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1. 发明申请

US20120128647A1 DELIVERY OF COMPOUNDS WITH REHYDRATED BLOOD CELLS 有权
标题翻译：递送化合物与再生血液细胞
公开(公告)号：US20120128647A1
公开(公告)日：2012-05-24
申请号：US11863462
申请日：2007-09-28
申请人： Timothy C. Nichols , Thomas Fischer , Marjorie S. Read
发明人： Timothy C. Nichols , Thomas Fischer , Marjorie S. Read
IPC分类号： A61K35/14 , A61P7/02 , A61P7/04 , C12N5/078 , A61P31/12
CPC分类号： A61K38/02 , A01N1/02 , A01N1/0215 , A61K31/00 , A61K31/7088 , A61K35/18 , A61K35/19 , A61K45/06 , A61K47/6901 , Y10S977/905 , A61K2300/00
摘要： Fixed-dried blood cells carrying an active agent are described, along with methods of making the same, methods of using the same, and compositions containing the same. The blood cells are preferably blood platelets.
摘要翻译：描述了携带活性剂的固定干细胞及其制备方法，以及使用它们的方法，以及含有它们的组合物。血细胞优选为血小板。

2. 发明授权

US07901674B2 Aldehyde-fixed platelets with internalized paramagnetic or magnetic nanoparticles 有权
标题翻译：具有内在顺磁性或磁性纳米粒子的醛固定血小板
公开(公告)号：US07901674B2
公开(公告)日：2011-03-08
申请号：US11751295
申请日：2007-05-21
申请人： Timothy C. Nichols , Thomas Fischer , Marjorie S. Read
发明人： Timothy C. Nichols , Thomas Fischer , Marjorie S. Read
IPC分类号： A61B5/055 , A01N63/00
CPC分类号： A61K38/02 , A01N1/02 , A01N1/0215 , A61K31/00 , A61K31/7088 , A61K35/18 , A61K35/19 , A61K45/06 , A61K47/6901 , Y10S977/905 , A61K2300/00
摘要： Fixed-dried blood cells carrying an active agent are described, along with methods of making the same, methods of using the same, and compositions containing the sane. The blood cells may be red blood cells or blood platelets.
摘要翻译：描述了携带活性剂的固定干细胞，以及制备它们的方法，使用它们的方法，以及包含理智的组合物。血细胞可能是红细胞或血小板。

3. 发明授权

US07294455B2 Fixed-dried platelets cross-linked to protein 有权
标题翻译：固定干燥的血小板与蛋白质交联
公开(公告)号：US07294455B2
公开(公告)日：2007-11-13
申请号：US10845045
申请日：2004-05-13
申请人： Timothy C. Nichols , Thomas Fischer , Marjorie S. Read
发明人： Timothy C. Nichols , Thomas Fischer , Marjorie S. Read
IPC分类号： A01N1/02 , A01N63/00
CPC分类号： A61K38/02 , A01N1/02 , A01N1/0215 , A61K31/00 , A61K31/7088 , A61K35/18 , A61K35/19 , A61K45/06 , A61K47/6901 , Y10S977/905 , A61K2300/00
摘要： Fixed-dried blood cells carrying an active agent are described, along with methods of making the same, methods of using the same, and compositions containing the same. The blood cells may be red blood cells or blood platelets.
摘要翻译：描述了携带活性剂的固定干细胞及其制备方法，以及使用它们的方法，以及含有它们的组合物。血细胞可能是红细胞或血小板。

4. 发明授权

US08492081B2 Aldehyde-fixed, dried platelets with covalently attached exogenous active agent and method of making thereof 有权
标题翻译：具有共价连接的外源活性剂的醛固定的干燥血小板及其制备方法
公开(公告)号：US08492081B2
公开(公告)日：2013-07-23
申请号：US11863462
申请日：2007-09-28
申请人： Timothy C. Nichols , Thomas Fischer , Marjorie S. Read
发明人： Timothy C. Nichols , Thomas Fischer , Marjorie S. Read
IPC分类号： A01N1/02 , A01N63/00
CPC分类号： A61K38/02 , A01N1/02 , A01N1/0215 , A61K31/00 , A61K31/7088 , A61K35/18 , A61K35/19 , A61K45/06 , A61K47/6901 , Y10S977/905 , A61K2300/00
摘要： Fixed-dried blood cells carrying an active agent are described, along with methods of making the same, methods of using the same, and compositions containing the same. The blood cells are preferably blood platelets.
摘要翻译：描述了携带活性剂的固定干细胞及其制备方法，以及使用它们的方法，以及含有它们的组合物。血细胞优选为血小板。

