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1. 发明申请

US20060131239A1 Agent for capturing substance having anionic substituent 有权
公开(公告)号：US20060131239A1
公开(公告)日：2006-06-22
申请号：US10547050
申请日：2004-03-04
申请人： Tohru Koike , Yohsuke Yamamoto , Hironori Takeda , Yoshio Sano , Satoko Yougai
发明人： Tohru Koike , Yohsuke Yamamoto , Hironori Takeda , Yoshio Sano , Satoko Yougai
IPC分类号： C07F3/10 , B01J39/00 , B01D15/00
CPC分类号： B01J20/265 , B01J20/0244 , B01J20/261 , B01J20/262 , B01J20/267 , B01J20/28016 , B01J20/28023 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3265 , B01J20/3425 , B01J20/3475 , B01J45/00 , B01J2220/58
摘要： A polymer carrier to which a prescribed zinc complex group is binding directly or through a spacer, having property to bond, under a certain condition, to an anionic substituent (a phosphate group, for example), showing low solubility to a solvent (preferably insolubility to a solvent) as a whole, and being capable of capturing, separating and purifying easily a substance having an anionic substituent (a phosphate group, for example).

2. 发明授权

US07473781B2 Agent for capturing substance having anionic substituent 有权
标题翻译：用于捕获具有阴离子取代基的物质的试剂
公开(公告)号：US07473781B2
公开(公告)日：2009-01-06
申请号：US10547050
申请日：2004-03-04
申请人： Tohru Koike , Yohsuke Yamamoto , Hironori Takeda , Yoshio Sano , Satoko Yougai
发明人： Tohru Koike , Yohsuke Yamamoto , Hironori Takeda , Yoshio Sano , Satoko Yougai
IPC分类号： C07F3/06 , C07K17/00 , C08G79/00
CPC分类号： B01J20/265 , B01J20/0244 , B01J20/261 , B01J20/262 , B01J20/267 , B01J20/28016 , B01J20/28023 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3265 , B01J20/3425 , B01J20/3475 , B01J45/00 , B01J2220/58
摘要： A polymer carrier to which a prescribed zinc complex group is binding directly or through a spacer, having property to bond, under a certain condition, to an anionic substituent (a phosphate group, for example), showing low solubility to a solvent (preferably insolubility to a solvent) as a whole, and being capable of capturing, separating and purifying easily a substance having an anionic substituent (a phosphate group, for example).
摘要翻译：规定的锌络合物基团直接结合或通过间隔基结合的聚合物载体，具有在一定条件下与阴离子取代基（例如磷酸酯基）键合的特性，对溶剂的溶解度低（优选不溶性）作为溶剂），并且能够容易地捕获，分离和纯化具有阴离子取代基的物质（例如磷酸酯基）。

3. 发明申请

US20080317701A1 Phosphate Ion Adsorbent 审中-公开
标题翻译：磷酸盐离子吸附剂
公开(公告)号：US20080317701A1
公开(公告)日：2008-12-25
申请号：US11664333
申请日：2005-10-04
申请人： Tohru Koike , Hironori Takeda , Yoshio Sano , Yoshio Okada
发明人： Tohru Koike , Hironori Takeda , Yoshio Sano , Yoshio Okada
IPC分类号： A61K31/787 , C08F301/00 , A61P3/00
CPC分类号： A61K31/787 , A61M1/3679 , B01J20/26 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/265 , B01J20/267 , B01J20/3208 , B01J20/3212 , B01J20/3219 , B01J20/3251 , B01J20/3265 , C08F8/44
摘要： The present invention is directed to a phosphate ion adsorbent comprising a polymer or a salt thereof with a metal complex group represented by the following general formula (II): bound thereto directly or through a spacer. The phosphate ion adsorbent of the present invention is advantageous not only in that the adsorbent specifically adsorbs phosphate ions in a living body, but also in that the adsorbent has high adsorbability to phosphate ions, thus useful in removing the phosphate ions from the living body.
摘要翻译：本发明涉及一种磷酸盐离子吸附剂，其包含聚合物或其盐与由以下通式（II）表示的金属络合物：直接或通过间隔物结合。本发明的磷酸盐离子吸附剂的优点不仅在于吸附剂特异性地吸附活体中的磷酸根离子，而且吸附剂对磷酸根离子具有高吸附性，因此可用于从活体中除去磷酸根离子。

