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1. 发明授权

US07181268B2 Ischemia detection 失效
标题翻译：缺血检测
公开(公告)号：US07181268B2
公开(公告)日：2007-02-20
申请号：US10304112
申请日：2002-11-25
申请人： Todd J. Sheldon , Lee Stylos , Shannon D. Nelson , Robert W. Stadler
发明人： Todd J. Sheldon , Lee Stylos , Shannon D. Nelson , Robert W. Stadler
IPC分类号： A61B5/0402
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/36585
摘要： Techniques for detection and treatment of myocardial ischemia are described that monitor both the electrical and dynamic mechanical activity of the heart to detect and verify the occurrence of myocardial ischemia in a more reliable manner. The occurrence of myocardial ischemia can be detected by monitoring changes in an electrical signal such as an ECG or EGM, and changes in dynamic mechanical activity of the heart that are sensed by an accelerometer sensor. The heart acceleration signal can be obtained from an single- or multiple-axis accelerometer and/or a pressure sensor deployed within or near the heart. The techniques correlate contractility changes detected by an accelerometer or pressure sensor with changes in the ST electrogram segment detected by the electrodes to increase the reliability of ischemia detection.
摘要翻译：描述了用于检测和治疗心肌缺血的技术，其监测心脏的电和动态机械活性以更可靠的方式检测和验证心肌缺血的发生。可以通过监测诸如ECG或EGM的电信号的变化以及由加速度计传感器感测到的心脏的动态机械活动的变化来检测心肌缺血的发生。心脏加速度信号可以从部署在心脏内部或附近的单轴或多轴加速度计和/或压力传感器获得。该技术将由加速度计或压力传感器检测到的收缩性变化与由电极检测到的ST电描绘部分的变化相关联，以增加缺血检测的可靠性。

2. 发明授权

US06937899B2 Ischemia detection 有权
标题翻译：缺血检测
公开(公告)号：US06937899B2
公开(公告)日：2005-08-30
申请号：US09945179
申请日：2001-08-30
申请人： Todd J. Sheldon , Lee Stylos , Shannon D. Nelson , Robert W. Stadler
发明人： Todd J. Sheldon , Lee Stylos , Shannon D. Nelson , Robert W. Stadler
IPC分类号： A61B5/04 , A61B5/0452 , A61B5/11 , A61N1/365 , A61N1/368 , A61N1/362
CPC分类号： A61B5/4839 , A61B5/04011 , A61B5/0452 , A61B5/1107 , A61B5/6869 , A61B5/7203 , A61B2562/028 , A61B2562/222 , A61N1/36542 , A61N1/368
摘要： Techniques for detection and treatment of myocardial ischemia are described that monitor both the electrical and dynamic mechanical activity of the heart to detect and verify the occurrence of myocardial ischemia in a more reliable manner. The occurrence of myocardial ischemia can be detected by monitoring changes in an electrical signal such as an ECG or EGM, and changes in dynamic mechanical activity of the heart. Dynamic mechanical activity can be represented, for example, by a heart acceleration signal or pressure signal. The electrical signal can be obtained from a set of implanted or external electrodes. The heart acceleration signal can be obtained from an accelerometer or pressure sensor deployed within or near the heart. The techniques correlate contractility changes detected by an accelerometer or pressure sensor with changes in the ST electrogram segment detected by the electrodes to increase the reliability of ischemia detection.
摘要翻译：描述了用于检测和治疗心肌缺血的技术，其监测心脏的电和动态机械活性以更可靠的方式检测和验证心肌缺血的发生。可以通过监测诸如ECG或EGM的电信号的变化以及心脏的动态机械活动的变化来检测心肌缺血的发生。动态机械活动可以例如通过心脏加速度信号或压力信号来表示。电信号可以从一组植入电极或外部电极获得。可以从部署在心脏内部或附近的加速度计或压力传感器获得心脏加速度信号。该技术将由加速度计或压力传感器检测到的收缩性变化与由电极检测到的ST电描绘部分的变化相关联，以增加缺血检测的可靠性。

