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1. 发明申请

US20050203146A1 Amino-benzazoles as P2Y1 receptor inhibitors 有权
标题翻译：氨基 - 苯并唑类作为P2Y1受体抑制剂
公开(公告)号：US20050203146A1
公开(公告)日：2005-09-15
申请号：US11038862
申请日：2005-01-19
申请人： Timothy Herpin , George Morton , Robert Rehfuss , R. Lawrence , Michael Poss , Jacques Roberge , Timur Gungor
发明人： Timothy Herpin , George Morton , Robert Rehfuss , R. Lawrence , Michael Poss , Jacques Roberge , Timur Gungor
IPC分类号： A61K31/4178 , A61K31/423 , A61K31/428 , A61K31/4439 , C07D235/30 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/02 , C07D413/12 , C07D413/14 , C07D417/02 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/04 , C07D513/04 , C07D43/02
CPC分类号： C07D401/12 , C07D235/30 , C07D401/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/04 , C07D513/04
摘要： The present invention provides novel amino-benzazoles and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译：本发明提供了新的氨基 - 苯并唑类似物，它们是人P2Y 1受体的选择性抑制剂。本发明还提供了相同的各种药物组合物以及治疗对P2Y受体活性的调节作用的疾病的方法。

2. 发明申请

US20050267119A1 Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions 有权
标题翻译： P2Y1受体的尿素拮抗剂可用于治疗血栓形成
公开(公告)号：US20050267119A1
公开(公告)日：2005-12-01
申请号：US11126915
申请日：2005-05-11
申请人： Hannguang Chao , Huji Tuerdi , Timothy Herpin , Jacques Roberge , Yalei Liu , R. Lawrence , Robert Rehfuss , Charles Clark , Jennifer Qiao , Timur Gungor , Patrick Lam , Tammy Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora Schnur
发明人： Hannguang Chao , Huji Tuerdi , Timothy Herpin , Jacques Roberge , Yalei Liu , R. Lawrence , Robert Rehfuss , Charles Clark , Jennifer Qiao , Timur Gungor , Patrick Lam , Tammy Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora Schnur
IPC分类号： A61K31/4439 , A61K31/444 , A61K31/501 , C07C275/30 , C07C275/32 , C07D213/40 , C07D213/75 , C07D213/89 , C07D231/40 , C07D231/50 , C07D237/22 , C07D333/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07F7/18 , C07D43/02 , C07D41/02
CPC分类号： C07D409/14 , C07C275/30 , C07C275/32 , C07D213/40 , C07D213/75 , C07D213/89 , C07D231/40 , C07D231/50 , C07D237/22 , C07D333/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07F7/1804
摘要： The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译：本发明提供了新的吡啶基或苯基脲及其类似物，它们是人P2Y 1受体的选择性抑制剂。本发明还提供了相同的各种药物组合物以及治疗对P2Y受体活性的调节作用的疾病的方法。

4. 发明授权

US08575321B2 Benzylbenzene derivatives and methods of use 有权
标题翻译：苄苯衍生物和使用方法
公开(公告)号：US08575321B2
公开(公告)日：2013-11-05
申请号：US13333295
申请日：2011-12-21
申请人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Roberge
发明人： Yuanwei Chen , Huawei Cheng , Shengbin Li , Yuelin Wu , Yan Feng , Binhua Lv , Baihua Xu , Brian Seed , Michael Hadd , Yanli Song , Jiyan Du , Congna Wang , Jacques Roberge
IPC分类号： C07H1/00
CPC分类号： C07H7/04 , C07D309/10 , C07D407/12
摘要： Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.
摘要翻译：提供对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用的化合物。本发明还提供药物组合物，制备化合物的方法，合成中间体，以及独立地或与其它治疗剂组合使用化合物治疗受SGLT抑制影响的疾病和病症的方法。

5. 发明申请

US20060223832A1 Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 有权
公开(公告)号：US20060223832A1
公开(公告)日：2006-10-05
申请号：US10917031
申请日：2004-08-12
申请人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
发明人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
IPC分类号： A61K31/497 , C07D487/14
CPC分类号： C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
摘要： Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