4. 发明申请

US20050038258A1 Zinc complexes capable of capturing substances having anionic substituents 有权
标题翻译：能够捕获具有阴离子取代基的物质的锌络合物
公开(公告)号：US20050038258A1
公开(公告)日：2005-02-17
申请号：US10878131
申请日：2004-06-21
申请人： Tohru Koike , Masatatsu Suzuki , Mitsuhiko Shionoya
发明人： Tohru Koike , Masatatsu Suzuki , Mitsuhiko Shionoya
IPC分类号： C07F3/00 , C07F9/12 , C07F9/6596 , C07D211/68
CPC分类号： C07F9/6596 , C07F3/003 , C07F9/12
摘要： A zinc complex represented by formula (I-0): {wherein R may be the same or different from each other and represents H; an alkyl group having 1 to 16 carbon atoms; an acyl group, a carboxyalkyl group, an acylalkyl group, a carbamoylalkyl group, a cyanoalkyl group, a hydroxyalkyl group, an aminoalkyl group or a haloalkyl group (here, a carbon number at an alkyl portion of these groups is 1 to 16); a carboxyl group; a carbamoyl group; a hydroxyl group; a cyano group; an amino group or; a halogeno group (provided that all are Hs are excluded)} which is capable of capturing a substance having an anionic substituent.
摘要翻译：由式（I-0）表示的锌络合物：其中R可以相同或不同，表示H; 具有1至16个碳原子的烷基; 酰基，羧基烷基，酰基烷基，氨基甲酰基烷基，氰基烷基，羟烷基，氨基烷基或卤代烷基（这里，这些基团的烷基部分的碳数为1〜16）。羧基; 氨基甲酰基; 羟基; 氰基; 氨基或能够捕获具有阴离子取代基的物质的卤代基团（除了全部为H以外）}。

5. 发明授权

US07804592B2 Method for measuring a surface plasmon resonance and noble metal compound used for the same 有权
标题翻译：用于测量表面等离子体共振的方法和用于其的贵金属化合物
公开(公告)号：US07804592B2
公开(公告)日：2010-09-28
申请号：US10575714
申请日：2004-10-12
申请人： Tohru Koike , Akihiko Kawasaki , Tatsuhiro Kobashi , Makoto Takahagi
发明人： Tohru Koike , Akihiko Kawasaki , Tatsuhiro Kobashi , Makoto Takahagi
IPC分类号： G01J3/44
CPC分类号： G01N21/553 , C07D213/38 , G01J3/44 , G01N21/554 , G01N21/658 , G01N33/54373
摘要： The present invention provides a method for measuring a surface plasmon resonance, the method enabling easy detection of the existence of a phosphorylated peptide (protein) and determination whether a peptide is phosphorylated or not in biological materials. The present invention also provides a noble metal compound having high capability of coordination to a phosphorylated peptide, and being conveniently usable in the method. A first method for measuring surface plasmon resonance of the present invention comprises: placing a noble metal compound on a bottom face of a prism, irradiating a light to the prism to detect a reflected light, wherein, the noble metal compound has substituents of following formula (I) on a side opposite to a side contacting the prism, and a subject sample is added to a side having the substituent groups (I) in the noble metal compound. [wherein, X represents a linker group]
摘要翻译：本发明提供了一种测定表面等离子体共振的方法，该方法能够容易地检测磷酸化肽（蛋白质）的存在并确定生物材料中肽是否被磷酸化。本发明还提供了与磷酸化肽具有高配位能力的贵金属化合物，并且在该方法中可以方便地使用。用于测量本发明的表面等离子体共振的第一种方法包括：将贵金属化合物放置在棱镜的底面上，向棱镜照射光以检测反射光，其中贵金属化合物具有下式的取代基（I）在与棱镜接触的一侧相反的一侧，并且在贵金属化合物中的具有取代基（I）的一侧加入被检样品。 [其中，X表示连接基团]

