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1. 发明授权

US5465733A Guide wire for catheters and method for its use 失效
标题翻译：导管导丝及其使用方法
公开(公告)号：US5465733A
公开(公告)日：1995-11-14
申请号：US137321
申请日：1993-10-14
申请人： Tomoaki Hinohara , James W. Vetter
发明人： Tomoaki Hinohara , James W. Vetter
IPC分类号： A61M25/00 , A61M25/09
CPC分类号： A61M25/09 , A61M2025/09175 , A61M25/09033
摘要： An improved guide wire for use with cardiovascular catheters, particularly angioplasty or balloon dilatation catheters. The guide wire has a solid core wire which makes up the proximal end of the guide wire. The core wire is tapered toward the distal end to increase flexibility. The tapered distal end of the core wire is surrounded by a coil spring, which may be made completely or partially from a highly radiopaque material. A tapered transition device is attached to the coil spring at a selected distance from the distal end of the guide wire. The transition device is roughly bullet-shaped with a tapered distal edge which provides a smooth transition to aid the dilatation catheter in crossing a stenosis. The tapered transition device also serves to predilate very tight stenoses, making it easier to cross the lesion with an angioplasty balloon or other therapeutic device. The transition device can be made of metal or plastic with a radiopaque filler for easier visualization by x-ray or fluoroscopy. A removably attachable handle for maneuvering the guide wire and a method of use for the improved guide wire are also disclosed. An angioplasty catheter with a reinforced proximal shaft, which allows easier one-handed operation of the catheter and guide wire system, is also presented.
摘要翻译：用于心血管导管，特别是血管成形术或球囊扩张导管的改进的导丝。引导线具有构成导丝的近端的实心芯线。芯线朝向远端逐渐变细，以增加灵活性。芯线的锥形远端由螺旋弹簧围绕，螺旋弹簧可以由高度不透射线的材料完全或部分地制成。锥形过渡装置以与导丝的远端一定距离的螺旋弹簧连接。过渡装置大致为子弹状，具有锥形远端边缘，其提供平滑过渡以帮助扩张导管横穿狭窄。锥形过渡装置还用于预防非常紧张的狭窄，使得更容易用血管成形术球囊或其它治疗装置穿过病变。过渡装置可以由具有不透射线填充物的金属或塑料制成，以通过X射线或荧光透视来更容易地观察。还公开了用于操纵导丝的可拆卸地安装的手柄和用于改进的导丝的方法。还提供了具有加强的近侧轴的血管成形术导管，其允许更容易地单手操作导管和导丝系统。

2. 发明授权

US5417699A Device and method for the percutaneous suturing of a vascular puncture site 失效
标题翻译：用于经皮缝合血管穿刺部位的装置和方法
公开(公告)号：US5417699A
公开(公告)日：1995-05-23
申请号：US989611
申请日：1992-12-10
申请人： Enrique J. Klein , T. Daniel Gross , Tomoaki Hinohara , James W. Vetter
发明人： Enrique J. Klein , T. Daniel Gross , Tomoaki Hinohara , James W. Vetter
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61B17/12 , A61F2/00
CPC分类号： A61B17/0625 , A61B17/0057 , A61B17/0469 , A61B17/0401 , A61B17/0482 , A61B17/06066 , A61B2017/00004 , A61B2017/00637 , A61B2017/00641 , A61B2017/00663 , A61B2017/00867 , A61B2017/0458 , A61B2017/0464 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/06057 , A61F2002/30093 , A61F2210/0019 , Y10S604/90
摘要： A suture applying device comprises a shaft which carries a pair of needles near its distal end. The needles are joined by a length of suture, and the shaft is used to both introduce the needles into a lumen of a body structure and to push the needles back through tissue on either side of the puncture site. After the needles have passed through the tissue, they are captured on the shaft and drawn outward through the tract, leaving a loop of suture behind to close the puncture site near the body lumen. The suture can then be tied and the knot pushed back through the tract to complete the closure. Alternatively, a locking fastener formed of a resorbable material can be placed into the penetration over the sutures and the sutures tied over the fastener.
摘要翻译：缝合施加装置包括在其远端附近承载一对针的轴。针通过一定长度的缝合线连接，并且该轴用于将针引入体结构的内腔并将针推回穿刺部位两侧的组织。针穿过组织后，它们被捕获在轴上并向外穿过管道，留下一条缝合线，以闭合身体内腔附近的穿刺部位。然后可以将缝合线缝合，并将结通过管道推回以完成闭合。或者，由可再吸收材料形成的锁定紧固件可以被放置在缝合线上的穿透物中，并且缝合线被绑在紧固件上。

