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1. 发明申请

US20050267342A1 Noninvasive analyzer sample probe interface method and apparatus 有权
标题翻译：无创分析仪样品探针接口方法和装置
公开(公告)号：US20050267342A1
公开(公告)日：2005-12-01
申请号：US11117104
申请日：2005-04-27
申请人： Thomas Blank , George Acosta , Timothy Ruchti , Mutua Mattu , Alexander Lorenz , Kevin Hazen , James Henderson
发明人： Thomas Blank , George Acosta , Timothy Ruchti , Mutua Mattu , Alexander Lorenz , Kevin Hazen , James Henderson
IPC分类号： A61B5/00 , G01N21/35
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/1495 , A61B5/4869 , A61B2560/0223 , A61B2560/0233 , A61B2562/0242 , G01N21/359
摘要： A method and apparatus are provided for noninvasive sampling. More particularly, the method and apparatus relate to control of motion of an optical sample probe interface relative to a tissue sample site. A dynamic probe interface, is used to collect spectra of a targeted sample, control positioning of the sample probe relative to the tissue sample in terms of at least one of x-, y-, and z-axes, and/or control of sample tissue displacement to minimize spectral variations resulting from the sampling process and increase analyte property estimation precision and accuracy.
摘要翻译：提供了一种用于无创采样的方法和装置。更具体地，该方法和装置涉及光学样本探针界面相对于组织样本位点的运动的控制。使用动态探针接口来收集目标样品的光谱，根据x-，y-和z-轴中的至少一个来控制样品探针相对于组织样品的定位和/或样品的控制组织位移以最小化由采样过程导致的频谱变化，并增加分析物质的估计精度和精度。

2. 发明申请

US20050203359A1 Optical sampling interface system for in-vivo measurement of tissue 有权
标题翻译：用于体内测量组织的光学取样界面系统
公开(公告)号：US20050203359A1
公开(公告)日：2005-09-15
申请号：US11008001
申请日：2004-12-08
申请人： Thomas Blank , George Acosta , Mutua Mattu , Marcy Makarewicz , Stephen Monfre , Alexander Lorenz , Timothy Ruchti , Kevin Hazen , Donovan Berry , Roxanne Abul-Haj
发明人： Thomas Blank , George Acosta , Mutua Mattu , Marcy Makarewicz , Stephen Monfre , Alexander Lorenz , Timothy Ruchti , Kevin Hazen , Donovan Berry , Roxanne Abul-Haj
IPC分类号： A61B5/00 , G01N21/35
CPC分类号： G01N21/359 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/6833
摘要： An optical sampling interface system is disclosed that minimizes and compensates for errors that result from sampling variations and measurement site state fluctuations. Embodiments of the invention use a guide that does at least one of, induce the formation of a tissue meniscus, minimize interference due to surface irregularities, control variation in the volume of tissue sampled, use a two-part guide system, use a guide that controls rotation of a sample probe and allows z-axis movement of the probe, use a separate base module and sample module in conjunction with a guide, and use a guide that controls rotation. Optional components include an occlusive element and a coupling fluid.
摘要翻译：公开了一种光学采样接口系统，其最小化并补偿由采样变化和测量位置状态波动引起的误差。本发明的实施例使用至少一个引导组织弯液面的形成的引导件，使由于表面不规则性引起的干扰最小化，控制组织体积的变化，使用两部分引导系统，使用指导控制样品探针的旋转并允许探针的z轴移动，使用独立的基本模块和样品模块与导轨结合使用，并使用控制旋转的指南。可选组件包括闭塞元件和耦合流体。

