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1. 发明授权

US4596803A Piperazine derivatives and a medicine containing the same 失效
标题翻译：哌嗪衍生物和含有其的药物
公开(公告)号：US4596803A
公开(公告)日：1986-06-24
申请号：US587545
申请日：1984-03-08
申请人： Tomoh Masaki , Toshiro Kamishiro , Takashi Okazoe , Koichi Kumakura , Mitsuo Masaki
发明人： Tomoh Masaki , Toshiro Kamishiro , Takashi Okazoe , Koichi Kumakura , Mitsuo Masaki
IPC分类号： C07D295/10 , A61K31/495 , A61K31/496 , A61K31/505 , A61P9/00 , A61P9/08 , A61P9/10 , C07D213/74 , C07D213/75 , C07D239/42 , C07D295/18 , C07D295/185 , C07D303/48 , C07D405/12 , C07D405/14
CPC分类号： C07D303/48 , Y02P20/55
摘要： A compound is disclosed which has the formula, ##STR1## where R.sup.1 is a hydrogen atom, or a straight or branched chain alkyl group having 1 to 4 carbon atoms, and R.sup.2 is a straight or branched chain alkyl group having 1 to 4 carbon atoms, ##STR2## in which n is an integer of 0 to 3, or a pharmaceutically acceptable salt thereof. A process for producing the compound and a medicine containing the compound are also disclosed. Such medicine is effectively useful for inhibiting myocardial infarction.
摘要翻译：公开了具有下式的化合物，其中R 1是氢原子，或具有1至4个碳原子的直链或支链烷基，R 2是具有1至4个碳原子的直链或支链烷基，其中n为0〜3的整数， + TR ，或其药学上可接受的盐。还公开了制备该化合物的方法和含有该化合物的药物。这种药物有效地用于抑制心肌梗死。

2. 发明授权

US4507297A Piperazine derivatives and a medicine containing the same 失效
公开(公告)号：US4507297A
公开(公告)日：1985-03-26
申请号：US361506
申请日：1982-03-25
申请人： Tomoh Masaki , Toshiro Kamishiro , Takashi Okazoe , Koichi Kumakura , Mitsuo Masaki
发明人： Tomoh Masaki , Toshiro Kamishiro , Takashi Okazoe , Koichi Kumakura , Mitsuo Masaki
IPC分类号： C07D295/10 , A61K31/495 , A61K31/496 , A61K31/505 , A61P9/00 , A61P9/08 , A61P9/10 , C07D213/74 , C07D213/75 , C07D239/42 , C07D295/18 , C07D295/185 , C07D303/48 , C07D405/12
CPC分类号： C07D303/48 , Y02P20/55
摘要： A compound is disclosed which has the formula, ##STR1## where R.sup.1 is a hydrogen atom, or a straight or branched chain alkyl group having 1 to 4 carbon atoms, and R.sup.2 is a straight or branched chain alkyl group having 1 to 4 carbon atoms, ##STR2## in which n is an integer of 0 to 3, or a pharmaceutically acceptable salt thereof. A process for producing the compound and a medicine containing the compound are also disclosed. Such medicine is effectively useful for inhibiting myocardial infarction.

3. 发明授权

US5294569A Endothelin DNA and use thereof 失效
标题翻译：内皮素DNA及其用途
公开(公告)号：US5294569A
公开(公告)日：1994-03-15
申请号：US9764
申请日：1993-01-27
申请人： Tomoh Masaki , Masashi Yanagisawa , Akihiro Inoue
发明人： Tomoh Masaki , Masashi Yanagisawa , Akihiro Inoue
IPC分类号： A61K38/00 , C07K14/575 , C12N1/21 , C12N15/12 , C12N15/16 , C07H15/12 , C12N1/22 , C12P21/06
CPC分类号： C07K14/57536 , A61K38/00 , Y10S930/26
摘要： Disclosed are (1) a DNA sequence containing a segment coding for endothelin-2 or human endothelin-3, (2) a precursor protein and a mature peptide of endothelin-2 or human endothelin-3, (3) a transformant carrying a DNA sequence containing a DNA segment coding for endothelin-2 or human endothelin-3 and (4) a method for preparing mature endothelin-2 or endothelin-3 which comprises culturing the transformant described in (3), producing and accumulating a protein in a culture medium, and collecting the same.Cells transfected or transformed with the DNA allow large amounts of endothelin-2 or endothelin-3 to be produced, which causes the advantageous production of endothelin-2 or endothelin-3.Endothelin-2 and endothelin-3 can be utilized as hypotension therapeutic agents or local vasoconstrictors to animals including humans.
摘要翻译：公开了（1）含有编码内皮素-2或人内皮素-3的区段的DNA序列，（2）内皮素-2或人内皮素-3的前体蛋白质和成熟肽，（3）携带DNA的转化体包含编码内皮素-2或人内皮素-3的DNA区段的序列和（4）制备成熟内皮素-2或内皮素-3的方法，其包括培养（3）中所述的转化体，在培养物中产生和积累蛋白质中等，收集相同。用DNA转染或转化的细胞允许产生大量的内皮素-2或内皮素-3，这导致有利地产生内皮素-2或内皮素-3。内皮素-2和内皮素-3可用作包括人在内的动物的低血压治疗剂或局部血管收缩剂。

