专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06108607A Method of rate calculation 失效
标题翻译：费率计算方法
公开(公告)号：US06108607A
公开(公告)日：2000-08-22
申请号：US899605
申请日：1997-07-24
申请人： Toshiaki Kono , Hidechika Hayashi , Tetsufumi Matsumoto
发明人： Toshiaki Kono , Hidechika Hayashi , Tetsufumi Matsumoto
IPC分类号： C12Q1/00 , C12M1/34
CPC分类号： C12Q1/00
摘要： A method of rate calculation in which, in connection with a reaction in which the substrate of an enzyme undergoes the action of the enzyme to be converted to a reaction product, a signal correlated to the concentration of the reaction product is measured at different points of time, those measured values obtained which exceed the upper limit preset in accordance with the detection limit of a detector to be used are excluded while selecting those measured values obtained at different points of time at least equal in number to the independent parameters of the approximating function and which are not greater than said upper limit and the measured values thus selected are weighted by a finite value to effect approximation by said function, provided that said finite value for weighting at least a portion of the measured values are changed continuously in accordance with the magnitudes of said specific measured values. This method is capable of calculating the rate of enzyme activity to accomplish precise quantification of a substance without impairing the continuity of a calibration curve even if measurements are conducted at discontinuous points of time over a measurement range where the rate will change under the influence of the concentrations of the substrate and the reaction product in the reaction mixture.
摘要翻译：一种速率计算方法，其中，在酶的底物经受酶转化为反应产物的作用的反应中，与反应产物的浓度相关的信号在不同点时间，排除所获得的超过根据所使用的检测器的检测限所预先设定的上限的测量值，同时选择在与近似函数的独立参数数量至少相等的不同时间点获得的测量值并且不大于所述上限，并且由此选择的测量值由有限值加权以实现所述函数的近似，条件是根据所述上限的至少一部分测量值的加权的所述有限值被连续地改变所述具体测量值的大小。该方法能够计算酶活性的速率来实现物质的精确定量，而不损害校准曲线的连续性，即使在不确定时间点进行测量，在测量范围内，速率将在反应混合物中底物和反应产物的浓度。

2. 发明授权

US5882594A Device and method for automatic sample pretreatment 失效
标题翻译：自动样品预处理的装置和方法
公开(公告)号：US5882594A
公开(公告)日：1999-03-16
申请号：US869597
申请日：1997-06-05
申请人： Seiji Kawaguchi , Toshiaki Kono , Hidechika Hayashi
发明人： Seiji Kawaguchi , Toshiaki Kono , Hidechika Hayashi
IPC分类号： G01N1/36 , G01N35/02 , G01N35/04 , G01N35/10
CPC分类号： G01N35/025 , G01N35/1083 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998
摘要： An automatic sample pretreatment device is provided which is capable of conducting a series of treatments or reactions from pretreatment to measurement automatically in a short time by employing a separate reaction system from the reaction system for measurement. The automatic sample pretreatment device comprises a sample rack, a pretreatment vessel and a measurement vessel, a liquid dispenser, a first vessel-transfer apparatus having a vessel holder for holding and transferring the vessels, a pretreatment vessel feeding apparatus for feeding the pretreatment vessel to the vessel holder of the first vessel transfer apparatus, a measurement vessel feeding apparatus for feeding the measurement vessel to the vessel holder of the first vessel-transfer apparatus, a vessel discarding hole for discarding the vessel after use, a second vessel-transfer device for transferring the used vessel held at the vessel holder of the first vessel-transfer apparatus to the vessel discarding hole, an incubator equipped with a measurement device for measuring a sample, and a third vessel-transfer device for transferring the vessel held by the vessel holder of the first vessel-transfer apparatus to the incubator.
摘要翻译：提供了一种自动样品预处理装置，其能够通过使用与反应系统进行测量的单独的反应系统，在短时间内进行一系列预处理或测量的处理或反应。自动样品预处理装置包括样品架，预处理容器和测量容器，液体分配器，具有用于保持和转移容器的容器保持器的第一容器转移装置，用于将预处理容器进给的预处理容器进料装置第一容器传送装置的容器保持器，用于将测量容器供给到第一容器转移装置的容器保持器的测量容器进给装置，使用后丢弃容器的容器废弃孔，用于将保持在第一容器传送装置的容器保持器处的二手容器转移到容器废弃孔，装备有用于测量样品的测量装置的培养箱和用于转移由容器保持器容纳的容器的第三容器转移装置的第一个血管转移装置。

