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1. 发明申请

US20060194724A1 Methods and systems for nerve regeneration 审中-公开
标题翻译：神经再生的方法和系统
公开(公告)号：US20060194724A1
公开(公告)日：2006-08-31
申请号：US11066993
申请日：2005-02-25
申请人： Todd Whitehurst , James McGivern , Rafael Carbunaru , Kelly McClure , Kristen Jaax
发明人： Todd Whitehurst , James McGivern , Rafael Carbunaru , Kelly McClure , Kristen Jaax
IPC分类号： A61K38/18 , A61N1/18
CPC分类号： A61K38/185 , A61K9/0024 , A61K38/45 , A61N1/326
摘要： An exemplary method of regenerating a nerve within a patient includes implanting a system control unit within the patient and applying a stimulus to the nerve with the system control unit in accordance with one or more control parameters. The stimulus is configured to promote regeneration of the nerve. An exemplary system for regenerating a nerve within a patient includes a system control unit configured to apply a stimulus to the nerve in accordance with one or more control parameters. The system control unit is implanted within the patient and the stimulus promotes the regeneration of the nerve.
摘要翻译：在患者内再生神经的示例性方法包括将系统控制单元植入患者体内，并根据一个或多个控制参数与系统控制单元向神经施加刺激。刺激被配置成促进神经再生。用于再生患者内的神经的示例性系统包括系统控制单元，其被配置为根据一个或多个控制参数将刺激应用于神经。系统控制单元植入患者体内，刺激促进神经再生。

2. 发明申请

US20050267555A1 Engagement tool for implantable medical devices 审中-公开
标题翻译：可植入医疗器械的接合工具
公开(公告)号：US20050267555A1
公开(公告)日：2005-12-01
申请号：US11136938
申请日：2005-05-24
申请人： Goran Marnfeldt , Rafael Carbunaru , Kelly McClure , Matthew Haller , Tom He , Todd Whitehurst , Meredith Anderson , James Makous , Kristen Jaax , Peter Johnson
发明人： Goran Marnfeldt , Rafael Carbunaru , Kelly McClure , Matthew Haller , Tom He , Todd Whitehurst , Meredith Anderson , James Makous , Kristen Jaax , Peter Johnson
IPC分类号： A61B17/22 , A61B17/32 , A61B17/34 , A61B19/00 , A61N1/00 , A61N1/05 , A61N1/08
CPC分类号： A61B17/3417 , A61B17/221 , A61B17/32056 , A61B17/3468 , A61B90/30 , A61B2017/00358 , A61B2017/22035 , A61B2017/2215 , A61B2017/320044 , A61N1/05 , A61N1/08
摘要： Systems for adjusting a position of an implanted medical device within a patient include an engagement tool configured to couple to the implanted medical device. The engagement tool adjusts the position of the medical device when coupled to the implanted medical device. Methods of adjusting a position of an implanted medical device within a patient include locating the implanted medical device, coupling an engagement tool to the medical device, and adjusting a position of the engagement tool to adjust the position of the medical device.
摘要翻译：用于调整患者内植入的医疗装置的位置的系统包括被配置为耦合到植入的医疗装置的接合工具。接合工具当耦合到植入的医疗装置时调节医疗装置的位置。调整患者内的植入医疗装置的位置的方法包括定位植入的医疗装置，将接合工具联接到医疗装置，以及调整接合工具的位置以调整医疗装置的位置。

3. 发明申请

US20070049988A1 Optimal electrode contact polarity configurations for implantable stimulation systems 审中-公开
标题翻译：可植入刺激系统的最佳电极接触极性配置
公开(公告)号：US20070049988A1
公开(公告)日：2007-03-01
申请号：US11322788
申请日：2005-12-30
申请人： Rafael Carbunaru , Kristen Jaax , Todd Whitehurst , James Makous
发明人： Rafael Carbunaru , Kristen Jaax , Todd Whitehurst , James Makous
IPC分类号： A61N1/00
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/37205 , A61N1/3756
摘要： Systems for treating a patient with a medical condition include a lead having an array of electrode contacts each being programmable to have either a first polarity or a second polarity and a programming device configured to test a multiplicity of different electrode contact polarity configurations in which a programmed polarity of one or more of the electrode contacts is varied. Methods of using an implantable stimulator system include implanting a lead having an array of programmable electrode contacts disposed thereon in communication with a stimulation site, testing a multiplicity of different electrode contact polarity configurations in which a programmed polarity of one or more of the electrode contacts is varied, selecting an optimal electrode contact polarity configuration out of the multiplicity of different electrode contact polarity configurations, and applying the stimulation current via the optimal electrode contact polarity configuration to the stimulation site in accordance with one or more stimulation parameters.
摘要翻译：用于治疗患有医疗状况的患者的系统包括具有每个可编程为具有第一极性或第二极性的电极接触阵列的引线和被配置为测试多个不同电极接触极性配置的编程设备，其中编程一个或多个电极触点的极性是变化的。使用可植入刺激器系统的方法包括植入具有与刺激部位连通的可编程电极触点阵列的引线，测试多个不同的电极接触极性配置，其中一个或多个电极触点的编程极性为根据一个或多个刺激参数，通过不同电极接触极性配置的多重性选择最佳电极接触极性配置，并通过最佳电极接触极性配置将刺激电流施加到刺激部位。