3. 发明申请

US20130030492A1 METHOD FOR DISCRIMINATING ANODAL AND CATHODAL CAPTURE 有权
标题翻译：用于分析阳极和阴极捕获的方法
公开(公告)号：US20130030492A1
公开(公告)日：2013-01-31
申请号：US13192713
申请日：2011-07-28
申请人： Robert W. Stadler , Todd J. Sheldon , Vincent E. Splett , Wade M. Demmer
发明人： Robert W. Stadler , Todd J. Sheldon , Vincent E. Splett , Wade M. Demmer
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/3684 , A61N1/3686 , A61N1/3712
摘要： An implantable device and associated method detect anodal capture during electrical stimulation. A first pacing pulse is delivered using a first cathode and a first anode. A second pacing pulse is delivered using the first cathode and a second anode. A first response to the first pacing pulse and a second response to the second pacing pulse are measured. Anodal capture of the first pacing pulse at the first anode is detected in response to a first difference between the first response and the second response.
摘要翻译：可植入装置和相关方法在电刺激期间检测阳极捕获。使用第一阴极和第一阳极传送第一起搏脉冲。使用第一阴极和第二阳极传送第二起搏脉冲。测量对第一起搏脉冲的第一响应和对第二起搏脉冲的第二响应。响应于第一响应和第二响应之间的第一差异来检测在第一阳极处的第一起搏脉冲的阳极捕获。

4. 发明申请

US20130030491A1 METHOD FOR DISCRIMINATING ANODAL AND CATHODAL CAPTURE 有权
标题翻译：用于分析阳极和阴极捕获的方法
公开(公告)号：US20130030491A1
公开(公告)日：2013-01-31
申请号：US13192697
申请日：2011-07-28
申请人： Robert W. Stadler , Todd J. Sheldon , Vincent E. Splett , Wade W. Demmer
发明人： Robert W. Stadler , Todd J. Sheldon , Vincent E. Splett , Wade W. Demmer
IPC分类号： A61N1/362
CPC分类号： A61N1/3712
摘要： An implantable device and associated method discriminate between cathodal and anodal capture during electrical stimulation. A control response to a pacing pulse delivered using a candidate cathode electrode and a universal anode and responses to bipolar pacing pulses delivered using candidate bipoles including the candidate cathode are measured. Responsive to the control response meeting a threshold response, the control response is classified as normal and each of the responses for the candidate bipoles are compared to the control response. The responses for the candidate bipoles are each classified based on the comparison.
摘要翻译：可植入装置和相关方法在电刺激期间区分阴极和阳极捕获。测量使用候选阴极电极和通用阳极传送的起搏脉冲的控制响应以及使用包括候选阴极的候选双极传送的双极起搏脉冲的响应。响应于满足阈值响应的控制响应，将控制响应分类为正常，并将候选双极的每个响应与控制响应进行比较。根据比较对候选双极的响应进行分类。

5. 发明授权

US08527050B2 Method for discriminating anodal and cathodal capture 有权
标题翻译：鉴别阳极和阴极捕获的方法
公开(公告)号：US08527050B2
公开(公告)日：2013-09-03
申请号：US13192697
申请日：2011-07-28
申请人： Robert W. Stadler , Todd J. Sheldon , Vincent E. Splett , Wade M. Demmer
发明人： Robert W. Stadler , Todd J. Sheldon , Vincent E. Splett , Wade M. Demmer
IPC分类号： A61N1/368
CPC分类号： A61N1/3712
摘要： An implantable device and associated method discriminate between cathodal and anodal capture during electrical stimulation. A control response to a pacing pulse delivered using a candidate cathode electrode and a universal anode and responses to bipolar pacing pulses delivered using candidate bipoles including the candidate cathode are measured. Responsive to the control response meeting a threshold response, the control response is classified as normal and each of the responses for the candidate bipoles are compared to the control response. The responses for the candidate bipoles are each classified based on the comparison.
摘要翻译：可植入装置和相关方法在电刺激期间区分阴极和阳极捕获。测量使用候选阴极电极和通用阳极传送的起搏脉冲的控制响应以及使用包括候选阴极的候选双极传送的双极起搏脉冲的响应。响应于满足阈值响应的控制响应，将控制响应分类为正常，并将候选双极的每个响应与控制响应进行比较。根据比较对候选双极的响应进行分类。

