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1. 发明授权

US5194445A Ascorbic acid derivative 失效
标题翻译：抗坏血酸衍生物
公开(公告)号：US5194445A
公开(公告)日：1993-03-16
申请号：US700176
申请日：1991-05-20
申请人： Toshio Satoh , Yasunori Niiro , Hisao Kakegawa , Hitoshi Matsumoto
发明人： Toshio Satoh , Yasunori Niiro , Hisao Kakegawa , Hitoshi Matsumoto
IPC分类号： C07D307/62
CPC分类号： C07D307/62
摘要： The preparation for preventing and curing organ dysfunctions, provided by the present invention, is a medicament having the activity to prevent and cure organ dysfunctions which active oxygen species and active organic radical species would cause, and unconventionally improved in stability in vivo by containing, as an active component, the ascorbic acid derivative of the formula, ##STR1## wherein R.sub.2 is a group selected from the class consisting of an alkylcarbonyl lower alkyl group of which the terminal alkyl group has 7 inclusive to 15 inclusive carbon atoms, an alkyl group having 9 inclusive to 17 inclusive alkyl groups and an alkoxycarbonyl lower alkyl group of which the terminal alkoxy group has 7 inclusive to 20 inclusive carbon atoms; and the ascorbic acid derivative of the above formula in which R.sub.2 is an alkylcarbonyl lower alkyl group of which the terminal alkyl group has 7 inclusive to 15 inclusive carbon atoms is novel and disclosed in the present specification together with the process for its preparation.
摘要翻译： PCT No.PCT / JP90 / 01157 Sec。 371日期1991年5月20日 102（e）日期1991年5月20日PCT提交1990年9月11日PCT公布。公开号WO90 / 03471 1991年3月21日。本发明提供的预防和治疗器官功能障碍的制剂是具有预防和治疗活性氧物质和活性有机自由基物质将引起的器官功能障碍的活性的药物，并且非常规地改善通过含有作为活性组分的下式的抗坏血酸衍生物，其中R2是选自末端烷基的烷基羰基低级烷基（包括末端烷基）为7以上的基团碳原子数为9〜20的烷基，末端烷氧基为碳原子数为7〜20的烷氧基羰基低级烷基，和上述式的抗坏血酸衍生物，其中R2是末端烷基具有7个包括15个碳原子的烷基羰基低级烷基，在本说明书中与其制备方法一起是新的和公开的。

2. 发明授权

US5143648A Ascorbic acid derivative and use as antioxidant 失效
标题翻译：抗坏血酸衍生物，用作抗氧化剂
公开(公告)号：US5143648A
公开(公告)日：1992-09-01
申请号：US748176
申请日：1991-08-20
申请人： Toshio Satoh , Yasunori Niiro , Hisao Kakegawa , Hitoshi Matsumoto
发明人： Toshio Satoh , Yasunori Niiro , Hisao Kakegawa , Hitoshi Matsumoto
IPC分类号： C07D307/62 , C07D405/12 , C07D405/14 , C07D407/04
CPC分类号： C07D405/12 , C07D307/62 , C07D405/14 , C07D407/04
摘要： This invention relates to a novel ascorbic acid derivative having excellent antioxidant action and a process for preparing the same.Furthermore, this invention also relates to a novel antioxidant comprising the aforementioned ascorbic acid derivative or other known ascorbic acid derivatives.
摘要翻译：本发明涉及一种具有优异抗氧化作用的新型抗坏血酸衍生物及其制备方法。此外，本发明还涉及包含上述抗坏血酸衍生物或其它已知抗坏血酸衍生物的新型抗氧化剂。

3. 发明授权

US5004742A Benzothiazine-1,1-dioxide derivatives 失效
标题翻译：苯并噻嗪-1,1-二氧化物衍生物
公开(公告)号：US5004742A
公开(公告)日：1991-04-02
申请号：US392899
申请日：1989-08-14
申请人： Toshio Satoh , Yasunori Niiro , Hisao Kakegawa , Hitoshi Matsumoto
发明人： Toshio Satoh , Yasunori Niiro , Hisao Kakegawa , Hitoshi Matsumoto
IPC分类号： C12N9/99 , A61K31/54 , A61P29/00 , A61P37/08 , A61P43/00 , C07D279/02 , C07D417/12
CPC分类号： C07D417/12 , C07D279/02
摘要： The present invention relates to novel benzothiazine-1,1-dioxide derivatives. These benzothiazine-1,1-dioxide derivatives have a high hyaluronidase-inhibiting activity and accordingly can be used in drugs such as anti-inflammatory agent, anti-allergic agent and the like.

