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1. 发明授权

US07875342B2 Porous ceramic composite bone grafts 有权
标题翻译：多孔陶瓷复合骨移植
公开(公告)号：US07875342B2
公开(公告)日：2011-01-25
申请号：US10490492
申请日：2002-09-24
申请人： Timothy J. N. Smith , Hendry Jason , M. Pugh Sydney , Smith Reginald
发明人： Timothy J. N. Smith , Hendry Jason , M. Pugh Sydney , Smith Reginald
IPC分类号： B32B3/26 , A61F2/28
CPC分类号： A61L27/46 , A61L27/425 , A61L27/56 , A61L2400/18 , B33Y80/00 , Y10T428/249967 , Y10T428/249978 , Y10T428/249979 , Y10T428/249981 , Y10T428/249987
摘要： The invention relates to porous ceramic composites incorporating biodegradable polymers for use as a bone substitute in the fields of orthopedics and dentistry or as a scaffold for tissue engineering applications. The porous ceramic composite implant for connective tissue replacement comprises a porous ceramic matrix having a biodegradable polymer provided on internal and external surfaces of the ceramic matrix. The biodegradable polymer allows for the passage and/or delivery of a variety of agents throughout the porous ceramic matrix and improves mechanical properties of the implant in vivo.
摘要翻译：本发明涉及结合生物可降解聚合物的多孔陶瓷复合材料，其用作骨科和牙科领域的骨替代物或组织工程应用的支架。用于结缔组织置换的多孔陶瓷复合植入物包括在陶瓷基质的内表面和外表面上提供可生物降解的聚合物的多孔陶瓷基质。可生物降解的聚合物允许在整个多孔陶瓷基体中通过和/或递送多种试剂，并改善植入物在体内的机械性能。

2. 再颁专利

USRE41251E1 Synthetic biomaterial compound of calcium phosphate phases particularly adapted for supporting bone cell activity 有权
标题翻译：磷酸钙相的合成生物材料化合物特别适用于支持骨细胞活性
公开(公告)号：USRE41251E1
公开(公告)日：2010-04-20
申请号：US12022946
申请日：2008-01-30
申请人： Sydney M. Pugh , Timothy J. N. Smith , Michael Sayer , Sarah D. Langstaff
发明人： Sydney M. Pugh , Timothy J. N. Smith , Michael Sayer , Sarah D. Langstaff
IPC分类号： C04B35/447 , C04B41/87 , A61L27/00
CPC分类号： A61K35/32 , A61F2310/00293 , A61L27/12 , A61L27/3821 , A61L27/3895 , A61L27/505 , A61L27/56 , C04B35/447 , C04B38/00 , C04B2111/00836 , C23C24/08 , C23C30/00 , C04B38/0064 , C04B38/067
摘要： The present invention is directed to a synthetic biomaterial compound based on stabilized calcium phosphates and more particularly to the molecular, structural and physical characterization of this compound. The compound comprises calcium, oxygen and phosphorous, wherein at least one of the elements is substituted with an element having an ionic radius of approximately 0.1 to 1.1 Å. The knowledge of the specific molecular and chemical properties of the compound allows for the development of several uses of the compound in various bone-related clinical conditions.
摘要翻译：本发明涉及一种基于稳定的磷酸钙的合成生物材料化合物，更具体地涉及该化合物的分子，结构和物理表征。化合物包括钙，氧和磷，其中至少一个元素被离子半径约为0.1至1.1的元素取代。对化合物的具体分子和化学性质的了解允许在各种骨相关临床条件下开发化合物的多种用途。

3. 发明授权

US07498043B2 Silicon substituted oxyapatite 有权
标题翻译：硅取代的羟基磷灰石
公开(公告)号：US07498043B2
公开(公告)日：2009-03-03
申请号：US11088094
申请日：2005-03-24
申请人： Michael Sayer , Joel Reid , Timothy J. N. Smith , Jason Hendry
发明人： Michael Sayer , Joel Reid , Timothy J. N. Smith , Jason Hendry
IPC分类号： A61K9/14 , A61K33/42 , A61K33/00 , A61F2/00 , A01N59/26 , A01N59/00
CPC分类号： A61L27/425 , A61L27/12 , A61L27/32 , A61L27/46 , A61L27/54 , A61L2300/412 , A61L2300/43 , A61L2430/02 , C01B25/32
摘要： The invention is a silicon substituted oxyapatite compound (Si—OAp) for use as a synthetic bone biomaterial either used alone or in biomaterial compositions. The silicon substituted oxyapatite compound has the formula Ca5(PO4)3-x(SiO4)xO(1-x)/2, where 0
摘要翻译：本发明是单独使用或用于生物材料组合物中的用作合成骨生物材料的硅取代的氧磷灰石化合物（Si-OAp）。硅取代的氧磷灰石化合物具有式Ca 5（PO 4）3-x（SiO 4）x O（1-x）/ 2，其中0