3. 发明申请

US20050149300A1 Method and apparatus for enhanced estimation of an analyte property through multiple region transformation 有权
标题翻译：用于通过多区域变换增强对分析物特性的估计的方法和装置
公开(公告)号：US20050149300A1
公开(公告)日：2005-07-07
申请号：US10976530
申请日：2004-10-29
申请人： Timothy Ruchti , Alexander Lorenz , Kevin Hazen
发明人： Timothy Ruchti , Alexander Lorenz , Kevin Hazen
IPC分类号： A61B5/00 , G01N21/35 , G06F17/10
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/1495 , A61B2560/0223 , G01N21/359
摘要： The invention provides for transformation of a section of a data block independently of the transformation of separate or overlapping data blocks to determine a property related to the original matrix, where each of the separate or overlapping data blocks are derived from an original data matrix. The transformation enhances parameters of a first data block over a given region of an axis of the data matrix, such as signal-to-noise, without affecting analysis of a second data block derived from the data matrix. This allows for enhancement of analysis of an analyte property, such as concentration, represented within the original data matrix. In a first embodiment of the invention, a separate decomposition and factor selection for each selected data matrix is performed with subsequent score matrix concatenization. The combined score matrix is used to generate a model that is subsequently used to estimate a property, such as concentration represented in the original data matrix. In a second embodiment, each data matrix is independently preprocessed. Demonstration of the invention is performed through glucose concentration estimation from noninvasive spectra of the body.
摘要翻译：本发明提供了数据块的一部分的变换，独立于单独或重叠的数据块的变换，以确定与原始矩阵相关的属性，其中分离的或重叠的数据块中的每一个从原始数据矩阵导出。该变换增强了数据矩阵的轴的给定区域（例如信号到噪声）上的第一数据块的参数，而不影响从数据矩阵导出的第二数据块的分析。这允许增强在原始数据矩阵内表示的分析物质（例如浓度）的分析。在本发明的第一实施例中，对于每个选择的数据矩阵进行单独的分解和因子选择，随后的得分矩阵连接。组合得分矩阵用于生成随后用于估计属性的模型，例如在原始数据矩阵中表示的浓度。在第二实施例中，每个数据矩阵是独立预处理的。本发明的演示通过来自身体的非侵入性光谱的葡萄糖浓度估计来进行。

4. 发明申请

US20060017923A1 Analyte filter method and apparatus 失效
标题翻译：分析物过滤方法和装置
公开(公告)号：US20060017923A1
公开(公告)日：2006-01-26
申请号：US11188064
申请日：2005-07-22
申请人： Timothy Ruchti , Alexander Lorenz , Kevin Hazen
发明人： Timothy Ruchti , Alexander Lorenz , Kevin Hazen
IPC分类号： G01J3/28
CPC分类号： G01N21/274 , G01J3/28 , G01J3/433 , G01N21/359 , G01N2201/129 , G01N2201/1293
摘要： The invention comprises a method and apparatus for enhancing the analysis of noninvasive spectra, resulting in improved analytical performance. More particularly, the invention comprises a method and apparatus for processing noninvasive spectra with an analyte filter that preferably rejects variation likely to be detrimental to the measurement system, while passing signal that probabilistically is unique to the target analyte. Subsequently, the analyte filtered data are used to estimate an analyte property, such as a glucose concentration, in the presence of noise, interferences, state changes, and/or across analyzers.
摘要翻译：本发明包括用于增强非侵入光谱分析的方法和装置，从而提高分析性能。更具体地，本发明包括用分析物过滤器处理非侵入光谱的方法和装置，其优选地拒绝可能对测量系统有害的变化，同时传递概率地对目标分析物是唯一的信号。随后，分析物过滤的数据用于在存在噪声，干扰，状态变化和/或跨分析仪的情况下估计分析物质（例如葡萄糖浓度）。

