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1. 发明授权

US08822732B2 1,5-diphenyl-penta-1,4-dien-3-one compounds 有权
标题翻译： 1,5-二苯基 - 戊-1,4-二烯-3-酮化合物
公开(公告)号：US08822732B2
公开(公告)日：2014-09-02
申请号：US13210728
申请日：2011-08-16
申请人： Charles C-Y Shih , Toshio Kitamura , Qian Shi , Toshiyuki Kawashima , Hui-Kang Wang
发明人： Charles C-Y Shih , Toshio Kitamura , Qian Shi , Toshiyuki Kawashima , Hui-Kang Wang
IPC分类号： C07F15/00 , C07C49/00 , A61K31/12
CPC分类号： C07C49/248 , C07C49/235 , C07C49/255 , C07C69/16 , C07C217/22 , C07C217/60 , C07C235/82 , C07C307/02 , C07C309/65 , C07C309/66 , C07C309/73 , C07C317/24 , C07C2601/14 , C07C2601/16 , C07D213/68 , C07D295/112 , C07D295/13 , C07F9/06 , C07F9/09 , C07F9/12 , C07F9/32 , C07F9/3282
摘要： This invention relates to compounds of Formula (I), (II), or (III) as shown in the specification, which contain a 1,5-diphenylpenta-1,4-dien-3-one backbone. These compounds can be used to treat cancer, inflammatory disease, or autoimmune disease.
摘要翻译：本发明涉及说明书中所示的含有1,5-二苯基戊-1,4-二烯-3-酮骨架的式（I），（II）或（III）的化合物。这些化合物可用于治疗癌症，炎性疾病或自身免疫性疾病。

2. 发明申请

US20090280483A1 Methods for Screening Interleukin-6 (IL-6) Signal Transduction Inhibitors 审中-公开
标题翻译：筛选白细胞介素-6（IL-6）信号转导抑制剂的方法
公开(公告)号：US20090280483A1
公开(公告)日：2009-11-12
申请号：US12085324
申请日：2005-11-22
申请人： Toshio Kitamura , Toshiyuki Kawashima
发明人： Toshio Kitamura , Toshiyuki Kawashima
IPC分类号： C12Q1/02 , C12Q1/68 , C12Q1/48 , C07C49/255 , C07C49/213 , C07C215/20 , C07C275/28 , C07D333/68 , C07D277/38
CPC分类号： G01N33/6869 , A61K31/095 , A61K31/12 , A61K31/167 , A61K31/381 , A61K31/426 , G01N2333/5412 , G01N2500/10
摘要： The present invention provides methods for screening compounds which inhibit activation of a member of the IL-6 signaling pathways, comprising: (a) a positive screening step using a cell capable of being killed by IL-6 stimulation to select compounds which inhibit death of the cell when it is stimulated by IL-6; and then (b) a biochemical screening step to further select compounds which inhibit activation of a member of the IL-6 signaling pathways by a biochemical means from the compounds selected in step (a). The present invention also provides compounds which inhibit activation of a member of the IL-6 signaling pathways identified using said methods.
摘要翻译：本发明提供了筛选抑制IL-6信号通路成员活化的化合物的方法，其包括：（a）使用能够被IL-6刺激杀死的细胞的阳性筛选步骤，以选择抑制当细胞被IL-6刺激时; 然后（b）生物化学筛选步骤，通过生物化学方法从步骤（a）中选择的化合物进一步选择抑制IL-6信号通路成员活化的化合物。本发明还提供抑制使用所述方法鉴定的IL-6信号通路成员活化的化合物。

3. 发明申请

US20120046247A1 1,5-DIPHENYL-PENTA-1,4-DIEN-3-ONE COMPOUNDS 有权
标题翻译： 1,5-二苯基-1,4-二烯-3-酮化合物
公开(公告)号：US20120046247A1
公开(公告)日：2012-02-23
申请号：US13210728
申请日：2011-08-16
申请人： Charles C-Y Shih , Toshio Kitamura , Qian Shi , Toshiyuki Kawashima , Hui-Kang Wang
发明人： Charles C-Y Shih , Toshio Kitamura , Qian Shi , Toshiyuki Kawashima , Hui-Kang Wang
IPC分类号： A61K31/6615 , C07C309/67 , C07D211/74 , C07C235/82 , C07F9/12 , C07F9/32 , C07C225/16 , C07C49/255 , C07C307/02 , C07D295/112 , A61K31/12 , A61K31/255 , A61K31/45 , A61K31/165 , A61K31/663 , A61K31/138 , A61K31/661 , A61K31/4453 , A61K31/5375 , A61P35/00 , A61P35/02 , C07C49/248
CPC分类号： C07C49/248 , C07C49/235 , C07C49/255 , C07C69/16 , C07C217/22 , C07C217/60 , C07C235/82 , C07C307/02 , C07C309/65 , C07C309/66 , C07C309/73 , C07C317/24 , C07C2601/14 , C07C2601/16 , C07D213/68 , C07D295/112 , C07D295/13 , C07F9/06 , C07F9/09 , C07F9/12 , C07F9/32 , C07F9/3282
摘要： This invention relates to compounds of Formula (I), (II), or (III) as shown in the specification, which contain a 1,5-diphenylpenta-1,4-dien-3-one backbone. These compounds can be used to treat cancer, inflammatory disease, or autoimmune disease.
摘要翻译：本发明涉及说明书中所示的含有1,5-二苯基戊-1,4-二烯-3-酮骨架的式（I），（II）或（III）的化合物。这些化合物可用于治疗癌症，炎性疾病或自身免疫性疾病。