3. 发明授权

US6157852A Catheter apparatus for treating arterial occlusions 失效
标题翻译：用于治疗动脉闭塞的导管器械
公开(公告)号：US6157852A
公开(公告)日：2000-12-05
申请号：US8033
申请日：1998-01-16
申请人： Matthew R. Selmon , James W. Vetter , Tomoaki Hinohara , Charles F. Milo
发明人： Matthew R. Selmon , James W. Vetter , Tomoaki Hinohara , Charles F. Milo
IPC分类号： A61B8/12 , A61B17/00 , A61B17/22 , A61B17/30 , A61B17/32 , A61B19/00 , A61M25/01 , A61M29/02 , A61B5/00
CPC分类号： A61B17/3207 , A61B8/12 , A61B17/320725 , A61B17/320758 , A61B2017/00247 , A61B2017/00252 , A61B2017/22077 , A61B2017/308 , A61B2017/320004 , A61B2017/320044 , A61B2018/00392 , A61B2090/3784 , A61M2025/1097 , A61M25/0147
摘要： An apparatus is described for treating arterial occlusions combining an intraluminally operable catheter, having an occlusion-crossing working element, with a micro-invasive extraluminally operable locator for imaging the progress of the working element through the occlusion. Conical, abrasive, blunt-dissecting, and sharp-pointed, and steering and non-steering working elements including guide wires are described. Acoustic transducers and a flexible imaging tube are described for the locator. A suction cup is described for removably anchoring the imaging tube to a surface. A signal-emitting working element and cooperating signal-receiving locator are described. A method for treating arterial occlusions is described.
摘要翻译：描述了一种用于治疗动脉闭塞的装置，其组合具有阻塞交叉工作元件的可透光操作的导管与微创外向可操作的定位器，用于通过闭塞成像工作元件的进展。描述了包括导丝在内的锥形，磨料，钝性解剖和锋利的转向和非转向工作元件。描述了定位器的声学换能器和柔性成像管。描述了用于可移除地将成像管固定到表面的吸盘。描述信号发射工作元件和配合信号接收定位器。描述了治疗动脉闭塞的方法。

4. 发明授权

US6081738A Method and apparatus for the guided bypass of coronary occlusions 失效
标题翻译：冠状动脉闭塞引导旁路的方法和装置
公开(公告)号：US6081738A
公开(公告)日：2000-06-27
申请号：US7434
申请日：1998-01-15
申请人： Tomoaki Hinohara , Matthew R. Selmon , James W. Vetter , Charles F. Milo
发明人： Tomoaki Hinohara , Matthew R. Selmon , James W. Vetter , Charles F. Milo
IPC分类号： A61B8/12 , A61B17/00 , A61B17/22 , A61B17/30 , A61B17/32 , A61B19/00 , A61M25/01 , A61M29/02 , A61B5/05
CPC分类号： A61B17/3207 , A61B8/12 , A61B17/320725 , A61B17/320758 , A61B2017/00247 , A61B2017/00252 , A61B2017/22077 , A61B2017/308 , A61B2017/320004 , A61B2017/320044 , A61B2018/00392 , A61B2090/3784 , A61M2025/1097 , A61M25/0147
摘要： Described herein is a catheter method and apparatus for the guided intraluminal bypass of a coronary occlusion. A method is described employing an intraluminally operable catheter shaft including an optionally steerable working element, combined with an extraluminally operable locator including an imaging device, to selectively direct the working element to create a fluid path from the artery proximal to the occlusion into the vein and further from the vein back into the artery distal to the occlusion, to perfuse myocardium distal to the occlusion. Methods are described for creating a fluid path from the artery proximal to the occlusion into an adjacent vein and thereafter either stent grafting the fluid path to the vein, directing arterial blood distally within the vein, or stenting the fluid path and occluding the vein proximal thereto, in either case arterializing the venous system distal to the stent or stent graft. A catheter shaft is described for creating and perfusing the fluid path. Conical, guide wire and tissue-penetrating working elements are described. A scanning acoustic transducer and flexible imaging tube, and suction devices for anchoring are described for the locator. A signal-emitting working element and signal-detecting locator cooperating therewith are described.
摘要翻译：本文描述了用于冠状动脉闭塞引导的腔内旁路的导管方法和装置。描述了一种采用可腔内操作的导管轴的方法，该导管轴包括可选择的可操纵的工作元件，与包括成像装置的外部可操作的定位器组合，以选择性地引导工作元件以创建从靠近闭塞到静脉的动脉的流体路径，进一步从静脉回到动脉远端闭塞，将心肌远端灌注到闭塞。描述了用于创建从靠近闭塞的动脉到相邻静脉的流体路径的方法，之后任一支架将流体路径移植到静脉，将动脉血液定向在静脉内远端，或支架化流体路径并闭塞其附近的静脉在任何一种情况下动脉化远端支架或支架植入物的静脉系统。描述了用于创建和灌注流体路径的导管轴。描述了锥形，导丝和组织穿透工作元件。描述了扫描声换能器和柔性成像管，以及用于锚定的抽吸装置。描述与之配合的信号发射工作元件和信号检测定位器。