5. 发明授权

US07358039B2 Fixed-dried red blood cells 失效
标题翻译：固定干红细胞
公开(公告)号：US07358039B2
公开(公告)日：2008-04-15
申请号：US11041560
申请日：2005-01-24
申请人： Thomas H. Fischer , Marjorie S. Read , Arthur P. Bode , Timothy C. Nichols
发明人： Thomas H. Fischer , Marjorie S. Read , Arthur P. Bode , Timothy C. Nichols
IPC分类号： A01N1/02 , A01N63/00
CPC分类号： A01N1/0226 , A01N1/02 , A01N1/0284 , A01N1/0289 , A61K35/18
摘要： Fixed-dried red blood cells (RBCs), and processes for preparing the same are disclosed. The red blood cells, upon reconstitution with distilled water or appropriate buffer: bind oxygen with native affinities, have partial deformability, present minimal thrombogenicity to platelets, and have oblated blood group antigens. The RBCs are preferably fixed by means of cross-linkers with aldehyde functions such as paraformaldehyde or glutaraldehyde either alone or in combination. Native oxygen kinetics are achieved by preparing the red blood cells with 1,6-diphosphofructose. Blood group antigens and chemical functions that render the lyophilized RBCs thrombogenic are occluded by chemically attaching polyoxyethylene glycol polymers to the surface membrane of the red blood cells. The cross-linked red blood cells are preferably died by lyophilization.
摘要翻译：公开了固定干红细胞（RBC）及其制备方法。红细胞在用蒸馏水或适当的缓冲液重构后，与氧化天然亲和力结合，具有部分变形能力，对血小板具有最小的血栓形成，并且具有扁平的血型抗原。 RBCs优选通过具有醛官能团的交联剂例如多聚甲醛或戊二醛单独或组合固定。通过制备具有1,6-二磷酸果糖的红细胞来实现天然氧动力学。通过将聚氧乙烯二醇聚合物化学连接到红细胞的表面膜上，使冻干的RBC血栓形成的血型抗原和化学功能被阻断。交联的红细胞优选通过冻干死亡。

6. 发明授权

US06884573B2 Fixed dried red blood cells and method of use 失效
标题翻译：固定干红细胞和使用方法
公开(公告)号：US06884573B2
公开(公告)日：2005-04-26
申请号：US10231635
申请日：2002-08-30
申请人： Thomas H. Fischer , Marjorie S. Read , Arthur P. Bode , Timothy C. Nichols
发明人： Thomas H. Fischer , Marjorie S. Read , Arthur P. Bode , Timothy C. Nichols
IPC分类号： A01N1/02 , A61K35/18 , A01N63/00
CPC分类号： A01N1/0226 , A01N1/02 , A01N1/0284 , A01N1/0289 , A61K35/18
摘要： Fixed-dried red blood cells (RBCs), and processes for preparing the same are disclosed. The red blood cells, upon reconstitution with distilled water or appropriate buffer: bind oxygen with native affinities, have partial deformability, present minimal thrombogenicity to platelets, and have oblated blood group antigens. The RBCs are preferably fixed by means of cross-linkers with aldehyde functions such as paraformaldehyde or glutaraldehyde either alone or in combination. Native oxygen kinetics are achieved by preparing the red blood cells with 1,6-diphosphofructose. Blood group antigens and chemical functions that render the lyophilized RBCs thrombogenic are occluded by chemically attaching polyoxyethylene glycol polymers to the surface membrane of the red blood cells. The cross-linked red blood cells are preferably died by lyophilization.
摘要翻译：公开了固定干红细胞（RBC）及其制备方法。红细胞在用蒸馏水或适当的缓冲液重构后，与氧化天然亲和力结合，具有部分变形能力，对血小板具有最小的血栓形成，并且具有扁平的血型抗原。 RBCs优选通过具有醛官能团的交联剂例如多聚甲醛或戊二醛单独或组合固定。通过制备具有1,6-二磷酸果糖的红细胞来实现天然氧动力学。通过将聚氧乙烯二醇聚合物化学连接到红细胞的表面膜上，使冻干的RBC血栓形成的血型抗原和化学功能被阻断。交联的红细胞优选通过冻干死亡。

7. 发明申请

US20150066671A1 MERCHANT POINT OF SALE SECURITY SYSTEM 有权
标题翻译：销售安全系统的销售点
公开(公告)号：US20150066671A1
公开(公告)日：2015-03-05
申请号：US14012793
申请日：2013-08-28
申请人： Timothy C. Nichols , Ramaneek Khanna , Geoffrey W. Chatterton
发明人： Timothy C. Nichols , Ramaneek Khanna , Geoffrey W. Chatterton
IPC分类号： G06Q20/20
CPC分类号： G06Q20/20 , G06Q20/4016 , G07G3/00
摘要： A point of sale (POS) security system includes a POS device including a non-transitory memory, one or more hardware processors, and one or more environment sensors. A plurality of POS instructions are located on the non-transitory memory in the POS device and executable by the one or more hardware processors in the POS device to provide a POS engine that is configured to receive and transmit payment information for conducting a payment transaction associated with a purchase. A plurality of security instructions are located on the non-transitory memory in the POS device and are executable by the one or more hardware processors in the POS device to provide a security engine that is configured to receive environment signals from the one or more environment sensors in the POS device and analyze those environment signals to determine a security breach.
摘要翻译：销售点（POS）安全系统包括包括非暂时性存储器，一个或多个硬件处理器以及一个或多个环境传感器的POS设备。多个POS指令位于POS设备中的非暂时性存储器上，并且可由POS设备中的一个或多个硬件处理器执行，以提供POS引擎，该POS引擎被配置为接收和发送支付信息，用于执行相关联的支付交易购买。多个安全指令位于POS设备中的非暂时存储器上，并且可由POS设备中的一个或多个硬件处理器执行，以提供被配置为从一个或多个环境传感器接收环境信号的安全引擎在POS设备中分析这些环境信号以确定安全漏洞。

