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1. 发明授权

US06605475B1 Apparatus and method for sample delivery 有权
标题翻译：用于样品传送的装置和方法
公开(公告)号：US06605475B1
公开(公告)日：2003-08-12
申请号：US09293314
申请日：1999-04-16
申请人： Todd A. Taylor , William W. Carson , Xian-Wei Yao
发明人： Todd A. Taylor , William W. Carson , Xian-Wei Yao
IPC分类号： G01N110
CPC分类号： G01N27/44791 , G01N27/44743 , Y10T436/2575
摘要： Apparatus and methods have been developed to deliver automatically a sample to a reaction vessel, an analytical device or any location where sample introduction or deposition is desired. A sample delivery system of the invention generally includes a housing defining a channel, e.g., a capillary, and a volume controller, which is a temperature control device, in thermal communication with the channel. The channel preferably is closed at one end, and contains an opening for introduction of a sample. The closed end of the channel is associated thermally with the temperature control device. The temperature control device heats and cools a thermally expandable fluid in the channel which controls movement of a sample into, within and out of the channel.
摘要翻译：已经开发了装置和方法，以将样品自动递送到反应容器，分析装置或需要样品引入或沉积的任何位置。本发明的样品输送系统通常包括限定通道的壳体，例如毛细管，以及与通道热连通的温度控制装置的体积控制器。通道优选在一端封闭，并且包含用于引入样品的开口。通道的封闭端与温度控制装置热连接。温度控制装置加热和冷却通道中的热膨胀流体，其控制样品进入通道内和外通道的运动。

2. 发明授权

US5958202A Capillary electrophoresis enzyme immunoassay 失效
标题翻译：毛细管电泳酶免疫测定
公开(公告)号：US5958202A
公开(公告)日：1999-09-28
申请号：US792933
申请日：1997-01-22
申请人： Fred E. Regnier , Xian-Wei Yao , Todd A. Taylor , Martin Fuchs , Dieter Schmalzing , Lance Koutny , Wassim Nashabeh
发明人： Fred E. Regnier , Xian-Wei Yao , Todd A. Taylor , Martin Fuchs , Dieter Schmalzing , Lance Koutny , Wassim Nashabeh
IPC分类号： G01N33/561 , G01N27/447 , G01N33/537 , G01N33/543 , G01N33/78 , G01N27/26 , C12Q1/68 , G01N33/53
CPC分类号： G01N27/44747 , G01N27/44726 , G01N33/537 , G01N33/54306 , G01N33/54366 , G01N33/78
摘要： Disclosed are methods and apparatus for performing highly sensitive enzyme-amplified assays using channel electrophoresis of an enzyme having a biorecognition moiety. Combining a binding reaction of an analyte and an enzyme having a biorecognition moiety, and an electrophoretic separation which uses enzyme-amplified detection methodology, assay methods and apparatus are provided that offer simplicity, quantitative sensitivity and rapid analysis. Also disclosed are highly sensitive catalytically-amplified assays using a capillary electrophoresis format in which the binding reaction prior to electrophoresis is heterogeneous or homogeneous, and direct or competitive. The methods and apparatus for conducting sensitive automated catalytically-amplified assays using electrophoresis may be conducted in a microscale format.
摘要翻译：公开了使用具有生物识别部分的酶的通道电泳进行高度灵敏的酶扩增测定的方法和装置。结合分析物和具有生物识别部分的酶的结合反应以及使用酶扩增检测方法的测定方法和装置，提供了简单性，定量灵敏度和快速分析的电泳分离。还公开了使用毛细管电泳方式的高度敏感的催化扩增测定法，其中电泳前的结合反应是异质或均相的，直接的或竞争性的。使用电泳进行敏感的自动化催化扩增测定的方法和装置可以以微型格式进行。

