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1. 发明授权

US4673684A Amide derivatives and 5-lipoxygenase inhibitors containing the same as an active ingredient 失效
标题翻译：含有与活性成分相同的酰胺衍生物和5-脂氧合酶抑制剂
公开(公告)号：US4673684A
公开(公告)日：1987-06-16
申请号：US719131
申请日：1985-04-02
申请人： Toshio Wakabayashi , Makoto Takai , Shuji Ichikawa , Jun-ichiro Arai , Seiitsu Murota
发明人： Toshio Wakabayashi , Makoto Takai , Shuji Ichikawa , Jun-ichiro Arai , Seiitsu Murota
IPC分类号： C07C33/46 , C07C45/71 , C07C47/575 , C07C59/64 , C07D211/46 , C07D213/66 , C07D277/16 , C07D295/088 , C07D295/13 , C07D295/185 , C07D295/192 , C07D295/205 , C07D317/60 , C07D401/06 , C07D417/12 , C07D473/08 , A61K31/445 , C07D405/12
CPC分类号： C07D213/66 , C07C33/46 , C07C45/71 , C07C47/575 , C07C59/64 , C07D211/46 , C07D277/16 , C07D295/088 , C07D295/13 , C07D295/185 , C07D295/192 , C07D295/205 , C07D317/60 , C07D401/06 , C07D417/12 , C07D473/08 , Y10S514/826
摘要： According to the invention, there are provided novel amide derivatives and 5-lipoxygenase inhibitors containing the same as an effective ingredient.The above-mentioned compounds of the invention have been demonstrated to posses 5-lipoxygenase-inhibiting activities. These compounds can inhibit the production of leucotrienes such as LTC.sub.4 and LTD.sub.4 which are allergy-inducing factors by inhibiting the activity of 5-lipoxygenase. Accordingly, the amide derivatives can be used as 5-lipoxygenase inhibitors effective for allergic asthma, allergic rhinitis and the like.
摘要翻译：根据本发明，提供了含有与有效成分相同的酰胺衍生物和5-脂氧合酶抑制剂。已经证明了本发明的上述化合物具有5-脂氧合酶抑制活性。这些化合物可通过抑制5-脂氧合酶的活性来抑制作为过敏诱导因子的白三烯如LTC4和LTD4的产生。因此，酰胺衍生物可以用作对过敏性哮喘，过敏性鼻炎等有效的5-脂氧合酶抑制剂。

2. 发明授权

US4859673A Amide derivatives and antiallergic agents containing the same 失效
标题翻译：酰胺衍生物和含有其的抗过敏剂
公开(公告)号：US4859673A
公开(公告)日：1989-08-22
申请号：US41441
申请日：1987-04-23
申请人： Makoto Takai , Kazuhiro Omori , Takahiro Kumonaka , Shinji Ozawa , Toshio Wakabayashi
发明人： Makoto Takai , Kazuhiro Omori , Takahiro Kumonaka , Shinji Ozawa , Toshio Wakabayashi
IPC分类号： C07D241/04 , C07D211/46 , C07D295/13 , C07D307/20 , C07D405/12
CPC分类号： C07D295/13 , C07D211/46 , C07D307/20 , C07D405/12
摘要： Novel amide derivatives are disclosed. As examples of said amide derivatives are mentioned 1-[2-(5-(3-methoxy-4-benzyloxyphenyl)-2,4-pentadienoyl)aminoethyl]-4-diphenylmethoxypiperidine, 1-[2-(5-(3-methoxy-4-pentadienoyl)aminoethyl]-4-diphenylmethoxypiperidine and 1-[2-(5-(3-methoxy-4-ethoxymethoxyphenyl)-2,4-pentadienoyl)aminoethyl]-4-diphenylmethoxypiperidine. These amide derivatives are useful as antiallergic agents.
摘要翻译：公开了新型酰胺衍生物。提及所述酰胺衍生物的实例是1- [2-（5-（3-甲氧基-4-苄氧基苯基）-2,4-戊二烯酰基）氨基乙基] -4-基苯基甲氧基哌啶，1- [2-（5-（3 - 甲氧基-4-戊二烯酰基）氨基乙基] -4-二苯基甲氧基哌啶和1- [2-（5-（3-甲氧基-4-乙氧基甲氧基苯基）-2,4-戊二烯酰基）氨基乙基] -4-二苯基甲氧基哌啶这些酰胺衍生物是有用的作为抗过敏剂。

