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1. 发明申请

US20050090500A1 Stable polymorph of N-(3-ethynylphenyl)-6, 7-bis (2-methoxyethoxy)-4-quinazolinamine hydrochloride, methods of production, and pharmaceutical uses thereof 有权
标题翻译： N-（3-乙炔基苯基）-6,7-双（2-甲氧基乙氧基）-4-喹唑啉胺盐酸盐的稳定多晶型物，生产方法及其制药用途
公开(公告)号：US20050090500A1
公开(公告)日：2005-04-28
申请号：US10992266
申请日：2004-11-18
申请人： Timothy Norris , Jeffrey Raggon , Richard Connell , James Moyer , Michael Morin , Shama Kajiji , Barbara Foster , Karen Ferrante , Sandra Silberman
发明人： Timothy Norris , Jeffrey Raggon , Richard Connell , James Moyer , Michael Morin , Shama Kajiji , Barbara Foster , Karen Ferrante , Sandra Silberman
IPC分类号： A61K31/517 , A61K45/06 , C07D239/94 , A61K31/498
CPC分类号： C07D239/94 , A61K31/517 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a stable crystalline form of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride designated the B polymorph, its production in essentially pure form, and its use. The invention also relates to the pharmaceutical compositions containing the stable polymorph B form of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine as hydrochloride, as well other forms of the compound, and to methods of treating hyperproliferative disorders, such as cancer, by administering the compound.
摘要翻译：本发明涉及称为B多晶型物的N-（3-乙炔基苯基）-6,7-双（2-甲氧基乙氧基）-4-喹唑啉胺盐酸盐的稳定结晶形式，其基本上纯的形式及其用途。本发明还涉及含有作为盐酸盐的N-（3-乙炔基苯基）-6,7-双（2-甲氧基乙氧基）-4-喹唑啉胺的稳定多晶型物B形式的药物组合物，以及其它形式的化合物，以及通过施用化合物治疗过度增殖性疾病如癌症的方法。

2. 发明申请

US20050119288A1 Dosing schedule for a novel anticancer agent 审中-公开
标题翻译：一种新型抗癌剂的给药方案
公开(公告)号：US20050119288A1
公开(公告)日：2005-06-02
申请号：US10919831
申请日：2004-08-17
申请人： Samit Bhattacharya , Richard Connell , Jitesh Jani , James Moyer , Dennis Noe , Stefanus Steyn
发明人： Samit Bhattacharya , Richard Connell , Jitesh Jani , James Moyer , Dennis Noe , Stefanus Steyn
IPC分类号： A61K31/00 , A61K31/506 , A61K31/517 , A61P35/00
CPC分类号： A61K31/00 , A61K31/506 , A61K31/517 , A61K2300/00
摘要： The invention is directed to methods for the a method for treating overexpression of the erbB2 in a mammal in need of treatment by administering to the mammal a therapeutically effective amount of a first inhibitor of an erbB2 receptor and then, after an interval of less than 24 hours, administering to the mammal from one to six therapeutically effective amounts of the same or different inhibitor of the erbB2 receptor. The invention is also directed to a slow daily infusion of the erbB2 inhibitor. The overexpression of the erbB2 receptor can result in abnormal cell growth and lead to cancer. By the methods of the invention, the efficacy and safety of the inhibitors is increased. The invention is also directed to kits for facilitating the dose administration method of the invention.
摘要翻译：本发明涉及用于治疗需要治疗的哺乳动物中erbB2的过度表达的方法，其通过向哺乳动物施用治疗有效量的第一种erbB2受体抑制剂，然后在间隔小于24 小时，向哺乳动物施用1至6个治疗有效量的相同或不同的erbB2受体抑制剂。本发明还涉及缓慢的每日输注erbB2抑制剂。 erbB2受体的过度表达可导致细胞生长异常并导致癌症。通过本发明的方法，抑制剂的功效和安全性增加。本发明还涉及用于促进本发明的剂量给药方法的试剂盒。