4. 发明申请

US20120155590A1 METHOD OF DETERMINING NUCLEAR FUSION IRRADIATION COORDINATES, DEVICE FOR DETERMINING NUCLEAR FUSION IRRADIATION COORDINATES, AND NUCLEAR FUSION DEVICE 有权
标题翻译：确定核熔融辐射坐标的方法，用于确定核熔融辐射坐标的装置和核熔融装置
公开(公告)号：US20120155590A1
公开(公告)日：2012-06-21
申请号：US13388500
申请日：2010-07-20
申请人： Masakatsu Murakami , Nobuhiko Sarukura , Hiroshi Azechi , Ryo Yasuhara , Toshiyuki Kawashima , Hirofumi Kan
发明人： Masakatsu Murakami , Nobuhiko Sarukura , Hiroshi Azechi , Ryo Yasuhara , Toshiyuki Kawashima , Hirofumi Kan
IPC分类号： G21B1/00 , G06F17/10
CPC分类号： G21B1/23 , H05H1/22
摘要： An object of the present invention is to efficiently improve uniformity of energy lines to be irradiated. A method of determining nuclear fusion irradiation coordinates according to the present invention is a method of calculating irradiation coordinates when energy lines are irradiated onto a nuclear fusion target, and comprises an initial arrangement step S202 of virtually arranging electric charges Qi at initial coordinates of the number of irradiation coordinates NB on a spherical surface S0 set by using random numbers, a coordinate analysis step S203 of analyzing coordinates ri of the electric charges Qi in time series based on coulomb forces acting among the electric charges Qi by constraining the coordinates ri onto the spherical surface S0, potential evaluation steps S205 and S206 of determining a timing at which potential energies of the electric charges Qi were stabilized based on the coordinates ri, and an irradiation coordinate deriving step S207 of deriving coordinates ri at the timing at which potential energies were stabilized as irradiation coordinates of energy lines in a case where a nuclear fusion target is arranged at the center of the spherical surface S0.
摘要翻译：本发明的目的在于有效地提高被照射的能量线的均匀性。根据本发明的确定核聚变照射坐标的方法是当将能量线照射到核聚变靶上时计算辐射坐标的方法，包括在数字的初始坐标处虚拟地布置电荷Qi的初始布置步骤S202 在通过使用随机数设置的球面S0上的照射坐标NB的坐标分析步骤S203，其基于通过将坐标ri约束到球面上来分析基于通过电荷Qi之间的库仑力的时间序列的电荷Qi的坐标ri 表面S0，基于坐标ri确定电荷Qi的势能的定时的电位评估步骤S205和S206以及在势能稳定的定时导出坐标ri的照射坐标导出步骤S207 作为能量线的照射坐标将核聚变靶设置在球面S0的中央的情况。

5. 发明授权

US07888623B2 Illumination device and display device 失效
标题翻译：照明装置和显示装置
公开(公告)号：US07888623B2
公开(公告)日：2011-02-15
申请号：US12378173
申请日：2009-02-11
申请人： Toshiyuki Kawashima , Shinji Ogawa , Takeshi Kodama
发明人： Toshiyuki Kawashima , Shinji Ogawa , Takeshi Kodama
IPC分类号： G01J1/32 , H05B37/02 , F21V9/00
CPC分类号： G01J1/32 , H04N9/3182 , H04N9/3194 , H05B33/0869 , H05B33/0872
摘要： An illumination device includes: a light emitting element to be a light source; a light amount detecting means for detecting the amount of light emitted by the light emitting element; a light emitting element drive means for controlling drive current supplied to the light emitting element so that the difference between the light mount detected by the light amount detecting means and a light amount target value becomes small; a junction temperature detecting means for calculating junction temperature of the light emitting element; and a setting means for setting the light amount target value in accordance with the junction temperature detected by the junction temperature detecting means.
摘要翻译：照明装置包括：作为光源的发光元件; 光量检测装置，用于检测由发光元件发射的光量; 发光元件驱动装置，用于控制提供给发光元件的驱动电流，使得由光量检测装置检测的光安装座之间的差异与光量目标值变小; 结温检测装置，用于计算发光元件的结温; 以及设定装置，用于根据由结温检测装置检测的结温来设定光量目标值。