5. 发明申请

US20150011849A1 MULTIPLEXED PATHLENGTH RESOLVED NONINVASIVE ANALYZER APPARATUS WITH STACKED FILTERS AND METHOD OF USE THEREOF 有权
标题翻译：多路复用解决方案解决方案使用堆叠过滤器的非分析分析仪器及其使用方法
公开(公告)号：US20150011849A1
公开(公告)日：2015-01-08
申请号：US14493266
申请日：2014-09-22
申请人： Timothy Ruchti , Alan Abul-Haj , Kevin Hazen
发明人： Timothy Ruchti , Alan Abul-Haj , Kevin Hazen
IPC分类号： A61B5/1455 , A61B5/00 , A61B5/145
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/6801 , A61B2562/04 , A61B2562/046
摘要： A noninvasive analyzer apparatus and method of use thereof is described using a plurality of sample illumination zones optically coupled to at least two optically stacked two-dimensional optical filter arrays. Sectioned pixels and/or zones of a detector array are optionally filtered for different light throughput and/or are passed through various pathlengths using the stacked two-dimensional optical filter arrays. Resulting pathlength resolved/wavelength controlled groups of spectra are subsequently analyzed to determine an analyte property.
摘要翻译：使用光学耦合到至少两个光学堆叠的二维光学滤波器阵列的多个采样照明区域来描述非侵入性分析仪装置及其使用方法。可选地，为了不同的光通过量滤波检测器阵列的截面像素和/或区域，和/或使用堆叠的二维光学滤波器阵列通过各种路径长度。随后分析得到的光程长度解析/波长控制的光谱组，以确定分析物质。

6. 发明申请

US20060195023A1 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 审中-公开
公开(公告)号：US20060195023A1
公开(公告)日：2006-08-31
申请号：US11326958
申请日：2006-01-05
申请人： George Acosta , James Henderson , N. Abul Haj , Timothy Ruchti , Stephen Monfre , Thomas Blank , Kevin Hazen
发明人： George Acosta , James Henderson , N. Abul Haj , Timothy Ruchti , Stephen Monfre , Thomas Blank , Kevin Hazen
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/14532 , A61B5/1495 , A61B5/6833 , A61B5/7203 , A61B5/7225 , A61B5/726 , A61B2560/0223 , A61B2560/0233 , A61B2560/0252 , A61B2560/0412 , A61B2560/0443 , A61B2560/0456 , A61B2562/0242 , A61B2562/146 , A61B2562/227 , A61B2562/228 , G01N21/359 , G01N21/49
摘要： The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyte is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.

7. 发明申请

US20060116562A1 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 审中-公开
标题翻译：用于通过近红外光谱法无损测量葡萄糖的紧凑装置
公开(公告)号：US20060116562A1
公开(公告)日：2006-06-01
申请号：US11335067
申请日：2006-01-18
申请人： George Acosta , James Henderson , N. Abul Haj , Timothy Ruchti , Stephen Monfre , Thomas Blank , Kevin Hazen
发明人： George Acosta , James Henderson , N. Abul Haj , Timothy Ruchti , Stephen Monfre , Thomas Blank , Kevin Hazen
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/14532 , A61B5/1495 , A61B5/6833 , A61B5/7203 , A61B5/7225 , A61B5/726 , A61B2560/0223 , A61B2560/0233 , A61B2560/0252 , A61B2560/0412 , A61B2560/0443 , A61B2560/0456 , A61B2562/0242 , A61B2562/146 , A61B2562/227 , A61B2562/228 , G01N21/359 , G01N21/49
摘要： The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyte is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.
摘要翻译：本发明涉及通过紧凑型分析仪监测生物参数。优选的装置是基于光谱仪的系统，其连续地或半连续地连接到人类受试者并收集用于确定采样组织中的生物学参数的光谱测量。优选的目标分析物是葡萄糖。优选的分析仪是用于测定体内葡萄糖浓度的基于近红外的葡萄糖分析仪。

