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1. 发明申请

US20130194972A1 Network Reconfiguration Method 有权
标题翻译：网络重新配置方法
公开(公告)号：US20130194972A1
公开(公告)日：2013-08-01
申请号：US12673544
申请日：2007-08-14
申请人： Torsten Mueller , Herbert Leuwer , Thorsten Kaiser , Thomas Alberty
发明人： Torsten Mueller , Herbert Leuwer , Thorsten Kaiser , Thomas Alberty
IPC分类号： H04L12/24
CPC分类号： H04L41/0813 , H04L12/437 , H04L12/462 , H04L45/02
摘要： A method of reconfiguring a data unit communication network that comprises bridge nodes is described. Each bridge node comprises two or more ports for receiving and sending data units, a controller for controlling said bridge node and for handling received data units, and a record for associating data unit address information with port identification information. The controller is capable of querying said record for determining which one or more ports to forward a received data unit to. The method comprises performing a topology reconfiguration procedure for said data unit communication network when detecting an occurrence of any one of one or more topology reconfiguration conditions, and performing a purge procedure of the records of the bridge nodes when detecting an occurrence of an indication of an upcoming topology reconfiguration of the data unit communication network, the indication being different from any of said topology reconfiguration conditions, and continuing to handle data units in the bridge nodes during the purge procedure.
摘要翻译：描述了重新配置包括网桥节点的数据单元通信网络的方法。每个网桥节点包括用于接收和发送数据单元的两个或更多个端口，用于控制所述网桥节点并用于处理接收到的数据单元的控制器，以及用于将数据单元地址信息与端口识别信息相关联的记录。控制器能够查询所述记录以确定哪一个或多个端口将接收的数据单元转发到。该方法包括当检测到一个或多个拓扑重新配置条件中的任何一个的发生时，对所述数据单元通信网络执行拓扑重新配置过程，并且当检测到所述网桥节点的指示的发生时，执行所述网桥节点的记录的清除过程数据单元通信网络的即将到来的拓扑重新配置，该指示不同于任何所述拓扑重新配置条件，并且在清除过程期间继续处理网桥节点中的数据单元。

2. 发明授权

US08743741B2 Network reconfiguration method 有权
标题翻译：网络重构方法
公开(公告)号：US08743741B2
公开(公告)日：2014-06-03
申请号：US12673544
申请日：2007-08-14
申请人： Torsten Mueller , Herbert Leuwer , Thorsten Kaiser , Thomas Alberty
发明人： Torsten Mueller , Herbert Leuwer , Thorsten Kaiser , Thomas Alberty
IPC分类号： H04L12/24
CPC分类号： H04L41/0813 , H04L12/437 , H04L12/462 , H04L45/02
摘要： A method of reconfiguring a data unit communication network that comprises bridge nodes is described. Each bridge node comprises two or more ports for receiving and sending data units, a controller for controlling said bridge node and for handling received data units, and a record for associating data unit address information with port identification information. The controller is capable of querying said record for determining which one or more ports to forward a received data unit to. The method comprises performing a topology reconfiguration procedure for said data unit communication network when detecting an occurrence of any one of one or more topology reconfiguration conditions, and performing a purge procedure of the records of the bridge nodes when detecting an occurrence of an indication of an upcoming topology reconfiguration of the data unit communication network, the indication being different from any of said topology reconfiguration conditions, and continuing to handle data units in the bridge nodes during the purge procedure.
摘要翻译：描述了重新配置包括网桥节点的数据单元通信网络的方法。每个网桥节点包括用于接收和发送数据单元的两个或更多个端口，用于控制所述网桥节点并用于处理接收到的数据单元的控制器，以及用于将数据单元地址信息与端口识别信息相关联的记录。控制器能够查询所述记录以确定哪一个或多个端口将接收的数据单元转发到。该方法包括当检测到一个或多个拓扑重新配置条件中的任何一个的发生时，对所述数据单元通信网络执行拓扑重新配置过程，并且当检测到所述网桥节点的指示的发生时，执行所述网桥节点的记录的清除过程数据单元通信网络的即将到来的拓扑重新配置，该指示不同于任何所述拓扑重新配置条件，并且在清除过程期间继续处理网桥节点中的数据单元。

