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    • 1. 发明授权
    • Mass spectrometer system
    • 质谱仪系统
    • US07932486B2
    • 2011-04-26
    • US12330374
    • 2008-12-08
    • Akihiro SanoAtsumu HirabayashiYasushi TeruiKinya KobayashiKiyomi YoshinariKenko UchidaToshiyuki Yokosuka
    • Akihiro SanoAtsumu HirabayashiYasushi TeruiKinya KobayashiKiyomi YoshinariKenko UchidaToshiyuki Yokosuka
    • H01J49/26
    • G01N33/6851G01N33/6848H01J49/0031H01J49/0036H01J49/004
    • During the structural analysis of a protein or peptide by tandem mass spectroscopy, a peptide ion derived from a protein that has already been measured and that is expressed in great quantities is avoided as a tandem mass spectroscopy target. A peptide derived from a minute amount of protein, which has heretofore been difficult to analyze, can be automatically determined as a tandem mass spectroscopy target within the real time of measurement. Data concerning a protein that has already been measured and a peptide derived from the protein is automatically stored in an internal database. The stored data is collated with measured data with high accuracy to determine an isotope peak. In this way, the process of selecting a peptide peak that has not been measured as the target for the next tandem analysis can be performed within the real time of measurement and a redundant measurement of peptides derived from the same protein can be avoided. The information contained in the MSn spectrum is effectively utilized in each step of the MSn involving a multi-stage dissociation and mass spectroscopy (MSn), so that the flows for the determination of the next analysis content and the selection of the parent ion for the MSn+1 analysis, for example, can be optimized within the real time of measurement and with high efficiency and accuracy. Thus, a target of concern to the user can be subjected to tandem mass spectroscopy without wasteful measurement.
    • 在通过串联质谱法对蛋白质或肽进行结构分析期间,作为串联质谱目标,可以避免衍生自已经测量并且大量表达的蛋白质的肽离子。 迄今为止难以分析的,从微量蛋白质衍生的肽可以在实时测定中作为串联质谱图目标自动确定。 关于已经测量的蛋白质和来自蛋白质的肽的数据被自动存储在内部数据库中。 存储的数据与测量数据高精度对照以确定同位素峰。 以这种方式,可以在测量的实际时间内进行未被测定为下一个串联分析的靶标的肽峰的过程,并且可以避免衍生自相同蛋白质的肽的冗余测量。 包含在MSn谱中的信息在涉及多级解离和质谱(MSn)的MSn的每个步骤中被有效地利用,使得用于确定下一个分析内容的流程和为母体离子的选择 例如,MSn + 1分析可以在实时测量和高效率和精确度下进行优化。 因此,用户关注的目标可以进行串联质谱,无需浪费测量。
    • 2. 发明授权
    • Tandem type mass analysis system and method
    • 串联式质量分析系统及方法
    • US07544930B2
    • 2009-06-09
    • US11624248
    • 2007-01-18
    • Kiyomi YoshinariYasushi TeruiToshiyuki YokosukaKinya KobayashiAtsumu Hirabayashi
    • Kiyomi YoshinariYasushi TeruiToshiyuki YokosukaKinya KobayashiAtsumu Hirabayashi
    • H01J49/00
    • H01J49/02H01J49/004
    • The present invention provides a tandem type mass analysis system capable of carrying out the differential analysis with high efficiency by the tandem type mass analysis. A predetermined number of m/z regions are set up for carrying out the mass analysis with the all ions included therein being dissociated collectively for each m/z region so as to obtain measurement MS2 data. By comparing the measurement MS2 data with reference MS2 data stored in a reference data base, a difference thereof is detected. For the m/z region with a differential component detected, the mass analysis is carried out collectively without dissociation for the all ions included therein so as to obtain measurement MS1 data. By comparing the measurement MS1 data with the reference MS1 data, a difference thereof is detected. From the difference thereof, a parent ion considered to be the differential component factor is presumed for carrying out the mass analysis with the same being dissociated.