4. 发明授权

US09452288B2 Multimodal neurostimulation systems and methods 有权
标题翻译：多模式神经刺激系统和方法
公开(公告)号：US09452288B2
公开(公告)日：2016-09-27
申请号：US11951987
申请日：2007-12-06
申请人： Todd Whitehurst , Rafael Carbunaru , Kristen Jaax , Andrew DiGiore , Brett D Schleicher
发明人： Todd Whitehurst , Rafael Carbunaru , Kristen Jaax , Andrew DiGiore , Brett D Schleicher
IPC分类号： A61N1/00 , A61N1/36 , A61N1/372 , A61B18/12 , A61N1/37
CPC分类号： A61N1/37241 , A61B18/12 , A61N1/36017 , A61N1/3625 , A61N1/37 , A61N1/37211 , A61N1/37247 , A61N1/37288 , A61N1/39
摘要： A system for performing a neurostimulation trial comprises an external trial stimulator capable of delivering stimulation energy to a plurality of electrodes carried by one or more stimulation leads. The external trial stimulator is configurable to operate in a plurality of stimulation energy delivery modes to respectively emulate one of different neurostimulator types. The system may further comprise a programmer capable of configuring the external trial stimulator to operate in one of the stimulation energy delivery modes. The programmer may be capable of generating a first programming screen capable of allowing a first set of stimulation parameters to be defined for the first neurostimulator type, and a second programming screen capable of allowing a second set of stimulation parameters to be defined for a second neurostimulator type.
摘要翻译：用于执行神经刺激试验的系统包括能够将刺激能量递送到由一个或多个刺激引线携带的多个电极的外部刺激器。外部刺激器可配置为在多个刺激能量递送模式中操作以分别模拟不同神经刺激器类型之一。该系统还可以包括能够配置外部试用刺激器以在刺激能量递送模式之一中操作的编程器。程序员可能能够生成第一编程屏幕，其能够允许为第一神经刺激器类型定义第一组刺激参数;以及第二编程屏幕，其能够允许为第二神经刺激器定义第二组刺激参数类型。

5. 发明申请

US20100145357A1 BURR HOLE PLUG HAVING DUAL SLIDABLE CLAMPING MECHANISMS 有权
标题翻译：带双滑动夹紧机构的双孔插头
公开(公告)号：US20100145357A1
公开(公告)日：2010-06-10
申请号：US12630761
申请日：2009-12-03
申请人： Courtney Lane , Jesse Geroy , James C. Makous , Todd Whitehurst , Matthew Flowers , John Michael Barker , Terry Ferrell , John Swoyer , Brett Schleicher , Jeff Gagnon , Andrew Digiore , Ellis Garai , Kristen Jaax , Rafael Carbunaru
发明人： Courtney Lane , Jesse Geroy , James C. Makous , Todd Whitehurst , Matthew Flowers , John Michael Barker , Terry Ferrell , John Swoyer , Brett Schleicher , Jeff Gagnon , Andrew Digiore , Ellis Garai , Kristen Jaax , Rafael Carbunaru
IPC分类号： A61N1/05 , A61B17/00
CPC分类号： A61B17/0057 , A61B90/10 , A61B2090/103 , A61N1/0534 , A61N1/0539
摘要： A burr hole plug comprises a plug base configured for being mounted around a burr hole. The plug base includes an aperture through which an elongated medical device exiting the burr hole may pass. The burr hole plug further comprises a retainer configured for being mounted within the aperture of the plug base. The retainer further includes first and second slidable clamping mechanisms configured for securing the medical devices therebetween within the aperture of the plug base. A method comprises introducing the medical device through the burr hole, mounting a plug base around the burr hole, such that the medical device extends through the plug base aperture, mounting the retainer within the aperture of the plug base, and sliding the first and second clamping mechanisms secure the medical device therebetween.
摘要翻译：毛刺孔塞包括构造成围绕钻孔安装的塞子基座。插头基座包括一个孔，通过该孔可以使离开钻孔的细长医疗装置通过。毛刺孔塞还包括保持器，其构造成用于安装在插头基座的孔内。保持器还包括第一和第二可滑动夹紧机构，其被构造用于将医疗装置固定在插头基座的孔内。一种方法包括：通过毛刺孔引导医疗装置，将插头基座安装在毛刺孔周围，使得医疗装置延伸穿过插头基座孔口，将保持器安装在插头基座的孔内，并将第一和第二夹紧机构将医疗装置固定在其间。

