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1. 发明授权

US09078781B2 Sterile cover for compressible stents used in percutaneous device delivery systems 有权
标题翻译：用于经皮装置输送系统的可压缩支架的无菌盖
公开(公告)号：US09078781B2
公开(公告)日：2015-07-14
申请号：US11329440
申请日：2006-01-11
申请人： Timothy R. Ryan , Jack Lemmon
发明人： Timothy R. Ryan , Jack Lemmon
IPC分类号： A61M5/32 , A61F2/958 , A61F2/95
CPC分类号： A61F2/958 , A61F2002/9522
摘要： A stent cover for enclosing a compressible stent during a stent crimping process, the stent cover having an outer sheath with a proximal end, a distal end, an end portion at the distal end of the sheath having a first diameter, and a stent-retaining portion adjacent to the end portion and having an uncompressed diameter that is larger than the first diameter of the end portion for retaining a stent in its uncompressed condition.
摘要翻译：一种用于在支架压接过程中封闭可压缩支架的支架盖，所述支架盖具有外护套，所述外护套具有近端，远端，所述护套的远端处的端部具有第一直径，以及支架保持并且具有比用于将支架保持在未压缩状态的端部的第一直径大的未压缩直径。

2. 发明授权

US09011528B2 Flexible annuloplasty prosthesis 有权
标题翻译：弹性瓣膜成形假体
公开(公告)号：US09011528B2
公开(公告)日：2015-04-21
申请号：US11411274
申请日：2006-04-26
申请人： Timothy R. Ryan , Charles P. Tabor
发明人： Timothy R. Ryan , Charles P. Tabor
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2442 , A61F2/2448 , A61F2210/0076 , A61F2220/0075 , A61F2230/0019 , A61F2250/0098
摘要： A flexible annuloplasty prosthesis for repairing a heart valve having a valve annulus. The annuloplasty prosthesis comprises a flexible body defining an exterior of the prosthesis formed of a biocompatible material and configured to rest against and support the heart valve annulus upon implantation. The flexible annuloplasty prosthesis has a height of not more than 2.5 mm. This low profile characteristic enhances a surgeon's ability to implant the prosthesis. In one preferred embodiment, the flexible body is a fabric material folded onto itself along a length thereof, with the annuloplasty prosthesis being characterized by an elevated longitudinal stiffness.
摘要翻译：一种用于修复具有瓣膜环的心脏瓣膜的柔性瓣环成形假体。瓣膜成形假体包括柔性体，其限定由生物相容性材料形成的假体的外部并且被配置为在植入时抵靠并支撑心脏瓣膜环。弹性瓣膜成形假体的高度不大于2.5mm。这种低轮廓特征增强了外科医生植入假体的能力。在一个优选实施例中，柔性体是沿其长度折叠到其自身上的织物材料，瓣环成形术假体的特征在于纵向刚度升高。

3. 发明授权

US08585614B2 Annuloplasty band and method 有权
公开(公告)号：US08585614B2
公开(公告)日：2013-11-19
申请号：US12059495
申请日：2008-03-31
申请人： Timothy R. Ryan , Joseph C. Morrow
发明人： Timothy R. Ryan , Joseph C. Morrow
IPC分类号： A61B5/103
CPC分类号： A61F2/2445 , A61F2/2448 , A61F2/2466 , A61F2/2496
摘要： An annuloplasty band comprising a sheath, and a generally arcuate stiffening element disposed within the sheath. The stiffening element extends from a first end to a second end, and preferably includes eyelets at its first and second ends adapted to receive sutures to secure the annuloplasty band to a valve annulus. The annuloplasty band preferably has a low profile (e.g., a thickness less than 3 mm). In embodiments intended for mitral valve repair, the eyelets are particularly adapted to receive sutures to secure the annuloplasty band to the antero-lateral trigone and postero-medial trigone. A holder and sizer device useful with the annuloplasty band are also provided.