3. 发明申请

US20060049773A1 Fault protection scheme for CCFL integrated circuits 审中-公开
标题翻译： CCFL集成电路故障保护方案
公开(公告)号：US20060049773A1
公开(公告)日：2006-03-09
申请号：US11210542
申请日：2005-08-23
申请人： James Moyer , Paul Ueunten
发明人： James Moyer , Paul Ueunten
IPC分类号： H05B37/02
CPC分类号： H05B41/2855 , H01L2924/0002 , H01L2924/00
摘要： In one embodiment, an apparatus is provided. The apparatus includes a power bridge suitable for coupling to a CCFL (cold cathode fluorescent lamp) load and providing an operating current to the load. The apparatus also includes a replica component coupled to the power bridge to provide a replica current proportional to the operating current. The apparatus further includes a reference component receptacle to produce a reference current in conjunction with an external reference component. The apparatus also includes a comparison component coupled to the replica component and the reference component to compare the replica component to the reference component.
摘要翻译：在一个实施例中，提供了一种装置。该装置包括适于耦合到CCFL（冷阴极荧光灯）负载并向负载提供工作电流的电源桥。该装置还包括耦合到功率桥的复制部件，以提供与工作电流成比例的复制电流。该装置还包括参考部件插座，以与外部参考部件一起产生参考电流。该装置还包括耦合到复本组件和参考组件的比较组件，以将复本组件与参考组件进行比较。

4. 发明申请

US20050285548A1 Method and apparatus for driving an external electrode fluorescent lamp 失效
标题翻译：用于驱动外部电极荧光灯的方法和装置
公开(公告)号：US20050285548A1
公开(公告)日：2005-12-29
申请号：US11165783
申请日：2005-06-23
申请人： James Moyer , Timothy Rust
发明人： James Moyer , Timothy Rust
IPC分类号： H05B37/02 , H05B41/28
CPC分类号： H05B41/2806 , Y02B20/22
摘要： A technique for driving one or more EEFLs, having first and second ends, in a bank of EEFLs involves driving the EEFLs at both the first and second ends. In a non-limiting embodiment, a device constructed according to the technique may include a bank of EEFLs connected in parallel. The device may further include a first transformer, wherein a first of the secondary windings of the first transformer is coupled to the first end of the bank of EEFLs. The device may further include a second transformer, wherein a first of the secondary windings of the second transformer is coupled to the second end of the bank of EEFLs.
摘要翻译：用于驱动具有第一和第二端的一个或多个EEFL在EEFL组中的技术涉及在第一和第二端驱动EEFL。在非限制性实施例中，根据该技术构造的设备可以包括并联连接的一组EEFL。该装置还可以包括第一变压器，其中第一变压器的次级绕组中的第一个耦合到EEFL组的第一端。该装置还可以包括第二变压器，其中第二变压器的次级绕组中的第一个耦合到EEFL组的第二端。