4. 发明授权

US5061812A Ascorbic acid derivative 失效
标题翻译：抗坏血酸衍生物
公开(公告)号：US5061812A
公开(公告)日：1991-10-29
申请号：US382270
申请日：1989-07-20
申请人： Toshio Satoh , Yasunori Niiro , Hisao Kakegawa , Hitoshi Matsumoto
发明人： Toshio Satoh , Yasunori Niiro , Hisao Kakegawa , Hitoshi Matsumoto
IPC分类号： C07D307/62 , C07D405/12 , C07D405/14 , C07D407/04
CPC分类号： C07D405/12 , C07D307/62 , C07D405/14 , C07D407/04
摘要： This invention relates to a novel ascorbic acid derivative having excellent antioxidant action and a process for preparing the same.Furthermore, this invention also relates to a novel antioxidant comprising the aforementioned ascorbic acid derivative or other known ascorbic acid derivatives.
摘要翻译：本发明涉及一种具有优异抗氧化作用的新型抗坏血酸衍生物及其制备方法。此外，本发明还涉及包含上述抗坏血酸衍生物或其它已知抗坏血酸衍生物的新型抗氧化剂。

5. 发明授权

US5034543A Ascorbic acid derivative and use as antioxidants 失效
标题翻译：抗坏血酸衍生物，用作抗氧化剂
公开(公告)号：US5034543A
公开(公告)日：1991-07-23
申请号：US382269
申请日：1989-07-20
申请人： Toshio Satoh , Yasunori Niiro , Hisao Kakegawa , Hitoshi Matsumoto
发明人： Toshio Satoh , Yasunori Niiro , Hisao Kakegawa , Hitoshi Matsumoto
IPC分类号： C07D405/14 , C07D407/04 , C09K15/06
CPC分类号： C07D405/14 , C07D407/04 , C09K15/06
摘要： This invention relates to a novel ascorbic acid derivative having excellent antioxidant action, particularly eliminating action on superoxides and a process for preparing the same. Furthermore, this invention also relates to a novel antioxidant comprising the afore-mentioned novel ascorbic acid derivative or other known ascorbic acid derivatives.
摘要翻译：本发明涉及具有优异抗氧化作用的抗坏血酸衍生物，特别是除去对超氧化物的作用及其制备方法。此外，本发明还涉及包含上述新型抗坏血酸衍生物或其它已知抗坏血酸衍生物的新型抗氧化剂。

6. 发明授权

US5264421A Food composition 失效
标题翻译：食物组成
公开(公告)号：US5264421A
公开(公告)日：1993-11-23
申请号：US852167
申请日：1992-04-06
申请人： Toshio Satoh , Hitoshi Matsumoto , Yasunori Niiro , Hisao Kakegawa , Tokutaro Miki
发明人： Toshio Satoh , Hitoshi Matsumoto , Yasunori Niiro , Hisao Kakegawa , Tokutaro Miki
IPC分类号： A23L1/214 , A23L1/218 , A23L1/30 , A61K36/00 , A61K36/48 , A61K31/70 , A23B7/10 , A61K35/78
CPC分类号： A61K36/48 , A23L33/105
摘要： A food composition prepared from a lactic acid fermented aqueous liquorice extract which is free of the disadvantages of extremely strong sweetness which makes liquorice extracts unsuitable for maintaining and enhancing the pharmacological activities (both disease preventing and treating effects) of treating ulcers and hepatic diseases.

7. 发明授权

US5011949A Ascorbic acid derivative 失效
标题翻译：抗坏血酸衍生物
公开(公告)号：US5011949A
公开(公告)日：1991-04-30
申请号：US382771
申请日：1989-07-20
申请人： Toshio Satoh , Yasunori Niiro , Hisao Kakegawa , Hitoshi Matsumoto
发明人： Toshio Satoh , Yasunori Niiro , Hisao Kakegawa , Hitoshi Matsumoto
IPC分类号： C07D307/62 , C07D407/04 , G06F21/10 , H04N7/167 , H04N7/171
CPC分类号： C07D407/04 , C07D307/62
摘要： This invention relates to a novel ascorbic acid derivative having excellent antioxidant action, particularly eliminating action on superoxides and a process for preparing the same.Furthermore, this invention also relates to a novel antioxidant comprising the aforementioned novel ascorbic acid derivative or other known ascorbic acid derivatives.
摘要翻译：本发明涉及具有优异抗氧化作用的抗坏血酸衍生物，特别是除去对超氧化物的作用及其制备方法。此外，本发明还涉及包含上述新型抗坏血酸衍生物或其它已知抗坏血酸衍生物的新型抗氧化剂。