3. 发明授权

US4795752A Amide derivatives and antiallergic agents containing the same 失效
标题翻译：酰胺衍生物和含有其的抗过敏剂
公开(公告)号：US4795752A
公开(公告)日：1989-01-03
申请号：US939135
申请日：1986-12-08
申请人： Shin Hattori , Makoto Takai , Kazuhiro Omori , Shinji Ozawa , Toshio Wakabayashi
发明人： Shin Hattori , Makoto Takai , Kazuhiro Omori , Shinji Ozawa , Toshio Wakabayashi
IPC分类号： C07D295/12 , A61K31/443 , A61K31/445 , A61K31/495 , A61P37/08 , C07D211/14 , C07D211/26 , C07D211/44 , C07D211/46 , C07D211/58 , C07D295/13 , C07D405/12
CPC分类号： C07D295/13 , C07D211/14
摘要： Novel amide derivatives are disclosed. As examples of said amide derivatives are mentioned 1-[2-[5-(3-methoxy-4-ethoxycarbonyloxyphenyl)-2,4-pentadienoyl]-aminoethyl]-4-benzhydroxypiperidine, 1-[2-[3-(3-methoxy-4-ethoxycarbonyloxyphenyl)-2-propenoyl]aminoethyl]-4-benzhydroxypiperidine, 1-[3-[5-(3-methoxy-4-ethoxycarbonyloxyphenyl)-2,4-pentadienoyl]aminopropyl]-4-benzhydrylpiperazine and the like. These amide derivatives are useful as antiallergic agents.
摘要翻译：公开了新型酰胺衍生物。所述酰胺衍生物的实例包括1- [2- [5-（3-甲氧基-4-乙氧基羰基氧基苯基）-2,4-戊二烯酰基] - 氨基]苯基] -4-苯并羟基哌啶，1- [2- [3- 3-甲氧基-4-乙氧基羰氧基苯基）-2-丙烯酰基]氨基乙基] -4-苯并羟基哌啶，1- [3- [5-（3-甲氧基-4-乙氧基羰氧基苯基）-2,4-戊二烯酰基]氨基] 二苯甲基哌嗪等。这些酰胺衍生物可用作抗过敏剂。

4. 发明授权

US4906631A Amide derivatives and antiallergic agents containing the same 失效
标题翻译：酰胺衍生物和含有其的抗过敏剂
公开(公告)号：US4906631A
公开(公告)日：1990-03-06
申请号：US238604
申请日：1988-08-31
申请人： Shin Hattori , Makoto Takai , Kazuhiro Omori , Shinji Ozawa , Toshio Wakabayashi
发明人： Shin Hattori , Makoto Takai , Kazuhiro Omori , Shinji Ozawa , Toshio Wakabayashi
IPC分类号： C07D295/12 , A61K31/443 , A61K31/445 , A61K31/495 , A61P37/08 , C07D211/14 , C07D211/26 , C07D211/44 , C07D211/46 , C07D211/58 , C07D295/13 , C07D405/12
CPC分类号： C07D295/13 , C07D211/14
摘要： Novel amide derivatives are disclosed. As examples of said amide derivatives are mentioned 1-[2-[5-(3-methoxy-4-ethoxycarbonyloxyphenyl)-2,4-pentadienoyl]-aminoethyl]-4-benzhydroxypiperidine, 1-[2-[3-(3-methoxy-4-ethoxycarbonyloxyphenyl)-2-propenoyl]-4-benzhydroxypiperidine, 1-[3-[-(3-methoxy-4-ethoxycarbonyloxyphenyl)-2,4-pentadienoyl]aminopropyl]-4-benzhydrylpiperazine and the like. These amide derivatives are useful as antiallergic agents.

5. 发明授权

US4816486A Amide derivatives and 5-lypoxygenase inhibitors containing the same 失效
标题翻译：酰胺衍生物和含有其的5-lypoxygenase抑制剂
公开(公告)号：US4816486A
公开(公告)日：1989-03-28
申请号：US912261
申请日：1986-09-29
申请人： Makoto Takai , Noriie Itoh , Shin Hattori , Hirokazu Hasegawa , Toshio Wakabayashi
发明人： Makoto Takai , Noriie Itoh , Shin Hattori , Hirokazu Hasegawa , Toshio Wakabayashi
IPC分类号： C12N9/99 , A61K31/16 , A61K31/165 , A61P11/00 , A61P27/16 , A61P37/08 , A61P43/00 , C07C67/00 , C07C231/00 , C07C233/12 , C07C235/38
CPC分类号： A61K31/16 , C07C233/12
摘要： Novel amide derivatives are disclosed. As examples of said amide derivatives are mentioned N-cyclohexyl-N-methyl-(2-(3-(3-methoxy-4-hydroxyphenyl)-2-(propenoylamino)-3, 5-dibromobenzyl)amine and N-cyclohexyl-N-methyl-(2-(5-(3-methoxy-4-hydroxyphenyl)-2,4-pentadienoylamino )-3,5-dibromobenzyl)amine. These amide derivatives have a 5-lipoxygenase inhibitory activity and are useful as an antiallergic agent.
摘要翻译：公开了新型酰胺衍生物。提及所述酰胺衍生物的实例是N-环己基-N-甲基 - （2-（3-（3-甲氧基-4-羟苯基）-2-（丙烯酰氨基）-3,5-二溴苄基）胺和N-环己基 -N-甲基 - （2-（5-（3-甲氧基-4-羟基苯基）-2,4-戊二烯并氨基）-3,5-二溴苄基）胺这些酰胺衍生物具有5-脂氧合酶抑制活性，作为抗过敏剂。