6. 发明申请

US20120101546A1 METHOD AND APPARATUS TO DETERMINE THE RELATIVE ENERGY EXPENDITURE FOR A PLURALITY OF PACING VECTORS 有权
标题翻译：确定多边形矢量相对能源支出的方法和装置
公开(公告)号：US20120101546A1
公开(公告)日：2012-04-26
申请号：US13194100
申请日：2011-07-29
申请人： Robert W. Stadler , Wade M. Demmer , Todd J. Sheldon
发明人： Robert W. Stadler , Wade M. Demmer , Todd J. Sheldon
IPC分类号： A61N1/08 , A61N1/37
CPC分类号： A61N1/3712 , A61N1/3622 , A61N1/3686 , A61N1/3708
摘要： A medical device system determines and displays relative energy expenditure information for programmable parameter values. The system establishes a programmable parameter and multiple values of the parameter to be compared. A module performs a measurements for each of the multiple values and related to energy expenditure of a battery of an implantable medical device when operating according to each of the multiple parameter values. An energy expenditure for each of the values is computed using the measurements, and a graphical user interface is generated for displaying information corresponding to the computed energy expenditure for multiple parameter values.
摘要翻译：医疗设备系统确定并显示可编程参数值的相对能量消耗信息。系统建立可编程参数和要比较的参数的多个值。当根据多个参数值中的每个参数值进行操作时，模块对可植入医疗装置的电池的能量消耗进行测量。使用测量来计算每个值的能量消耗，并且生成用于显示与多个参数值的计算能量消耗相对应的信息的图形用户界面。

7. 发明授权

US09037238B2 Method for efficient delivery of dual site pacing 有权
标题翻译：双位置起搏有效运送的方法
公开(公告)号：US09037238B2
公开(公告)日：2015-05-19
申请号：US13301084
申请日：2011-11-21
申请人： Robert W. Stadler , Wade M. Demmer , Vincent E. Splett , Todd J. Sheldon
发明人： Robert W. Stadler , Wade M. Demmer , Vincent E. Splett , Todd J. Sheldon
IPC分类号： A61N1/00 , A61N1/368 , A61N1/37
CPC分类号： A61N1/3684 , A61N1/368 , A61N1/3686 , A61N1/3712
摘要： An implantable device and associated method for delivering a multi-site pacing therapy includes electrodes for sensing cardiac signals and delivering cardiac pacing pulses to a first pacing site along a heart chamber and a therapy delivery module for delivering cardiac pacing pulses to a patient's heart via the electrodes. A sensing module measures an activation time at multiple pacing electrode sites along the heart chamber in response to delivering pacing pulses at the first pacing site. A controller is configured to identify a second pacing site from the plurality of pacing electrode sites in response to the activation times measured during pacing at the first site.
摘要翻译：用于递送多部位起搏治疗的可植入装置和相关联的方法包括用于感测心脏信号并将心脏起搏脉冲输送到沿着心脏室的第一起搏部位的电极和用于经由心脏起搏器将心脏起搏脉冲输送到患者心脏的治疗递送模块电极。响应于在第一起搏部位输送起搏脉冲，感测模块测量沿着心室的多个起搏电极部位的激活时间。控制器被配置为响应于在第一站点的起搏期间测量的激活时间，从多个起搏电极位置识别第二起搏部位。

