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    • 1. 发明授权
      US06911429B2 Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans 失效
    • Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
    • 用于治疗细胞对损伤和由透明质酸和透明质酸调节的增殖细胞疾病的反应的组合物和方法
    • US06911429B2
    • 2005-06-28
    • US09978309
    • 2001-10-15
    • Tony Cruz , Aleksandra Pastrak , Eva A. Turley
    • Tony Cruz , Aleksandra Pastrak , Eva A. Turley
    • A61K38/17 , A61P3/10 , A61P9/10 , A61P25/02 , A61P37/00 , C07K14/00 , C07K14/47 , C07K16/18 , A61K38/04 , C07H5/04
    • C07K14/47 , A61K2039/505 , C07K14/00 , C07K16/18
    • The present invention provides compositions and methods for treating a tissue disorder associated with a response-to-injury process or proliferating cells in a mammal. These tissue disorders are associated with a novel cellular phenotype designated as “transition cells” which are described herein. This cellular phenotype is characterized in having an activated erk kinase signaling activity, a stimulated AP-1 binding activity, and at least one characteristic selected from the group consisting of: (a) increased podosome formation, (b) increased flux of intracellular or extracellular hyaluronans or hyaladherins, (c) increased expression of a hyaladherin, (d) an inability to form focal adhesions, (e) increased metalloproteinase activity, and (f) increased expression of a hyaladherin. Example tissue disorders include fibrosis, inflammation, degeneration and invasive disorders such as occur in cancerous cells. The methods provided herein include administering to the mammal, an effective amount of a composition that alters the activity of transition molecules within a cell Transition molecules are shown to be comprised of hyaladherins, hyaluronans and associated molecules that regulate the transitional phenotype. A novel cell culture comprising transition cells is also provided, as well as compositions comprising particular peptides, polypeptides, and antibodies that affect the transitional phenotype.
    • 本发明提供用于治疗与哺乳动物的应答损伤过程或增殖细胞相关的组织病症的组合物和方法。 这些组织障碍与本文所述的被称为“过渡细胞”的新型细胞表型相关。 该细胞表型的特征在于具有激活的erk激酶信号传导活性，受刺激的AP-1结合活性，以及​​选自以下的至少一种特征：（a）增加的podosome形成，（b）增加细胞内或细胞外通量 透明质酸或透明质酸，（c）透明质酸的表达增加，（d）不能形成局灶性粘连，（e）增加的金属蛋白酶活性，和（f）增加的表达。 示例性组织病症包括纤维化，炎症，变性和侵入性疾病，例如在癌细胞中发生。 本文提供的方法包括向哺乳动物施用有效量的改变细胞内过渡分子活性的组合物。过渡分子显示为由透明质酸，透明质酸和调节过渡表型的相关分子组成。 还提供了包含过渡细胞的新型细胞培养物，以及包含影响过渡表型的特定肽，多肽和抗体的组合物。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Espacenet 法律信息 同族专利 专利引用
    • 9. 发明申请
      US20050058646A1 Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyalurons 审中-公开
    • Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyalurons
    • 用于治疗细胞对损伤和由透明质酸和透明质酸调节的增殖细胞疾病的反应的组合物和方法
    • US20050058646A1
    • 2005-03-17
    • US10898675
    • 2004-11-29
    • Eva Turley , Tony Cruz
    • Eva Turley , Tony Cruz
    • A61K38/00 , A61K38/17 , C07K14/00 , C07K14/47 , C07K14/705 , A61K39/395
    • C07K14/705 , A61K38/00 , C07K14/00 , C07K14/47
    • The present invention provides compositions and methods for treating a tissue disorder associated with a response-to-injury process or proliferating cells in a mammal. These tissue disorders are associated with a novel cellular phenotype designated as “transition cells” which are described herein. This cellular phenotype is characterized in having an activated erk kinase signaling activity, a stimulated AP-1 binding activity, and at least one characteristic selected from the group consisting of: (a) increased podosome formation, (b) increased flux of intracellular or extracellular hyaluronans or hyaladherins, (c) increased expression of a hyaladherin, (d) an inability to form focal adhesions, (e) increased metalloproteinase activity, and (f) increased expression of a hyaladherin. Example tissue disorders include fibrosis, inflammation, degeneration and invasive disorders such as occur in cancerous cells. The methods provided herein include administering to the mammal, an effective amount of a composition that alters the activity of transition molecules within a cell Transition molecules are shown to be comprised of hyaladherins, hyaluronans and associated molecules that regulate the transitional phenotype. A novel cell culture comprising transition cells is also provided, as well as compositions comprising particular peptides, polypeptides, and antibodies that affect the transitional phenotype.
    • 本发明提供用于治疗与哺乳动物的应答损伤过程或增殖细胞相关的组织病症的组合物和方法。 这些组织障碍与本文所述的被称为“过渡细胞”的新型细胞表型相关。 该细胞表型的特征在于具有激活的erk激酶信号传导活性，受刺激的AP-1结合活性，以及​​选自以下的至少一种特征：（a）增加的podosome形成，（b）增加细胞内或细胞外通量 透明质酸或透明质酸，（c）透明质酸的表达增加，（d）不能形成局灶性粘连，（e）增加的金属蛋白酶活性，和（f）增加的表达。 示例性组织病症包括纤维化，炎症，变性和侵入性疾病，例如在癌细胞中发生。 本文提供的方法包括向哺乳动物施用有效量的改变细胞内过渡分子活性的组合物。过渡分子显示为由透明质酸，透明质酸和调节过渡表型的相关分子组成。 还提供了包含过渡细胞的新型细胞培养物，以及包含影响过渡表型的特定肽，多肽和抗体的组合物。
    • 基本信息 添加关注 加入工作空间 PDF全文 PDF下载 全文下载 相似专利 双屏查看 权利要求书 说明书全文 Global Dossier Espacenet 法律信息 同族专利 专利引用
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