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1. 发明授权

US08728485B2 Peptide library obtained from multi-clade chimeric immunogens derived from highly conserved regions of the human immunodeficiency virus type 1 (HIV-1) consensus proteome 有权
标题翻译：从源自人类免疫缺陷病毒1型（HIV-1）共有蛋白质组的高度保守区域的多克隆嵌合免疫原获得的肽文库
公开(公告)号：US08728485B2
公开(公告)日：2014-05-20
申请号：US12725651
申请日：2010-03-17
申请人： Tomas Hanke , Andrew James McMichael
发明人： Tomas Hanke , Andrew James McMichael
IPC分类号： A61K39/21 , A61K38/00 , A61K38/04 , C40B40/10
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , C07K2319/00 , C12N2710/10343 , C12N2740/16022 , C12N2740/16034 , C12N2740/16071
摘要： The present invention provides artificial fusion proteins (AFPs) designed to elicit an anti-HIV immune response, as well as nucleic acid molecules and expression vectors encoding those proteins. The AFPs of the invention may comprise domains from various HIV proteins, such as Gag, Pol, Vif, and Env proteins, which are partial sequences. HIVCON is an AFP in which the HIV domains are from several HIV Glade consensus sequences and which optionally contains additional domains which may be useful, for example, in monitoring expression levels or laboratory animal immune responses. Other aspects of the invention may include compositions and methods for inducing an anti-HIV immune response in a subject, preferably with a DNA prime-MVA boost strategy, and to induce a cell-mediated immune response.
摘要翻译：本发明提供设计用于引发抗HIV免疫应答的人工融合蛋白（AFP），以及编码这些蛋白质的核酸分子和表达载体。本发明的AFP可以包含来自各种HIV蛋白的结构域，例如作为部分序列的Gag，Pol，Vif和Env蛋白。 HIVCON是一种AFP，其中HIV结构域来自几种HIV Glade共有序列，并且任选地含有可能有用的其它结构域，例如监测表达水平或实验室动物免疫应答。本发明的其它方面可以包括用于在受试者中诱导抗HIV免疫应答的组合物和方法，优选使用DNA初始 - MVA增强策略，并诱导细胞介导的免疫应答。

2. 发明申请

US20100266635A1 HIVCON: AN HIV IMMUNOGEN AND USES THEREOF 有权
标题翻译： HIVCON：HIV免疫力及其用途
公开(公告)号：US20100266635A1
公开(公告)日：2010-10-21
申请号：US12725651
申请日：2010-03-17
申请人： Tomas HANKE , Andrew James McMichael
发明人： Tomas HANKE , Andrew James McMichael
IPC分类号： A61K39/21 , A61P31/18 , C40B40/10
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , C07K2319/00 , C12N2710/10343 , C12N2740/16022 , C12N2740/16034 , C12N2740/16071
摘要： The present invention provides artificial fusion proteins (AFPs) designed to elicit an anti-HIV immune response, as well as nucleic acid molecules and expression vectors encoding those proteins. The AFPs of the invention may comprise domains from various HIV proteins, such as Gag, Pol, Vif, and Env proteins, which are partial sequences. HIVCON is an AFP in which the HIV domains are from several HIV Glade consensus sequences and which optionally contains additional domains which may be useful, for example, in monitoring expression levels or laboratory animal immune responses. Other aspects of the invention may include compositions and methods for inducing an anti-HIV immune response in a subject, preferably with a DNA prime-MVA boost strategy, and to induce a cell-mediated immune response.
摘要翻译：本发明提供设计用于引发抗HIV免疫应答的人工融合蛋白（AFP），以及编码这些蛋白质的核酸分子和表达载体。本发明的AFP可以包含来自各种HIV蛋白的结构域，例如作为部分序列的Gag，Pol，Vif和Env蛋白。 HIVCON是一种AFP，其中HIV结构域来自几种HIV Glade共有序列，并且任选地含有可能有用的其它结构域，例如监测表达水平或实验室动物免疫应答。本发明的其它方面可以包括用于在受试者中诱导抗HIV免疫应答的组合物和方法，优选使用DNA初始 - MVA增强策略，并诱导细胞介导的免疫应答。