6. 发明授权

US07358363B2 Zinc complexes capable of capturing substances having anionic substituents 有权
标题翻译：能够捕获具有阴离子取代基的物质的锌络合物
公开(公告)号：US07358363B2
公开(公告)日：2008-04-15
申请号：US10878131
申请日：2004-06-21
申请人： Tohru Koike , Masatatsu Suzuki , Mitsuhiko Shionoya
发明人： Tohru Koike , Masatatsu Suzuki , Mitsuhiko Shionoya
IPC分类号： C07D471/22
CPC分类号： C07F9/6596 , C07F3/003 , C07F9/12
摘要： A zinc complex represented by formula (I-0): {wherein R may be the same or different from each other and represents H; an alkyl group having 1 to 16 carbon atoms; an acyl group, a carboxyalkyl group, an acylalkyl group, a carbamoylalkyl group, a cyanoalkyl group, a hydroxyalkyl group, an aminoalkyl group or a haloalkyl group (here, a carbon number at an alkyl portion of these groups is 1 to 16); a carboxyl group; a carbamoyl group; a hydroxyl group; a cyano group; an amino group or; a halogeno group (provided that all are Hs are excluded)} which is capable of capturing a substance having an anionic substituent.
摘要翻译：由式（I-0）表示的锌络合物：其中R可以相同或不同，表示H; 具有1至16个碳原子的烷基; 酰基，羧基烷基，酰基烷基，氨基甲酰基烷基，氰基烷基，羟烷基，氨基烷基或卤代烷基（这里，这些基团的烷基部分的碳数为1〜16）。羧基; 氨基甲酰基; 羟基; 氰基; 氨基或能够捕获具有阴离子取代基的物质的卤代基团（除了全部为H以外）}。

7. 发明申请

US20110165523A1 SUBSTRATE TREATING SOLUTION AND METHOD EMPLOYING THE SAME FOR TREATING A RESIST SUBSTRATE 审中-公开
标题翻译：基板处理方法及其使用方法，用于处理耐蚀基板
公开(公告)号：US20110165523A1
公开(公告)日：2011-07-07
申请号：US13063666
申请日：2009-09-14
申请人： Xiaowei Wang , Wenbing Kang , Tomohide Katayama , Yuriko Matsuura , Tohru Koike
发明人： Xiaowei Wang , Wenbing Kang , Tomohide Katayama , Yuriko Matsuura , Tohru Koike
IPC分类号： G03F7/32
CPC分类号： G03F7/422
摘要： The present invention provides a resist substrate treating solution and a method employing the solution for treating a resist substrate. This treating solution enables to remove efficiently resist residues remaining on a surface of the resist substrate after development, and further to miniaturize a resist pattern. The solution is used for treating a resist substrate having a developed photoresist pattern, and comprises a solvent incapable of dissolving the photoresist pattern and a polymer soluble in the solvent. The developed resist substrate is brought into contact with the treating solution, and then washed with a rinse solution such as water to remove efficiently resist residues remaining on the resist substrate surface. The solvent and the polymer are preferably water and a water-soluble polymer, respectively.
摘要翻译：本发明提供一种抗蚀剂基板处理液和使用该抗蚀剂基板处理用溶液的方法。该处理液能够有效地除去显影后残留在抗蚀剂基板的表面上的残留物，进一步使抗蚀剂图案小型化。该溶液用于处理具有显影的光致抗蚀剂图案的抗蚀剂基板，并且包括不能溶解光致抗蚀剂图案的溶剂和可溶于溶剂的聚合物。使显影的抗蚀剂基板与处理溶液接触，然后用诸如水的冲洗溶液洗涤以有效地除去残留在抗蚀剂基板表面上的残留物。溶剂和聚合物分别优选为水和水溶性聚合物。

8. 发明授权

US07901559B2 Polyacrylamide gel for electrophoresis, polyacrylamide gel electrophoresis method using the same, method of producing the same, and acrylamide compound 有权
标题翻译：用于电泳的聚丙烯酰胺凝胶，使用其的聚丙烯酰胺凝胶电泳法，其制备方法和丙烯酰胺化合物
公开(公告)号：US07901559B2
公开(公告)日：2011-03-08
申请号：US11988968
申请日：2005-08-01
申请人： Tohru Koike , Akihiko Kawasaki , Tatsuhiro Kobashi
发明人： Tohru Koike , Akihiko Kawasaki , Tatsuhiro Kobashi
IPC分类号： G01N27/26 , C07D213/56 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/72 , C07D213/78 , C07D471/22
CPC分类号： C07D213/80 , C07D213/82 , C08F220/60 , C08F230/04
摘要： It is intended to provide a method for easily detecting a phosphorylated peptide (protein) in a test sample by using SDS-polyacrylamide gel electrophoresis (SDS-PAGE) which has been conventionally employed in analyzing a protein; a polyacrylamide gel for electrophoresis to be used in the method; a method of producing the gel; and a synthesizing intermediate in producing the gel. The polyacrylamide gel for electrophoresis to be used in the method of the invention is characterized in that at least a part of the structure thereof has a structure represented by the following formula (I); wherein M2+represents a transition metal ion; and X represents a linker group.
摘要翻译：本发明旨在提供一种通过使用已经用于分析蛋白质的SDS-聚丙烯酰胺凝胶电泳（SDS-PAGE）容易地检测测试样品中的磷酸化肽（蛋白质）的方法。用于电泳的聚丙烯酰胺凝胶用于该方法; 制备凝胶的方法; 以及制造凝胶的合成中间体。用于本发明方法的电泳用聚丙烯酰胺凝胶的特征在于，其结构的至少一部分具有由下式（I）表示的结构。其中M2 +表示过渡金属离子; X表示连接基团。