3. 发明授权

US5357117A Method of monitoring the presence or absence of liquid and apparatus therefor 失效
标题翻译：监测液体存在或不存在的方法及其设备
公开(公告)号：US5357117A
公开(公告)日：1994-10-18
申请号：US59369
申请日：1993-05-12
申请人： Hidechika Hayashi , Yukio Mitsuhisa
发明人： Hidechika Hayashi , Yukio Mitsuhisa
IPC分类号： B01J4/00 , B67D7/02 , G01N35/10 , G01P13/00 , G01N15/06
CPC分类号： G01N35/1016 , G01P13/0086
摘要： A method of monitoring a discharge of a liquid comprises the steps of: measuring a presence or absence of a liquid discharged at an optional area of a passage for the liquid during discharging the liquid of a vessel through the passage; comparing a measurement result obtained in said measuring step with a reference measurement result which are to be obtained when a discharge of the liquid is reliably carried out; and determining as to whether a discharge operation for the liquid has been reliably performed. And an apparatus for performing the method.
摘要翻译：一种监测液体排放的方法包括以下步骤：测量在通过通道排放容器的液体期间在液体的通道的任选区域排出的液体的存在或不存在; 将所述测量步骤中获得的测量结果与可靠地执行液体排出时获得的参考测量结果进行比较; 并且确定液体的排出操作是否已被可靠地执行。以及用于执行该方法的装置。

4. 发明授权

US4763460A Sealing foil breaker for analyzer test cups 失效
标题翻译：用于分析仪测试杯的密封箔断路器
公开(公告)号：US4763460A
公开(公告)日：1988-08-16
申请号：US052333
申请日：1987-05-21
申请人： Yuji Higo , Hidechika Hayashi
发明人： Yuji Higo , Hidechika Hayashi
IPC分类号： G01N33/48 , B26F1/18 , B26F3/00 , B67B7/48 , B67B7/52 , G01N33/53 , G01N33/543 , G01N35/00 , G01N35/02
CPC分类号： B67B7/24 , Y10T83/9314
摘要： A reciprocable vertical shafts 21 has a pyramid shaped lower tip for piercing a sealing foil 8d secured across the top of an analyzer test cup containing an active substance. The edges of the pyramid divide the foil into triangular segments which are pressed against the inner wall of the cup by the cylindrical root portion of the shaft such that they do not engage any of the active substance or interfere with subsequent injections into or withdrawals from the cup.

5. 发明授权

US5973330A Fluorescence detection apparatus 失效
标题翻译：荧光检测装置
公开(公告)号：US5973330A
公开(公告)日：1999-10-26
申请号：US898785
申请日：1997-07-23
申请人： Hidechika Hayashi
发明人： Hidechika Hayashi
IPC分类号： C12M1/34 , C12Q1/00 , G01N21/64 , G01N33/573
CPC分类号： G01N21/645 , G01N2021/6421
摘要： A fluorescence detection apparatus is provided which has a partial reflection mirror 8 for transmitting a part of fluorescence light emitted from a fluorescent substance by projecting excitation light and reflecting the rest of the fluorescence light, and a pair of a first and a second photodiode 2,3 for measuring the light transmitted through or reflected by partial reflection mirror 8 respectively at a selected wavelength, and the pair of the first and the second diodes are arranged to be optically equivalent relative to the partial reflection mirror 8. This fluorescence detection apparatus is affected less by positional deviation of the measurement cell relative to the optical measurement system.
摘要翻译：提供一种荧光检测装置，其具有：部分反射镜8，用于通过投射激发光并反射剩余的荧光来透射从荧光物质发射的一部分荧光;以及一对第一和第二光电二极管2， 3，用于测量分别以选定波长透射或反射的部分反射镜8的光，并且该对第一和第二二极管被布置为相对于部分反射镜8光学等效。该荧光检测装置受到影响较小的测量单元相对于光学测量系统的位置偏差。