5. 发明授权

US5860991A Method for the percutaneous suturing of a vascular puncture site 失效
标题翻译：血管穿刺部位经皮缝合方法
公开(公告)号：US5860991A
公开(公告)日：1999-01-19
申请号：US916353
申请日：1997-08-22
申请人： Enrique J. Klein , T. Daniel Gross , Tomoaki Hinohara , James W. Vetter
发明人： Enrique J. Klein , T. Daniel Gross , Tomoaki Hinohara , James W. Vetter
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61B17/12 , A61F2/00
CPC分类号： A61B17/0625 , A61B17/0057 , A61B17/0469 , A61B17/0401 , A61B17/0482 , A61B17/06066 , A61B2017/00004 , A61B2017/00637 , A61B2017/00641 , A61B2017/00663 , A61B2017/00867 , A61B2017/0458 , A61B2017/0464 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/06057 , A61F2002/30093 , A61F2210/0019 , Y10S604/90
摘要： A suture applying device comprises a shaft which carries a pair of needles near its distal end. The needles are joined by a length of suture, and the shaft is used to both introduce the needles into a lumen of a body structure and to push the needles back through tissue on either side of the puncture site. After the needles have passed through the tissue, they are captured on the shaft and drawn outward through the tract, leaving a loop of suture behind to close the puncture site near the body lumen. The suture can then be tied and the knot pushed back through the tract to complete the closure. Alternatively, a locking fastener formed of a resorbable material can be placed into the penetration over the sutures and the sutures tied over the fastener.
摘要翻译：缝合施加装置包括在其远端附近承载一对针的轴。针通过一定长度的缝合线连接，并且该轴用于将针引入体结构的内腔并将针推回穿刺部位两侧的组织。针穿过组织后，它们被捕获在轴上并向外穿过管道，留下一条缝合线，以闭合身体内腔附近的穿刺部位。然后可以将缝合线缝合，并将结通过管道推回以完成闭合。或者，由可再吸收材料形成的锁定紧固件可以被放置在缝合线上的穿透物中，并且缝合线被绑在紧固件上。

6. 发明授权

US06266550B1 Catheter apparatus for treating arterial occlusions 有权
标题翻译：用于治疗动脉闭塞的导管器械
公开(公告)号：US06266550B1
公开(公告)日：2001-07-24
申请号：US09483173
申请日：2000-01-13
申请人： Matthew R. Selmon , James W. Vetter , Tomoaki Hinohara , Charles F. Milo
发明人： Matthew R. Selmon , James W. Vetter , Tomoaki Hinohara , Charles F. Milo
IPC分类号： A61B1732
CPC分类号： A61B17/3207 , A61B8/12 , A61B17/320725 , A61B17/320758 , A61B2017/22077 , A61B2017/308 , A61B2017/320004 , A61B2017/320044 , A61B2090/3784 , A61M25/0147
摘要： An apparatus is described for treating arterial occlusions combining an intraluminally operable catheter, having an occlusion-crossing working element, with a micro-invasive extraluminally operable locator for imaging the progress of the working element through the occlusion. Conical, abrasive, blunt-dissecting, and sharp-pointed, and steering and non-steering working elements including guide wires are described. Acoustic transducers and a flexible imaging tube are described for the locator. A suction cup is described for removably anchoring the imaging tube to a surface. A signal-emitting working element and cooperating signal-receiving locator are described. A method for treating arterial occlusions is described.
摘要翻译：描述了一种用于治疗动脉闭塞的装置，其组合具有阻塞交叉工作元件的可透光操作的导管与微创外向可操作的定位器，用于通过闭塞成像工作元件的进展。描述了包括导丝在内的锥形，磨料，钝性解剖和锋利的转向和非转向工作元件。描述了定位器的声学换能器和柔性成像管。描述了用于可移除地将成像管固定到表面的吸盘。描述信号发射工作元件和配合信号接收定位器。描述了治疗动脉闭塞的方法。