6. 发明授权

US4792553A Diene derivatives and vasodilators containing the same 失效
标题翻译：二烯衍生物和含有相同的血管扩张剂
公开(公告)号：US4792553A
公开(公告)日：1988-12-20
申请号：US10477
申请日：1987-02-03
申请人： Shin Hattori , Makoto Takai , Toshio Wakabayashi , Yasusi Suwabe , Syozo Miyaoka
发明人： Shin Hattori , Makoto Takai , Toshio Wakabayashi , Yasusi Suwabe , Syozo Miyaoka
IPC分类号： A61K31/495 , A61P9/08 , A61P9/10 , C07D295/02 , C07D295/03 , C07D295/06 , C07D295/073 , C07D295/08 , C07D295/096
CPC分类号： C07D295/03 , C07D295/073 , C07D295/096
摘要： Novel dienyl derivatives are disclosed. As examples of said diene derivative are mentioned 1-benzhydryl-4-(5-phenyl-2,4-pentadienyl)piperazine, 1-(4,4'-difluorobenzhydryl)-4-(5-phenyl-2,4-pentadienyl)piperazine, 1-benzhydryl-4-(5-(3,4,5-trimethoxyphenyl)-2,4-pentadienyl)piperazine, 1-(4,4'-difluorobenzhydryl)-4-(5-(2,4-dimethoxyphenyl)-2,4-pentadienyl)piperazine, 1-benzhydryl-4-(5-(2,3,4-trimethoxyphenyl)-2,4-pentadienyl)piperazine, 1-(4,4'-difluorobenzhydryl)-4-(5-(2,3,4-trimethoxyphenyl)-2,4-pentadienyl)piperazine and the like. These dienyl derivatives are useful as vasodilators.
摘要翻译：公开了新的二烯基衍生物。作为所述二烯衍生物的实例，提及1-二苯甲基-4-（5-苯基-2,4-戊二烯基）哌嗪，1-（4,4'-二氟二苯甲基）-4-（5-苯基-2,4-戊二烯基））哌嗪，1-二苯甲基-4-（5-（3,4,5-三甲氧基苯基）-2,4-戊二烯基）哌嗪，1-（4,4'-二氟二苯甲基）-4-（5-（2,4 -1-（4,4'-二氟二苯甲基） - 哌嗪，1-二苯甲基-4-（5- 4-（5-（2,3,4-三甲氧基苯基）-2,4-戊二烯基）哌嗪等。这些二烯基衍生物可用作血管扩张剂。

7. 发明授权

US4764528A 2,4-pentadienoic acid derivatives and platelet aggregation inhibitors containing the same 失效
标题翻译： 2,4-戊二烯酸衍生物和含有它们的血小板聚集抑制剂
公开(公告)号：US4764528A
公开(公告)日：1988-08-16
申请号：US026993
申请日：1987-03-10
申请人： Keiko Chiba , Makoto Takai , Toshio Wakabayashi
发明人： Keiko Chiba , Makoto Takai , Toshio Wakabayashi
IPC分类号： C07C57/13 , C07C405/00 , C07C59/46 , A61K31/19
CPC分类号： C07C405/0083
摘要： Novel 2,4-pentadienoic acid derivatives are disclosed. As the examples are mentioned 3-(4-carboxy-trans, trans-1,3-butadienyl)-6-exo-(3.alpha.-hydroxy-trans-1-octenyl)-7-endo-hydroxybicyclo[3.3.0]oct-2-ene, 3-(5-carboxy-trans, trans-2,4-pentadienyl)-6-exo-(3.alpha.-hydroxy-trans-1-octenyl)-7-endo-hydroxybicyclo[3.3.0]oct-2-ene and the like. These compounds are useful as a platelet aggregation inhibitor, especially as a thrombosis-prophylactic agent.