4. 发明授权

US09133236B2 Connective tissue stimulating peptides 有权
标题翻译：结缔组织刺激肽
公开(公告)号：US09133236B2
公开(公告)日：2015-09-15
申请号：US12378591
申请日：2009-02-17
申请人： Dennis R. Sindrey , Sydney M. Pugh , Timothy J. N. Smith
发明人： Dennis R. Sindrey , Sydney M. Pugh , Timothy J. N. Smith
IPC分类号： A61K38/00 , A61K38/03 , C07K2/00 , C07K5/103 , C07K5/117 , C07K14/78
CPC分类号： C07K7/06 , A61K38/00 , A61K38/08 , A61K45/06 , A61L27/12 , A61L27/54 , A61L27/58 , A61L2300/25 , A61L2300/412 , A61L2430/02 , A61L2430/06 , C07K5/1008 , C07K5/101 , C07K5/1024 , C07K7/08 , C07K14/78 , C07K2319/00
摘要： Novel peptides are described which comprise an amino acid motif selected from the group consisting of “PG”, “GP”, “PI” and “IG” and having up to 10 amino acids upstream and/or downstream of the amino acid motif, wherein “P” in the motif is proline or hydroxyproline and the peptide stimulates the development, maintenance and repair of bone, cartilage and associated connective tissue. The invention further relates to pharmaceutical compositions of these peptides, as well as therapeutic and prophylactic uses of such peptides.
摘要翻译：描述了包含选自“PG”，“GP”，“PI”和“IG”并且在氨基酸基序的上游和/或下游具有多达10个氨基酸的氨基酸基序的新型肽，其中图案中的“P”是脯氨酸或羟脯氨酸，肽刺激骨，软骨和相关结缔组织的发育，维持和修复。本发明还涉及这些肽的药物组合物，以及这些肽的治疗和预防用途。

5. 发明授权

US08492140B2 Automated tissue engineering system 有权
标题翻译：自动组织工程系统
公开(公告)号：US08492140B2
公开(公告)日：2013-07-23
申请号：US10510777
申请日：2003-04-08
申请人： Timothy J. N. Smith , Martin R. Pecaric , Sydney J. Pugh , Rupert Hagg , Roberto Tommasini , Yves Larcher , Lowell D. Misner
发明人： Timothy J. N. Smith , Martin R. Pecaric , Sydney J. Pugh , Rupert Hagg , Roberto Tommasini , Yves Larcher , Lowell D. Misner
IPC分类号： C12M1/00 , C12M1/34 , C12N3/00
CPC分类号： C12M21/08 , C12M23/28 , C12M23/42 , C12M23/52 , C12M25/14 , C12M29/04 , C12M41/46 , C12M41/48 , C12M45/09 , C12M47/06 , C12M47/12 , C12N5/0068 , C12N5/0618 , C12N5/0654 , C12N5/0655 , C12N2509/00
摘要： The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.
摘要翻译：本发明提供用于组织工程产品的自动化培养，增殖，分化，生产和维护的系统，模块，生物反应器和方法。一方面是一种自动化组织工程系统，其包括壳体，由壳体支撑的至少一个生物反应器，促进生理细胞功能的生物反应器和/或从细胞和/或组织来源产生一种或多种组织构建体。流体容纳系统由壳体支撑并且与生物反应器流体连通。一个或多个传感器与壳体，生物反应器或流体容纳系统中的一个或多个相关联，用于监测与生理细胞功能相关的参数和/或组织构建体的产生; 以及连接到一个或多个传感器的微处理器。本发明的系统，方法和产品可用于各种临床和实验室设置。

6. 发明授权

US08029817B2 Silicon substituted oxyapatite 有权
标题翻译：硅取代的羟基磷灰石
公开(公告)号：US08029817B2
公开(公告)日：2011-10-04
申请号：US12245554
申请日：2008-10-03
申请人： Michael Sayer , Joel Reid , Timothy J. N. Smith , Jason Hendry
发明人： Michael Sayer , Joel Reid , Timothy J. N. Smith , Jason Hendry
IPC分类号： A61F2/00 , A61K9/14 , A61K33/42 , A61K33/00 , C01F11/00 , C01B25/32 , C01B33/24 , A01N59/26 , A01N59/00
CPC分类号： A61L27/425 , A61L27/12 , A61L27/32 , A61L27/46 , A61L27/54 , A61L2300/412 , A61L2300/43 , A61L2430/02 , C01B25/32
摘要： The invention is a silicon substituted oxyapatite compound (Si-OAp) for use as a synthetic bone biomaterial either used alone or in biomaterial compositions. The silicon substituted oxyapatite compound has the formula Ca5(PO4)3-x(SiO4)xO(1-x)/2, where 0
摘要翻译：本发明是单独使用或用于生物材料组合物中的用作合成骨生物材料的硅取代的氧磷灰石化合物（Si-OAp）。硅取代的氧磷灰石化合物具有式Ca 5（PO 4）3-x（SiO 4）x O（1-x）/ 2，其中0

