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1. 发明申请

US20050075503A1 Substituted thiazoles 有权
公开(公告)号：US20050075503A1
公开(公告)日：2005-04-07
申请号：US10903553
申请日：2004-07-30
申请人： Timothy Robbins , Helen Zhu , Jun Shao
发明人： Timothy Robbins , Helen Zhu , Jun Shao
IPC分类号： C07C327/48 , C07D277/56 , C07D213/46
CPC分类号： C07D277/56 , C07C327/48
摘要： This invention is directed to processes for making substituted thiazoles. The substituted thiazole, ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate, also known as TEI-6720, is useful for treatment of gout and hyperuricemia. This compound belongs to a class of substituted thiazoles that inhibit xanthine oxidase and thus block uric acid production.

2. 发明申请

US20050027128A1 Substituted thiazoles 审中-公开
标题翻译：取代的噻唑
公开(公告)号：US20050027128A1
公开(公告)日：2005-02-03
申请号：US10630043
申请日：2003-07-30
申请人： Timothy Robbins , Helen Zhu , Jun Shao
发明人： Timothy Robbins , Helen Zhu , Jun Shao
IPC分类号： C07D277/56 , C12Q1/68 , C07C327/48 , C07
CPC分类号： C07D277/56
摘要： This invention is directed to processes for making substituted thiazoles. The substituted thiazole, ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate, also known as TEI-6720, is useful for treatment of gout and hyperuricemia. This compound belongs to a class of substituted thiazoles that inhibit xanthine oxidase and thus block uric acid production.
摘要翻译：本发明涉及制备取代噻唑的方法。取代的噻唑，2-（4-羟基苯基）-4-甲基-1,3-噻唑-5-羧酸乙酯，也称为TEI-6720，可用于治疗痛风和高尿酸血症。该化合物属于一类抑制黄嘌呤氧化酶并因此阻断尿酸生成的取代噻唑类。

3. 发明授权

US07541475B2 Substituted thiazoles 有权
标题翻译：取代的噻唑
公开(公告)号：US07541475B2
公开(公告)日：2009-06-02
申请号：US10903553
申请日：2004-07-30
申请人： Timothy A. Robbins , Helen Zhu , Jun Shao
发明人： Timothy A. Robbins , Helen Zhu , Jun Shao
IPC分类号： C07D277/04
CPC分类号： C07D277/56 , C07C327/48
摘要： This invention is directed to processes for making substituted thiazoles. The substituted thiazole, ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate, also known as TEI-6720, is useful for treatment of gout and hyperuricemia. This compound belongs to a class of substituted thiazoles that inhibit xanthine oxidase and thus block uric acid production.
摘要翻译：本发明涉及制备取代噻唑的方法。取代的噻唑，2-（4-羟基苯基）-4-甲基-1,3-噻唑-5-羧酸乙酯，也称为TEI-6720，可用于治疗痛风和高尿酸血症。该化合物属于一类抑制黄嘌呤氧化酶并因此阻断尿酸生成的取代噻唑类。

4. 发明申请

US20130189215A1 POLYIMIDAZOLES FOR USE AS BILE ACID SEQUESTRANTS 审中-公开
标题翻译：用作单酯酸序列的聚霉素
公开(公告)号：US20130189215A1
公开(公告)日：2013-07-25
申请号：US13581102
申请日：2011-02-24
申请人： Inez Lees , Kalpesh Biyani , Eric Connor , Scott Hecker , Hongmin Zhang , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
发明人： Inez Lees , Kalpesh Biyani , Eric Connor , Scott Hecker , Hongmin Zhang , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao , Xinnan Zhang
IPC分类号： C08F226/06 , A61K45/06 , C08G73/06 , A61K31/787
CPC分类号： C08F226/06 , A61K31/155 , A61K31/397 , A61K31/785 , A61K31/787 , A61K45/06 , C08G73/0273 , C08G73/0616 , C08G73/0627 , A61K2300/00
摘要： The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译：本发明提供了有效地从胃肠道结合和去除胆汁盐的交联的胺聚合物。这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。

