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1. 发明专利

JP2014061187A Packaging material and package structure using the same 有权
标题翻译：包装材料和包装结构使用相同
公开(公告)号：JP2014061187A
公开(公告)日：2014-04-10
申请号：JP2012208811
申请日：2012-09-21
申请人： Toyo Seikan Kaisha Ltd , 東洋製罐株式会社 , Nitto Denko Corp , 日東電工株式会社
发明人： ISHIZAKI YOICHI , OTA YOSHIHIRO , HANATANI AKINORI , SAKAMOTO SACHIKO , MUKAIHATA GO , IWAO YOSHIHIRO
IPC分类号： A61J1/00 , A61K9/70 , A61K31/138 , A61K45/00
CPC分类号： A61K9/7038 , A61K9/7061 , B32B7/12 , B32B15/082 , B32B15/095 , B32B27/08 , B32B27/308 , B32B27/36 , B32B27/40 , B32B2307/7244 , B32B2307/7246 , B32B2307/74 , B32B2439/80 , B65D75/30 , Y10T428/1379
摘要： PROBLEM TO BE SOLVED: To provide a packaging material that is capable of long term storage by preventing adsorption or transfer of an easily oxidizable component and an oily component in an adhesive of a patch to the packaging material, and also preventing discoloration and decrease in a drug effect due to oxidization.SOLUTION: Provided with a packaging material for a patch including: an inner layer made of polyethylene terephthalate having heat sealing properties; an oxygen-absorbing layer that includes an oxygen-absorbing resin having an unsaturated alicyclic structure as an oxygen-absorbing part; and an oxygen barrier layer made of aluminum foil as an outer layer.
摘要翻译：要解决的问题：提供一种能够通过防止粘合剂中的易氧化组分和油性组分吸附或转移到包装材料上而能够长期储存的包装材料，并且还防止变色和减少由于氧化引起的药物作用。解决方案：提供用于贴片的包装材料，包括：具有热封性的由聚对苯二甲酸乙二酯制成的内层; 氧吸收层，其包含具有不饱和脂环结构的氧吸收性树脂作为氧吸收部; 以及由铝箔制成的氧阻隔层作为外层。

2. 发明专利

JP2013060395A Composition for enhancing transdermal absorption and patch preparation 有权
标题翻译：用于增强超吸收和配制的组合物
公开(公告)号：JP2013060395A
公开(公告)日：2013-04-04
申请号：JP2011200023
申请日：2011-09-13
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： OKAZAKI ARIMICHI , MUKAIHATA GO , SAKAMOTO SACHIKO , HANATANI AKINORI
IPC分类号： A61K9/70 , A61K45/00 , A61K47/10 , A61K47/18
CPC分类号： A61K9/7038 , A61K9/0014 , A61K9/7084 , A61K31/405 , A61K31/41 , A61K31/422 , A61K31/565
摘要： PROBLEM TO BE SOLVED: To provide a composition for enhancing transdermal absorption which shows a sufficiently high enhancing effect on transdermal absorption of a drug, particularly, a composition for enhancing transdermal absorption which shows a sufficiently high enhancing effect on transdermal absorption of an acidic drug.SOLUTION: This invention relates to: a composition for enhancing transdermal absorption containing a 12-20C unsaturated higher alcohol and a 3-8C polyhydric alcohol; and a composition for enhancing transdermal absorption containing a 12-20C unsaturated higher alcohol, a 3-8C polyhydric alcohol and a 2-9C organic amine.
摘要翻译：待解决的问题：提供一种用于增强经皮吸收的组合物，其对药物的经皮吸收具有足够高的增强效果，特别是用于增强经皮吸收的组合物，其对于经皮吸收的透皮吸收具有足够高的增强作用酸性药物。解决方案：本发明涉及：含有12-20℃不饱和高级醇和3-8C多元醇的用于增强经皮吸收的组合物; 和含有12-20℃不饱和高级醇，3-8C多元醇和2-9C有机胺的增强经皮吸收的组合物。版权所有（C）2013，JPO＆INPIT