7. 发明授权

US5766669A Sintering process for producing thin films of calcium phosphate entities 失效
标题翻译：用于生产磷酸钙实体薄膜的烧结工艺
公开(公告)号：US5766669A
公开(公告)日：1998-06-16
申请号：US960702
申请日：1997-10-30
申请人： Sydney M. Pugh , Timothy J. N. Smith
发明人： Sydney M. Pugh , Timothy J. N. Smith
IPC分类号： A61L27/00 , A61F2/00 , A61L27/32 , C01B25/32 , C03C17/25 , C04B35/447 , C04B41/50 , B05D3/02 , B05D5/00
CPC分类号： A61L27/32 , C03C17/25 , C04B41/5048 , A61F2310/00796 , C03C2217/23 , C03C2218/113 , C03C2218/32
摘要： An improved process for producing a thin film of calcium phosphate entities to support bone cell activity thereon. The material to be sintered is prepared by combining a solution of ammonium phosphate with a solution of calcium nitrate to form a sol-gel containing hydroxyapatite. A film of the sol gel is applied to at least one side of the substrate and the film coated on the substrate is sintered to form a solid film of calcium phosphate entities. The improvement in the process comprising sintering the film at temperatures selected from a range of temperatures which optimize a composition of calcium phosphate entities in the film. The sintering step converts hydroxyapatite to .alpha.-tricalcium phosphate where extent of such conversion is temperature dependent. The optimized composition comprises a ratio of hydroxyapatite to .alpha.-tricalcium phosphate in the range of 50:50 to 20:80. A sintering temperature is selected to provide these ratios. The sintering temperature is selected from a range of 920.degree. C. up to 1100.degree. C. where the higher the select temperature, the greater the amount of .alpha.-tricalcium phosphate in the ratio.
摘要翻译：一种用于生产磷酸钙实体薄膜以支持骨细胞活性的改进方法。待烧结的材料通过将磷酸铵溶液与硝酸钙溶液组合以形成含羟基磷灰石的溶胶 - 凝胶来制备。将溶胶凝胶膜施加到基材的至少一侧，并将涂覆在基材上的膜烧结以形成磷酸钙实体的固体膜。该方法的改进包括在选自优化膜中磷酸钙实体的组成的温度范围内的温度下烧结膜。烧结步骤将羟基磷灰石转化为α-磷酸三钙，其中这种转化的程度是温度依赖性的。优化的组合物包含羟基磷灰石与α-磷酸三钙的比例为50:50至20:80。选择烧结温度以提供这些比例。烧结温度选择在920℃至1100℃的范围内，其中选择温度越高，α磷酸三钙的量越大。

8. 发明授权

US5695857A Actively sterile surfaces 失效
标题翻译：积极无菌的表面
公开(公告)号：US5695857A
公开(公告)日：1997-12-09
申请号：US78223
申请日：1993-08-23
申请人： Robert Edward Burrell , Aron Marcus Rosenfeld , Timothy J. N. Smith
发明人： Robert Edward Burrell , Aron Marcus Rosenfeld , Timothy J. N. Smith
IPC分类号： A61L15/00 , A61F2/00 , A61L15/46 , A61L27/54 , A61L29/16 , A61L31/00 , A61L31/16 , A61M35/00 , B32B3/00
CPC分类号： A61L2/232 , A61F2/0077 , A61L15/46 , A61L2/238 , A61L27/54 , A61L29/16 , A61L31/16 , A61F2250/0067 , A61L2300/102 , A61L2300/404 , A61L2300/608 , Y10S604/905 , Y10T428/24917 , Y10T428/31504 , Y10T428/31678 , Y10T428/31681 , Y10T428/31692
摘要： An actively antimicrobial surface for a substrate and for use in a biologically dynamic environment, such as for treating and preventing microbial infections, comprises a film consisting of at least an antimicrobial element and another electrochemically nobler element and which forms multitudinous galvanic cells with electrolyte containing biological fluids, such as body fluids from wounds, etc., for releasing the antimicrobial element at the surface.
摘要翻译： PCT No.PCT / CA91 / 00453 Sec。 371日期：1993年8月23日 102（e）日期1993年8月23日PCT 1991年12月23日PCT公布。出版物WO92 / 11043 日期1992年7月9日一种用于底物并用于生物动态环境（例如用于治疗和预防微生物感染）的积极的抗微生物表面包含由至少一种抗微生物元件和另一种电化学元素组成的膜，并形成多种电流含有生物流体的电解质的细胞，例如来自伤口的体液等，用于在表面释放抗微生物元件。