5. 发明申请

US20090271628A1 METHOD AND SYSTEM FOR KEY EXCHANGE AND METHOD AND APPARATUS FOR REDUCING PARAMETER TRANSMISSION BANDWIDTH 有权
标题翻译：关键交换方法与系统及减少参数传输带宽的方法及装置
公开(公告)号：US20090271628A1
公开(公告)日：2009-10-29
申请号：US12482821
申请日：2009-06-11
申请人： Zhenfu Cao , Xiaolei Dong , Jun Shao , Jiwei Wei
发明人： Zhenfu Cao , Xiaolei Dong , Jun Shao , Jiwei Wei
IPC分类号： H04L9/00
CPC分类号： H04L9/0841
摘要： The embodiments of the present disclosure disclose a method and apparatus for reducing the parameter transmission bandwidth. The parameter sender reduces the values of the parameters before sending the parameters to the parameter receiver. This scheme reduces the bandwidth consumed during parameter transmission, thus makes the transmission more efficient. The embodiment of the present disclosure also discloses a method for key exchange. This method reduces the values of the transmission parameters before sending the transmission parameters. This saves the bandwidth compared with the protocol in the prior art. Besides, the embodiment of the present disclosure discloses a system for key exchange. The parameter sender sends the transmission parameters to the bandwidth processing unit. The bandwidth processing unit performs a modulo operation on the received transmission parameters and then sends the processed transmission parameters to the parameter receiver, thus reducing the bandwidth consumed in the transmission of transmission parameters.
摘要翻译：本公开的实施例公开了一种用于减少参数传输带宽的方法和装置。在将参数发送给参数接收器之前，参数发送器减少参数的值。该方案减少参数传输期间消耗的带宽，从而使传输更有效率。本公开的实施例还公开了一种用于密钥交换的方法。该方法在发送传输参数之前减少传输参数的值。这节省了与现有技术中的协议相比的带宽。此外，本公开的实施例公开了一种用于密钥交换的系统。参数发送方将传输参数发送到带宽处理单元。带宽处理单元对所接收的传输参数进行模运算，然后将经处理的传输参数发送到参数接收机，从而减少传输参数传输中消耗的带宽。

6. 发明申请

US20070135383A1 Phospholipase inhibitors, including multi-valent phospholipase inhibitors, and use thereof, including as lumen-localized phospholipase inhibitors 审中-公开
标题翻译：磷脂酶抑制剂，包括多价磷脂酶抑制剂及其用途，包括作为内腔定位的磷脂酶抑制剂
公开(公告)号：US20070135383A1
公开(公告)日：2007-06-14
申请号：US11593176
申请日：2006-11-03
申请人： Han-Ting Chang , Dominque Charmot , Tomasz Glinka , Michael Cope , Elizabeth Goka , Jun Shao , Damien Cartigny , Shiah-yun Chen , Jerry Buysse
发明人： Han-Ting Chang , Dominque Charmot , Tomasz Glinka , Michael Cope , Elizabeth Goka , Jun Shao , Damien Cartigny , Shiah-yun Chen , Jerry Buysse
IPC分类号： A61K31/685 , A61K31/66 , A61K31/503 , A61K31/4745 , A61K31/405 , A61K31/365
CPC分类号： A61K31/404 , A61K9/0019 , A61K9/0095 , A61K31/41 , A61K31/66 , A61K47/10 , A61K47/20 , A61K47/55 , A61K47/58
摘要： The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in a gastrointestinal lumen.
摘要翻译：本发明提供了治疗磷脂酶相关病症的方法和组合物。特别地，本发明提供了一种在动物受试者中治疗胰岛素相关，体重相关病症和/或胆固醇相关病症的方法。该方法通常涉及施用定位在胃肠腔中的未吸收和/或流出的磷脂酶A2抑制剂。

7. 发明申请

US20130022570A1 CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS 有权
标题翻译：交联的聚乙烯胺，聚甲基丙烯酸和聚乙烯亚胺作为双酸序列使用
公开(公告)号：US20130022570A1
公开(公告)日：2013-01-24
申请号：US13581049
申请日：2011-02-24
申请人： Jordan Kopping , Kalpesh Biyani , Eric Connor , Scott Hecker , Inez Lees , Grace Quaker , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao
发明人： Jordan Kopping , Kalpesh Biyani , Eric Connor , Scott Hecker , Inez Lees , Grace Quaker , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao
IPC分类号： C08F226/02 , A61P3/06 , A61K31/785
CPC分类号： A61K31/785 , A61K45/06 , C08F20/52 , C08F22/385 , C08F222/385 , C08F226/02 , C08F232/08
摘要： The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译：本发明提供了一种有效地从胃肠道结合和除去胆汁盐的交联的胺和酰胺聚合物。这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。