3. 发明专利

JP2014172885A Composition for enhancing transdermal absorption and patch preparation 有权
标题翻译：用于增强超吸收和配制的组合物
公开(公告)号：JP2014172885A
公开(公告)日：2014-09-22
申请号：JP2013048450
申请日：2013-03-11
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： MUKAIHATA GO , OKAZAKI ARIMICHI , HANATANI AKINORI , SAKAMOTO SACHIKO
IPC分类号： A61K9/70 , A61K31/422 , A61K47/10 , A61K47/12
CPC分类号： A61K47/12 , A61K9/0014 , A61K9/7038 , A61K9/7053 , A61K9/7061 , A61K9/7084 , A61K31/138 , A61K31/405 , A61K31/421 , A61K47/10
摘要： PROBLEM TO BE SOLVED: To provide a composition for enhancing transdermal absorption that shows a superior drug transdermal absorption-enhancing effect, and a patch preparation that has a superior drug transdermal absorption property.SOLUTION: The present invention relates to a composition for enhancing transdermal absorption of a drug, containing a polyvalent alcohol having 3 to 8 carbon atoms, an organic acid having 2 to 20 carbon atoms, and a higher alcohol having 12 to 20 carbon atoms, and a patch preparation containing a drug-containing adhesive layer 2 containing the composition and a drug on one surface of a support 5.
摘要翻译：要解决的问题：提供显示出优异的药物透皮吸收增强作用的用于增强经皮吸收的组合物，以及具有优异的药物透皮吸收性的贴片制剂。解决方案：本发明涉及用于增强经皮吸收的组合物含有碳原子数3〜8的多元醇，碳原子数2〜20的有机酸和碳原子数12〜20的高级醇的药物，以及含有含有粘合剂层2的药物粘合剂层2的贴剂组合物和药物在支持体5的一个表面上。

4. 发明专利

JP2013082700A Method for manufacturing patch preparation 有权
标题翻译：制造配方的方法
公开(公告)号：JP2013082700A
公开(公告)日：2013-05-09
申请号：JP2012215943
申请日：2012-09-28
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： SAKAMOTO SACHIKO , HANATANI AKINORI , OKAZAKI ARIMICHI , MUKAIHATA GO
IPC分类号： A61K9/70 , A61K31/196 , A61K31/34 , A61K31/4152 , A61K31/554
CPC分类号： A61K9/7053 , A61K9/7061
摘要： PROBLEM TO BE SOLVED: To provide an economical method for manufacturing a patch preparation causing reduced manufacturing loss, which can provide a patch preparation which has a sufficiently high skin permeation amount of a drug without increasing the area and thickness of an adhesive layer, and hardly causes precipitation of crystal of the drug in the extreme.SOLUTION: The method for manufacturing the patch preparation 1 includes: pouring a composition for forming the adhesive layer into a container 11 having a concave part 12 with a shape corresponding to a patch preparation to be manufactured, wherein the composition contains a drug, an adhesive polymer and an organic solvent; removing the organic solvent from the composition through drying to form a drug-containing adhesive layer 3 in the concave part 12; and then laminating a support 2 on the drug-containing adhesive layer 3 to give the patch preparation 1 comprising the drug-containing adhesive layer 3 formed on one surface of the support 2.
摘要翻译：待解决的问题：提供一种经济的制造造成制造损失减小的贴片制剂的方法，其可以提供具有足够高的药物皮肤渗透量的贴剂，而不增加粘合剂层的面积和厚度，极难造成药物晶体沉淀。制造贴剂1的方法包括：将用于形成粘合剂层的组合物倒入具有与要制造的贴片制剂相对应的形状的具有凹部12的容器11中，其中所述组合物含有药物，粘合剂聚合物和有机溶剂; 通过干燥从组合物中除去有机溶剂，以在凹部12中形成含药物的粘合剂层3; 然后将载体2层压在含药物粘合剂层3上，得到包含在载体2的一个表面上形成的含药物粘合剂层3的贴片制剂1.（C）2013，JPO＆INPIT

