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1. 发明授权

US07317038B2 Nerve regeneration promoters containing semaphorin inhibitor as the active ingredient 失效
标题翻译：神经再生启动子含有信号素抑制剂作为活性成分
公开(公告)号：US07317038B2
公开(公告)日：2008-01-08
申请号：US11508965
申请日：2006-08-24
申请人： Toru Kimura , Kaoru Kikuchi , Kazuo Kumagai , Nobuo Hosotani , Akiyoshi Kishino
发明人： Toru Kimura , Kaoru Kikuchi , Kazuo Kumagai , Nobuo Hosotani , Akiyoshi Kishino
IPC分类号： A61K31/405 , C07D311/80 , C07D311/00 , C12Q1/50
CPC分类号： C07D493/04 , C07D311/78 , C07D311/86
摘要： To provide a semaphorin inhibitor; a peripheral or central nerve regeneration promoter which contains said semaphorin inhibitor as an active ingredient; and a preventive or remedy for a neuropathic disease and a neurodegenerative disease containing said nerve regeneration promoter, or the like.A low-molecular weight compound, which acts at a concentration of 10 μg/ml or below to inhibit the growth cone collapse activity of semaphorin such as semaphorin 3A, semaphorin 6C or the like and/or the nerve outgrowth inhibitory activity of semaphorin in a collagen gel and which does not substantially affect cell proliferation, is obtained from the culture of strain SPF-3059 belonging to the genus Penicillium. The low-molecular weight compound with the semaphorin inhibitory activity thus obtained exhibits the in vivo nerve-regeneration promoting action.
摘要翻译：提供信号素抑制剂; 包含所述信号素抑制剂作为活性成分的外周或中枢神经再生促进剂; 以及包含所述神经再生促进剂的神经病和神经变性疾病的预防或治疗方法等。低分子量化合物以10ug / ml或更低的浓度起作用以抑制semaphorin如semaphorin 3A，semaphorin 6C等信号素的生长锥塌陷活性和/或信号素在神经生长抑制活性中的作用胶原凝胶，其基本上不影响细胞增殖，从属于青霉属的菌株SPF-3059的培养物获得。由此获得的具有信号素抑制活性的低分子化合物表现出体内神经再生促进作用。

2. 发明申请

US20070015820A1 Nerve regeneration promoters containing semaphorin inhibitor as the active ingredient 失效
公开(公告)号：US20070015820A1
公开(公告)日：2007-01-18
申请号：US11508965
申请日：2006-08-24
申请人： Toru Kimura , Kaoru Kikuchi , Kazuo Kumagai , Nobuo Hosotani , Akiyoshi Kishino
发明人： Toru Kimura , Kaoru Kikuchi , Kazuo Kumagai , Nobuo Hosotani , Akiyoshi Kishino
IPC分类号： A61K31/353 , C07D405/02
CPC分类号： C07D493/04 , C07D311/78 , C07D311/86
摘要： To provide a semaphorin inhibitor; a peripheral or central nerve regeneration promoter which contains said semaphorin inhibitor as an active ingredient; and a preventive or remedy for a neuropathic disease and a neurodegenerative disease containing said nerve regeneration promoter, or the like. A low-molecular weight compound, which acts at a concentration of 10 μg/ml or below to inhibit the growth cone collapse activity of semaphorin such as semaphorin 3A, semaphorin 6C or the like and/or the nerve outgrowth inhibitory activity of semaphorin in a collagen gel and which does not substantially affect cell proliferation, is obtained from the culture of strain SPF-3059 belonging to the genus Penicillium. The low-molecular weight compound with the semaphorin inhibitory activity thus obtained exhibits the in vivo nerve-regeneration promoting action.