6. 发明申请

US20090149917A1 MULTIMODAL NEUROSTIMULATION SYSTEMS AND METHODS 有权
标题翻译：多模式神经系统和方法
公开(公告)号：US20090149917A1
公开(公告)日：2009-06-11
申请号：US11951987
申请日：2007-12-06
申请人： Todd Whitehurst , Rafael Carbunaru , Kristen Jaax , Andrew DiGiore , Brett D. Schleicher
发明人： Todd Whitehurst , Rafael Carbunaru , Kristen Jaax , Andrew DiGiore , Brett D. Schleicher
IPC分类号： A61N1/08
CPC分类号： A61N1/37241 , A61B18/12 , A61N1/36017 , A61N1/3625 , A61N1/37 , A61N1/37211 , A61N1/37247 , A61N1/37288 , A61N1/39
摘要： A system for performing a neurostimulation trial comprises an external trial stimulator capable of delivering stimulation energy to a plurality of electrodes carried by one or more stimulation leads. The external trial stimulator is configurable to operate in a plurality of stimulation energy delivery modes to respectively emulate one of different neurostimulator types. The system may further comprise a programmer capable of configuring the external trial stimulator to operate in one of the stimulation energy delivery modes. The programmer may be capable of generating a first programming screen capable of allowing a first set of stimulation parameters to be defined for the first neurostimulator type, and a second programming screen capable of allowing a second set of stimulation parameters to be defined for a second neurostimulator type.
摘要翻译：用于执行神经刺激试验的系统包括能够将刺激能量递送到由一个或多个刺激引线携带的多个电极的外部刺激器。外部刺激器可配置为在多个刺激能量递送模式中操作以分别模拟不同神经刺激器类型之一。该系统还可以包括能够配置外部试用刺激器以在刺激能量递送模式之一中操作的编程器。程序员可能能够生成第一编程屏幕，其能够允许为第一神经刺激器类型定义第一组刺激参数;以及第二编程屏幕，其能够允许为第二神经刺激器定义第二组刺激参数类型。

7. 发明申请

US20090112327A1 BURR HOLE PLUG DESIGNS 审中-公开
标题翻译： BURR HOLE插头设计
公开(公告)号：US20090112327A1
公开(公告)日：2009-04-30
申请号：US12258382
申请日：2008-10-24
申请人： Courtney Lane , Jesse Geroy , James C. Makous , Todd Whitehurst , Matthew Flowers , John Michael Barker , Terry Ferrell , John Swoyer , Brett Schleicher , Jeff Gagnon , Andrew Digiore , Ellis Garai , Kristen Jaax , Rafael Carbunaru
发明人： Courtney Lane , Jesse Geroy , James C. Makous , Todd Whitehurst , Matthew Flowers , John Michael Barker , Terry Ferrell , John Swoyer , Brett Schleicher , Jeff Gagnon , Andrew Digiore , Ellis Garai , Kristen Jaax , Rafael Carbunaru
IPC分类号： A61F2/02 , A61F2/28
CPC分类号： A61B17/0057 , A61B90/10 , A61B2090/103 , A61N1/0534 , A61N1/0539
摘要： A burr hole plug comprises a plug base including a flange configured for being mounted around a burr hole, an aperture through which an elongated medical device may pass, and tabs configured for extending within the cranial burr hole to center the plug base relative to the cranial burr hole. The burr hole plug further comprises a retainer configured for being mounted within the aperture of the plug base to secure the medical device. A method may comprise locating the plug base within a burr hole, such that the tabs are disposed within the burr hole to center the plug base relative to the cranial burr hole, introducing the elongated medical device through the cranial burr hole and into the brain tissue of the patient, mounting the retainer within the aperture of the plug base, and actuating the retainer to secure the medical device.
摘要翻译：一个钻孔塞包括一个插头基座，它包括一个凸缘，该凸缘被配置成安装在一个钻孔周围，一个细长的医疗设备可以通过的孔，以及在头部钻孔内延伸的突出部分，以使插头基座相对于头部钻孔。毛刺孔塞还包括保持器，其构造成安装在插头基座的孔内以固定医疗装置。一种方法可以包括将插头基座定位在钻孔内，使得突出部设置在毛刺孔内，以使塞子基座相对于头颅毛孔中心，将细长的医疗装置通过头颅毛孔引入脑组织将保持器安装在插头基座的孔内，并致动保持器以固定医疗装置。