    • 本发明提供一种能够通过串联型质量分析以高效率进行差示分析的串联式质量分析系统。 建立预定数量的m / z区域以进行质量分析,其中包含的全部离子为每个m / z区域共同解离,以获得测量MS2数据。 通过将测量MS2数据与参考数据库中存储的参考MS2数据进行比较,检测其差异。 对于检测到差分成分的m / z区域,对于其中包含的所有离子,不分离地进行质量分析,以获得测量MS1数据。 通过将测量MS1数据与参考MS1数据进行比较,检测其差异。 从它们的差异来看,推测认为是差分成分因子的母离子用于进行相同解离的质量分析。
    • 3. 发明申请
    • TANDEM TYPE MASS ANALYSIS SYSTEM AND METHOD
    • TANDEM类型质量分析系统和方法
    • US20070187588A1
    • 2007-08-16
    • US11624248
    • 2007-01-18
    • Kiyomi YoshinariYasushi TeruiToshiyuki YokosukaKinya KobayashiAtsumu Hirabayashi
    • Kiyomi YoshinariYasushi TeruiToshiyuki YokosukaKinya KobayashiAtsumu Hirabayashi
    • H01J49/00
    • H01J49/02H01J49/004
    • The present invention provides a tandem type mass analysis system capable of carrying out the differential analysis with high efficiency by the tandem type mass analysis. A predetermined number of m/z regions are set up for carrying out the mass analysis with the all ions included therein being dissociated collectively for each m/z region so as to obtain measurement MS2 data. By comparing the measurement MS2 data with reference MS2 data stored in a reference data base, a difference thereof is detected. For the m/z region with a differential component detected, the mass analysis is carried out collectively without dissociation for the all ions included therein so as to obtain measurement MS1 data. By comparing the measurement MS1 data with the reference MS1 data, a difference thereof is detected. From the difference thereof, a parent ion considered to be the differential component factor is presumed for carrying out the mass analysis with the same being dissociated.
    • 本发明提供一种能够通过串联型质量分析以高效率进行差示分析的串联式质量分析系统。 设定预定数量的m / z区域,用于进行质量分析,其中包含的全部离子为每个m / z区域共同解离,以获得测量MS 2的数据。 通过将测量MS 2 SUP数据与存储在参考数据库中的参考MS 2 SUP数据进行比较,检测其差异。 对于检测到差分成分的m / z区域,对于包含在其中的全部离子而不解离地进行质量分析,以获得测量MS 1的数据。 通过将测量MS< 1>数据与参考MS< 1>数据进行比较,检测其差异。 从它们的差异来看,推测认为是差分成分因子的母离子用于进行相同解离的质量分析。
    • 6. 发明申请
    • MASS SPECTROMETER SYSTEM
    • 质谱仪系统
    • US20090189063A1
    • 2009-07-30
    • US12330374
    • 2008-12-08
    • Akihiro SanoAtsumu HirabayashiYasushi TeruiKinya KobayashiKiyomi YoshinariKenko UchidaToshiyuki Yokosuka
    • Akihiro SanoAtsumu HirabayashiYasushi TeruiKinya KobayashiKiyomi YoshinariKenko UchidaToshiyuki Yokosuka
    • H01J49/00
    • G01N33/6851G01N33/6848H01J49/0031H01J49/0036H01J49/004
    • During the structural analysis of a protein or peptide by tandem mass spectroscopy, a peptide ion derived from a protein that has already been measured and that is expressed in great quantities is avoided as a tandem mass spectroscopy target. A peptide derived from a minute amount of protein, which has heretofore been difficult to analyze, can be automatically determined as a tandem mass spectroscopy target within the real time of measurement. Data concerning a protein that has already been measured and a peptide derived from the protein is automatically stored in an internal database. The stored data is collated with measured data with high accuracy to determine an isotope peak. In this way, the process of selecting a peptide peak that has not been measured as the target for the next tandem analysis can be performed within the real time of measurement and a redundant measurement of peptides derived from the same protein can be avoided. The information contained in the MSn spectrum is effectively utilized in each step of the MSn involving a multi-stage dissociation and mass spectroscopy (MSn), so that the flows for the determination of the next analysis content and the selection of the parent ion for the MSn+1 analysis, for example, can be optimized within the real time of measurement and with high efficiency and accuracy. Thus, a target of concern to the user can be subjected to tandem mass spectroscopy without wasteful measurement.