3. 发明授权

US07981430B2 Multi-clade chimeric immunogens derived from highly conserved regions of the human immunodeficiency virus type 1 (HIV-1) consensus proteome 有权
标题翻译：衍生自人类免疫缺陷病毒1型（HIV-1）共识蛋白质组的高度保守区域的多克隆嵌合免疫原
公开(公告)号：US07981430B2
公开(公告)日：2011-07-19
申请号：US11844301
申请日：2007-08-23
申请人： Tomas Hanke , Andrew James McMichael
发明人： Tomas Hanke , Andrew James McMichael
IPC分类号： A61K39/21 , A61K39/295
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , C07K2319/00 , C12N2710/10343 , C12N2740/16022 , C12N2740/16034 , C12N2740/16071
摘要： The present invention provides artificial fusion proteins (AFPs) designed to elicit an anti-HIV immune response, as well as nucleic acid molecules and expression vectors encoding those proteins. The AFPs of the invention may comprise domains from various HIV proteins, such as Gag, Pol, Vif, and Env proteins, which are partial sequences. HIVCON is an AFP in which the HIV domains are from several HIV clade consensus sequences and which optionally contains additional domains which may be useful, for example, in monitoring expression levels or laboratory animal immune responses. Other aspects of the invention may include compositions and methods for inducing an anti-HIV immune response in a subject, preferably with a DNA prime-MVA boost strategy, and to induce a cell-mediated immune response.
摘要翻译：本发明提供设计用于引发抗HIV免疫应答的人工融合蛋白（AFP），以及编码这些蛋白质的核酸分子和表达载体。本发明的AFP可以包含来自各种HIV蛋白的结构域，例如作为部分序列的Gag，Pol，Vif和Env蛋白。 HIVCON是一种AFP，其中HIV结构域来自几个HIV进化枝共有序列，并且任选地含有可能有用的其它结构域，例如在监测表达水平或实验室动物免疫应答中。本发明的其它方面可以包括用于在受试者中诱导抗HIV免疫应答的组合物和方法，优选使用DNA初始 - MVA增强策略，并诱导细胞介导的免疫应答。

4. 发明申请

US20080306244A1 Renta: an HIV immunogen and uses thereof 审中-公开
标题翻译： Renta：HIV免疫原及其用途
公开(公告)号：US20080306244A1
公开(公告)日：2008-12-11
申请号：US11436958
申请日：2006-05-12
申请人： Tomas Hanke , Andrew James McMichael
发明人： Tomas Hanke , Andrew James McMichael
IPC分类号： C07K14/00
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/70 , C07K14/005 , C07K2319/40 , C12N2710/24143 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334
摘要： The present invention provides artificial fusion proteins (AFPs) designed to elicit an anti-HIV immune response, as well as nucleic acid molecules and expression vectors encoding those proteins. The AFPs of the invention may comprise domains from various HIV proteins, including Reverse Trancriptase (RT), Env (gp41), Nef and Tat proteins, as well as at least one HIV CTL epitope associated with long-term, non-progression to AIDS; these domains are biologically-inactivated for one or more of the normal activity of those proteins or are partial protein sequences (and similarly biologically-inactivated). RENTA is an AFP in which the HIV domains are from an HIV Clade A consensus sequence and contains additional domains, useful for example, in monitoring expression levels or laboratory animal immune responses. Such domains are optionally included in the AFPs. Other aspects of the invention may include compositions for and methods of inducing an anti-HIV immune response in a subject, preferably using a DNA prime-MVA boost strategy, and preferably to induce a cell-mediated immune response.
摘要翻译：本发明提供设计用于引发抗HIV免疫应答的人工融合蛋白（AFP），以及编码这些蛋白质的核酸分子和表达载体。本发明的AFP可以包含来自各种HIV蛋白质的结构域，包括反向拉伸酶（RT），Env（gp41），Nef和Tat蛋白质，以及与长期，非进展性AIDS相关的至少一种HIV CTL表位 ; 这些结构域对于一种或多种这些蛋白质的正常活性是生物灭活的，或是部分蛋白质序列（和类似于生物灭活的）。 RENTA是一种法新社，艾滋病毒领域来自艾滋病毒分子A共有序列，并包含其他领域，例如用于监测表达水平或实验室动物免疫反应。这些结构域可选地包括在AFP中。本发明的其它方面可以包括在受试者中诱导抗HIV免疫应答的组合物和方法，优选使用DNA初始 - MVA增强策略，优选诱导细胞介导的免疫应答。