8. 发明授权

US5416242A Hydroquinone derivative 失效
标题翻译：对苯二酚衍生物
公开(公告)号：US5416242A
公开(公告)日：1995-05-16
申请号：US283713
申请日：1994-08-01
申请人： Toshio Satoh , Hitoshi Matsumoto , Yasunori Niiro
发明人： Toshio Satoh , Hitoshi Matsumoto , Yasunori Niiro
IPC分类号： C07C43/23 , C07C43/205
CPC分类号： C07C43/23
摘要： Novel hydroquinone derivatives of the formulae (I) and (II), ##STR1## wherein R.sup.1 is an alkyl group having 7 to 11 carbon atoms, ##STR2## wherein each of R.sup.2 to R.sup.5 is independently a hydrogen atom, a lower alkyl group or a lower alkoxy group provided that at least one of R.sup.2 to R.sup.5 is a lower alkyl group or a lower alkoxy group, and R.sup.6 is an alkyl group having a carbon chain of at least 2 carbon atoms. as compounds having antioxidant activity and tumor incidence inhibiting activity, and an antioxidant and a tumor incidence inhibitor containing, as an active ingredient, a hydroquinone derivative of the formula (III), ##STR3## wherein each of R.sup.7 to R.sup.10 is independently a hydrogen atom, a lower alkyl group or a lower alkoxy group, and R.sup.11 is an alkyl group having a carbon chain of at least 2 carbon atoms, and/or a salt thereof.
摘要翻译：式（I）和（II）的新型氢醌衍生物，其中R1是具有7-11个碳原子的烷基，其中R2至R5各自独立地为氢原子低级烷基或低级烷氧基，条件是R 2至R 5中的至少一个为低级烷基或低级烷氧基，R 6为具有至少2个碳原子的碳链的烷基。作为具有抗氧化活性和肿瘤发生抑制活性的化合物，以及含有式（III）的氢醌衍生物作为活性成分的抗氧化剂和肿瘤发生抑制剂，其中R7至R10各自独立地为氢原子，低级烷基或低级烷氧基，R11为碳原子数为2以上的烷基，和/或其盐。

9. 再颁专利

USRE36139E Hydroquinone derivative 失效
标题翻译：对苯二酚衍生物
公开(公告)号：USRE36139E
公开(公告)日：1999-03-09
申请号：US571717
申请日：1995-12-13
申请人： Toshio Satoh , Hitoshi Matsumoto , Yasunori Niiro
发明人： Toshio Satoh , Hitoshi Matsumoto , Yasunori Niiro
IPC分类号： C07C43/23 , C07C43/205 , A61K31/085
CPC分类号： C07C43/23
摘要： Novel hydroquinone derivatives of the formulae (I) and (II), ##STR1## wherein R.sup.1 is an alkyl group having 7 to 11 carbon atoms, ##STR2## wherein each of R.sup.2 to R.sup.5 is independently a hydrogen atom, a lower alkyl group or a lower alkoxy group provided that at least one of R.sup.2 to R.sup.5 is a lower alkyl group or a lower alkoxy group, and R.sup.6 is an alkyl group having a carbon chain of at least 2 carbon atoms. as compounds having antioxidant activity and tumor incidence inhibiting activity, and an antioxidant and a tumor incidence inhibitor containing, as an active ingredient, a hydroquinone derivative of the formula (III), ##STR3## wherein each of R.sup.7 to R.sup.10 is independently a hydrogen atom, a lower alkyl group or a lower alkoxy group, and R.sup.11 is an alkyl group having a carbon chain of at least 2 carton atoms, and/or a salt thereof.
摘要翻译：式（I）和（II）的新型氢醌衍生物，其中R1是具有7-11个碳原子的烷基，其中R2至R5各自独立地为氢原子低级烷基或低级烷氧基，条件是R 2至R 5中的至少一个为低级烷基或低级烷氧基，R 6为具有至少2个碳原子的碳链的烷基。作为具有抗氧化活性和肿瘤发生抑制活性的化合物，以及含有式（III）的氢醌衍生物作为活性成分的抗氧化剂和肿瘤发生抑制剂，其中R7至R10各自独立地为氢原子，低级烷基或低级烷氧基，R11为碳链为2个以上的碳原子的烷基和/或其盐。

10. 发明授权

US5276058A 3,4-dihydroxychalcone derivatives 失效
标题翻译： 3,4-二羟基查耳酮衍生物
公开(公告)号：US5276058A
公开(公告)日：1994-01-04
申请号：US73423
申请日：1993-06-09
申请人： Toshio Satoh , Hitoshi Matsumoto , Yasunori Niiro
发明人： Toshio Satoh , Hitoshi Matsumoto , Yasunori Niiro
IPC分类号： A61K31/12 , C07C49/835 , C07C49/84 , C07C225/22 , A61K31/135
CPC分类号： A61K31/12 , C07C225/22 , C07C49/835 , C07C49/84
摘要： Novel 3,4-dihydroxychalcone derivatives useful as a pharmaceutical material, and novel anti-inflammatory preparations. The 3,4-dihydroxychalcone derivatives are compounds of the formula [I], ##STR1## wherein X is a substituted phenyl group represented, e.g., by the formula (i), ##STR2## in which R.sup.1 is a hydrogen atom or an alkyl group and R.sup.2 is an alkyl group, an alkoxy group or an --OH group (excluding an OH-group in the 4-position)or salts thereof. The anti-inflammatory preparations contain one of the above 3,4-dihydroxychalcone derivatives as an active ingredient.
摘要翻译：用作药物的新型3,4-二羟基查耳酮衍生物和新型抗炎制剂。 3,4-二羟基查耳酮衍生物是式（I）化合物，（*化学结构*）（I）其中X是以式（ⅰ）代表的取代苯基，（*化学结构*）（ i）其中R1是氢原子或烷基，R2是烷基，烷氧基或-OH基团（不包括4-位OH基）或其盐。抗炎制剂含有上述3,4-二羟基查耳酮衍生物之一作为有效成分。

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