8. 发明授权

US08682433B2 Method for efficient delivery of dual site pacing 有权
标题翻译：双位置起搏有效运送的方法
公开(公告)号：US08682433B2
公开(公告)日：2014-03-25
申请号：US13301113
申请日：2011-11-21
申请人： Todd J. Sheldon , Vincent E. Splett , Robert W. Stadler , Wade M. Demmer
发明人： Todd J. Sheldon , Vincent E. Splett , Robert W. Stadler , Wade M. Demmer
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/3686 , A61N1/371
摘要： An implantable device and associated method for delivering a multi-site pacing therapy includes electrodes for sensing cardiac signals and delivering cardiac pacing pulses. Electrodes positioned at first and second selected pacing sites are used to deliver pacing pulses to a first heart chamber using a bipole comprising the first electrode and the second electrode. A controller is configured to determine if anodal and cathodal capture can be achieved during pacing using the bipole. Responsive to anodal and cathodal capture being achieved, the controller selects a multi-site pacing configuration comprising the bipole for singly pacing the first and second pacing sites.
摘要翻译：用于递送多部位起搏治疗的可植入装置和相关联的方法包括用于感测心脏信号和递送心脏起搏脉冲的电极。使用位于第一和第二选定的起搏部位的电极，使用包括第一电极和第二电极的双极将起搏脉冲输送到第一心室。控制器被配置为确定在使用双极的起搏期间是否可以实现阳极和阴极捕获。响应于实现阳极和阴极捕获，控制器选择包括用于单步起搏第一和第二起搏部位的双极的多位置起搏配置。

9. 发明授权

US08626291B2 Method for discriminating anodal and cathodal capture 有权
标题翻译：鉴别阳极和阴极捕获的方法
公开(公告)号：US08626291B2
公开(公告)日：2014-01-07
申请号：US13192713
申请日：2011-07-28
申请人： Robert W. Stadler , Todd J. Sheldon , Vincent E. Splett , Wade M. Demmer
发明人： Robert W. Stadler , Todd J. Sheldon , Vincent E. Splett , Wade M. Demmer
IPC分类号： A61N1/365
CPC分类号： A61N1/371 , A61N1/3684 , A61N1/3686 , A61N1/3712
摘要： An implantable device and associated method detect anodal capture during electrical stimulation. A first pacing pulse is delivered using a first cathode and a first anode. A second pacing pulse is delivered using the first cathode and a second anode. A first response to the first pacing pulse and a second response to the second pacing pulse are measured. Anodal capture of the first pacing pulse at the first anode is detected in response to a first difference between the first response and the second response.
摘要翻译：可植入装置和相关方法在电刺激期间检测阳极捕获。使用第一阴极和第一阳极传送第一起搏脉冲。使用第一阴极和第二阳极传送第二起搏脉冲。测量对第一起搏脉冲的第一响应和对第二起搏脉冲的第二响应。响应于第一响应和第二响应之间的第一差异来检测在第一阳极处的第一起搏脉冲的阳极捕获。

10. 发明申请

US20130131749A1 METHOD FOR EFFICIENT DELIVERY OF DUAL SITE PACING 有权
标题翻译：双层高效交付方法
公开(公告)号：US20130131749A1
公开(公告)日：2013-05-23
申请号：US13301113
申请日：2011-11-21
申请人： Todd J. Sheldon , Vincent E. Splett , Robert W. Stadler , Wade M. Demmer
发明人： Todd J. Sheldon , Vincent E. Splett , Robert W. Stadler , Wade M. Demmer
IPC分类号： A61N1/37 , A61N1/365
CPC分类号： A61N1/3627 , A61N1/3686 , A61N1/371
摘要： An implantable device and associated method for delivering a multi-site pacing therapy includes electrodes for sensing cardiac signals and delivering cardiac pacing pulses. Electrodes positioned at first and second selected pacing sites are used to deliver pacing pulses to a first heart chamber using a bipole comprising the first electrode and the second electrode. A controller is configured to determine if anodal and cathodal capture can be achieved during pacing using the bipole. Responsive to anodal and cathodal capture being achieved, the controller selects a multi-site pacing configuration comprising the bipole for singly pacing the first and second pacing sites
摘要翻译：用于递送多部位起搏治疗的可植入装置和相关联的方法包括用于感测心脏信号和递送心脏起搏脉冲的电极。使用位于第一和第二选定的起搏部位的电极，使用包括第一电极和第二电极的双极将起搏脉冲输送到第一心室。控制器被配置为确定在使用双极的起搏期间是否可以实现阳极和阴极捕获。响应于实现阳极和阴极捕获，控制器选择包括用于单步起搏第一和第二起搏部位的双极的多位置起搏配置

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