8. 发明申请

US20060206165A1 Occipital nerve stimulation to treat headaches and other conditions 审中-公开
标题翻译：枕神经刺激治疗头痛等症状
公开(公告)号：US20060206165A1
公开(公告)日：2006-09-14
申请号：US11256356
申请日：2005-10-21
申请人： Kristen Jaax , Todd Whitehurst , Rafael Carbunaru , James Makous
发明人： Kristen Jaax , Todd Whitehurst , Rafael Carbunaru , James Makous
IPC分类号： A61N1/34
CPC分类号： A61N1/0529 , A61N1/0534 , A61N1/08 , A61N1/36071
摘要： A method of treating headaches includes stimulating a nerve in a patient's head with an electrode implanted over the skull on a posterior or superior portion of the patient's head to alleviate headache pain.
摘要翻译：治疗头痛的方法包括用位于患者头部的后部或上部的颅骨上植入的电极刺激患者头部的神经以减轻头痛。

9. 发明申请

US20060195154A1 Methods and systems for stimulating a motor cortex of the brain to treat a medical condition 失效
标题翻译：刺激大脑运动皮层治疗医疗状况的方法和系统
公开(公告)号：US20060195154A1
公开(公告)日：2006-08-31
申请号：US11067286
申请日：2005-02-25
申请人： Kristen Jaax , Todd Whitehurst , Rafael Carbunaru
发明人： Kristen Jaax , Todd Whitehurst , Rafael Carbunaru
IPC分类号： A61N1/08
CPC分类号： A61N1/36082 , A61N1/37205
摘要： Methods of treating a medical condition include applying at least one stimulus to a motor cortex within a brain of a patient with an implanted system control unit in accordance with one or more stimulation parameters. Systems for treating a medical condition include a system control unit implanted within the patient that is configured to apply at least one stimulus to a motor cortex within a brain of a patient in accordance with one or more stimulation parameters.
摘要翻译：治疗医疗状况的方法包括根据一个或多个刺激参数，用植入的系统控制单元向患者的脑内的运动皮质施加至少一种刺激。用于治疗医疗状况的系统包括植入患者体内的系统控制单元，其被配置为根据一个或多个刺激参数将至少一个刺激施加到患者脑内的运动皮质。

10. 发明申请

US20060178709A1 Methods and systems for treating a medical condition by promoting neural remodeling within the brain 有权
标题翻译：通过促进大脑内的神经重塑来治疗疾病的方法和系统
公开(公告)号：US20060178709A1
公开(公告)日：2006-08-10
申请号：US11393565
申请日：2006-03-29
申请人： Allison Foster , Rafael Carbunaru , Kristen Jaax , Todd Whitehurst
发明人： Allison Foster , Rafael Carbunaru , Kristen Jaax , Todd Whitehurst
IPC分类号： A61N1/18
CPC分类号： A61M5/14276 , A61M2210/0693 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/3605 , A61N1/36082 , A61N1/37205
摘要： Methods of treating a medical condition include applying at least one stimulus to a stimulation site within the brain of a patient with an implanted stimulator in accordance with one or more stimulation parameters. The at least one stimulus is configured to promote neural remodeling within the brain of the patient. Systems for treating a medical condition include an implantable stimulator configured to apply at least one stimulus to a stimulation site within the brain of a patient in accordance with one or more stimulation parameters. The at least one stimulus is configured to promote neural remodeling within the brain of the patient.
摘要翻译：治疗医疗状况的方法包括根据一个或多个刺激参数用植入的刺激器将至少一种刺激应用于患者脑内的刺激部位。所述至少一个刺激被配置为促进患者脑内的神经重建。用于治疗医疗状况的系统包括可植入刺激器，其被配置为根据一个或多个刺激参数将至少一个刺激施加到患者脑内的刺激部位。所述至少一个刺激被配置为促进患者脑内的神经重建。

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