6. 发明授权

US07733425B2 Automatic picture conditioning based upon user input choosing a video label 失效
标题翻译：基于用户输入选择视频标签的自动图像调理
公开(公告)号：US07733425B2
公开(公告)日：2010-06-08
申请号：US10403825
申请日：2003-03-31
申请人： Toshiyuki Kawashima , Frank L. Medeiros, Jr.
发明人： Toshiyuki Kawashima , Frank L. Medeiros, Jr.
IPC分类号： H04N5/268 , G06F3/00 , H04N5/50 , H04N5/46 , H04N7/16
CPC分类号： H04N21/43622 , H04N5/44513 , H04N5/44543 , H04N21/4325 , H04N21/4402 , H04N21/485
摘要： A method and apparatus for optimizing picture quality of a video signal. The method includes displaying a user menu having a plurality of choices of video labels; receiving a choice of video label from the plurality via an input from a user; translating the video label into a label code; receiving at least a first video processing parameter from a look-up table corresponding to the label code; and configuring a video processor according to the first video processing parameter. The apparatus includes a microprocessor; a memory associated with the microprocessor, the memory for storing video parameters associated with video processing; a video input selector coupled to a plurality of video inputs, the video input selector also coupled to the microprocessor to receive a choice of video inputs therefrom; and a video processor connected to the microprocessor for receiving video parameters therefrom, the video processor also coupled to the video input selector to receive a video signal therefrom and to condition the video signal using the video parameters. The invention may be implemented in software, hardware, firmware, microcode, and other such media.
摘要翻译：一种用于优化视频信号的图像质量的方法和装置。该方法包括显示具有多个视频标签选择的用户菜单; 通过来自用户的输入从多个接收多个视频标签的选择; 将视频标签翻译成标签代码; 从与所述标签代码对应的查找表中接收至少第一视频处理参数; 以及根据第一视频处理参数配置视频处理器。该装置包括微处理器; 与微处理器相关联的存储器，用于存储与视频处理相关联的视频参数的存储器; 耦合到多个视频输入的视频输入选择器，所述视频输入选择器还耦合到所述微处理器以从其接收视频输入的选择; 以及连接到微处理器以从其接收视频参数的视频处理器，视频处理器还耦合到视频输入选择器以从其接收视频信号，并使用视频参数来调节视频信号。本发明可以在软件，硬件，固件，微代码和其他这样的媒体中实现。

7. 发明申请

US20070189346A1 Solid-state laser apparatus 审中-公开
标题翻译：固态激光装置
公开(公告)号：US20070189346A1
公开(公告)日：2007-08-16
申请号：US10573114
申请日：2004-08-23
申请人： Toshiyuki Kawashima , Tadashi Kanabe , Sadao Nakai , Hirofumi Kan
发明人： Toshiyuki Kawashima , Tadashi Kanabe , Sadao Nakai , Hirofumi Kan
IPC分类号： H01S3/04 , H01S3/16
CPC分类号： H01S3/0606 , H01S3/025 , H01S3/0407 , H01S3/042 , H01S3/0615 , H01S3/08072 , H01S3/08095 , H01S3/0941 , H01S3/1611 , H01S3/1643
摘要： A solid-state laser apparatus which can cool a solid-state laser medium such that the solid-state laser medium attains a uniform temperature along the propagating direction of light to be amplified is provided. In a solid-state laser apparatus 1, a coolant circulating through flow paths 12a, 12b comes into direct contact with a pair of reflecting end faces 5a, 5b of a solid-state laser medium 3, whereby the laser medium 3 heated by pumping light emitted from semiconductor lasers 9 can efficiently be cooled. Since the coolant circulates through the flow paths 12a, 12b in a direction substantially perpendicular to a propagating surface P of light to be amplified L, the solid-state laser medium 3 can be cooled such as to attain a uniform temperature along a propagating direction of the light L. This can lower the thermal lens effect and thermal birefringence effect in the solid-state laser medium 3.
摘要翻译：提供一种可以冷却固态激光介质以使得固体激光介质沿着要放大的光的传播方向达到均匀温度的固态激光装置。在固体激光装置1中，通过流路12a，12b的循环的冷却剂与固体激光介质3的一对反射端面5a，5b直接接触，由此激光介质3 通过泵浦从半导体激光器9发射的光来加热可以有效地被冷却。由于冷却剂在与要放大的光L的传播面P大致正交的方向上通过流路12a，12b进行循环，所以能够冷却固体激光介质3，使其沿着传播的方向达到均匀的温度可以降低固体激光介质3中的热透镜效应和热双折射效应。

