8636 , C12Y204/02009 , A61K9/08 , A61K35/761 , A61K35/763 , A61K47/02 , A61K2039/505 , A61K2039/5256 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C12N7/00 , C12N9/1077 , C12N9/80 , C12N2710/24121 , C12N2710/24132 , C12N2799/023 , C12Y305/01023
摘要： The present invention provides an oncolytic virus comprising nucleotide sequence(s) encoding one or more immune checkpoint modulator(s). It also concerns a pharmaceutical composition comprising effective amount of said oncolytic virus and, eventually, a pharmaceutically acceptable vehicle and its use for treating proliferative diseases such as cancers.

5. 发明授权

US10555981B2 Oncolytic virus for expression of immune checkpoint modulators 有权
公开(公告)号：US10555981B2
公开(公告)日：2020-02-11
申请号：US15325562
申请日：2015-07-16
申请人： Transgene SA
发明人： Nathalie Silvestre , Michel Geist , Karola Rittner , Jean-Baptiste Marchand , Christine Thioudellet
IPC分类号： A61K35/768 , C07K16/28 , A61K9/00 , C07K14/535 , C12N7/00 , C12N9/10 , C12N9/80 , A61K39/00
摘要： The present invention provides an oncolytic virus comprising nucleotide sequence(s) encoding one or more immune checkpoint modulator(s). It also concerns a pharmaceutical composition comprising effective amount of said oncolytic virus and, eventually, a pharmaceutically acceptable vehicle and its use for treating proliferative diseases such as cancers.

6. 发明申请

US20170157188A1 ONCOLYTIC VIRUS FOR EXPRESSION OF IMMUNE CHECKPOINT MODULATORS 审中-公开
公开(公告)号：US20170157188A1
公开(公告)日：2017-06-08
申请号：US15325562
申请日：2015-07-16
申请人： Transgene SA
发明人： Nathalie Silvestre , Michel Geist , Karola Rittner , Jean-Baptiste Marchand , Christine Thioudellet
IPC分类号： A61K35/768 , C07K16/28 , A61K45/06 , C12N9/10 , C07K14/535 , A61K9/00 , C12N7/00 , C12N9/80
摘要： The present invention provides an oncolytic virus comprising nucleotide sequence(s) encoding one or more immune checkpoint modulator(s). It also concerns a pharmaceutical composition comprising effective amount of said oncolytic virus and, eventually, a pharmaceutically acceptable vehicle and its use for treating proliferative diseases such as cancers.

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