4. 发明授权

US5811263A DNA encoding human endothelin-3, and use thereof 失效
标题翻译：编码人内皮素-3的DNA及其用途
公开(公告)号：US5811263A
公开(公告)日：1998-09-22
申请号：US645771
申请日：1996-05-14
申请人： Tomoh Masaki , Masashi Yanagisawa , Akihiro Inoue
发明人： Tomoh Masaki , Masashi Yanagisawa , Akihiro Inoue
IPC分类号： A61K38/00 , C07K14/575 , C12N1/21 , C12N15/12 , C12N15/16 , C12N5/10 , C12N15/63
CPC分类号： C07K14/57536 , A61K38/00 , Y10S930/26
摘要： A cloned DNA molecule is disclosed. The DNA molecule encodes a human endothelin-3 protein having the amino acid sequence: Glu-Gly-Ala-Pro-Glu-His-His-Arg-Ser-Arg-Arg-Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-Ile-Asn-Thr-Pro-Glu or any portion of said amino acid sequence containing Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp. Also disclosed is a method of producing mature endothelin-3 protein. In the method, the host cell is cultured, allowing mature endothelin-3 to accumulate in the culture medium, and the mature endothelin-3 protein is separated from the culture medium.
摘要翻译：公开了克隆的DNA分子。 DNA分子编码具有以下氨基酸序列的人内皮素-3蛋白：Glu-Gly-Ala-Pro-Glu-His-His-Arg-Ser-Arg-Arg-Cys-Thr-Cys-Phe-Thr-Tyr- Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-Ile-Asn-Thr-Pro-Glu或含有Cys- Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp。还公开了生产成熟内皮素-3蛋白的方法。在该方法中，培养宿主细胞，允许成熟的内皮素-3在培养基中积累，并将成熟的内皮素-3蛋白从培养基中分离。

5. 发明授权

US5548061A Human endothelin-3 precursor protein 失效
标题翻译：人内皮素-3前体蛋白
公开(公告)号：US5548061A
公开(公告)日：1996-08-20
申请号：US163030
申请日：1993-12-06
申请人： Tomoh Masaki , Masashi Yanagisawa , Akihiro Inoue
发明人： Tomoh Masaki , Masashi Yanagisawa , Akihiro Inoue
IPC分类号： A61K38/00 , C07K14/575 , C12N1/21 , C12N15/12 , C12N15/16 , C07K14/00 , A61K38/16
CPC分类号： C07K14/57536 , A61K38/00 , Y10S930/26
摘要： Disclosed are (1) a DNA sequence containing a DNA segment coding for endothelin-2 or human endothelin-3, (2) a precursor protein and a mature peptide of endothelin-2 or human endothelin-3, (3) a transformant carrying a DNA sequence containing a DNA segment coding for endothelin-2 or human endothelin-3 and (4) a method for preparing mature endothelin-2 or endothelin-3 which comprises culturing the transformant described in (3), producing and accumulating a protein in a culture medium, and collecting the same. Cells transfected or transformed with the DNA allow large amounts of endothelin-2 or endothelin-3 to be produced, which causes the advantageous production of endothelin-2 or endothelin-3. Endothelin-2 and endothelin-3 can be utilized as hypotension therapeutic agents or local vasoconstrictors to animals including humans.
摘要翻译：公开了（1）含有编码内皮素-2或人内皮素-3的DNA区段的DNA序列，（2）前体蛋白质和内皮素-2或人内皮素-3的成熟肽，（3）携带含有编码内皮素-2或人内皮素-3的DNA区段的DNA序列和（4）制备成熟内皮素-2或内皮素-3的方法，其包括培养（3）中所述的转化体，产生和积累蛋白质培养基，并收集。用DNA转染或转化的细胞允许产生大量的内皮素-2或内皮素-3，这导致有利地产生内皮素-2或内皮素-3。内皮素-2和内皮素-3可用作包括人在内的动物的低血压治疗剂或局部血管收缩剂。

6. 发明授权

US4981950A Vasoconstrictor peptide 失效
标题翻译：血管收缩肽
公开(公告)号：US4981950A
公开(公告)日：1991-01-01
申请号：US249429
申请日：1988-09-26
申请人： Tomoh Masaki , Katsutoshi Goto , Sadao Kimura , Youji Mitsui , Yoshio Yazaki , Masashi Yanagisawa , Hiroki Kurihara
发明人： Tomoh Masaki , Katsutoshi Goto , Sadao Kimura , Youji Mitsui , Yoshio Yazaki , Masashi Yanagisawa , Hiroki Kurihara
IPC分类号： A61K38/00 , C07K14/575
CPC分类号： C07K14/57536 , A61K38/00
摘要： Disclosed is a vasoconstrictor peptide called Endothelin having a molecular weight of 2,500.+-.300. Endothelin contains 21 amino acid residues, wherein four cysteines form two sets of S--S bond.In order to obtain the vasoconstrictor factors of the present invention, it is preferable to culture the endothelial cells collected from the vascular inner walls in a serum-free medium.The vasoconstrictor peptides of the present invention can be utilized as hypotension therapeutic agents or local vasoconstrictors to animals including humans.

7. 发明授权

US5231166A Endothelin 失效
标题翻译：内托林
公开(公告)号：US5231166A
公开(公告)日：1993-07-27
申请号：US422132
申请日：1989-10-16
申请人： Tomoh Masaki , Masashi Yanagisawa , Akihiro Inoue
发明人： Tomoh Masaki , Masashi Yanagisawa , Akihiro Inoue
IPC分类号： A61K38/00 , C07K14/575 , C12N1/21 , C12N15/12 , C12N15/16
CPC分类号： C07K14/57536 , A61K38/00 , Y10S930/26
摘要： Endothelin-2 and a big type of endothelin-2 proteins are described. The proteins contain the amino acid sequence: Cys Ser Cys Ser Ser Trp Leu Asp Lys Glu Cys Val Tyr Phe Cys His Leu Asp Ile Ile Trp.

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