3. 发明授权

US08325742B2 Network bridge and a method of operating thereof 有权
标题翻译：网桥及其操作方法
公开(公告)号：US08325742B2
公开(公告)日：2012-12-04
申请号：US12527695
申请日：2007-02-28
申请人： Torsten Mueller , Herbert Leuwer , Thorsten Kaiser , Thomas Alberty
发明人： Torsten Mueller , Herbert Leuwer , Thorsten Kaiser , Thomas Alberty
IPC分类号： H04L12/28
CPC分类号： H04L12/4625 , H04L1/0003 , H04L45/123 , H04L45/48 , H04L2001/0092 , H04W40/12 , H04W40/248 , H04W92/02
摘要： A network bridge comprising two ports for connection to two networks, a spanning tree controller and a wireless bridge link controller for each port. The ports employ an adaptive modulation technique. The wireless bridge link controller is connected to the port to exchange physical layer information with said port. When the port detects a change of its PHY mode, it sets the path cost of the link to a value configured for the new PHY mode and forces the bridge to recalculate its spanning tree. The wireless bridge link controller is also connected to the spanning tree controller. If the bridge detects that it has not received BPDUs for a certain time period and the timer will expire soon, the bridge forces the port, via the wireless bridge link controller, to use a more robust PHY mode.
摘要翻译：包括用于连接到两个网络的两个端口的网桥，每个端口的生成树控制器和无线桥接链路控制器。端口采用自适应调制技术。无线桥接链路控制器连接到端口，与所述端口交换物理层信息。当端口检测到其PHY模式的变化时，它将链路的路径开销设置为为新的PHY模式配置的值，并强制桥重新计算其生成树。无线桥接链路控制器也连接到生成树控制器。如果桥接器检测到它在一段时间内没有接收到BPDU，并且定时器将很快到期，桥接器将通过无线桥接链路控制器强制端口使用更强大的PHY模式。

4. 发明申请

US20110044346A1 Network Bridge and a Method of Operating Thereof 有权
标题翻译：网桥及其操作方法
公开(公告)号：US20110044346A1
公开(公告)日：2011-02-24
申请号：US12527695
申请日：2007-02-28
申请人： Torsten Mueller , Herbert Leuwer , Thorsten Kaiser , Thomas Alberty
发明人： Torsten Mueller , Herbert Leuwer , Thorsten Kaiser , Thomas Alberty
IPC分类号： H04L12/56
CPC分类号： H04L12/4625 , H04L1/0003 , H04L45/123 , H04L45/48 , H04L2001/0092 , H04W40/12 , H04W40/248 , H04W92/02
摘要： A network bridge comprising two ports for connection to two networks, a spanning tree controller and a wireless bridge link controller for each port. The ports employ an adaptive modulation technique. The wireless bridge link controller is connected to the port to exchange physical layer information with said port. When the port detects a change of its PHY mode, it sets the path cost of the link to a value configured for the new PHY mode and forces the bridge to recalculate its spanning tree. The wireless bridge link controller is also connected to the spanning tree controller. If the bridge detects that it has not received BPDUs for a certain time period and the timer will expire soon, the bridge forces the port, via the wireless bridge link controller, to use a more robust PHY mode.
摘要翻译：包括用于连接到两个网络的两个端口的网桥，每个端口的生成树控制器和无线桥接链路控制器。端口采用自适应调制技术。无线桥接链路控制器连接到端口，与所述端口交换物理层信息。当端口检测到其PHY模式的变化时，它将链路的路径开销设置为为新的PHY模式配置的值，并强制桥重新计算其生成树。无线桥接链路控制器也连接到生成树控制器。如果桥接器检测到它在一段时间内没有接收到BPDU，并且定时器将很快到期，桥接器将通过无线桥接链路控制器强制端口使用更强大的PHY模式。

5. 发明申请

US20070082402A1 Device and process for the quantitative evaluation of the polypeptides and markers contained in a sample of body fluid for recognizing pathological conditions 审中-公开
标题翻译：用于定量评估用于识别病理状况的体液样品中包含的多肽和标记物的装置和方法
公开(公告)号：US20070082402A1
公开(公告)日：2007-04-12
申请号：US10570708
申请日：2004-09-03
申请人： Harald Mischak , Stefan Wittke , Thorsten Kaiser
发明人： Harald Mischak , Stefan Wittke , Thorsten Kaiser
IPC分类号： G01N24/00
CPC分类号： G01N33/6848 , G01N2550/00 , Y10T436/24
摘要： Devices and processes for the quantitative evaluation of the polypeptides contained in a sample of body fluid and markers for recognizing pathological conditions are described. The polypeptides are compared with reference values stored in a data base. These reference values are stored as data records of polypeptides relevant to the condition, which respectively comprise at least some information about the probability of the occurrence and/or the concentration of the polypeptides for a pathological condition in samples of healthy and diseased subjects.
摘要翻译：描述用于定量评价体液样品中所含多肽的装置和方法以及用于识别病理状况的标记物。将多肽与存储在数据库中的参考值进行比较。这些参考值被存储为与条件相关的多肽的数据记录，其分别包含关于健康和患病受试者样品中病理状态的多肽的发生概率和/或浓度的至少一些信息。

