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    • 1. 发明申请
    • O/W Emulsified Composition
    • O / W乳化成分
    • US20110206628A1
    • 2011-08-25
    • US13125982
    • 2009-10-27
    • Tomiko TakakuraTakafumi KurosawaIsao YajimaNozomi Fujiyama
    • Tomiko TakakuraTakafumi KurosawaIsao YajimaNozomi Fujiyama
    • A61K8/06A61K8/37A61Q17/04
    • A61Q17/04A61K8/062A61K8/068A61K8/40A61K8/496A61K8/4966A61K8/86
    • The present invention provides an O/W emulsified composition which contains an organic UV absorber in an oil state such as octocrylene and a solid organic UV absorber, and is excellent in UV protection ability, formulation stability, and feeling in use. The composition according to the present invention is an O/W emulsified composition, comprising: (a) an organic UV absorber in an oil state at 20° C., comprising (a1) octocrylene; (b) an organic UV absorber in a solid state at 20° C., selected from (b1) bis-ethylhexyloxyphenol methoxyphenyl triazine and (b2) methylene bis-benzotriazolyl tetramethylbutylphenol; and (c) a polyoxyethylene/polyoxyalkylene alkyl ether block polymer represented by formula (1) or (2): R1O—(PO)m-(EO)n-H  (1) wherein R1 is a hydrocarbon group having 16 to 18 carbon atoms; PO is an oxypropylene group, EU is an oxyethylene group, and PO and EO are added to each other in block form; and m and n respectively represent average addition mole number of PO and EO, 70>m>4, 70>n>10, and n>m; R2O-(AO)p-(EO)q-R3  (2) wherein R2 and R3 are either identical to or different from each other, and each of them is a hydrocarbon group having 1 to 4 carbon atoms; AO is an oxyalkylene group having 3 to 4 carbon atoms, EO is an oxyethylene group, and AO and EO are added to each other in block form; and p and q respectively represent average addition mole number of AO and EO, 1≦p≦70, 1≦q≦70, and 0.2
    • 本发明提供一种O / W乳化组合物,其含有油状态的有机紫外线吸收剂,如辛酸和固体有机紫外线吸收剂,并且具有优异的紫外线防护能力,制剂稳定性和使用感。 根据本发明的组合物是O / W乳化组合物,其包含:(a)在20℃的油状态的有机UV吸收剂,包含(a1) (b)在20℃下为固态的有机紫外线吸收剂,选自(b1)双 - 乙基己氧基苯酚甲氧基苯基三嗪和(b2)亚甲基双苯并三唑基四甲基丁基苯酚; 和(c)由式(1)或(2)表示的聚氧乙烯/聚氧化烯烷基醚嵌段聚合物:R1O-(PO)m-(EO)n-H(1)其中R1是具有16-18个碳原子的烃基; PO是氧化亚丙基,EU是氧化乙烯基,PO和EO以嵌段形式彼此相加; m和n分别表示PO和EO的平均加成摩尔数,70> m> 4,70> n> 10,n> m; R2O-(AO)对(EO)q-R3(2)其中R2和R3彼此相同或不同,并且它们各自是具有1至4个碳原子的烃基; AO是具有3〜4个碳原子的氧化烯基,EO是氧化乙烯基,AO和EO以嵌段形式彼此相加; 和p和q分别表示AO和EO的平均加成摩尔数,1&nlE; p&nlE; 70,1&nlE; q&nlE; 70和0.2(q /(p + q))<0.8, 包含组分(a)的相是700nm或更小。
    • 2. 发明授权
    • O/W emulsified composition
    • O / W乳化组合物
    • US08691191B2
    • 2014-04-08
    • US13125982
    • 2009-10-27
    • Tomiko TakakuraTakafumi KurosawaIsao YajimaNozomi Fujiyama
    • Tomiko TakakuraTakafumi KurosawaIsao YajimaNozomi Fujiyama
    • A61K8/06A61K8/86A61K8/90A61Q17/04
    • A61Q17/04A61K8/062A61K8/068A61K8/40A61K8/496A61K8/4966A61K8/86