5. 发明专利

JP2011225536A Patch preparation, and method for producing the same 有权
标题翻译：配方的制备及其制造方法
公开(公告)号：JP2011225536A
公开(公告)日：2011-11-10
申请号：JP2011061515
申请日：2011-03-18
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： SAKAMOTO SACHIKO , HANATANI AKINORI , OKAZAKI ARIMICHI , AKEMI HITOSHI , IWAO YOSHIHIRO , MATSUOKA KENSUKE
IPC分类号： A61K9/70
CPC分类号： A61K9/7061 , A61K9/7053
摘要： PROBLEM TO BE SOLVED: To provide a patch preparation dispensing with increase of an area and a thickness of a pressure sensitive adhesive layer, capable of acquiring a sufficiently high skin penetration amount of a medicine (namely, excellent releasability of the medicine), and enduring long-term patching with excellent adhesiveness to a skin, and to provide a method for producing the patch preparation.SOLUTION: In the patch preparation including a pressure sensitive adhesive layer containing a medicine on one surface of a support, though a crystal of the medicine is not formed in the pressure sensitive adhesive layer just after a physical stimulus is applied to the pressure sensitive adhesive layer, the crystal of the medicine is formed when being held longer.
摘要翻译：要解决的问题：为了提供能够获得足够高的药物的皮肤渗透量（即，药物的脱模性优异）的粘合剂层的面积和厚度增加的贴剂，并且具有对皮肤的优异粘合性的持久的长期修补，并且提供制备贴剂的方法。解决方案：在包含在载体的一个表面上含有药物的压敏粘合剂层的贴片制剂中，尽管在将物理刺激施加到压力之后没有在压敏粘合剂层中形成药物的晶体当保持较长时，形成药物的结晶。版权所有（C）2012，JPO＆INPIT

6. 发明专利

JP2013060394A Composition for enhancing transdermal absorption and patch preparation 有权
标题翻译：用于增强超吸收和配制的组合物
公开(公告)号：JP2013060394A
公开(公告)日：2013-04-04
申请号：JP2011200021
申请日：2011-09-13
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： OKAZAKI ARIMICHI , MUKAIHATA GO , SAKAMOTO SACHIKO , HANATANI AKINORI
IPC分类号： A61K47/18 , A61K9/70 , A61K31/405 , A61K31/41 , A61K47/10
CPC分类号： A61K9/7061 , A61K31/41 , A61K31/422
摘要： PROBLEM TO BE SOLVED: To provide a composition for enhancing transdermal absorption which shows a sufficiently high enhancing effect on transdermal absorption of an acidic drug.SOLUTION: This composition for enhancing transdermal absorption of an acidic drug includes a 3-8C polyhydric alcohol, a 12-20C higher alcohol and a 2-9C organic amine.
摘要翻译：要解决的问题：提供一种增强透皮吸收的组合物，其对酸性药物的经皮吸收具有足够高的增强作用。解决方案：用于增强酸性药物的经皮吸收的该组合物包括3-8C多元醇，12-20℃高级醇和2-9C有机胺。版权所有（C）2013，JPO＆INPIT