    • 在通过串联质谱法对蛋白质或肽进行结构分析期间,作为串联质谱目标,可以避免衍生自已经测量并且大量表达的蛋白质的肽离子。 迄今为止难以分析的,从微量蛋白质衍生的肽可以在实时测定中作为串联质谱图目标自动确定。 关于已经测量的蛋白质和源自蛋白质的肽的数据被自动存储在内部数据库中。 存储的数据与测量数据高精度对照以确定同位素峰。 以这种方式,可以在测量的实际时间内进行未被测定为下一个串联分析的靶标的肽峰的过程,并且可以避免衍生自相同蛋白质的肽的冗余测量。 包含在MSn谱中的信息在涉及多级解离和质谱(MSn)的MSn的每个步骤中被有效地利用,使得用于确定下一个分析内容的流程和为母体离子的选择 例如,MSn + 1分析可以在实时测量和高效率和精确度下进行优化。 因此,用户关注的目标可以进行串联质谱,无需浪费测量。
    • 7. 发明授权
    • Mass spectrometer system
    • 质谱仪系统
    • US07473892B2
    • 2009-01-06
    • US10849517
    • 2004-05-20
    • Akihiro SanoAtsumu HirabayashiYasushi TeruiKinya KobayashiKiyomi YoshinariKenko UchidaToshiyuki Yokosuka
    • Akihiro SanoAtsumu HirabayashiYasushi TeruiKinya KobayashiKiyomi YoshinariKenko UchidaToshiyuki Yokosuka
    • H01J49/26B01D59/44
    • G01N33/6851G01N33/6848H01J49/0031H01J49/0036H01J49/004
    • During the structural analysis of a protein or peptide by tandem mass spectroscopy, a peptide ion derived from a protein that has already been measured and that is expressed in great quantities is avoided as a tandem mass spectroscopy target. A peptide derived from a minute amount of protein, which has heretofore been difficult to analyze, can be automatically determined as a tandem mass spectroscopy target within the real time of measurement. Data concerning a protein that has already been measured and a peptide derived from the protein is automatically stored in an internal database. The stored data is collated with measured data with high accuracy to determine an isotope peak. In this way, the process of selecting a peptide peak that has not been measured as the target for the next tandem analysis can be performed within the real time of measurement and a redundant measurement of peptides derived from the same protein can be avoided. The information contained in the MSn spectrum is effectively utilized in each step of the MSn involving a multi-stage dissociation and mass spectroscopy (MSn), so that the flows for the determination of the next analysis content and the selection of the parent ion for the MSn+1 analysis, for example, can be optimized within the real time of measurement and with high efficiency and accuracy. Thus, a target of concern to the user can be subjected to tandem mass spectroscopy without wasteful measurement.
    • 在通过串联质谱法对蛋白质或肽进行结构分析期间,作为串联质谱目标,可以避免衍生自已经测量并且大量表达的蛋白质的肽离子。 迄今为止难以分析的,从微量蛋白质衍生的肽可以在实时测定中作为串联质谱图目标自动确定。 关于已经测量的蛋白质和来自蛋白质的肽的数据被自动存储在内部数据库中。 存储的数据与测量数据高精度对照以确定同位素峰。 以这种方式,可以在测量的实际时间内进行未被测定为下一个串联分析的靶标的肽峰的过程,并且可以避免衍生自相同蛋白质的肽的冗余测量。 包含在MSn谱中的信息在涉及多级解离和质谱(MSn)的MSn的每个步骤中被有效地利用,使得用于确定下一个分析内容的流程和为母体离子的选择 例如,MSn + 1分析可以在实时测量和高效率和精确度下进行优化。 因此,用户关注的目标可以进行串联质谱,无需浪费测量。
    • 10. 发明申请
    • Mass analysis system
    • 质量分析系统
    • US20070221836A1
    • 2007-09-27
    • US11698105
    • 2007-01-26
    • Kinya KobayashiKiyomi YoshinariToshiyuki YokosukaAtsumu Hirabayashi
    • Kinya KobayashiKiyomi YoshinariToshiyuki YokosukaAtsumu Hirabayashi
    • B01D59/44
    • H01J49/02H01J49/0027
    • An object of the present invention is to evaluate quantitatively a peptide derived from a protein, whose analysis has been difficult so far, by analyzing a peptide ion derived from a protein already measured but having a different total ion amount as the tandem mass analysis target at the time of quantitatively evaluating a fluctuating component between different kinds of specimens by the tandem mass analysis of a protein or a peptide. In the present invention, in order to achieve the above-mentioned object, data of a derived peptide obtained by a first time measurement are stored automatically in an internal database and collated with second time measurement data highly accurately. The processing for selecting the peak of the already measured peptide with the relative amount fluctuation as the next tandem analysis target is implemented within the real time of the measurement for avoiding the analysis of a peptide without the relative amount fluctuation.
    • 本发明的目的是通过分析来自已经测量但已经具有不同总离子量的蛋白质的肽离子作为串联质量分析目标,定量评估来自蛋白质的肽,其分析迄今难以分析 通过蛋白质或肽的串联质量分析定量评估不同种类的标本之间波动成分的时间。 在本发明中,为了实现上述目的,将通过第一次测定得到的衍生肽的数据自动存储在内部数据库中,并与第二次测定数据进行高度准确的对照。 选择具有相对量波动的已测量肽的峰作为下一串联分析目标的处理在测量的实时内实现,以避免没有相对量波动的肽的分析。