3. 发明授权

US07244761B2 Nerve regeneration promoters containing semaphorin inhibitor as the active ingredient 有权
标题翻译：神经再生启动子含有信号素抑制剂作为活性成分
公开(公告)号：US07244761B2
公开(公告)日：2007-07-17
申请号：US10343125
申请日：2001-07-27
申请人： Toru Kimura , Kaoru Kikuchi , Kazuo Kumagai , Nobuo Hosotani , Akiyoshi Kishino
发明人： Toru Kimura , Kaoru Kikuchi , Kazuo Kumagai , Nobuo Hosotani , Akiyoshi Kishino
IPC分类号： A61K31/405 , C07D311/80 , C07D311/00 , C12Q1/50
CPC分类号： C07D493/04 , C07D311/78 , C07D311/86
摘要： To provide a semaphorin inhibitor; a peripheral or central nerve regeneration promoter which contains said semaphorin inhibitor as an active ingredient; and a preventive or remedy for a neuropathic disease and a neurodegenerative disease containing said nerve regeneration promoter, or the like.A low-molecular weight compound, which acts at a concentration of 10 μg/ml or below to inhibit the growth cone collapse activity of semaphorin such as semaphorin 3A, semaphorin 6C or the like and/or the nerve outgrowth inhibitory activity of semaphorin in a collagen gel and which does not substantially affect cell proliferation, is obtained from the culture of strain SPF-3059 belonging to the genus Penicillium. The low-molecular weight compound with the semaphorin inhibitory activity thus obtained exhibits the in vivo nerve-regeneration promoting action.
摘要翻译：提供信号素抑制剂; 包含所述信号素抑制剂作为活性成分的外周或中枢神经再生促进剂; 以及包含所述神经再生促进剂的神经病和神经变性疾病的预防或治疗方法等。低分子量化合物以10ug / ml或更低的浓度起作用以抑制semaphorin如semaphorin 3A，semaphorin 6C等信号素的生长锥塌陷活性和/或信号素在神经生长抑制活性中的作用胶原凝胶，其基本上不影响细胞增殖，从属于青霉属的菌株SPF-3059的培养物获得。由此获得的具有信号素抑制活性的低分子量化合物表现出体内神经再生促进作用。

4. 发明授权

US06902730B1 Semaphorin gene: Semaphorin W 失效
标题翻译：信号素基因：信号素W
公开(公告)号：US06902730B1
公开(公告)日：2005-06-07
申请号：US09284180
申请日：1997-10-03
申请人： Toru Kimura , Kaoru Kikuchi
发明人： Toru Kimura , Kaoru Kikuchi
IPC分类号： A61K38/00 , C07K14/47 , C12N1/21 , C12N15/12 , A01N63/00 , C07H21/02 , C07H21/04 , C12N15/00 , C12N15/63
CPC分类号： C07K14/4703 , A01K2217/05 , A61K38/00
摘要： The present invention provides Semaphorin W inhibiting neurite outgrowth, and a gene therefor, as well as other Semaphorins hybridizing to said Semaphorin W gene, modified proteins or partial peptides of said Semaphorin W, antibodies against said Semaphorin W, antisense nucleotides against said Semaphorin W gene, and the use of such substances as pharmaceutical or diagnostic agents or laboratory reagents. The present invention further provides a method of screening for Semaphorin W antagonists employing said Semaphorin W, Semaphorin W antagonists obtained by said screening method, pharmaceutical agents comprising such antagonists, and transgenic animals involving said Semaphorin W.
摘要翻译：本发明提供了抑制神经突生长的信号素W及其基因，以及与所述信号素W基因杂交的其他信号素，所述信号素W的修饰蛋白或部分肽，针对所述信号素W的抗体，针对所述信号素W基因的反义核苷酸，以及药物或诊断剂或实验室试剂等物质的使用。本发明还提供了使用所述筛选方法获得的所述信号素W，信号素W拮抗剂，包含这种拮抗剂的药物和涉及所述Semaphorin W的转基因动物筛选信号素W拮抗剂的方法。

5. 发明授权

US07273922B2 Semaphorin Z and gene encoding the same 失效
标题翻译：信号素Z和基因编码相同
公开(公告)号：US07273922B2
公开(公告)日：2007-09-25
申请号：US10391413
申请日：2003-03-19
申请人： Toru Kimura , Kaoru Kikuchi
发明人： Toru Kimura , Kaoru Kikuchi
IPC分类号： C07K14/00 , C07H21/04
CPC分类号： C07K14/4703
摘要： Novel semaphorin Z; a gene thereof; a partial peptide of the semaphorin Z; an antibody; a DNA or an RNA complementary to the semaphorin Z gene; a method for screening a semaphorin Z inhibitor by using the semaphorin Z; the semaphorin Z inhibitor obtained by the screening; and a CNS neuron regeneration promoter comprising the inhibitor.
摘要翻译：新的信札Z; 其基因; 信号素Z的部分肽; 抗体; 与semaphorin Z基因互补的DNA或RNA; 通过使用信号素Z筛选信号素Z抑制剂的方法; 通过筛选获得的semaphorin Z抑制剂; 和包含抑制剂的CNS神经元再生启动子。