7. 发明授权

US5613974A Apparatus and method for vascular closure 失效
标题翻译：用于血管闭合的装置和方法
公开(公告)号：US5613974A
公开(公告)日：1997-03-25
申请号：US252124
申请日：1994-06-01
申请人： Bernard H. Andreas , T. Daniel Gross , Tomoaki Hinohara , James W. Vetter
发明人： Bernard H. Andreas , T. Daniel Gross , Tomoaki Hinohara , James W. Vetter
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61B17/12 , A61F2/00
CPC分类号： A61B17/0625 , A61B17/0057 , A61B17/0469 , A61B17/0401 , A61B17/0482 , A61B17/06066 , A61B2017/00004 , A61B2017/00637 , A61B2017/00641 , A61B2017/00663 , A61B2017/00867 , A61B2017/0458 , A61B2017/0464 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/06057 , A61F2002/30093 , A61F2210/0019 , Y10S604/90
摘要： A suture-applying device comprises a guide body having a needle guide at its distal end. Needles are reciprocatably carried on a shaft so that they may be advanced through the needle guide and tissue into the guide body. The suturing device is used by placing the needle guide within a vascular puncture. A contact surface is provided on the guide body, and the needle guide is configured so that the vascular wall surrounding the puncture is fully exposed to the needles passing therethrough. The suturing device may be combined with a predilator to form a system for suturing vascular punctures.
摘要翻译：缝合施加装置包括在其远端具有针引导件的引导体。针可以可往复运动地携带在轴上，使得它们可以通过针引导件和组织推进到引导体中。通过将针引导件放置在血管穿刺中来使用缝合装置。接触表面设置在引导体上，针引导构造成使得围绕穿刺的血管壁完全暴露于穿过其中的针。缝合装置可以与预制器组合以形成用于缝合血管穿刺的系统。

8. 发明授权

US07445626B2 Device and method for suturing tissue 失效
标题翻译：用于缝合组织的装置和方法
公开(公告)号：US07445626B2
公开(公告)日：2008-11-04
申请号：US10737668
申请日：2003-12-16
申请人： Ronald W. Songer , James W. Vetter , Enrique J. Klein , Bernard A. Andreas , Michael Barrett , Mark J. Foley , Brian Gore , Lewis Isbell , T. Daniel Gross , Tomoaki Hinohara
发明人： Ronald W. Songer , James W. Vetter , Enrique J. Klein , Bernard A. Andreas , Michael Barrett , Mark J. Foley , Brian Gore , Lewis Isbell , T. Daniel Gross , Tomoaki Hinohara
IPC分类号： A61B17/06
CPC分类号： A61B17/11 , A61B17/0057 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/06066 , A61B17/3417 , A61B17/3421 , A61B2017/00004 , A61B2017/00637 , A61B2017/00641 , A61B2017/00663 , A61B2017/00867 , A61B2017/0458 , A61B2017/0464 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0496 , A61B2017/06057 , A61F2002/30093 , A61F2210/0019
摘要： Systems for suturing a tissue layer having two sides with a suture be releasably retaining at least a portion of the suture in a stationary position on one side of the tissue layer. The portion of the suture is retrieved through the tissue layer from the opposite side whereby the suture is drawn from one side to the opposite side. Systems for suturing the wall of a tubular graft having two sides is also provided using a suture by releasably retaining at least a portion of the suture on one side of the wall. the portion of the length of suture is retrieved through the wall of the graft to the opposite side of the wall.
摘要翻译：通过可靠地将至少一部分缝合线保持在组织层的一侧上的静止位置来提供用于用缝合线缝合具有两侧的组织层的系统。缝线的部分从相对侧通过组织层回收，由此将缝合线从一侧拉到相对侧。也可以使用缝合线通过可释放地将缝合线的至少一部分保持在壁的一侧上来缝合具有两侧的管状移植物的壁的系统。缝合长度的一部分通过移植物的壁回收到壁的相对侧。

