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1. 发明申请

US20080154007A1 Cross-Linked Polymer Particle and Manufacturing Method Thereof 审中-公开
标题翻译：交联聚合物颗粒及其制造方法
公开(公告)号：US20080154007A1
公开(公告)日：2008-06-26
申请号：US11722877
申请日：2005-12-28
申请人： Toshiyuki Mori , Koji Fujita , Koshin Ushizaki
发明人： Toshiyuki Mori , Koji Fujita , Koshin Ushizaki
IPC分类号： C08F220/10
CPC分类号： B01J20/26 , A61M1/3679 , C08F2/20 , C08F8/12 , C08F218/08 , C08F226/02 , C08F226/06 , C08F265/06 , C08F2222/1013 , C08F220/28
摘要： Crosslinked polymer particles that are useful as an adsorbent, or carrier thereof, for treatment of a liquid containing physiological substance and/or cells, etc., such as body fluid, and that is reduced in the activation of complement system and leukocytes; and a process for producing polymer particles being useful as an adsorbent/treating material, or carrier thereof, for treatment of body fluid. In particular, there are provided crosslinked polymer particles comprising as a constituent a polymerization unit containing a vinyl alcohol unit and nitrogen-containing polymerization unit, wherein the content of nitrogen base on the whole weight of grains in the dry state as determined by elementary analysis is in the range of 7.0 to 13.0 weight %, and wherein the surface nitrogen content determined by X-ray photoelectron spectroscopy (XPS) is in the range of 5.0 to 15.0 at %. Further, there are provided crosslinked polymer particles of 50 to 3000 μm volume average particle diameter, of which ≧80 volume % particles have a diameter of 0.8 to 1.2 times the volume average particle diameter, obtained by first forming liquid drops of uniform diameter consisting of a monomer mixture in a dispersion medium and subsequently polymerizing the liquid drops under conditions avoiding cohesion or additional dispersion thereof, optionally further conducting treatment or modification; and is provided a relevant process for producing polymer particles.
摘要翻译：可用作吸附剂或其载体的交联聚合物颗粒，用于处理含有生理物质和/或细胞等的液体，例如体液，并且减少补体系统和白细胞的活化; 以及用于制备用作治疗体液的吸附剂/处理材料或其载体的聚合物颗粒的方法。特别地，提供了包含含有乙烯醇单元和含氮聚合单元的聚合单元作为组分的交联聚合物颗粒，其中通过元素分析确定的干燥状态下的整个颗粒重量中的氮碱含量为在7.0〜13.0重量％的范围内，通过X射线光电子能谱（XPS）测定的表面氮含量为5.0〜15.0原子％。此外，提供了50〜3000μm体积平均粒径的交联聚合物粒子，其中> = 80体积％的粒子的直径为体积平均粒径的0.8〜1.2倍，通过首先形成均匀直径的液滴得到，的分散介质中的单体混合物，随后在避免内聚或其另外分散的条件下聚合液滴，任选进一步进行处理或改性; 并提供了生产聚合物颗粒的相关方法。

2. 发明申请

US20070270523A1 Method of Modifying Blood Contact Material and Blood Contact Material Inhibited from Activating Granulocyte 审中-公开
标题翻译：修改血液接触材料和血液接触材料抑制活化粒细胞的方法
公开(公告)号：US20070270523A1
公开(公告)日：2007-11-22
申请号：US11718386
申请日：2005-11-01
申请人： Koshin Ushizaki , Masaru Nakatani , Akira Kobayashi , Takehiro Nishimoto
发明人： Koshin Ushizaki , Masaru Nakatani , Akira Kobayashi , Takehiro Nishimoto
IPC分类号： A61F2/84 , A61K8/72
CPC分类号： A61L31/10 , A61L27/34 , A61L27/50 , A61L33/08 , C08L5/02
摘要： An object of the present invention is to provide a method of modifying a blood contact material capable of reducing granulocyte activating action of the blood contact material in medical equipment used for parts which get contact with the blood. The present invention provides a method of modifying blood contact material characterized by granulocyte activating action when in contact with blood,the modifying blood contact material is considerably reduced compared with an original blood contact material by immobilizing a tryptophan derivative and a polyanionic compound to the blood contact material. Examples of the tryptophan derivative include tryptophan. Further, examples of the polyanionic compound include dextran sulfate.
摘要翻译：本发明的目的是提供一种能够减少血液接触材料的血液接触材料的方法，所述血液接触材料能够减少用于与血液接触的部位的医疗设备中的血液接触材料的粒细胞激活作用。本发明提供了一种改变血液接触材料的方法，其特征在于与血液接触时的粒细胞活化作用，与原始血液接触材料相比，通过将色氨酸衍生物和聚阴离子化合物固定在血液接触中而使修饰的血液接触材料显着降低材料。色氨酸衍生物的实例包括色氨酸。此外，聚阴离子化合物的实例包括硫酸葡聚糖。

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