    • The present invention provides an O/W emulsified composition which contains an organic UV absorber in an oil state such as octocrylene and a solid organic UV absorber, and is excellent in UV protection ability, formulation stability, and feeling in use. The composition according to the present invention is an O/W emulsified composition, comprising: (a) an organic UV absorber in an oil state at 20° C., comprising (a1) octocrylene; (b) an organic UV absorber in a solid state at 20° C., selected from (b1) bis-ethylhexyloxyphenol methoxyphenyl triazine and (b2) methylene bis-benzotriazolyl tetramethylbutylphenol; and (c) a polyoxyethylene/polyoxyalkylene alkyl ether block polymer represented by formula (1) or (2): R1O—(PO)m-(EO)n-H  (1) wherein R1 is a hydrocarbon group having 16 to 18 carbon atoms; PO is an oxypropylene group, EU is an oxyethylene group, and PO and EO are added to each other in block form; and m and n respectively represent average addition mole number of PO and EO, 70>m>4, 70>n>10, and n>m; R2O-(AO)p-(EO)q-R3  (2) wherein R2 and R3 are either identical to or different from each other, and each of them is a hydrocarbon group having 1 to 4 carbon atoms; AO is an oxyalkylene group having 3 to 4 carbon atoms, EO is an oxyethylene group, and AO and EO are added to each other in block form; and p and q respectively represent average addition mole number of AO and EO, 1≦p≦70, 1≦q≦70, and 0.2
    • 本发明提供一种O / W乳化组合物,其含有油状态的有机紫外线吸收剂,如辛酸和固体有机紫外线吸收剂,并且具有优异的紫外线防护能力,制剂稳定性和使用感。 根据本发明的组合物是O / W乳化组合物,其包含:(a)在20℃的油状态的有机UV吸收剂,包含(a1) (b)在20℃下为固态的有机紫外线吸收剂,选自(b1)双 - 乙基己氧基苯酚甲氧基苯基三嗪和(b2)亚甲基双苯并三唑基四甲基丁基苯酚; 和(c)由式(1)或(2)表示的聚氧乙烯/聚氧化烯烷基醚嵌段聚合物:R1O-(PO)m-(EO)n-H(1)其中R1是具有16-18个碳原子的烃基; PO是氧化亚丙基,EU是氧化乙烯基,PO和EO以嵌段形式彼此相加; m和n分别表示PO和EO的平均加成摩尔数,70> m> 4,70> n> 10,n> m; R2O-(AO)对(EO)q-R3(2)其中R2和R3彼此相同或不同,并且它们各自是具有1至4个碳原子的烃基; AO是具有3〜4个碳原子的氧化烯基,EO是氧化乙烯基,AO和EO以嵌段形式彼此相加; 和p和q分别表示AO和EO的平均加成摩尔数,1&nlE; p&nlE; 70,1&nlE; q&nlE; 70和0.2(q /(p + q))<0.8, 包含组分(a)的相是700nm或更小。
    • 4. 发明授权
    • O/W emulsified composition
    • O / W乳化组合物
    • US08425884B2
    • 2013-04-23
    • US13126176
    • 2009-10-27
    • Tomiko TakakuraTakafumi Kurosawa
    • Tomiko TakakuraTakafumi Kurosawa
    • A61K8/00
    • A61K8/86A61K8/062A61K8/068A61K8/8152A61K8/891A61K2800/21A61Q17/04
    • The present invention provides an O/W emulsified composition excellent in formulation stability, feeling in use, and UV protection ability. The emulsified composition according to the present invention is an O/W emulsified composition, wherein (i) a first oil phase and (ii) a second oil phase are dispersed separately in an aqueous phase, (i) the first oil phase having average particle size of 700 nm or less, comprising an organic UV absorber, and being formed with, as an emulsifier, a polyoxyethylene/polyoxyalkylene alkyl ether block polymer represented by formula (1) or (2): R1O—(PO)m-(EO)n-H  (1) wherein R1 is a hydrocarbon group having 16 to 18 carbon atoms; PO is an oxypropylene group, EO is an oxyethylene group, and PO and EO are added to each other in block form; and m and n respectively represent average addition mole number of PO and EO, 70>m>4, 70>n>10, and n>m; and R2O-(AO)p-(EO)q-R3  (2) wherein R2 and R3 are either identical to or different from each other, and each of them is a hydrocarbon group having 1 to 4 carbon atoms; AO is an oxyalkylene group having 3 to 4 carbon atoms, EO is an oxyethylene group, and AO and EO are added to each other in block form; and p and q respectively represent average addition mole number of AO and EO, 1≦p≦70, 1≦q≦70, and 0.2