6. 发明授权

US06566094B1 Semaphorin gene: Semaphorin Y 失效
标题翻译：信号素基因：信号素Y
公开(公告)号：US06566094B1
公开(公告)日：2003-05-20
申请号：US09254594
申请日：1999-05-11
申请人： Toru Kimura , Kaoru Kikuchi
发明人： Toru Kimura , Kaoru Kikuchi
IPC分类号： C07H2104
CPC分类号： C07K14/4703 , A01K2217/05 , A61K38/00
摘要： Semaphorin Y inhibiting neurite outgrowth, and a nucleotide sequence therefor, as well as other Semaphorin sequences hybridizing to the Semaphorin Y sequence, modified proteins or partial peptides of Semaphorin Y, antibodies against Semaphorin Y, antisense nucleotides against Semaphorin Y gene, and the use of such substances as pharmaceutical or diagnostic agents or laboratory reagents are disclosed. Further, a method of screening for Semaphorin Y antagonists employing Semaphorin Y, Semaphorin Y antagonists obtained by the screening method, pharmaceutical agents comprising such antagonists, and transgenic animals involving Semaphorin Y are also disclosed.
摘要翻译：信号素Y抑制神经突生长及其核苷酸序列，以及与信号素Y序列杂交的其他信号素序列，信号素Y的修饰蛋白或部分肽，针对信号素Y的抗体，针对信号素Y基因的反义核苷酸，以及使用公开了诸如药物或诊断剂或实验室试剂的物质。此外，还公开了筛选使用信号素Y的信号素Y拮抗剂，通过筛选方法获得的信号素Y拮抗剂，包含这种拮抗剂的药剂和涉及信号素Y的转基因动物的信号素Y拮抗剂的方法。

7. 发明授权

US07407766B1 Screening method for agonists or antagonists of semaphorin 6C by determining the effect of a test compound on the interaction between semaphorin 6C and plexin-A1 失效
标题翻译：通过测定测试化合物对信号素6C和plexin-A1之间的相互作用的影响，对信号素6C的激动剂或拮抗剂的筛选方法
公开(公告)号：US07407766B1
公开(公告)日：2008-08-05
申请号：US10148409
申请日：2000-11-27
申请人： Hajime Fujisawa , Toru Kimura , Kaoru Kikuchi , Yasunori Murakami
发明人： Hajime Fujisawa , Toru Kimura , Kaoru Kikuchi , Yasunori Murakami
IPC分类号： G01N33/53 , C12P21/06 , C12N5/00 , C12N5/02 , C12N15/00
CPC分类号： G01N33/5008 , C07K14/47 , C07K14/4703 , C07K14/705 , C07K14/71 , C07K2319/00 , G01N33/502 , G01N33/68 , G01N33/6896 , G01N2333/4704 , G01N2500/00
摘要： The present invention provides screening methods for agonists or antagonists of Sema6C using Plexin-A1, and tools for the screening and the like. It evaluates a case of making a recombinant protein having an extracellular domain of Semaphorin 6C contact a protein having an extracellular domain of Plexin-A1 by comparing it with a case of contacting a recombinant protein and a target substance having an extracellular domain of Semaphorin 6C, or the target substance with a protein having an extracellular domain of Plexin-A1. The evaluation will be carried out by the connectivity of a protein having an extracellular domain of Semaphorin 6C, a growth cone collapse activity of Plexin-A1 expressing cell, or a contractile activity of Plexin-A1 expressing cell.
摘要翻译：本发明提供使用Plexin-A1的Sema6C的激动剂或拮抗剂的筛选方法，以及用于筛选的工具等。它评估了通过与将重组蛋白质和具有信号素6C细胞外结构域的靶物质接触的情况进行比较来制备具有信号素6C细胞外结构域的重组蛋白的情况与具有Plexin-A1细胞外结构域的蛋白质接触的情况，或具有Plexin-A1细胞外结构域的蛋白质的目标物质。评估将通过具有信号素6C的细胞外结构域的蛋白质，Plexin-A1表达细胞的生长锥塌陷活性或Plexin-A1表达细胞的收缩活性的连通性进行。