6. 发明授权

US5679769A Synthesis of asparagine-linked glycopeptides on a polymeric solid support 失效
标题翻译：在聚合物固体支持物上合成天冬酰胺连接的糖肽
公开(公告)号：US5679769A
公开(公告)日：1997-10-21
申请号：US477776
申请日：1995-06-07
申请人： Samuel J. Danishefsky , Jacques Roberge , Xenia Beebe
发明人： Samuel J. Danishefsky , Jacques Roberge , Xenia Beebe
IPC分类号： A61K38/00 , A61K39/00 , C07H3/06 , C07H15/10 , C07H15/18 , C07H17/02 , C07K1/04 , C07K9/00 , C07K16/30 , C07K16/44 , A61K31/02
CPC分类号： A61K39/0011 , C07H15/10 , C07H15/18 , C07H17/02 , C07H3/06 , C07K1/04 , C07K16/3015 , C07K16/44 , C07K9/005 , A61K38/00
摘要： The present invention provides a process for synthesizing a glycopeptide having the structure: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are each independently H, OH, OR.sup.1, NH.sub.2, NHCOR.sup.i, F, CH.sub.2 OH, CH.sub.2 OR.sup.i, or a substituted or unsubstituted linear or branched chain alkyl, arylalkyl or aryl group, where R.sup.i is H, CHO, CO.sub.2 R.sup.ii, a linear or branched chain alkyl, arylalkyl or aryl group, or an oligosaccharide moiety, etc., wherein R.sub.0 is H, a linear or branched chain alkyl, arylalkyl or aryl group; wherein R.sub.10 is a substituted or unsubstituted linear or branched chain acyl, arylacyl or aroyl group; wherein R.sub.11�x! represents X amino acid side-chains, and denotes position from the N-terminus, and R.sub.13�y! represents Y amino acid side-chains, and denotes position from the C-terminus, wherein a, b, c, h, i, j, r, s and t are each independently an integer between about 0 and about 3; wherein m and n are each independently an integer between about 0 and about 5; and wherein x, x'(N), y and y'(N) are each independently an integer between about 0 and,about 25; such glycopeptides being useful as a vaccine for inducing antibodies to human breast cancer cells in an adjuvant therapy therefor.
摘要翻译：本发明提供一种合成具有以下结构的糖肽的方法：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8各自独立地为H，OH，OR 1，NH 2，NHCOR 1 ，F，CH2OH，CH2ORi或取代或未取代的直链或支链烷基，芳烷基或芳基，其中R 1为H，CHO，CO 2 R 11，直链或支链烷基，芳烷基或芳基或寡糖部分等其中R 0是H，直链或支链烷基，芳烷基或芳基; 其中R 10是取代或未取代的直链或支链酰基，芳基酰基或芳酰基; 其中R11 [x]表示X氨基酸侧链，表示从N-末端的位置，R13 [y]表示Y氨基酸侧链，表示C末端的位置，其中a，b，c ，h，i，j，r，s和t各自独立地为约0和约3之间的整数; 其中m和n各自独立地为约0和约5之间的整数; 并且其中x，x'（N），y和y'（N）各自独立地为约0和约25之间的整数; 这样的糖肽可用作用于在其辅助治疗中诱导人乳腺癌细胞的抗体的疫苗。

7. 发明授权

US4636926A Assembly for mounting a light fixture to a support structure 失效
标题翻译：用于将灯具安装到支撑结构的组件
公开(公告)号：US4636926A
公开(公告)日：1987-01-13
申请号：US705692
申请日：1985-02-26
申请人： Jacques Roberge
发明人： Jacques Roberge
IPC分类号： F21V17/14 , F21V17/16 , F21V21/116 , F21V17/06
CPC分类号： F21V17/164 , F21V17/14 , F21V21/116
摘要： A series of resilient blades are circumferentially disposed on an annular member to which a light fixture is attached and are adapted, through a rotational sliding motion, to come in overlapping interengagement with a second series of resilient blades disposed circumferentially on a base member mounted to the structure supporting the light fixture.
摘要翻译：一系列弹性叶片周向地设置在环形构件上，照明装置被附接到环形构件上，并且通过旋转滑动运动适应与第二系列弹性叶片重叠地相互配合，所述第二系列弹性叶片周向设置在安装到结构支撑灯具。

8. 发明申请

US20050272799A1 Fused Heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 失效
标题翻译：融合的杂环琥珀酰亚胺化合物及其类似物，核激素受体功能的调节剂
公开(公告)号：US20050272799A1
公开(公告)日：2005-12-08
申请号：US11176810
申请日：2005-07-07
申请人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
发明人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
IPC分类号： A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D471/18 , C07D487/08 , C07D487/18 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00
CPC分类号： C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
摘要： Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
摘要翻译：稠合的环状化合物，使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法，以及含有这些化合物的药物组合物。

9. 发明申请

US20050192253A1 Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 有权
标题翻译：稠合的杂环琥珀酰亚胺化合物及其类似物，核激素受体功能的调节剂
公开(公告)号：US20050192253A1
公开(公告)日：2005-09-01
申请号：US10974049
申请日：2004-10-25
申请人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
发明人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
IPC分类号： A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D471/18 , C07D487/08 , C07D487/18 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , C07D487/14
CPC分类号： C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
摘要： Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
摘要翻译：稠合的环状化合物，使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法，以及含有这些化合物的药物组合物。

10. 发明申请

US20060264459A1 Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 有权
公开(公告)号：US20060264459A1
公开(公告)日：2006-11-23
申请号：US11338587
申请日：2006-02-15
申请人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
发明人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
IPC分类号： A61K31/4709 , A61K31/407 , C07D491/02
CPC分类号： C07D487/18
摘要： Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

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