9. 发明申请

US20080108815A1 Methods for preparing and using a zinc complex 有权
标题翻译：制备和使用锌络合物的方法
公开(公告)号：US20080108815A1
公开(公告)日：2008-05-08
申请号：US11906256
申请日：2007-10-01
申请人： Tohru Koike , Masatatsu Suzuki , Mitsuhiko Shionoya
发明人： Tohru Koike , Masatatsu Suzuki , Mitsuhiko Shionoya
IPC分类号： C07F3/06
CPC分类号： C07F9/6596 , C07F3/003 , C07F9/12
摘要： A method for capturing a substance having an anionic substituent by contacting a substance having an anionic substituent with a zinc complex such that the substance binds to the zinc complex, the zinc complex being represented by a formula (I): wherein each R is the same or different from each other and each R represents H; an alkyl group having 1 to 16 carbon atoms; an acyl group, a carboxyalkyl group, an acylalkyl group, a carbamoylalkyl group, a cyanoalkyl group, a hydroxyalkyl group, an aminoalkyl group or a haloalkyl group, wherein an alkyl portion of the acyl group, the carboxyalkyl group, the acylalkyl group, the carbamoylalkyl group, the cyanoalkyl group, the hydroxyalkyl group, the aminoalkyl group and the haloalkyl group has 1 to 16 carbon atoms; a carboxyl group; a carbamoyl group; a hydroxyl group; a cyano group; an amino group; or a halogeno group.
摘要翻译：通过使具有阴离子取代基的物质与锌络合物接触使得该物质与锌络合物结合的方法，所述锌络合物由式（I）表示：其中每个R相同或彼此不同，每个R代表H; 具有1至16个碳原子的烷基; 酰基，羧基烷基，酰基烷基，氨基甲酰基烷基，氰基烷基，羟基烷基，氨基烷基或卤代烷基，其中酰基，羧基烷基，酰基烷基，氨基甲酰基烷基，氰基烷基，羟基烷基，氨基烷基和卤代烷基具有1至16个碳原子; 羧基; 氨基甲酰基; 羟基; 氰基; 氨基; 或卤代基团。

10. 发明授权

US07202093B2 Method for labeling phosphorylated peptides, method for selectively adsorbing phosphorylated peptides, complex compounds used in the methods, process for producing the complex compounds, and raw material compounds for the complex compounds 有权
标题翻译：标记磷酸化肽的方法，选择性吸附磷酸化肽的方法，该方法中使用的复合化合物，复合化合物的制备方法以及配合物的原料化合物
公开(公告)号：US07202093B2
公开(公告)日：2007-04-10
申请号：US10784576
申请日：2004-02-23
申请人： Tohru Koike , Akihiko Kawasaki , Tatsuhiro Kobashi , Makoto Takahagi
发明人： Tohru Koike , Akihiko Kawasaki , Tatsuhiro Kobashi , Makoto Takahagi
IPC分类号： G01N33/532 , G01N33/533 , G01N21/76 , G01N33/42 , C07K1/13 , C07D213/00 , G01N24/00 , G01N33/53
CPC分类号： C07F9/6596 , C07D213/38 , G01N33/531 , Y10S435/961 , Y10S436/805 , Y10S436/815 , Y10T436/24
摘要： Provided are a method for easily detecting phosphorylated peptides, namely, proteins, in samples derived from living organisms or the like, a method for selectively adsorbing the phosphorylated peptides, and compounds that are highly coordinated to the phosphorylated peptides and usable in the methods. The complex compound is represented by the formula: wherein X is a linker moiety, and Y is a labeling group. The compound (I) is highly coordinated to a phosphorylated peptide, and has a labeling group. Accordingly, with use of the compound (I), the phosphorylated peptide can be easily identified.
摘要翻译：提供了一种用于容易地检测来自活生物体等的样品中的磷酸化肽，即蛋白质的方法，用于选择性吸附磷酸化肽的方法，以及与磷酸化肽高配位的化合物，并且可用于该方法。络合物由下式表示：

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