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1. 发明申请

US20150316547A1 Electrophoretic Separation Devices and Methods for Using the Same 审中-公开
标题翻译：电泳分离装置及其使用方法
公开(公告)号：US20150316547A1
公开(公告)日：2015-11-05
申请号：US14650520
申请日：2014-03-06
申请人： Todd A. DUNCOMBE , Kevin A. YAMAUCHI , Julea VLASSAKIS , Chi-Chih KANG , Zhuchen XU , Robert LIN , Elly SINKALA , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Amy E. Herr , Alex James Hughes , Elly Sinkala , Todd A. Duncombe , Kevin A. Yamauchi , Julea Vlassakis , Chi-Chih Kang , Zhuchen Xu , Robert Lin
IPC分类号： G01N33/561 , G01N27/447
CPC分类号： G01N33/561 , G01N27/44726 , G01N27/44747 , G01N27/44791
摘要： Electrophoretic separation devices and methods for using the same are provided. Aspects of the devices include a polymeric separation medium that includes a plurality of microwells. Also provided are methods, systems and kits in which the subject devices find use. The devices and methods find use in a variety of different electrophoretic separation applications.
摘要翻译：提供了电泳分离装置及其使用方法。装置的方面包括包括多个微孔的聚合物分离介质。还提供了主题装置找到使用的方法，系统和工具包。该装置和方法可用于各种不同的电泳分离应用。

2. 发明授权

US10267795B2 Electrophoretic separation devices and methods for using the same 有权
公开(公告)号：US10267795B2
公开(公告)日：2019-04-23
申请号：US14650520
申请日：2014-03-06
申请人： The Regents of the University of California
发明人： Amy E. Herr , Alex James Hughes , Elly Sinkala , Todd A. Duncombe , Kevin A. Yamauchi , Julea Vlassakis , Chi-Chih Kang , Zhuchen Xu , Robert Lin
IPC分类号： G01N27/447 , G01N27/453 , G01N33/561
摘要： Electrophoretic separation devices and methods for using the same are provided. Aspects of the devices include a polymeric separation medium that includes a plurality of microwells. Also provided are methods, systems and kits in which the subject devices find use. The devices and methods find use in a variety of different electrophoretic separation applications.

3. 发明授权

US10761056B2 Producing a separation medium using grayscale mask 有权
公开(公告)号：US10761056B2
公开(公告)日：2020-09-01
申请号：US15023800
申请日：2014-09-24
申请人： The Regents of the University of California
发明人： Chi-Chih Kang , Amy E. Herr , Todd A. Duncombe
IPC分类号： G01N27/44 , G03F1/00 , G03F1/50 , G03F7/20 , G01N27/447 , G03F1/54 , B01L3/00 , G03F1/32
摘要： Provided are methods for producing a separation medium, where the method includes exposing a separation medium precursor solution to light from a light source through a photomask that includes a region with varied light transmittance to produce the separation medium. Systems that find use in performing the methods, microfluidic devices that include the separation medium, as well as methods of using the microfluidic devices, are also provided. Embodiments of the present disclosure find use in a variety of different applications, including detecting whether an analyte is present in a fluid sample.

4. 发明申请

US20210048410A1 Tissue Projection Electrophoretic Separation of Protein 有权
公开(公告)号：US20210048410A1
公开(公告)日：2021-02-18
申请号：US16977175
申请日：2019-04-29
申请人： The Regents Of The University Of California
发明人： Amy E. Herr , Samantha Marie Grist , Chi-Chih Kang , Burcu Gumuscu Sefunc , Julea Vlassakis
IPC分类号： G01N27/453 , G01N33/48 , B01L3/00
摘要： Electrophoretic separation methods and devices for detecting a distribution of analytes in a tissue sample are provided. The methods and devices find use in a variety of different electrophoretic separation applications, such as tissue projection electrophoretic separation of proteins from a tissue sample, where analytes in a tissue sample can be detected to produce a map of the distribution of the analytes in the tissue sample.

5. 发明授权

US08431708B2 Fluorescent carbazole compounds for cancer diagnosis 有权
标题翻译：荧光咔唑化合物用于癌症诊断
公开(公告)号：US08431708B2
公开(公告)日：2013-04-30
申请号：US12613770
申请日：2009-11-06
申请人： Ta-Chau Chang , Chih-Chien Cho , Cheng-Chung Chang , Chi-Chih Kang , Zi-Fu Wang
发明人： Ta-Chau Chang , Chih-Chien Cho , Cheng-Chung Chang , Chi-Chih Kang , Zi-Fu Wang
IPC分类号： C07D209/82 , A61K31/454
CPC分类号： C07D401/14 , C09K11/06 , C09K2211/1029
摘要： A compound of formula (I): in which R1-R8, A, B, X, Y, m, and n are as defined herein. Also disclosed is a method for detecting a cancer cell using a compound of formula I.
摘要翻译：式（I）化合物：其中R 1 -R 8，A，B，X，Y，m和n如本文所定义。还公开了使用式I化合物检测癌细胞的方法。