5. 发明申请

US20160021848A1 Automated Animal Feeder 审中-公开
标题翻译：自动动物饲养机
公开(公告)号：US20160021848A1
公开(公告)日：2016-01-28
申请号：US14811787
申请日：2015-07-28
申请人： James Moyer
发明人： James Moyer
IPC分类号： A01K5/02 , F16M11/04 , A01K29/00
CPC分类号： A01K5/0258 , A01K5/0291 , A01K29/00
摘要： An automated animal feeder is disclosed having a storage area with a top at one end and the second feeding into a dispensing module containing a dispensing tube. An auger, connected to a support and motor, extends into the second opening of the storage area. Preferably the auger support is movable along the dispensing module to vary a distance between the length of the auger at the proximal opening of the dispensing tube. A programmable control panel controls the motor and can have a display screen, speaker and programming members, or the control panel can be controlled by remote control. Power can be from at least one from the group of replaceable battery, rechargeable battery, solar or electricity, power the control panel and motor. A deflection tab extends into the dispensing tube, spaced from the auger, to prevent the accumulation food on the auger. The hanging member on the top can affixed to a stand with a post having a first end, a second end and a pivot point, the pivot point being affixed to the stand. The first end has a connection member for the hanging member and said second end has a rotation prevention member and an anchor. The post can rotate upon the release of the anchor to a predetermined distance from the ground as determined by the rotation prevention member or be locked in an upright position by said anchor.
摘要翻译：公开了一种自动化动物给料器，其具有在一端具有顶部的存储区域，并且第二进料装入包含分配管的分配模块。连接到支撑和电机的螺旋钻延伸到存储区域的第二个开口。优选地，螺旋推运器支撑件可沿着分配模块移动以改变在分配管的近端开口处的螺旋钻的长度之间的距离。可编程控制面板可控制电机，并具有显示屏，扬声器和编程组件，也可通过遥控器控制控制面板。电源可以来自可更换电池，可充电电池，太阳能或电力组中的至少一个，为控制面板和电机供电。偏转翼片延伸到与螺旋钻间隔开的分配管中，以防止在螺旋钻上堆积食物。顶部的悬挂构件可以固定到具有第一端，第二端和枢转点的柱的支架上，枢转点固定在支架上。第一端具有用于悬挂构件的连接构件，并且所述第二端具有旋转防止构件和锚固件。该柱可以在锚定件释放到旋转防止构件所确定的离开地面预定距离时旋转，或者由所述锚定件锁定在直立位置。

6. 发明申请

US20070285033A1 METHODS AND PROTECTION SCHEMES FOR DRIVING DISCHARGE LAMPS IN LARGE PANEL APPLICATIONS 有权
标题翻译：在大面积应用中驱动放电灯的方法和保护方案
公开(公告)号：US20070285033A1
公开(公告)日：2007-12-13
申请号：US11842867
申请日：2007-08-21
申请人： Wei Chen , James Moyer , Paul Ueunten
发明人： Wei Chen , James Moyer , Paul Ueunten
IPC分类号： H05B41/36
CPC分类号： H05B41/2828
摘要： The present disclosure introduces a simple method and apparatus for converting DC power to AC power for driving discharge lamps such as a cold cathode fluorescent lamp (CCFL), an external electrode fluorescent lamp (EEFL), or a flat fluorescent lamp (FFL). Among other advantages, the invention allows the proper protection under short circuit conditions for applications where the normal lamp current is greater than safe current limit.
摘要翻译：本公开引入了用于将DC电力转换成用于驱动诸如冷阴极荧光灯（CCFL），外部电极荧光灯（EEFL）或平面荧光灯（FFL）等放电灯的AC电力的简单方法和装置。除了其他优点之外，本发明允许在短路条件下适当地保护正常灯电流大于安全电流限制的应用。

7. 发明申请

US20060007719A1 Method and apparatus for controlling a discharge lamp in a backlighted display 有权
公开(公告)号：US20060007719A1
公开(公告)日：2006-01-12
申请号：US11204960
申请日：2005-08-16
申请人： John Shannon , James Moyer , Michael Hsing
发明人： John Shannon , James Moyer , Michael Hsing
IPC分类号： H02M7/5387
CPC分类号： H05B41/2827 , H05B41/2824 , H05B41/2828 , H05B41/3927
摘要： The described DC to AC inverter efficiently controls the amount of electrical power used to drive a cold cathode fluorescent lamp (CCFL). The output is a fairly pure sine wave which is proportional to an input control voltage. The output waveform purity is ensured by driving a symmetrical rectangular waveform into a second-order, low pass filter at the resonant frequency of the filter for all conditions of line voltage and delivered power. Operating stress on the step-up transformer is minimized by placing the load (lamp) directly across the secondary side of the transformer. When configured to regulate delivered power, the secondary side may be fully floated which practically eliminates a thermometer effect on the operation of the lamp. All of the active elements, including the power switches, may be integrated into a monolithic silicon circuit.