7. 发明专利

JP2013060393A Composition for enhancing transdermal absorption and patch preparation 审中-公开
标题翻译：用于增强超吸收和配制的组合物
公开(公告)号：JP2013060393A
公开(公告)日：2013-04-04
申请号：JP2011200020
申请日：2011-09-13
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： OKAZAKI ARIMICHI , MUKAIHATA GO , SAKAMOTO SACHIKO , HANATANI AKINORI
IPC分类号： A61K47/10 , A61K9/70 , A61K31/405 , A61P29/00
CPC分类号： A61K9/7061 , A61K31/405
摘要： PROBLEM TO BE SOLVED: To provide a composition which shows a sufficiently high enhancing effect on transdermal absorption of a drug, and to provide a patch preparation containing the composition.SOLUTION: This invention relates to a composition containing a 14-20C higher alcohol and a 3-8C polyhydric alcohol, and a patch preparation containing the composition. The higher alcohol is preferably one or two or more kinds of alcohol selected from a group comprising myristyl alcohol, cetyl alcohol, hexyl decanol, stearyl alcohol, isostearyl alcohol, arachyl alcohol and octyl dodecanol. The polyhydric alcohol is preferably one or two or more kinds of alcohol selected from a group comprising propylene glycol, butylene glycol, glycerol, dipropylene glycol and octanediol.
摘要翻译：待解决的问题：提供对药物的经皮吸收具有足够高的增强效果的组合物，以及提供含有该组合物的贴剂。本发明涉及含有14-20℃高级醇和3-8C多元醇的组合物，以及含有该组合物的贴片制剂。高级醇优选为选自肉豆蔻醇，鲸蜡醇，己基癸醇，硬脂醇，异硬脂醇，花生醇和辛基十二烷醇的一种或两种以上的醇。多元醇优选为选自丙二醇，丁二醇，甘油，二丙二醇和辛二醇中的一种或两种以上的醇。版权所有（C）2013，JPO＆INPIT

8. 发明专利

ES2609247T3 Composición para mejorar la absorción transdérmica de un fármaco y preparado en parche 未知
公开(公告)号：ES2609247T3
公开(公告)日：2017-04-19
申请号：ES12184302
申请日：2012-09-13
申请人： NITTO DENKO CORP
发明人： OKAZAKI ARIMICHI , MUKOBATA TSUYOSHI , SAKAMOTO SACHIKO , HANATANI AKINORI
IPC分类号： A61K31/405 , A61K9/70
摘要： Una composición para mejorar la absorción transdérmica de un fármaco, que comprende un alcohol superior que tiene 14-20 átomos de carbono y un alcohol polivalente que tiene 3-4 átomos de carbono, en donde el alcohol superior es una o más clases seleccionadas del grupo que consiste en alcohol de estearilo, alcohol de isoestearilo y octildodecanol.

9. 发明专利

BRPI0912099A2 preparação percutaneamente absorvível 未知
公开(公告)号：BRPI0912099A2
公开(公告)日：2015-10-06
申请号：BRPI0912099
申请日：2009-05-28
申请人： EISAI R&D MAN CO LTD , NITTO DENKO CORP
发明人： HANATANI AKINORI , AKEMI HITOSHI , SEKIYA JUNICHI , SAKAMOTO SACHIKO , MARUYAMA SUMIYO
IPC分类号： A61K9/70 , A61K31/4465 , A61P25/28

10. 发明专利

CA2845165A1 COMPOSITION FOR ENHANCING TRANSDERMAL ABSORPTION OF DRUG AND PATCH PREPARATION 未知
公开(公告)号：CA2845165A1
公开(公告)日：2014-09-11
申请号：CA2845165
申请日：2014-03-07
申请人： NITTO DENKO CORP
发明人： MUKOBATA TSUYOSHI , OKAZAKI ARIMICHI , HANATANI AKINORI , SAKAMOTO SACHIKO
IPC分类号： A61K47/12 , A61K9/70 , A61K47/10
摘要： The present invention relates to a composition for enhancing transdermal absorption of a drug, containing a polyvalent alcohol having 3 to 8 carbon atoms, an organic acid having 2 to 20 carbon atoms, and a higher alcohol having 12 to 20 carbon atoms, and a patch preparation containing a support and a drug-containing adhesive layer containing the composition on one surface of the support.

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