8. 发明授权

US4780560A Nitrate derivatives and vasodilators containing the same 失效
标题翻译：含有相同的硝酸盐衍生物和血管扩张剂
公开(公告)号：US4780560A
公开(公告)日：1988-10-25
申请号：US20704
申请日：1987-03-02
申请人： Takahiro Kumonaka , Shigeru Taguchi , Yasushi Suwabe , Toshio Wakabayashi
发明人： Takahiro Kumonaka , Shigeru Taguchi , Yasushi Suwabe , Toshio Wakabayashi
IPC分类号： C07C233/57 , A61K31/21 , A61P9/08 , A61P9/10 , C07C67/00 , C07C231/00 , C07C233/12 , C07C235/28 , C07C77/02
CPC分类号： A61K31/21 , C07C233/12 , Y10S514/929
摘要： Novel nitrate derivatives are disclosed. As examples of said nitrate derivative are described N-(.beta.-hydroxyethyl)-5-(3,4,5-trimethoxyphenyl)2,4-pentadienoic acid amide nitrate, N-(.beta.-hydroxyethyl)-3,4,5-trimethoxycinnamic acid amide nitrate and the like. These nitrate derivatives are useful as vasodilators.
摘要翻译：公开了新的硝酸盐衍生物。所述硝酸酯衍生物的实例描述为N-（β-羟乙基）-5-（3,4,5-三甲氧基苯基）2,4-戊二烯酸酰胺硝酸盐，N-（β-羟乙基）三甲氧基肉桂酸酰胺硝酸盐等。这些硝酸盐衍生物可用作血管扩张剂。

9. 发明授权

US5446773A Fast Reactor Core 失效
标题翻译：快速反应堆核心
公开(公告)号：US5446773A
公开(公告)日：1995-08-29
申请号：US341972
申请日：1994-11-16
申请人： Toshio Wakabayashi
发明人： Toshio Wakabayashi
IPC分类号： G21C5/00 , G21C3/28 , G21C3/328 , G21C3/62 , G21C5/02 , G21D9/00 , G21F9/00 , G21G1/02
CPC分类号： G21C3/28 , G21C3/328 , G21C5/02 , G21D9/00 , Y02E30/34 , Y02E30/38 , Y10S376/901
摘要： The invention provides a heterogeneously loaded type of fast reactor core in which a reduced number of target fuel assemblies containing minor actinide nuclides are heterogeneously dispersed and loaded. A wrapper tube for each of the target fuel assemblies is of the same shape and size as a hexagonal wrapper tube for an ordinary core fuel assembly. Each of target fuel rods within the wrapper tube contains 20 to 50% of minor actinide nuclides, and has a diameter more reduced than that of an ordinary core fuel rod. The number of the ordinary core fuel rods loaded in the ordinary core fuel assembly is 271 while the number of the target fuel rods loaded in the target fuel assembly is 331 or 397. Thirty to 50 such target fuel assemblies are heterogeneously dispersed and loaded in the fast reactor core.
摘要翻译：本发明提供了一种异质负载型快堆，其中减少数量的含少量锕系元素的目标燃料组件是非均匀分散和加载的。用于每个目标燃料组件的包装管具有与用于普通核燃料组件的六边形包装管相同的形状和尺寸。包装管内的每个目标燃料棒包含20-50％的次要锕系核素，其直径比普通核心燃料棒的直径更小。装在普通核燃料组件中的普通核心燃料棒的数量是271，而装载在目标燃料组件中的目标燃料棒的数量是331或397。这样的目标燃料组件的三十到五十个这样的目标燃料组件被非均匀地分散并装载在快堆芯。

10. 发明授权

US4704393A 1-substituted 5-fluorouracil useful for inhibiting the aggregation of platelets 失效
标题翻译：可用于抑制血小板聚集的1-取代的5-氟尿嘧啶
公开(公告)号：US4704393A
公开(公告)日：1987-11-03
申请号：US749626
申请日：1985-06-17
申请人： Toshio Wakabayashi , Keiko Takahashi , Hajime Katayama
发明人： Toshio Wakabayashi , Keiko Takahashi , Hajime Katayama
IPC分类号： C07D239/54 , C07D239/553 , A61K31/50
CPC分类号： C07D239/553
摘要： 5-Fluorouracil derivatives represented by general; formula I: ##STR1## wherein R represents an acyl group derived from an unsaturated higher fatty acid selected from the group consisting of triene higher acids, pentaene higher acids, and hexaene higher fatty acids, can be used as for inhibiting platelet aggregation and an anticancer chemotherapeutic agent. They may be mixed with a pharmaceutically acceptable carrier or a diluent to form a medicinal preparation.
摘要翻译： PCT No.PCT / JP84 / 00499 Sec。 371日期：1985年6月17日 102（e）日期1985年6月17日PCT归档1984年10月19日PCT公布。第WO85 / 01729号公报 1985年4月25日1985.5氟尿嘧啶衍生物代表一般; 式I：其中R表示衍生自不饱和高级脂肪酸的酰基，其选自三烯高级酸，五苯高级酸和六烯高级脂肪酸，可用于抑制血小板聚集和抗癌化学治疗剂。它们可以与药学上可接受的载体或稀释剂混合以形成药物制剂。

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