4. 发明授权

US08535374B2 Annuloplasty device for tricuspid valve repair 有权
公开(公告)号：US08535374B2
公开(公告)日：2013-09-17
申请号：US12011482
申请日：2008-01-25
申请人： Jerald Redmond , Timothy R. Ryan , Jason L. Quill , Alexander J. Hill , Michael A. Gloss
发明人： Jerald Redmond , Timothy R. Ryan , Jason L. Quill , Alexander J. Hill , Michael A. Gloss
IPC分类号： A61F2/24
CPC分类号： A61F2/2445
摘要： Annuloplasty device for implantation adjacent an annulus of a tricuspid valve, the annulus comprising anterior, posterior and septal aspects adjacent anterior, posterior and septal leaflets, respectively, of the tricuspid valve, the device comprising: a ring body comprising: an anterior portion, a posterior portion and a septal portion shaped to conform to, and for implantation adjacent, the anterior, posterior and septal aspects of the annulus, respectively; and first and second ends; wherein the ring body is curvilinear, with substantially no flat portions, forming a shape, and the ends are configured such that when the device is implanted, the first end will be located near the junction of the septal and anterior aspects of the annulus and the second end will be located near the septal aspect of the annulus. Related methods.

5. 发明授权

US08506620B2 Prosthetic cardiac and venous valves 有权
标题翻译：假体心脏和静脉瓣
公开(公告)号：US08506620B2
公开(公告)日：2013-08-13
申请号：US12617850
申请日：2009-11-13
申请人： Timothy R. Ryan
发明人： Timothy R. Ryan
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2475 , A61F2220/0016 , A61F2220/005 , A61F2220/0066
摘要： A prosthetic heart or venous valve, the valve including a central tissue structure with multiple tissue lobes extending from a common central area, wherein each of the lobes includes a longitudinal slot. The valve further includes a plurality of leaflets, each extending from the central tissue structure and positioned between two adjacent lobes, wherein each of the leaflets has a free end spaced from the central tissue structure, and also has a compressible and expandable stent frame with a plurality of extending arms, wherein each of the extending arms of the stent frame is positioned at least partially within one of the longitudinal slots of the central tissue structure.
摘要翻译：假体心脏或静脉瓣，所述瓣膜包括具有从公共中心区域延伸的多个组织瓣的中心组织结构，其中每个凸起部包括纵向槽。瓣膜还包括多个小叶，每个小叶从中心组织结构延伸并且定位在两个相邻瓣之间，其中每个小叶具有与中心组织结构间隔开的自由端，并且还具有可压缩且可扩张的支架框架，其具有多个延伸臂，其中支架框架的每个延伸臂至少部分地位于中央组织结构的纵向狭槽之一内。

6. 发明申请

US20100057194A1 PROSTHETIC CARDIAC AND VENOUS VALVES 有权
标题翻译：预防心脏和呼吸阀
公开(公告)号：US20100057194A1
公开(公告)日：2010-03-04
申请号：US12617850
申请日：2009-11-13
申请人： Timothy R. Ryan
发明人： Timothy R. Ryan
IPC分类号： A61F2/24 , A61F2/82
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2475 , A61F2220/0016 , A61F2220/005 , A61F2220/0066
摘要： A prosthetic heart or venous valve, the valve including a central tissue structure with multiple tissue lobes extending from a common central area, wherein each of the lobes includes a longitudinal slot. The valve further includes a plurality of leaflets, each extending from the central tissue structure and positioned between two adjacent lobes, wherein each of the leaflets has a free end spaced from the central tissue structure, and also has a compressible and expandable stent frame with a plurality of extending arms, wherein each of the extending arms of the stent frame is positioned at least partially within one of the longitudinal slots of the central tissue structure.
摘要翻译：假体心脏或静脉瓣，所述瓣膜包括具有从公共中心区域延伸的多个组织瓣的中心组织结构，其中每个凸起部包括纵向槽。瓣膜还包括多个小叶，每个小叶从中心组织结构延伸并且定位在两个相邻瓣之间，其中每个小叶具有与中心组织结构隔开的自由端，并且还具有可压缩且可扩张的支架框架，其具有多个延伸臂，其中支架框架的每个延伸臂至少部分地位于中央组织结构的纵向狭槽之一内。