6. 发明申请

US20070098233A1 Cancer cell detecting devices 有权
标题翻译：癌细胞检测装置
公开(公告)号：US20070098233A1
公开(公告)日：2007-05-03
申请号：US11582867
申请日：2006-10-18
申请人： Ta-Chau Chang , Cheng-Chung Chang , Chi-Chih Kang , Ji-Yen Cheng
发明人： Ta-Chau Chang , Cheng-Chung Chang , Chi-Chih Kang , Ji-Yen Cheng
IPC分类号： G06K9/00 , C12Q1/00
CPC分类号： G01N21/6428
摘要： This invention relates to a device for detecting cancer cells. The device includes a light source for generating light (e.g., a light emitting diode), a first optical filter selected from the group consisting of a band pass filter and a long pass filter, a second optical filter (i.e., a band pass filter) disposed between the light source and the first optical filter, and a sample receiver for receiving a sample. The sample receiver is disposed between the first and second optical filters. The first optical filter, the sample receiver, and the second optical filter are aligned so that light emitted from the light source passes sequentially through the second optical filter, the sample receiver, and the first optical filter.
摘要翻译：本发明涉及一种用于检测癌细胞的装置。该装置包括用于产生光的光源（例如，发光二极管），从由带通滤波器和长通滤波器组成的组中选择的第一滤光器，第二滤光器（即，带通滤光器）设置在光源和第一滤光器之间，以及用于接收样品的样品接收器。样品接收器设置在第一和第二滤光器之间。对准第一滤光器，样品接收器和第二滤光器，使得从光源发射的光顺序地通过第二滤光器，样品接收器和第一滤光器。

7. 发明申请

US20220323412A1 EXTRACELLULAR VESICLE-FENRETINIDE COMPOSITIONS, EXTRACELLULAR VESICLE-C-KIT INHIBITOR COMPOSITIONS, METHODS OF MAKING AND USES THEREOF 有权
公开(公告)号：US20220323412A1
公开(公告)日：2022-10-13
申请号：US17640749
申请日：2020-09-08
申请人： Chi-Chih Kang , Ishai Padawer , Pranali Prabhakar Deshpande , Catherine Rosemary Planey , Alexander Fen Mok , Zachary Swinney
发明人： Chi-Chih Kang , Ishai Padawer , Pranali Prabhakar Deshpande , Catherine Rosemary Planey , Alexander Fen Mok , Zachary Swinney
IPC分类号： A61K31/404 , A61K9/127
摘要： Provided herein is a method of preparation of a therapeutic formulation comprising extracellular vesicles packaged with fenretinide.

8. 发明申请

US20110111429A1 FLUORESCENT CARBAZOLE COMPOUNDS FOR CANCER DIAGNOSIS 有权
标题翻译：用于癌症诊断的荧光卡博唑化合物
公开(公告)号：US20110111429A1
公开(公告)日：2011-05-12
申请号：US12613770
申请日：2009-11-06
申请人： Ta-Chau Chang , Chih-Chien Cho , Cheng-Chung Chang , Chi-Chih Kang , Zi-Fu Wang
发明人： Ta-Chau Chang , Chih-Chien Cho , Cheng-Chung Chang , Chi-Chih Kang , Zi-Fu Wang
IPC分类号： G01N33/53 , C07D211/68
CPC分类号： C07D401/14 , C09K11/06 , C09K2211/1029
摘要： A compound of formula (I): in which R1-R8, A, B, X, Y, m, and n are as defined herein. Also disclosed is a method for detecting a cancer cell using a compound of formula I.
摘要翻译：式（I）化合物：其中R 1 -R 8，A，B，X，Y，m和n如本文所定义。还公开了使用式I化合物检测癌细胞的方法。

9. 发明授权

US07691624B2 Cancer cell detecting devices 有权
标题翻译：癌细胞检测装置
公开(公告)号：US07691624B2
公开(公告)日：2010-04-06
申请号：US11582867
申请日：2006-10-18
申请人： Ta-Chau Chang , Cheng-Chung Chang , Chi-Chih Kang , Ji-Yen Cheng
发明人： Ta-Chau Chang , Cheng-Chung Chang , Chi-Chih Kang , Ji-Yen Cheng
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N21/6428
摘要： This invention relates to a device for detecting cancer cells. The device includes a light source for generating light (e.g., a light emitting diode), a first optical filter selected from the group consisting of a band pass filter and a long pass filter, a second optical filter (i.e., a band pass filter) disposed between the light source and the first optical filter, and a sample receiver for receiving a sample. The sample receiver is disposed between the first and second optical filters. The first optical filter, the sample receiver, and the second optical filter are aligned so that light emitted from the light source passes sequentially through the second optical filter, the sample receiver, and the first optical filter.
摘要翻译：本发明涉及一种用于检测癌细胞的装置。该装置包括用于产生光的光源（例如，发光二极管），从由带通滤波器和长通滤波器组成的组中选择的第一滤光器，第二滤光器（即，带通滤光器）设置在光源和第一滤光器之间，以及用于接收样品的样品接收器。样品接收器设置在第一和第二滤光器之间。对准第一滤光器，样品接收器和第二滤光器，使得从光源发射的光顺序地通过第二滤光器，样品接收器和第一滤光器。

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