8. 发明申请

US20050244408A1 Antibodies to insulin-like growth factor I receptor 有权
标题翻译：胰岛素样生长因子I受体的抗体
公开(公告)号：US20050244408A1
公开(公告)日：2005-11-03
申请号：US11144248
申请日：2005-06-02
申请人： Bruce Cohen , Jean Beehe , Penelope Miller , James Moyer , Jose Corvalan , Michael Gallo
发明人： Bruce Cohen , Jean Beehe , Penelope Miller , James Moyer , Jose Corvalan , Michael Gallo
IPC分类号： A01K67/027 , A61K39/395 , A61K45/00 , A61K48/00 , A61K49/00 , A61P35/00 , C07K14/72 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , G01N33/574 , G01N33/577 , G01N33/68
CPC分类号： C07K16/2863 , A01K2217/05 , A61K31/138 , A61K31/513 , A61K31/517 , A61K31/704 , A61K39/39541 , A61K39/39558 , A61K48/00 , A61K2039/505 , C07K14/72 , C07K16/30 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/574 , G01N33/57492 , G01N2333/65 , G01N2333/71 , A61K2300/00
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及特异性结合胰岛素样生长因子I受体（IGF-1R）的抗体及其抗原结合部分，其优选为人IGF-1R。本发明还涉及人抗IGF-1R抗体，包括嵌合，双特异性，衍生的单链抗体或融合蛋白的部分。本发明还涉及衍生自抗IGF-1R抗体和编码这种分子的核酸分子的分离的重链和轻链免疫球蛋白分子。本发明还涉及制备抗IGF-1R抗体的方法，包含这些抗体的药物组合物和使用抗体及其组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗IGF-1R抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的基因治疗方法和转基因动物。

9. 发明授权

US08541987B2 Low loss discharge circuits for EMI filter capacitors 有权
标题翻译：用于EMI滤波电容器的低损耗放电电路
公开(公告)号：US08541987B2
公开(公告)日：2013-09-24
申请号：US12956351
申请日：2010-11-30
申请人： Donald R. Disney , Michael Hsing , James Nguyen , James Moyer
发明人： Donald R. Disney , Michael Hsing , James Nguyen , James Moyer
IPC分类号： H02J7/00 , H02J7/04
CPC分类号： H02M1/44 , H02M1/32 , H02M2001/322
摘要： A discharge circuit for an EMI filter capacitor includes normally-ON transistors. The normally-ON transistors may be controlled to limit current through them when an AC source is coupled across the discharge circuit. When the AC source is disconnected from the discharge circuit, the normally-ON transistors turn ON to allow current flow through them. The current flow allows the EMI filter capacitor to be discharged by a discharge resistor.
摘要翻译：用于EMI滤波电容器的放电电路包括常开晶体管。当AC源耦合在放电电路两端时，可以控制常ON晶体管以限制通过它们的电流。当交流电源与放电电路断开连接时，常开晶体管导通，允许电流流过它们。电流流过允许EMI滤波电容通过放电电阻放电。

10. 发明申请

US20060076900A1 Methods and protection schemes for driving discharge lamps in large panel applications 失效
公开(公告)号：US20060076900A1
公开(公告)日：2006-04-13
申请号：US11250161
申请日：2005-10-13
申请人： Wei Chen , James Moyer , Paul Ueunten
发明人： Wei Chen , James Moyer , Paul Ueunten
IPC分类号： H05B39/04
CPC分类号： H05B41/2828
摘要： The present disclosure introduces a simple method and apparatus for converting DC power to AC power for driving discharge lamps such as a cold cathode fluorescent lamp (CCFL), an external electrode fluorescent lamp (EEFL), or a flat fluorescent lamp (FFL). Among other advantages, the invention allows the proper protection under short circuit conditions for applications where the normal lamp current is greater than safe current limit.

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