6. 发明授权

US5176880A Automated biochemical analyzer 失效
标题翻译：自动化学分析仪
公开(公告)号：US5176880A
公开(公告)日：1993-01-05
申请号：US555728
申请日：1990-07-23
申请人： Shuji Iwasaki , Toshi Kagayama , Kazuya Kamata , Hidechika Hayashi
发明人： Shuji Iwasaki , Toshi Kagayama , Kazuya Kamata , Hidechika Hayashi
IPC分类号： G01N33/543 , B01L3/00 , G01N1/10 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10
CPC分类号： B01L3/545 , G01N35/00594 , G01N35/02 , G01N2001/1006 , G01N2035/00564 , G01N2035/00752 , G01N2035/0436 , G01N35/00693 , G01N35/1079 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998
摘要： An automated analyzer for automatically assaying a specific component in a sample by utilizing a top-opened reaction vessel containing a reagent capable of reacting with the specific component, and which is sealed with a seal foil on which a symbol for the reagent is shown: said analyzer comprising a seal foil breaker for breaking the seal foil, a sample dispenser for dispensing the sample to the vessel, and a detector for detecting a reaction signal caused by a reaction with the specific component and the reagent; a transfer device for transferring the reaction vessel and a symbol discriminator for discriminating the symbol shown on the seal foil, which is placed at a position on a transfer route of the reaction vessels transferred by the transfer device and at a position before the seal-foil breaker.

7. 发明授权

US06438499B1 Chromatogram analyzer 失效
标题翻译：色谱仪分析仪
公开(公告)号：US06438499B1
公开(公告)日：2002-08-20
申请号：US09393194
申请日：1999-09-10
申请人： Hidechika Hayashi
发明人： Hidechika Hayashi
IPC分类号： G01N3086
CPC分类号： G01N30/8624
摘要： A chromatogram analyzer which analyzes a chromatogram obtained by applying a sample containing n analytes (wherein n is a natural number of at least 2) to chromatography to detect peaks attributable to the n analytes.
摘要翻译：分析色谱图，分析通过将含有n种分析物（其中n为至少2的天然数）的样品应用于色谱以检测归因于n种分析物的峰值而获得的色谱图。

8. 发明授权

US5792662A Method of determination of fluorescent substance and method of assay of enzyme activity 失效
标题翻译：荧光物质的测定方法和酶活性测定方法
公开(公告)号：US5792662A
公开(公告)日：1998-08-11
申请号：US842405
申请日：1997-04-24
申请人： Hidechika Hayashi , Kazuya Kamata
发明人： Hidechika Hayashi , Kazuya Kamata
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , G01N2021/6441 , G01N21/276 , Y10T436/10
摘要： A method for determining a fluorescent substance in a broader concentration range with higher measurement accuracy is provided which is applicable to assay of enzyme activity in enzyme-label immunoassay, enzyme-label DNA hybridization, etc. A method for assaying enzyme activity is also provided which employs the above fluorescence measurement. In the method, a specimen containing an objective fluorescent substance to be determined and a reference substance is irradiated with excitation light capable of exciting both the objective fluorescent substance and the reference fluorescent substance; measuring a first fluorescence intensity at a first wavelength where fluorescence is emitted mainly by the objective fluorescent substance; measuring a second fluorescence intensity at a second wavelength where fluorescence is emitted mainly by the reference fluorescent substance; and calculating the concentration of the objective fluorescent substance from the equation: 1/(y-c)=a/x+b where x is the concentration of the objective fluorescent substance, and y is a ratio of the first fluorescence intensity to the second fluorescence intensity.
摘要翻译：本发明提供了一种测定精度更高的浓度范围内的荧光物质的方法，其适用于酶标免疫测定，酶标DNA杂交等酶活性的测定。还提供了测定酶活性的方法采用上述荧光测量。在该方法中，对能够激发目标荧光物质和参照荧光物质的激发光照射含有待测定目的荧光物质的试样和对照物质; 测量主要由目标荧光物质发出荧光的第一波长处的第一荧光强度; 测量第二波长处的第二荧光强度，其中荧光主要由参考荧光物质发射; 并从以下公式计算目标荧光物质的浓度：1 /（yc）= a / x + b其中x是目标荧光物质的浓度，y是第一荧光强度与第二荧光强度的比值。