8. 发明授权

US07237332B2 Method of manufacturing wiring board 失效
标题翻译：制造布线板的方法
公开(公告)号：US07237332B2
公开(公告)日：2007-07-03
申请号：US10820417
申请日：2004-04-07
申请人： Toshiyuki Kawashima , Nobuharu Tahara , Kenichi Ikeda
发明人： Toshiyuki Kawashima , Nobuharu Tahara , Kenichi Ikeda
IPC分类号： H05K3/36
CPC分类号： H05K3/4655 , B32B5/18 , B32B7/04 , B32B38/08 , B32B2305/026 , B32B2379/08 , B32B2398/10 , B32B2457/08 , H05K3/4652 , H05K2201/0116 , H05K2201/0154 , H05K2201/0195 , H05K2203/066 , H05K2203/1147 , Y10T29/49117 , Y10T29/49126 , Y10T29/49128 , Y10T29/49155 , Y10T428/249953 , Y10T428/24997 , Y10T428/249982
摘要： The present invention provides a method of manufacturing a wiring board, including the steps of preparing a composite sheet having an adherent sheet containing a thermosetting resin adhered to a porous film or impregnated with at least a part thereof, laminating at least the composite sheet on a wiring layer having a wiring pattern formed on an insulating layer, and heating and pressurizing the laminated product thus obtained or heating and pressurizing it after the pressurization to integrate the laminated product.
摘要翻译：本发明提供了一种制造布线板的方法，包括以下步骤：制备具有附着在多孔膜上或浸渍有至少一部分的热固性树脂的粘合片的复合片，至少将该复合片层压在布线层，其具有形成在绝缘层上的布线图案，并对由此获得的叠层产品进行加热和加压，或者在加压之后对其进行加压和加压以整合层压产品。

9. 发明授权

US6100926A Calibration of video displays using an integrator circuit 失效
标题翻译：使用积分电路对视频显示进行校准
公开(公告)号：US6100926A
公开(公告)日：2000-08-08
申请号：US15545
申请日：1998-01-29
申请人： Toshiyuki Kawashima
发明人： Toshiyuki Kawashima
IPC分类号： H04N5/225 , H04N9/31 , H04N17/00 , H04N17/04
CPC分类号： H04N9/28 , H04N17/04 , H04N9/31 , H04N2005/2255
摘要： A television system performs beam convergence in video displays. The system is implemented through one or more convergence sensors, which are exposed to two distinct convergence test patterns. The output signals from the sensors when exposed to the two test patterns are used in beam convergence calculations. The test patterns are selected to reduce the dynamic range requirement for an A/D converter in the television system supplied with the sensor output signals.
摘要翻译：电视系统在视频显示器中执行光束会聚。该系统通过一个或多个会聚传感器实现，它们暴露于两个不同的收敛测试模式。当暴露于两个测试图案时，来自传感器的输出信号用于波束收敛计算。选择测试模式以减小提供有传感器输出信号的电视系统中A / D转换器的动态范围要求。

10. 发明申请

US20140226772A1 RADIATION GENERATING APPARATUS AND RADIATION GENERATING METHOD 有权
标题翻译：辐射发生装置和辐射发生方法
公开(公告)号：US20140226772A1
公开(公告)日：2014-08-14
申请号：US14348137
申请日：2012-08-08
申请人： Takeshi Watari , Katsunobu Nishihara , Masaru Takagi , Nakahiro Satoh , Toshiyuki Kawashima , Hirofumi Kan
发明人： Takeshi Watari , Katsunobu Nishihara , Masaru Takagi , Nakahiro Satoh , Toshiyuki Kawashima , Hirofumi Kan
IPC分类号： G21B3/00
CPC分类号： G21B3/006 , H05G2/005 , H05G2/006 , H05H3/06
摘要： A radiation generating apparatus comprises a fuel storage unit 20 for storing a mixed liquid 61, a pressure application unit 10 for applying a pressure to the mixed liquid 61, a jet formation unit 30 for forming a jet 61a of the mixed liquid 61, a reaction unit 44 for forming the jet 61a of the mixed liquid 61 therein, a pressure adjustment unit 41 for setting a pressure in the reaction unit 44 lower than an internal pressure of the jet formation unit 30, and a light source unit 45 for irradiating a particle group 63a with laser light L1.
摘要翻译：辐射发生装置包括用于储存混合液体61的燃料存储单元20，用于向混合液体61施加压力的压力施加单元10，用于形成混合液体61的喷射61a的射流形成单元30，用于在其中形成混合液体61的喷射61a的单元44，用于将反应单元44中的压力设定为低于喷射形成单元30的内压的压力调节单元41，以及用于照射粒子的光源单元45 63a组激光L1。

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