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1. 发明申请

US20140179606A1 LEFT VENTRICULAR DIASTOLIC FUNCTION IMPROVING AGENT 有权
标题翻译：左心室肌纤维功能改善剂
公开(公告)号：US20140179606A1
公开(公告)日：2014-06-26
申请号：US14236474
申请日：2012-08-01
申请人： Toshiya Kanaji , Kazuhiro Fuchibe , Masaya Takahashi
发明人： Toshiya Kanaji , Kazuhiro Fuchibe , Masaya Takahashi
IPC分类号： A61K31/4015 , A61K45/06
CPC分类号： A61K31/4015 , A61K9/0019 , A61K9/2054 , A61K45/06 , C07D207/26 , A61K2300/00
摘要： An agent for treating heart failure, which improves left ventricular diastolic function itself without depending on the diuretic effect or vasodilation effect; controls the pathological condition of diastolic functional failure; and prevents the recurrence, and can prevent dyspnea and death from the pathological condition, is provided.By directly acting on a heart, 4-[(2-{(2R)-2-[(1E,3S)-4-(4-fluorophenyl)-3-hydroxy-1-buten-1-yl]-5-oxo-1-pyrrolidinyl}ethyl)thio]butanoic acid improves left ventricular diastolic function, and can effectively treat diastolic functional failure among heart failure types. Accordingly, by present invention, a new agent for treating heart failure that can relieve diastolic functional failure, for which no effective therapeutic method has been established, can be provided.
摘要翻译：用于治疗心力衰竭的药剂，其不依赖于利尿作用或血管舒张作用而改善左心室舒张功能; 控制舒张功能衰竭的病理状况; 并防止复发，并且可以预防病理状况下的呼吸困难和死亡。通过直接作用于心脏的4 - [（2 - {（2R）-2 - [（1E，3S）-4-（4-氟苯基）-3-羟基-1-丁烯-1-基] 氧代-1-吡咯烷基}乙基）硫代]丁酸改善左心室舒张功能，可有效治疗心力衰竭类型的舒张功能衰竭。因此，通过本发明，可以提供一种用于治疗可缓解舒张功能衰竭的心力衰竭的新药剂，其没有建立有效的治疗方法。

2. 发明授权

US09682065B2 Left ventricular diastolic function improving agent 有权
公开(公告)号：US09682065B2
公开(公告)日：2017-06-20
申请号：US14236474
申请日：2012-08-01
申请人： Toshiya Kanaji , Kazuhiro Fuchibe , Masaya Takahashi
发明人： Toshiya Kanaji , Kazuhiro Fuchibe , Masaya Takahashi
IPC分类号： A61K31/4015 , A61K9/00 , A61K9/20 , C07D207/26 , A61K45/06
CPC分类号： A61K31/4015 , A61K9/0019 , A61K9/2054 , A61K45/06 , C07D207/26 , A61K2300/00
摘要： An agent for treating heart failure, which improves left ventricular diastolic function itself without depending on the diuretic effect or vasodilation effect; controls the pathological condition of diastolic functional failure; and prevents the recurrence, and can prevent dyspnea and death from the pathological condition, is provided.By directly acting on a heart, 4-[(2-{(2R)-2-[(1E,3S)-4-(4-fluorophenyl)-3-hydroxy-1-buten-1-yl]-5-oxo-1-pyrrolidinyl}ethyl)thio]butanoic acid improves left ventricular diastolic function, and can effectively treat diastolic functional failure among heart failure types. Accordingly, by present invention, a new agent for treating heart failure that can relieve diastolic functional failure, for which no effective therapeutic method has been established, can be provided.

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