9. 发明授权

US06241667B1 Catheter apparatus for guided transvascular treatment of arterial occlusions 失效
标题翻译：用于导管经血管内治疗动脉闭塞的导管器
公开(公告)号：US06241667B1
公开(公告)日：2001-06-05
申请号：US09008198
申请日：1998-01-15
申请人： James W. Vetter , Tomoaki Hinohara , Matthew R. Selmon , Charles F. Milo
发明人： James W. Vetter , Tomoaki Hinohara , Matthew R. Selmon , Charles F. Milo
IPC分类号： A61B1700
CPC分类号： A61B17/3207 , A61B8/12 , A61B17/320725 , A61B17/320758 , A61B2017/00247 , A61B2017/00252 , A61B2017/22077 , A61B2017/308 , A61B2017/320004 , A61B2017/320044 , A61B2018/00392 , A61B2090/3784 , A61M25/0147 , A61M2025/1097
摘要： An apparatus is described for treating arterial occlusions combining an intraluminally operable catheter having an occlusion-crossing working element, with an extraluminally operable locator for imaging the progress of the working element through the occlusion. Suction coupling means are described for removably anchoring the locator to a surface proximate the heart. A method for treating arterial occlusions is described in which the distal end of the catheter shaft exits a lumen of the locator, penetrates the arterial wall distal to the occlusion, crosses the occlusion retrograde and passes into a separately introduced standard intravascular catheter, whereupon the distal end of the shaft may be manipulated from the proximal end of the standard catheter. The proximal end of the shaft is then released from external attachments and drawn into the artery to perform treatment or guiding functions. Spatial interrelationships are observed real-time via the locator. Conical, abrasive, blunt-dissecting, sharp-pointed and guide-wire type working elements, steerable and non-steering, are described. Acoustic transducers and a flexible imaging tube are described for the locator. A signal-emitting working element and cooperating signal-receiving locator are described.
摘要翻译：描述了一种用于治疗动脉闭塞的装置，其组合具有阻塞交叉工作元件的可内窥术操作的导管与可外部操作的定位器，用于通过闭塞成像工作元件的进展。吸入联接装置被描述为用于可移除地将定位器锚定到靠近心脏的表面。描述了治疗动脉闭塞的方法，其中导管轴的远端离开定位器的内腔，穿过远端阻塞的动脉壁，逆行阻塞并进入单独引入的标准血管内导管，于是远端可以从标准导管的近端操纵轴的端部。然后将轴的近端从外部附件释放并拉入动脉以执行治疗或引导功能。通过定位器实时观察空间相互关系。描述了锥形，磨料，钝性解剖，尖锐和导丝式工作元件，可转向和非转向。描述了定位器的声学换能器和柔性成像管。描述信号发射工作元件和配合信号接收定位器。

10. 发明授权

US5779719A Device and method for the percutaneous suturing of a vascular puncture site 失效
公开(公告)号：US5779719A
公开(公告)日：1998-07-14
申请号：US259410
申请日：1994-06-14
申请人： Enrique J. Klein , T. Daniel Gross , Tomoaki Hinohara , James W. Vetter
发明人： Enrique J. Klein , T. Daniel Gross , Tomoaki Hinohara , James W. Vetter
IPC分类号： A61B17/00 , A61B17/04 , A61B17/06 , A61B17/12 , A61F2/00
CPC分类号： A61B17/0625 , A61B17/0057 , A61B17/0469 , A61B17/0401 , A61B17/0482 , A61B17/06066 , A61B2017/00004 , A61B2017/00637 , A61B2017/00641 , A61B2017/00663 , A61B2017/00867 , A61B2017/0458 , A61B2017/0464 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/06057 , A61F2002/30093 , A61F2210/0019 , Y10S604/90
摘要： A suture applying device comprises a shaft which carries a pair of needles near its distal end. The needles are joined by a length of suture, and the shaft is used to both introduce the needles into a lumen of a body structure and to push the needles back through tissue on either side of the puncture site. After the needles have passed through the tissue, they are captured on the shaft and drawn outward through the tract, leaving a loop of suture behind to close the puncture site near the body lumen. The suture can then be tied and the knot pushed back through the tract to complete the closure. Alternatively, a locking fastener formed of a resorbable material can be placed into the penetration over the sutures and the sutures tied over the fastener.

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