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1. 发明授权

US6037351A Method of inhibiting hepatitis B virus 失效
标题翻译：抑制乙型肝炎病毒的方法
公开(公告)号：US6037351A
公开(公告)日：2000-03-14
申请号：US676153
申请日：1996-07-11
申请人： Timothy M. Block , Baruch S. Blumberg , Raymond A. Dwek
发明人： Timothy M. Block , Baruch S. Blumberg , Raymond A. Dwek
IPC分类号： C07D211/46 , A61K31/445 , A61P31/12 , A61P31/20
CPC分类号： A61K31/445
摘要： A method is disclosed for the treatment of hepatitis B virus (HBV) infections which comprises administering to the infected host an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which the alkyl group contains from 3 to 6 carbon atoms.
摘要翻译： PCT No.PCT / US94 / 14548 Sec。 371日期1996年7月11日 102（e）日期1996年7月11日PCT 1994年12月23日PCT PCT。 WO95 / 19172 PCT出版物日期1995年7月20日公开了用于治疗乙型肝炎病毒（HBV）感染的方法，其包括向感染的宿主施用1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇的N-烷基衍生物，其中该烷基含有3至6个碳原子。

2. 发明授权

US06465487B1 Inhibition of membrane-associated viral replication 有权
标题翻译：抑制膜相关病毒复制
公开(公告)号：US06465487B1
公开(公告)日：2002-10-15
申请号：US09209033
申请日：1998-12-10
申请人： Timothy M. Block , Raymond A. Dwek , Baruch S. Blumberg , Anand Mehta , Frances Platt , Terry D. Butters , Nicole Zitzmann
发明人： Timothy M. Block , Raymond A. Dwek , Baruch S. Blumberg , Anand Mehta , Frances Platt , Terry D. Butters , Nicole Zitzmann
IPC分类号： A61K31445
CPC分类号： A61K31/00 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Methods for inhibiting morphogenesis of host cell membrane-budding viruses and infections caused thereby using compounds that inhibit host cell glucosidase or glucosyltransferase enzymes. Methods for treating lipid storage diseases using compounds that inhibit glucosyl transferance enzymes.
摘要翻译：抑制宿主细胞膜出芽病毒的形态发生和由此引起的感染的方法使用抑制宿主细胞葡糖苷酶或葡糖基转移酶的化合物的方法。使用抑制葡糖基转移酶的化合物治疗脂质储存疾病的方法。

3. 发明授权

US4937074A Method of treating retrovirus infection 失效
标题翻译：治疗逆转录病毒感染的方法
公开(公告)号：US4937074A
公开(公告)日：1990-06-26
申请号：US174695
申请日：1988-03-29
申请人： Pinayur S. Venkateswaran , Irving Millman , Baruch S. Blumberg
发明人： Pinayur S. Venkateswaran , Irving Millman , Baruch S. Blumberg
IPC分类号： A61K36/18 , A61K20060101 , A61K36/47 , A61P31/12 , C07G99/00
CPC分类号： A61K36/47 , Y10S514/885
摘要： Method of treating retrovirus infection by administering extract of Phyllanthus niruri.
摘要翻译：通过施用竹叶提取物治疗逆转录病毒感染的方法。

4. 发明授权

US4673575A Composition, pharmaceutical preparation and method for treating viral hepatitus 失效
标题翻译：组合物，药物制剂和治疗病毒性肝炎的方法
公开(公告)号：US4673575A
公开(公告)日：1987-06-16
申请号：US727452
申请日：1985-04-26
申请人： Pinayur S. Venkateswaran , Irving Millman , Baruch S. Blumberg
发明人： Pinayur S. Venkateswaran , Irving Millman , Baruch S. Blumberg
IPC分类号： A61K36/47 , A61K35/78
CPC分类号： A61K36/47
摘要： A pharmaceutical preparation comprising the methanol extractable components of Phyllanthus niruri L. is administered to patients suffering from hepatitis B virus infection in an amount effective for inhibiting the growth of said virus.
摘要翻译：对于患有乙型肝炎病毒感染的患者，以对抑制所述病毒生长有效的量，给予包含竹the蓉的甲醇可提取成分的药物制剂。

5. 发明授权

US4189464A Hepatitis B testing reagent and method 失效
标题翻译：乙型肝炎检测试剂及方法
公开(公告)号：US4189464A
公开(公告)日：1980-02-19
申请号：US903238
申请日：1978-05-05
申请人： Baruch S. Blumberg , Irving Millman
发明人： Baruch S. Blumberg , Irving Millman
IPC分类号： G01N33/576 , G01N33/16 , A61K43/00 , G21H5/02
CPC分类号： G01N33/5764 , Y10S436/804 , Y10S436/809 , Y10S436/81 , Y10S436/82
摘要： A test reagent reagent for HB.sub.s A.sub.g is prepared by applying to a suitable substrate, such as a polystyrene bead, a first coat of purified HB.sub.s A.sub.g to an extent which will permit complete coverage by anti-HB.sub.s. After washing HB.sub.s A.sub.g coated substrate, serum containing anti-HB.sub.s, or an IgG fraction of serum containing anti-HB.sub.s, is applied as a second coat as a second coat in an amount which substantially completely occupies the reacting sites of the HB.sub.s A.sub.g on the outside of the substrate and leaves an excess of antibody reacting groups in a free state, and any unattached material is washed off.A test sample which is to be tested for HB.sub.s A.sub.g is then contacted with the reagent thus produced, permitting attachment of HB.sub.s A.sub.g if present, and washing is done.Then a source of anti-HB.sub.s, such as an IgG fraction containing anti-HB.sub.s, which has been radioactively labeled, is brought into contact with the reagent is brought into contact with the reagent, and any unattached material is washed off. The presence or absence of HB.sub.s A.sub.g in the test sample is determined sample is determined from the presence or absence of significant additional radiation coming from the reagent as compared with a control.This method and its double coated test reagent permits securing high sensitivity without any manufacture of "dissociated" anti-HB.sub.s separately from the process itself, for use at any stage of the process, which separate manufacture of "dissociated" anti-HB.sub.s is a difficult and expensive procedure which adds greatly to the expense of any radioimmunoassay which calls for it to be done.
摘要翻译：通过将合适的底物例如聚苯乙烯珠，第一层纯化的HBsAg涂覆到允许抗HBs完全覆盖的程度来制备用于HBsAgis的试剂试剂。在洗涤HBsAg包被的底物之后，将含有抗-HBs的血清或含有抗HBs的血清的IgG部分作为第二涂层作为第二涂层施用，其量基本上完全占据HBsAg外部的HBsAg的反应位点底物并离开过量的抗体反应基团，并且任何未附着的材料被洗去。然后将待测试的HBsAg测试样品与所产生的试剂接触，如果存在HBsAg，则进行洗涤。然后将与放射性标记的含有抗HBs的抗HBs的来源与试剂接触，与试剂接触，并将任何未附着的材料冲洗掉。在测试样品中存在或不存在HBsAg时，与对照相比，测定样品是否存在或不存在来自试剂的显着额外辐射。该方法及其双涂层测试试剂可以确保高灵敏度，而不会与工艺本身分开制造“解离”的抗HBs，以便在该过程的任何阶段使用，分离制造“分离的”抗HBs是一个困难的和昂贵的程序，这大大增加了要求完成的任何放射免疫测定的费用。

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