    • 本发明提供了制剂稳定性,使用感和防紫外线性优异的O / W乳化组合物。 根据本发明的乳化组合物是O / W乳化组合物,其中(i)第一油相和(ii)第二油相分别分散在水相中,(i)第一油相具有平均颗粒 由式(1)或(2)表示的聚氧乙烯/聚氧化烯烷基醚嵌段聚合物作为乳化剂形成:含有有机紫外线吸收剂的大小为700nm以下的化合物:R1O-(PO)m-(EO )nH(1)其中R1是具有16至18个碳原子的烃基; PO是氧化丙烯基,EO是氧化乙烯基,PO和EO以嵌段形式彼此加入; m和n分别表示PO和EO的平均加成摩尔数,70> m> 4,70> n> 10,n> m; 和R2O-(AO)对(EO)q-R3(2),其中R2和R3彼此相同或不同,并且它们各自是具有1至4个碳原子的烃基; AO是具有3〜4个碳原子的氧化烯基,EO是氧化乙烯基,AO和EO以嵌段形式彼此相加; 和p和q分别表示AO和EO的平均加成摩尔数,1≤p≤70,1≤q≤70和0.2 <(q /(p + q))<0.8,和(ii)第二油相 其包含硅油,并且形成有作为乳化剂的烷基改性的羧基乙烯基聚合物。
    • 5. 发明申请
    • O/W Emulsified Composition
    • O / W乳化成分
    • US20110206627A1
    • 2011-08-25
    • US13126176
    • 2009-10-27
    • Tomiko TakakuraTakafumi Kurosawa
    • Tomiko TakakuraTakafumi Kurosawa
    • A61K8/90A61Q17/02
    • A61K8/86A61K8/062A61K8/068A61K8/8152A61K8/891A61K2800/21A61Q17/04
    • The present invention provides an O/W emulsified composition excellent in formulation stability, feeling in use, and UV protection ability. The emulsified composition according to the present invention is an O/W emulsified composition, wherein (i) a first oil phase and (ii) a second oil phase are dispersed separately in an aqueous phase, (i) the first oil phase having average particle size of 700 nm or less, comprising an organic UV absorber, and being formed with, as an emulsifier, a polyoxyethylene/polyoxyalkylene alkyl ether block polymer represented by formula (1) or (2): R1O—(PO)m-(EO)n-H  (1) wherein R1 is a hydrocarbon group having 16 to 18 carbon atoms; PO is an oxypropylene group, EO is an oxyethylene group, and PO and EO are added to each other in block form; and m and n respectively represent average addition mole number of PO and EO, 70>m>4, 70>n>10, and n>m; and R2O-(AO)p-(EO)q-R3  (2) wherein R2 and R3 are either identical to or different from each other, and each of them is a hydrocarbon group having 1 to 4 carbon atoms; AO is an oxyalkylene group having 3 to 4 carbon atoms, EO is an oxyethylene group, and AO and EO are added to each other in block form; and p and q respectively represent average addition mole number of AO and EO, 1≦p≦70, 1≦q≦70, and 0.2
    • 本发明提供了制剂稳定性,使用感和防紫外线性优异的O / W乳化组合物。 根据本发明的乳化组合物是O / W乳化组合物,其中(i)第一油相和(ii)第二油相分别分散在水相中,(i)第一油相具有平均颗粒 由式(1)或(2)表示的聚氧乙烯/聚氧化烯烷基醚嵌段聚合物作为乳化剂形成:含有有机紫外线吸收剂的大小为700nm以下的化合物:R1O-(PO)m-(EO )nH(1)其中R1是具有16至18个碳原子的烃基; PO是氧化丙烯基,EO是氧化乙烯基,PO和EO以嵌段形式彼此加入; m和n分别表示PO和EO的平均加成摩尔数,70> m> 4,70> n> 10,n> m; 和R2O-(AO)对(EO)q-R3(2),其中R2和R3彼此相同或不同,并且它们各自是具有1至4个碳原子的烃基; AO是具有3〜4个碳原子的氧化烯基,EO是氧化乙烯基,AO和EO以嵌段形式彼此相加; 和p和q分别表示AO和EO的平均加成摩尔数,1&nlE; p&nlE; 70,1&nlE; q&nlE; 70和0.2(q /(p + q))<0.8,和(ii)第二油相 其包含硅油,并且形成有作为乳化剂的烷基改性的羧基乙烯基聚合物。