6. 发明申请

US20120177640A1 OPTIMIZING THE PRODUCTION OF ANTIBODIES 审中-公开
标题翻译：优化抗体生产
公开(公告)号：US20120177640A1
公开(公告)日：2012-07-12
申请号：US13386175
申请日：2010-07-22
申请人： Josef Burg , Bernhard Hilger , Thorsten Kaiser , Wolfgang Kuhne , Lars Stiens , Claus Wallerius , Frank Zettl
发明人： Josef Burg , Bernhard Hilger , Thorsten Kaiser , Wolfgang Kuhne , Lars Stiens , Claus Wallerius , Frank Zettl
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/32 , C07K1/18 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/24
摘要： A general method is provided for the production of purified antibodies by separation of an antibody molecule from an antibody variant by chromatographic methods, e.g. to enhance therapeutic efficacy, by for example choosing a specific harvesting time point and/or a specific purification scheme. The current invention thus reports a method for producing an antibody composition comprising an antibody molecule and a variant thereof, comprising the following steps: providing a sample comprising the antibody molecule and a variant thereof, determining the presence of the antibody molecule and/or a variant thereof and/or the ratio of the amount of the antibody molecule or variant thereof to the sum of the amounts of the antibody molecule and the variant thereof, in an aliquot of said sample, determining a subsequent harvesting time point and/or antibody purification scheme on basis of the data obtained before, thereby producing an antibody composition comprising the antibody molecule and a variant thereof.
摘要翻译：提供了通过色谱法分离抗体分子与抗体变体的纯化抗体的一般方法，例如，以通过例如选择特定的收获时间点和/或特定的纯化方案来增强治疗功效。因此，本发明报告了一种生产包含抗体分子及其变体的抗体组合物的方法，包括以下步骤：提供包含抗体分子及其变体的样品，确定抗体分子和/或变体的存在和/或所述样品的等分试样中抗体分子或其变体的量与抗体分子及其变体的量的总和的比例，确定随后的收获时间点和/或抗体纯化方案基于以前获得的数据，从而产生包含抗体分子及其变体的抗体组合物。

7. 发明申请

US20060286602A1 Method and markers for the diagnosis of renal diseases 审中-公开
标题翻译：用于诊断肾脏疾病的方法和标记
公开(公告)号：US20060286602A1
公开(公告)日：2006-12-21
申请号：US11126385
申请日：2005-05-10
申请人： Harald Mischak , Thorsten Kaiser , Stefan Wittke , Michael Walden
发明人： Harald Mischak , Thorsten Kaiser , Stefan Wittke , Michael Walden
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/347
摘要： Certain embodiments of the invention relate to means and methods for the diagnosis of a renal disease, particularly to differential diagnosis. Renal diseases of particular interest in the context of the invention are IgA-nephropathy, membranous glomerulonephritis (MGN), minimal-change-disease (MCD), focal segemental glomerulosclerosis (FSGS), and diabetic nephropathy. Particularly, the method comprises (a) measuring the presence or the absence of a polypeptide marker in a urine sample, wherein the polypeptide marker is selected from the group of polypeptide markers shown in tables 1 to 22, and (b) comparing the probability of the presence of this marker in a disease patient to the probability of the presence of this marker in a control patient, wherein the individual probabilities are as indicated in the tables, and wherein (c1) if the probability of the presence of this marker in a disease patient is higher than the probability of the presence of this marker in a control patient, the presence of this marker is indicative for a higher probability of having the disease, or (c2) if the probability of the presence of this marker in a disease patient is lower than the probability of the presence of this marker in a control patient, the absence of the marker is indicative for a higher probability of having the disease.
摘要翻译：本发明的某些实施例涉及用于诊断肾脏疾病的方法和方法，特别是鉴别诊断。在本发明的上下文中特别感兴趣的肾脏疾病是IgA肾病，膜性肾小球性肾炎（MGN），微小变化疾病（MCD），局灶性肾小球硬化症（FSGS）和糖尿病性肾病。特别地，该方法包括（a）测量尿样中多肽标记的存在或不存在，其中多肽标记选自表1至22所示的多肽标记组，和（b）比较疾病患者中该标记物存在于对照患者中存在该标志物的可能性，其中个体概率如表中所示，并且其中（c1）如果该标志物存在于疾病患者高于对照患者中该标志物存在的可能性，该标志物的存在表明患有该疾病的概率较高，或（c2）如果该疾病存在该标志物的可能性患者低于对照患者中该标志物存在的可能性，则不存在标志物指示患有该疾病的可能性更高。

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