9. 发明授权

US5055408A Automated immunoassay analyser 失效
标题翻译：自动免疫分析仪
公开(公告)号：US5055408A
公开(公告)日：1991-10-08
申请号：US590530
申请日：1990-09-28
申请人： Yuji Higo , Hidechika Hayashi , Shuji Iwasaki
发明人： Yuji Higo , Hidechika Hayashi , Shuji Iwasaki
IPC分类号： G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10
CPC分类号： G01N35/026 , G01N35/0098 , G01N2035/00386 , G01N2035/00534 , G01N2035/041 , G01N2035/0422 , G01N2035/0425 , G01N35/028 , G01N35/1079 , G01N35/1083 , Y10S436/809 , Y10T436/114165 , Y10T436/114998
摘要： An automated immunoassay analyzser comprising a transfer route on which test plates each having a plurality of chambers for immunological reaction opened upwards are transferred continually with a constant interval of time, and devices of at least A, B, C and D described below which are arranged on the transfer route from upstream to downstream in the order referred to in which the device A is for injecting the sample comprising a vertically and horizonally driven support, a pipet fixed to the support, and a nozzle tip usable for a single sample and removably attached to the lower end of the pipet, the device B is for B/F separation and the device C is for injecting the substrate solution and both devices are integratedly combined and comprise a vertically and horizontally driven support, a washing tube supported by the support, a temperature controllable solution reservoir block fixed to the support, a substrate injection tube provided to the lower side of the reservoir block, the washing tube and the substrate solution injection tube being arranged in alignment and spaced each other according to the pitch of the cup arrangement, and the device D is for photometry with which to measure optically detectable changes caused in the substrate in the chamber of immunological reaction.
摘要翻译：一种自动化免疫测定分析装置，其特征在于，具有转印路径，在所述转印路径上，将具有多个向上方开放的免疫反应室的试验板以恒定的时间间隔连续地传送，并且将下述的至少A，B，C，D的装置配置在从上游到下游的传输路线上，其中装置A用于注射包括垂直和水平驱动的支撑件的样品，固定到支撑件的移液管和可用于单个样品的喷嘴末端，并且可拆卸地附接在移液器的下端，装置B用于B / F分离，并且装置C用于注入基质溶液，并且两个装置被整体组合并且包括垂直和水平驱动的支撑件，由支撑件支撑的洗涤管，固定在支撑体上的温度可控的溶液储存器块，设置在储存器块的下侧的基底注入管铰链管和衬底溶液注入管根据杯装置的间距排列成对准并彼此隔开，并且装置D用于测光，以测量在免疫反应室中的基底中引起的光学上可检测的变化。

10. 发明授权

US4994240A Suction head and carrying reaction cups used in biochemical reaction analyzing apparatus 失效
标题翻译：吸头和携带反应杯用于生化反应分析仪
公开(公告)号：US4994240A
公开(公告)日：1991-02-19
申请号：US506536
申请日：1990-04-06
申请人： Hidechika Hayashi
发明人： Hidechika Hayashi
IPC分类号： B66C1/02 , B25J15/06 , B66C1/00 , G01N33/543 , G01N35/00 , G01N35/04 , G01N35/10
CPC分类号： G01N35/04 , B25J15/0616 , G01N35/0099 , G01N2035/00059 , G01N2035/0406 , G01N35/1079
摘要： A biochemical reaction analyzing apparatus having a reaction cup and a suction head for carrying the reaction cup, wherein the suction head can carry a reaction cup of light weight used for biochemical reaction analysis by hanging it by suction, wherein the head is provided with a cylindrical cavity as an air passage having a diameter approximately equal to that of an air suction and discharge opening formed at the lower end of the head body and extending up from the opening in the head body; further, if necessary, a plurality of circumferential grooves formed in the inner wall surrounding the cylindrical cavity or a vertically movable weight fitted in the cylindrical cavity is provided.
摘要翻译：一种具有反应杯和用于携带反应杯的吸头的生物化学反应分析装置，其中吸头可以通过抽吸悬挂而携带用于生化反应分析的重量轻的反应杯，其中头部设置有圆柱形空腔作为空气通道，其直径大致等于形成在头部本体的下端并从头体的开口向上延伸的吸气和排出口的直径; 此外，如果需要，提供形成在围绕圆柱形腔的内壁中的多个周向槽或装配在圆柱形腔中的可垂直移动的重物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式