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    • 1. 发明授权
    • Seamless capsule and method of manufacturing the same
    • 无缝胶囊及其制造方法
    • US5882680A
    • 1999-03-16
    • US757135
    • 1996-12-03
    • Toshiyuki SuzukiMasayuki IkedaMamoru Sugiyama
    • Toshiyuki SuzukiMasayuki IkedaMamoru Sugiyama
    • B01J13/14A61J3/07A61K9/14A61K9/50B01J13/04A61K9/48
    • A61K9/4833A61K9/5089B01J13/04A61K9/14
    • There are provided a seamless capsule containing therein a large quantity of an active ingredient which is difficultly soluble in water and oil and a method of manufacturing the seamless capsule. Encapsulating liquid 1, in which the active ingredient is difficultly soluble in water and oil is suspended in oil as particles each having the mean particle diameter of less than 20 .mu.m, is enclosed in hydrophilic outer shells. This seamless capsule SC is manufactured in such a manner that from a multiple nozzle 7, suspension, in which the active ingredient which is difficultly soluble in water and oil is dispersed in oil and the active ingredient in thus obtained dispersion is pulverized to obtain particles each having the mean particle diameter of less than 20 .mu.m, as encapsulating liquid 1, and aqueous liquid of a shell forming substance, as outer shell forming liquid 3, are dropped into hardening liquid 10.
    • 提供了含有大量易溶于水和油的活性成分的无缝胶囊和制造无缝胶囊的方法。 将活性成分难以溶于水和油的包封液1悬浮在油中,作为平均粒径小于20微米的颗粒被包封在亲水外壳中。 这种无缝胶囊SC的制造方法是从多个喷嘴7将难溶于水和油的活性成分分散在油中的悬浮液和由此得到的分散体中的活性成分粉碎,得到各自的颗粒 平均粒径小于20μm的封装液体1和作为外壳形成液3的壳形成物质的水性液体滴入硬化液10中。