7. 发明申请

US20090192605A1 Sizer Device Having a Plurality of Anterior-Posterior Ratios 审中-公开
标题翻译：具有多个前后比的Sizer装置
公开(公告)号：US20090192605A1
公开(公告)日：2009-07-30
申请号：US12358908
申请日：2009-01-23
申请人： Michael A. Gloss , Stephen Kuehn , Timothy R. Ryan
发明人： Michael A. Gloss , Stephen Kuehn , Timothy R. Ryan
IPC分类号： A61F2/24
CPC分类号： A61B5/1076 , A61F2/2448 , A61F2/2496
摘要： Described is a device for evaluating a heart valve annulus in order to choose a particular annuloplasty device to be attached to the annulus, wherein the annuloplasty device has an inter-trigonal or inter-commissural distance and an anterior-posterior ratio, the device comprising: a valve sizing element having one of a plurality of inter-trigonal or inter-commissural distances and comprising a plurality of indicia on the valve sizing element corresponding to a plurality of anterior-posterior ratios and used to compare to the annulus in order to indicate an anterior-posterior ratio of the annulus. Adjustable devices for evaluating a plurality of anterior-posterior ratios are also described. Also, methods of sizing a patient's heart valve annulus are described.
摘要翻译：描述了一种用于评估心脏瓣膜环的装置，以便选择要连接到环的特定瓣环成形术装置，其中瓣环成形术装置具有三角或连合间距和前后比，所述装置包括：阀门尺寸元件具有多个三角形或相互间的距离中的一个，并且包括对应于多个前后比率的阀门尺寸元件上的多个标记，并且用于与环形部分进行比较，以便指示环的前后比例。还描述了用于评估多个前后比率的可调节装置。此外，描述了确定病人心脏瓣膜环的尺寸的方法。

8. 发明申请

US20090036979A1 Annuloplasty device for tricuspid valve repair 有权
标题翻译：用于三尖瓣修复的瓣膜成形术装置
公开(公告)号：US20090036979A1
公开(公告)日：2009-02-05
申请号：US12011482
申请日：2008-01-25
申请人： Jerald Redmond , Timothy R. Ryan , Jason L. Quill , Alexander J. Hill , Michael A. Gloss
发明人： Jerald Redmond , Timothy R. Ryan , Jason L. Quill , Alexander J. Hill , Michael A. Gloss
IPC分类号： A61F2/24 , A61B6/00 , A61B5/05 , A61B8/13
CPC分类号： A61F2/2445
摘要： Annuloplasty device for implantation adjacent an annulus of a tricuspid valve, the annulus comprising anterior, posterior and septal aspects adjacent anterior, posterior and septal leaflets, respectively, of the tricuspid valve, the device comprising: a ring body comprising: an anterior portion, a posterior portion and a septal portion shaped to conform to, and for implantation adjacent, the anterior, posterior and septal aspects of the annulus, respectively; and first and second ends; wherein the ring body is curvilinear, with substantially no flat portions, forming a shape, and the ends are configured such that when the device is implanted, the first end will be located near the junction of the septal and anterior aspects of the annulus and the second end will be located near the septal aspect of the annulus. Related methods.
摘要翻译：用于植入邻近三尖瓣环的瓣膜成形术装置，所述瓣环分别包括邻近所述三尖瓣的前，后和间隔小叶的前部，后部和隔膜方面，所述装置包括：环体，包括：前部，后部和间隔部分，其分别成形为分别与环的前部，后部和间隔方面相邻并用于邻近; 第一和第二端; 其中所述环体是曲线的，基本上没有平坦部分，形成形状，并且所述端部构造成使得当所述装置被植入时，所述第一端将位于所述环的中隔和前部方面的接合处第二端将位于环空间隔附近。相关方法