8. 发明授权

US07718746B2 Anion-binding polymers and uses thereof 有权
标题翻译：阴离子结合聚合物及其用途
公开(公告)号：US07718746B2
公开(公告)日：2010-05-18
申请号：US12471220
申请日：2009-05-22
申请人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
发明人： Eric Connor , Dominique Charmot , Han-Ting Chang , Florence Roger , Gerrit Klaerner , Son Hoai Nguyen , Jonathan Mills , Jerry M. Buysse , Angela Lee , Deidre Madsen , Jun Shao , Michael J. Cope , John Fordtran
IPC分类号： C08F26/06 , C07C211/11
CPC分类号： C08G73/02 , A61K31/13 , A61K31/785 , C08G73/0206 , C08L39/02 , C08L79/02 , C08L2666/02
摘要： Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.
摘要翻译：描述了阴离子结合聚合物。阴离子结合聚合物在某些情况下是低溶胀阴离子结合聚合物。在一些情况下，阴离子结合聚合物具有孔体积分布，使得聚合物的分数不能用于高于聚合物的目标离子的一定百分比MW的非相互作用溶质。在一些情况下，阴离子结合聚合物的特征在于低离子结合干扰，其中相对于非干扰缓冲液在例如胃肠模拟物中测量干扰。还描述了药物组合物，使用方法和试剂盒。

9. 发明申请

US20100076049A1 NOVEL OXINDOLE DERIVATIVE 失效
标题翻译：新的氧化物衍生物
公开(公告)号：US20100076049A1
公开(公告)日：2010-03-25
申请号：US12513332
申请日：2007-11-05
申请人： Noriaki Shinobu , Jun Shao , Masataka Kobayashi , Takao Mori
发明人： Noriaki Shinobu , Jun Shao , Masataka Kobayashi , Takao Mori
IPC分类号： A61K31/403 , C07D209/04 , A61P35/00
CPC分类号： C07D405/14 , C07D403/14 , C07D409/14
摘要： A compound or a pharmaceutically acceptable salt thereof of the present invention is represented by the following general formula (I): [wherein, R1 to R8 may have a hydrogen atom, a halogen atom, a hydroxy group, a C1-C6 alkyl group, a C2-C8 alkenyl group, a C1-C6 alkylcarbonyl group or —COOR9 (wherein R9 represents a hydrogen atom, a C1-C6 alkyl group or a C2-C8 alkenyl group) as a substituent; and X represents a sulfur atom, an oxygen atom or NR10 (wherein R10 represents a hydrogen atom, a halogen atom, a hydroxy group, a C1-C6 alkyl group, a C2-C8 alkenyl group or a C1-C6 alkoxy group)].
摘要翻译：本发明的化合物或其药学上可接受的盐由以下通式（I）表示：[其中，R 1至R 8可以具有氢原子，卤素原子，羟基，C 1 -C 6烷基， C2-C8烯基，C1-C6烷基羰基或-COOR9（其中R9表示氢原子，C1-C6烷基或C2-C8烯基）作为取代基; X表示硫原子，氧原子或NR 10（式中，R 10表示氢原子，卤素原子，羟基，C 1〜C 6烷基，C 2〜C 8烯基或C 1〜C 6烷氧基）] 。

10. 发明申请

US20090318492A1 INDOLE COMPOUNDS HAVING C4-ACIDIC SUBSTITUENTS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS 审中-公开
标题翻译：具有C4-酸性取代基的单一化合物及其作为磷脂酶A2抑制剂的用途
公开(公告)号：US20090318492A1
公开(公告)日：2009-12-24
申请号：US12092380
申请日：2006-11-03
申请人： Han-Ting Chang , Dominique Charmot , Tomasz Glinka , Michael James Cope , Elizabeth Goka , Jun Shao , Shiah-yun Chen , Jerry M. Buysse
发明人： Han-Ting Chang , Dominique Charmot , Tomasz Glinka , Michael James Cope , Elizabeth Goka , Jun Shao , Shiah-yun Chen , Jerry M. Buysse
IPC分类号： A61K31/437 , A61K31/40 , C07D471/02 , C07D209/04
CPC分类号： C07D209/32
摘要： Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.
摘要翻译：公开了吲哚和吲哚相关化合物，组合物和方法。本发明的化合物可用作磷脂酶抑制剂。本发明的化合物和组合物可用于治疗动物受试者中磷脂酶相关病症，例如胰岛素相关，体重相关和/或胆固醇相关病症。

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