8. 发明申请

US20050014997A1 Method of sample control and calibration adjustment for use with a noninvasive analyzer 失效
标题翻译：用于无创分析仪的样品控制和校准调整方法
公开(公告)号：US20050014997A1
公开(公告)日：2005-01-20
申请号：US10849422
申请日：2004-05-18
申请人： Timothy Ruchti , Kevin Hazen , Thomas Blank
发明人： Timothy Ruchti , Kevin Hazen , Thomas Blank
IPC分类号： A61B5/00 , G02B20060101
CPC分类号： G01N21/274 , A61B5/14532 , A61B5/1455 , A61B5/1495 , G01N21/359
摘要： A method and apparatus for easing the use of an optically based noninvasive analyzer is presented. More particularly, a simplified algorithm is used that removes the daily requirement of collecting and using a noninvasive spectrum to update a calibration model. In another embodiment, a guide is used to substantially reduce variation in sample probe placement in relation to a skin tissue sampling site, resulting in the ability to maintain calibration performance with the use of a reference analyte concentration, with or without the use of a reference spectrum collected nearby in time.
摘要翻译：提出了一种用于缓解光学非侵入式分析仪的使用的方法和装置。更具体地，使用简化的算法，其消除收集和使用非侵入光谱以更新校准模型的每日需求。在另一个实施例中，引导件用于相对于皮肤组织取样部位显着减少样本探针放置的变化，从而产生使用参考分析物浓度来维持校准性能的能力，有或没有使用参考频谱在时间附近收集。

9. 发明授权

US09375170B2 Multiplexed pathlength resolved noninvasive analyzer apparatus with stacked filters and method of use thereof 有权
标题翻译：具有层叠滤波器的复用路径长度解析非侵入式分析仪器及其使用方法
公开(公告)号：US09375170B2
公开(公告)日：2016-06-28
申请号：US14938688
申请日：2015-11-11
申请人： Timothy Ruchti , Alan Abul-Haj , Kevin Hazen
发明人： Timothy Ruchti , Alan Abul-Haj , Kevin Hazen
IPC分类号： G01N5/02 , A61B5/1455 , A61B5/145 , A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/6801 , A61B2562/04 , A61B2562/046
摘要： A noninvasive analyzer apparatus and method of use thereof is described using a plurality of sample illumination zones optically coupled to at least two optically stacked two-dimensional optical filter arrays. Sectioned pixels and/or zones of a detector array are optionally filtered for different light throughput and/or are passed through various pathlengths using the stacked two-dimensional optical filter arrays. Resulting pathlength resolved/wavelength controlled groups of spectra are subsequently analyzed to determine an analyte property.
摘要翻译：使用光学耦合到至少两个光学堆叠的二维光学滤波器阵列的多个采样照明区域来描述非侵入性分析仪装置及其使用方法。可选地，为了不同的光通过量滤波检测器阵列的截面像素和/或区域，和/或使用堆叠的二维光学滤波器阵列通过各种路径长度。随后分析得到的光程长度解析/波长控制的光谱组，以确定分析物质。

10. 发明申请

US20160151002A1 MULTIPLEXED PATHLENGTH RESOLVED NONINVASIVE ANALYZER APPARATUS WITH DYNAMIC OPTICAL PATHS AND METHOD OF USE THEREOF 审中-公开
公开(公告)号：US20160151002A1
公开(公告)日：2016-06-02
申请号：US14943990
申请日：2015-11-17
申请人： Timothy Ruchti , Alan Abul-Haj , Kevin Hazen
发明人： Timothy Ruchti , Alan Abul-Haj , Kevin Hazen
IPC分类号： A61B5/1455 , A61B5/145
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/6801 , A61B2562/04 , A61B2562/046
摘要： A noninvasive analyzer apparatus and method of use thereof is described comprising a near-infrared source, a detector, and a photon transport system configured to direct photons from the source to the detector via an analyzer-sample optical interface. The photon transport system includes a dynamically position light directing unit used to, within a measurement time period for a single analyte concentration determination, change any of: radius, energy, intensity, position, incident angle, solid angle, and/or depth of penetration of a beam of photons entering skin of a subject.

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