5. 发明授权

US5972351A Plasmodium falciparum MHC class I-restricted CTL epitopes derived from pre-erythrocytic stage antigens 失效
标题翻译：恶性疟原虫MHC I类限制性CTL表位衍生自红细胞前期抗原
公开(公告)号：US5972351A
公开(公告)日：1999-10-26
申请号：US318856
申请日：1994-12-05
申请人： Adrian Vivian Sinton Hill , Frances Margaret Gotch , John Elvin , Andrew James McMichael , Hilton Carter Whittle
发明人： Adrian Vivian Sinton Hill , Frances Margaret Gotch , John Elvin , Andrew James McMichael , Hilton Carter Whittle
IPC分类号： A61K39/00 , A61P33/06 , C07K14/155 , C07K14/445 , A61K39/015 , A61K38/04
CPC分类号： C07K14/005 , C07K14/445 , A61K39/00 , C12N2740/15022
摘要： A method of identifying peptides of an antigen of interest which are capable of recognition by or induction of cytotoxic T lymphocytes, comprises the steps of: ascertaining a "motif" of peptides which bind to a chosen HLA class I allele; providing peptides having this motif which are present in the known sequence of the antigen of interest; screening the peptides using an HLA assembly assay; and screening the resulting peptides for recognition by or induction of cytotoxic T lymphocytes. The above peptides have been identified by this method, and the peptides and vaccines containing them are also claimed.
摘要翻译： PCT No.PCT / GB93 / 00711 Sec。 371日期1994年12月5日第 102（e）日期1994年12月5日PCT提交1992年4月5日PCT公布。 WO93 / 20103 PCT出版物日期1993年10月14日一种鉴定能够识别或诱导细胞毒性T淋巴细胞的感兴趣的抗原肽的方法包括以下步骤：确定结合所选HLA I类等位基因的肽的“基序”; 提供存在于目的抗原的已知序列中的具有该基序的肽; 使用HLA装配测定法筛选肽; 并筛选得到的肽以识别细胞毒性T淋巴细胞或诱导细胞毒性T淋巴细胞。已经通过该方法鉴定了上述肽，并且还要求保护含有它们的肽和疫苗。

6. 发明授权

US5683701A Peptide fragments of HIV 失效
标题翻译： HIV片段
公开(公告)号：US5683701A
公开(公告)日：1997-11-04
申请号：US354884
申请日：1994-12-09
申请人： Andrew James McMichael , Douglas Fraser Nixon , Alain Robert Michael Townsend
发明人： Andrew James McMichael , Douglas Fraser Nixon , Alain Robert Michael Townsend
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/21 , A61K49/00 , A61P31/12 , A61P31/18 , A61P37/00 , C07K7/08 , C07K14/005 , C07K14/155 , C07K14/16 , C07K14/195 , C07K14/52 , G01N33/569 , A61K38/04 , A61K39/38 , C07K1/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2740/16222
摘要： Peptides are described which have the amino acid sequence of a fragment of HIV (human immunodeficiency virus) which interacts specifically with a particular human leucocyte antigen (HLA) class I molecule, to stimulate cytotoxic T lymphocyte immunity. Such fragments can be used in a potential vaccine against AIDS (acquired immune deficiency syndrome), and for diagnostic and therapeutic purposes.
摘要翻译：描述了具有与特定的人类白细胞抗原（HLA）I类分子特异性相互作用的HIV（人类免疫缺陷病毒）的片段的氨基酸序列以刺激细胞毒性T淋巴细胞免疫的肽。这样的片段可以用于抗艾滋病（获得性免疫缺陷综合征）的潜在疫苗，并用于诊断和治疗目的。

7. 发明授权

US5700635A HIV-1 gag cytotoxic T-lymphocyte epitope and method of use 失效
标题翻译： HIV-1 gag细胞毒性T淋巴细胞表位和使用方法
公开(公告)号：US5700635A
公开(公告)日：1997-12-23
申请号：US359000
申请日：1994-12-19
申请人： Andrew James McMichael , Douglas Fraser Nixon , Alain Robert Michael Townsend
发明人： Andrew James McMichael , Douglas Fraser Nixon , Alain Robert Michael Townsend
IPC分类号： A61K38/00 , A61K39/00 , A61K39/21 , A61P31/12 , A61P31/18 , C07K7/08 , C07K14/155 , C07K14/16 , C07K19/00 , G01N33/569 , C12Q1/70 , G01N33/53 , G01N33/555
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16222
摘要： A novel human immunodeficiency virus type 1 (HIV-1) cytotoxic T-lymphocyte (CTL) epitope has been identified in the gag coding region. This epitope corresponds to amino acids 255-269 of Gag and has the following sequence: NH.sub.2 -asn-pro-pro-ile-pro-val-gly-glu-ile-tyr-lys-arg-trp-ile-ile-COOH. This peptide interacts specifically with human leukocyte antigen-B8 (HLA-B8). This peptide is useful for the identification HIV-1 gag-specific CTL.
摘要翻译：已经在gag编码区中鉴定了一种新的人类免疫缺陷病毒1型（HIV-1）细胞毒性T淋巴细胞（CTL）表位。该表位对应于Gag的氨基酸255-269，并具有以下序列：NH2-asn-pro-pro-pro-val-gly-glu-ile-tyr-lys-arg-trp-ile-ile-COOH 。该肽与人白细胞抗原-B8（HLA-B8）特异性相互作用。该肽可用于鉴定HIV-1 gag特异性CTL。

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