8. 发明申请

US20050249741A1 Novel Semaphorin gene: Semaphorin W 审中-公开
标题翻译：新的信号素基因：信号素W
公开(公告)号：US20050249741A1
公开(公告)日：2005-11-10
申请号：US10925970
申请日：2004-08-26
申请人： Toru Kimura , Kaoru Kikuchi
发明人： Toru Kimura , Kaoru Kikuchi
IPC分类号： A61K38/00 , C07K14/47 , C12N1/21 , C12N15/12 , A61K39/00 , C07H21/04 , C07K16/18 , C12N15/09
CPC分类号： C07K14/4703 , A01K2217/05 , A61K38/00
摘要： The present invention provides Semaphorin W inhibiting neurite outgrowth, and a gene therefor, as well as other Semaphorins hybridizing to said Semaphorin W gene, modified proteins or partial peptides of said Semaphorin W, antibodies against said Semaphorin W, antisense nucleotides against said Semaphorin W gene, and the use of such substances as pharmaceutical or diagnostic agents or laboratory reagents. The present invention further provides a method of screening for Semaphorin W antagonists employing said Semaphorin W, Semaphorin W antagonists obtained by said screening method, pharmaceutical agents comprising such antagonists, and transgenic animals involving said Semaphorin W.
摘要翻译：本发明提供了抑制神经突生长的信号素W及其基因，以及与所述信号素W基因杂交的其他信号素，所述信号素W的修饰蛋白或部分肽，针对所述信号素W的抗体，针对所述信号素W基因的反义核苷酸，以及药物或诊断剂或实验室试剂等物质的使用。本发明还提供了使用所述筛选方法获得的所述信号素W，信号素W拮抗剂，包含这种拮抗剂的药物和涉及所述Semaphorin W的转基因动物筛选信号素W拮抗剂的方法。

9. 发明授权

US06576441B1 Semaphorin Z and gene encoding the same 失效
标题翻译：信号素Z和基因编码相同
公开(公告)号：US06576441B1
公开(公告)日：2003-06-10
申请号：US09077940
申请日：1998-06-05
申请人： Toru Kimura , Kaoru Kikuchi
发明人： Toru Kimura , Kaoru Kikuchi
IPC分类号： C12P2106
CPC分类号： C07K14/4703
摘要： Novel semaphorin Z; a gene thereof; a partial peptide of the semaphorin Z; an antibody; a DNA or an RNA complementary to the semaphorin Z gene; a method for screening a semaphorin Z inhibitor by using the semaphorin Z; the semaphorin Z inhibitor obtained by the screening; and a CNS neuron regeneration promoter comprising the inhibitor.
摘要翻译：新的信札Z; 其基因; 信号素Z的部分肽; 抗体; 与semaphorin Z基因互补的DNA或RNA; 通过使用信号素Z筛选信号素Z抑制剂的方法; 通过筛选获得的semaphorin Z抑制剂; 和包含抑制剂的CNS神经元再生启动子。

10. 发明授权

US5939534A Factors mutated in the D1 cap region 失效
标题翻译： D1帽区域突变的因素
公开(公告)号：US5939534A
公开(公告)日：1999-08-17
申请号：US669284
申请日：1996-06-28
申请人： Makoto Inoue , Kaoru Kikuchi , Yoko Ishige , Akira Ito , Toru Kimura , Chikao Nakayama , Hiroshi Noguchi
发明人： Makoto Inoue , Kaoru Kikuchi , Yoko Ishige , Akira Ito , Toru Kimura , Chikao Nakayama , Hiroshi Noguchi
IPC分类号： C07K14/475 , C12N15/18 , C07K14/52 , C07K14/535
CPC分类号： C07K14/475
摘要： Human ciliary neurotrophic factor (human CNTF) mutants, in which at least the amino acid residue corresponding to position 153 of wild type human CNTF has been substituted with another amino acid residue in the amino acid sequence encoding human CNTF, exhibit an activity comparable or superior to that of wild type human CNTF. It is therefore expected that the human CNTF mutants would be effective as drugs with improved side effects such as reduction in appearance of an autoantibody, loss of body weight, anorexia, a dry cough, fatigue, etc.In cytokines having sequence similarity to human CNTF and abundant .alpha. helices (GH, PRL, EPO, G- CSF, LIF, IL-6, IL-2, IL-4, GM-CSF), there are further provided mutants in the D1 cap region.
摘要翻译： PCT No.PCT / JP94 / 02269 Sec。 371日期：1996年6月28日 102（e）日期1996年6月28日PCT 1994年12月27日PCT PCT。 WO95 / 18150 PCT公开号日期1995年7月6日人类睫状神经营养因子（人CNTF）突变体，其中至少对应于野生型人CNTF的位置153的氨基酸残基已被编码人CNTF的氨基酸序列中的另一个氨基酸残基取代，与野生型人CNTF相当或优于其活性的活性。因此，预期人CNTF突变体作为具有改善的副作用的药物是有效的，例如自身抗体的外观减少，体重减轻，厌食，干咳，疲劳等。在与人CNTF具有序列相似性的细胞因子中和丰富的α螺旋（GH，PRL，EPO，G-CSF，LIF，IL-6，IL-2，IL-4，GM-CSF），还在D1帽区域提供突变体。

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