3. 发明授权

US06375817B1 Apparatus and methods for sample analysis 有权
标题翻译：仪器和样品分析方法
公开(公告)号：US06375817B1
公开(公告)日：2002-04-23
申请号：US09293313
申请日：1999-04-16
申请人： Todd A. Taylor , William W. Carson , Lance Koutny
发明人： Todd A. Taylor , William W. Carson , Lance Koutny
IPC分类号： G01N2226
CPC分类号： G01N27/44743 , B01L3/502784 , B01L2200/0605 , B01L2300/0816 , B01L2300/0861 , B01L2400/0415 , B01L2400/0487 , G01N27/44791 , Y10T436/2575
摘要： The present invention is directed to apparatus and methods for rapid, automated, microscale sample analysis using pressure differentials. The invention includes an apparatus having intersecting channels for introduction of a sample and separation of that sample into its components. The sample introduction and separation channels preferably are etched in a microfabricated device, such as a microchip, to form a junction. Pressure gradients are applied to the channels to form a sample plug in the separation channel. The separation channel may have disposed within it a medium for separation of the components suspected to be contained in the sample. For example, with the proper medium, a voltage gradient may be applied along the separation channel to separate the components of the sample electrophoretically. The apparatus also may include means for detecting the components of the sample subsequent to separation.
摘要翻译：本发明涉及使用压力差的快速，自动化，微量样品分析的装置和方法。本发明包括具有用于引入样品和将样品分离成其组分的相交通道的装置。样品引入和分离通道优选在诸如微芯片的微制造装置中蚀刻以形成结。将压力梯度施加到通道以在分离通道中形成样品塞。分离通道可以在其内设置有用于分离怀疑包含在样品中的组分的介质。例如，使用适当的介质，可以沿着分离通道施加电压梯度以电泳分离样品的组分。该装置还可以包括用于在分离之后检测样品的组分的装置。

4. 发明授权

US5927551A Power assembly apparatus 失效
标题翻译：动力总成装置
公开(公告)号：US5927551A
公开(公告)日：1999-07-27
申请号：US742347
申请日：1996-11-01
申请人： Todd A. Taylor , Jeffrey Peck
发明人： Todd A. Taylor , Jeffrey Peck
IPC分类号： B65D83/00 , B65D35/28
CPC分类号： B65D83/0061
摘要： An improved fluid dispensing article is disclosed. The dispenser has a flexible, pleated and coated bag, securely seated within an enclosure. An improved inner container is provided with a seating member that substantially prevents movement within the enclosure.
摘要翻译：公开了改进的流体分配制品。分配器具有柔性，打褶和涂覆的袋，牢固地安置在外壳内。改进的内部容器设置有基本上防止在外壳内移动的就座构件。

5. 发明授权

US5491344A Method and system for examining the composition of a fluid or solid sample using fluorescence and/or absorption spectroscopy 失效
公开(公告)号：US5491344A
公开(公告)日：1996-02-13
申请号：US160514
申请日：1993-12-01
申请人： Jonathan E. Kenny , Todd A. Taylor
发明人： Jonathan E. Kenny , Todd A. Taylor
IPC分类号： G01J3/14 , G01N21/31 , G01N21/64 , G01N30/74
CPC分类号： G01N21/645 , G01J3/14 , G01N21/31 , G01N30/74
摘要： A method and system for examining the composition of a fluid or solid sample using fluorescence and/or absorption spectroscopy. In one embodiment, the system is adapted for use in examining liquid effluents as they elute from the end of a liquid chromatography column and comprises a Nd:YAG laser coupled to a harmonic generator. Pulses of the fourth harmonic therefrom are focused into a Raman shifter filled with a mixture of hydrogen and methane gases. The laser pulses have an intensity sufficient to produce an array of different-colored laser pulses by stimulated Raman scattering within the Raman shifter. These different-colored pulses are then dispersed according to their respective wavelengths and then launched into a plurality of optical fibers. The fibers tranmit the different-colored pulses to a specially-designed detection cell, where they simultaneously excite a flowing fluid sample contained within the cell at the same point of axial fluid flow. The fluid sample enters and exits the detection cell via tubes. Ultraviolet and visible lamp light is also used to illuminate the fluid sample, and the attenuation of this light is used to obtain an absorption spectrum of the sample. Optical fibers are used to transport fluorescent light, transmitted lamp light and a fraction of the Raman-shifted laser light to an imaging spectrograph. The light from each optical fiber is dispersed along a narrow strip by the spectrograph to produce an array of strips, each strip corresponding to one of the fibers, and is focused on the surface of a 2-dimensional CCD detector. The CCD detector converts each strip into electrical charges, which are digitized and processed by a computer to create an EEM. The aforementioned system is capable of obtaining an absorption spectrum from 200-479 nm with 0.5-5 nm spectral resolution and 10 fluorescence spectra simultaneously every 0.1-250 seconds for several hours, with crosstalk between channels of less than 10.sup.-4.

6. 外观设计

USD343359S Bottle holder 失效
公开(公告)号：USD343359S
公开(公告)日：1994-01-18
申请号：US746580
申请日：1991-08-19
申请人： Todd A. Taylor , Brian Taylor
设计人： Todd A. Taylor , Brian Taylor

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