9. 发明授权

US09499780B2 Advanced tissue engineering system 有权
标题翻译：高级组织工程系统
公开(公告)号：US09499780B2
公开(公告)日：2016-11-22
申请号：US11597550
申请日：2005-05-26
申请人： Timothy J. N. Smith , Sydney M. Pugh , Lowell Misener , Guy Oram , Rupert Hagg , Roberto Tommasini , Yves Larcher
发明人： Timothy J. N. Smith , Sydney M. Pugh , Lowell Misener , Guy Oram , Rupert Hagg , Roberto Tommasini , Yves Larcher
IPC分类号： C12M1/00 , C12M3/00 , C12M1/12
CPC分类号： C12M21/08 , C12M23/24 , C12M23/34 , C12M23/44 , C12M25/14 , C12M27/16 , C12M41/12 , C12M45/09 , C12M47/04
摘要： The invention is an automated advanced tissue engineering system that comprises a housing in which one or more tissue engineering modules are accommodated together with a central microprocessor that controls functioning of the tissue engineering modules. In one embodiment, the tissue engineering module comprises a housing supporting one or more bioreactor chamber assemblies and a fluid reservoir operationally engageable with the housing. The bioreactor chamber assemblies may be selected depending on the end product option desired and may include, for example, a cell therapy bioreactor chamber, a single implant bioreactor chamber and a multiple (mosaic) implant bioreactor chamber.
摘要翻译：本发明是一种自动化的高级组织工程系统，其包括壳体，其中一个或多个组织工程模块与控制组织工程模块功能的中央微处理器一起容纳在一起。在一个实施例中，组织工程模块包括支撑一个或多个生物反应器室组件的壳体和可操作地与壳体接合的流体储存器。可以根据期望的最终产品选择来选择生物反应器室组件，并且可以包括例如细胞治疗生物反应器室，单个植入物生物反应器室和多个（镶嵌）植入物生物反应器室。

10. 发明授权

US09399086B2 Implantable medical devices 有权
标题翻译：可植入医疗器械
公开(公告)号：US09399086B2
公开(公告)日：2016-07-26
申请号：US12508856
申请日：2009-07-24
申请人： Anthony J. Melkent , Brian R. Thoren , Timothy J. N. Smith , Ian D. Grant , Ian R. Dunkley
发明人： Anthony J. Melkent , Brian R. Thoren , Timothy J. N. Smith , Ian D. Grant , Ian R. Dunkley
IPC分类号： A61F2/28 , A61L27/56 , A61F2/44 , A61L27/42 , A61L27/58 , A61F2/30 , A61L27/46
CPC分类号： A61L31/121 , A61F2/30724 , A61F2/4455 , A61F2002/30029 , A61F2002/30034 , A61F2002/30062 , A61F2002/30187 , A61F2002/30957 , A61F2002/30973 , A61F2002/4475 , A61L27/425 , A61L27/46 , A61L27/56 , A61L27/58 , A61L2400/08 , A61L2400/18 , A61L2420/02 , A61L2420/04 , B05D1/18 , B05D3/0272 , B29C45/0055 , B29C45/14795 , B29C2045/0058 , B29K2071/00 , B29L2031/7532 , C04B38/0051 , C04B41/4586 , C04B41/81 , C04B2235/606 , C08L71/12
摘要： Implantable medical devices are provided. In one embodiment, a device includes a body having an external surface defining an outer profile of the device. The body includes a porous matrix including a series of interconnected macropores defined by a plurality of interconnected struts each including a hollow interior. A filler material substantially fills at least a portion of the series of interconnected macropores. The external surface of the body includes a plurality of openings communicating with the hollow interior of at least a portion of the plurality of interconnected struts. In a further aspect of this embodiment, the external surface includes exposed areas of the filler material and porous matrix in addition to the exposed openings. In another aspect, the porous matrix is formed from a bioresorbable ceramic and the filler material is a biologically stable polymeric material. Still, other aspects related to this and other embodiments are also disclosed.
摘要翻译：提供可植入的医疗设备。在一个实施例中，装置包括具有限定装置的外部轮廓的外表面的主体。主体包括多孔基体，其包括由多个相互连接的支柱限定的一系列相互连接的大孔，每个支柱包括中空的内部。填充材料基本上填充了一系列互连的大孔的至少一部分。主体的外表面包括与多个相互连接的支柱的至少一部分的中空内部连通的多个开口。在该实施例的另一方面，除了暴露的开口之外，外表面还包括填充材料和多孔基体的暴露区域。在另一方面，多孔基质由生物可吸收的陶瓷形成，填料是生物稳定的聚合材料。仍然，还公开了与该实施例和其他实施例相关的其它方面。

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