9. 发明授权

US07468073B2 Heart valve system 有权
标题翻译：心脏瓣膜系统
公开(公告)号：US07468073B2
公开(公告)日：2008-12-23
申请号：US11401800
申请日：2006-04-11
申请人： Keith M. Johnson , Jack D. Lemmon , Joseph C. Morrow , Timothy R. Ryan
发明人： Keith M. Johnson , Jack D. Lemmon , Joseph C. Morrow , Timothy R. Ryan
IPC分类号： A61F2/24
CPC分类号： A61F2/2439 , A61F2/2412 , A61F2/2427
摘要： A valve system including an aortic valve and a holder. The holder includes a holder body, which has a central portion, engagable with a holder handle, and downwardly extending leg portions that engage the valve in the areas between the commissure posts. The central portion of the holder further includes a spool located between the commissure posts, rotatable by an attached handle. Rotation of the spool draws in a tensile member passing through the commissure posts, drawing the commissure posts inward toward the spool. The tensile member passes through guides formed in the holder, configured such that they define the maximum available inward deflection of the commissure posts at the point at which the portions of the tensile member between the commissure posts assume straight configurations.
摘要翻译：一种包括主动脉瓣和支架的瓣膜系统。保持器包括保持器主体，其具有可与保持器手柄相接合的中心部分，以及在接合柱之间的区域中接合阀的向下延伸的腿部。保持架的中心部分还包括位于连接柱之间的线轴，可由附接的手柄旋转。卷轴的旋转吸入穿过合缝的拉伸构件，将连合柱向内拉向卷轴。拉伸构件通过形成在保持器中的引导件，构造成使得它们限定了在接合柱之间的拉伸构件的部分呈直线构型的点处的接合柱的最大可用向内偏移。

10. 发明申请

US20080228254A1 Delivery systems and methods of implantation for replacement prosthetic heart valves 有权
标题翻译：更换假体心脏瓣膜的输送系统和植入方法
公开(公告)号：US20080228254A1
公开(公告)日：2008-09-18
申请号：US12070382
申请日：2008-02-15
申请人： Timothy R. Ryan
发明人： Timothy R. Ryan
IPC分类号： A61F2/24 , A61F2/82
CPC分类号： A61F2/2418 , A61F2/24 , A61F2/2409 , A61F2/2433 , A61F2/2436 , A61F2/958 , A61F2210/0014 , A61F2220/005 , A61F2220/0075 , A61F2230/0054 , A61F2230/0069 , A61F2310/00023
摘要： A method of delivering a replacement prosthetic valve to a previously implanted prosthetic valve including the steps of compressing a replacement prosthetic valve having an expandable stent within a sheath of a delivery system, wherein the delivery system comprises a proximal end, a distal end, and a centering structure positioned between the proximal and distal ends, advancing the delivery system and compressed replacement prosthetic valve into a vessel of a patient until the distal end of the delivery system is positioned adjacent to a second side of a previously implanted prosthetic valve, deploying the centering structure to radially reposition the distal end of the delivery system, further advancing the delivery system toward the previously implanted prosthetic valve, and deploying the replacement prosthetic valve
摘要翻译：将置换的人工瓣膜递送到先前植入的假体瓣膜的方法，包括以下步骤：在输送系统的护套内压缩具有可扩张支架的置换假体瓣膜，其中所述输送系统包括近端，远端和定心结构定位在近端和远端之间，使输送系统和压缩的替代假体瓣进入患者血管，直到输送系统的远端邻近先前植入的假性瓣膜的第二侧定位，展开定心结构以径向地重新定位输送系统的远端，进一步使输送系统朝向先前植入的假性瓣膜前进，并将替换的人工瓣膜

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