8. 发明授权

US08572304B2 Systems and methods for configuring mobile devices for printing to wireless printers 失效
标题翻译：用于配置移动设备以打印到无线打印机的系统和方法
公开(公告)号：US08572304B2
公开(公告)日：2013-10-29
申请号：US12960740
申请日：2010-12-06
申请人： Timothy C. Nichols , Geoffrey W. Chatterton , Ramaneek Khanna , Eric D. Bauswell , Anthony R. Chvala
发明人： Timothy C. Nichols , Geoffrey W. Chatterton , Ramaneek Khanna , Eric D. Bauswell , Anthony R. Chvala
IPC分类号： G06F13/00 , G06F3/00
CPC分类号： G06F3/1204 , G06F3/1228 , G06F3/1292
摘要： The present disclosure is directed to systems and methods for configuring mobile communication devices to identify and communicate with wireless printing devices. These systems and methods may include determining available wireless printing devices, selecting a desired wireless printing device, attempting to establish communication between the mobile communication device and the wireless printing device using a first communication protocol, prompting a user to indicate the successfulness of the first communication protocol, and configuring the mobile communication device for printing to the wireless printing device using the first communication protocol if the first communication protocol successfully communicated with the wireless printing device. The systems and methods may further include prompting the user to indicate that the first communication protocol was not successful if the first communication protocol did not successfully communicate with the wireless printing device and repeating the method using another available communication protocol.
摘要翻译：本公开涉及用于配置移动通信设备以识别和与无线打印设备通信的系统和方法。这些系统和方法可以包括确定可用的无线打印设备，选择所需的无线打印设备，尝试使用第一通信协议在移动通信设备和无线打印设备之间建立通信，促使用户指示第一通信的成功并且如果第一通信协议与无线打印设备成功通信，则使用第一通信协议将移动通信设备配置为用于打印到无线打印设备。所述系统和方法还可以包括：如果第一通信协议没有成功地与无线打印设备通信并且使用另一可用通信协议重复该方法，则提示用户指示第一通信协议不成功。

9. 发明授权

US08535735B2 Identification of free-B-ring flavonoids as potent COX-2 inhibitors 有权
标题翻译：鉴定游离B环类黄酮作为有效的COX-2抑制剂
公开(公告)号：US08535735B2
公开(公告)日：2013-09-17
申请号：US13493820
申请日：2012-06-11
申请人： Qi Jia , Timothy C. Nichols , Eric E. Rhoden , Scott Waite
发明人： Qi Jia , Timothy C. Nichols , Eric E. Rhoden , Scott Waite
IPC分类号： A01N65/00
CPC分类号： A61K31/7048 , A61K31/353 , A61K36/539
摘要： The present invention provides a novel method for inhibiting the cyclooxygenase enzyme COX-2. The method is comprised of administering a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 mediated diseases and conditions. The method for preventing and treating COX-2 mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids and a pharmaceutically acceptable carrier.
摘要翻译：本发明提供抑制环加氧酶COX-2的新方法。该方法包括向含有需要的宿主施用含有游离B环类黄酮或含有游离B环类黄酮的混合物的组合物的组合物。本发明还包括预防和治疗COX-2介导的疾病和病症的新方法。预防和治疗COX-2介导的疾病和病症的方法包括向有需要的宿主施用有效量的含有游离B环类黄酮或含有游离B环类黄酮混合物的组合物和药学上可接受的载体。

10. 发明授权

US07427488B2 Purified and isolated platelet calcium channel nucleic acids and polypeptides and therapeutic and screening methods using same 失效
标题翻译：纯化和分离的血小板钙通道核酸和多肽以及使用其的治疗和筛选方法
公开(公告)号：US07427488B2
公开(公告)日：2008-09-23
申请号：US10726216
申请日：2003-12-02
申请人： Timothy C. Nichols , Nadia Malouf , Elizabeth Merricks
发明人： Timothy C. Nichols , Nadia Malouf , Elizabeth Merricks
IPC分类号： G01N33/53 , G01N33/567 , C12N15/00 , C12N5/00 , C07H21/04
CPC分类号： G01N33/6872 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K14/705 , G01N2500/10
摘要： Isolated and purified platelet voltage dependent calcium channel (VDCC) α1 subunit polypeptides, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids, and recombinant proteins are also disclosed, along with methods of producing each. Isolated and purified antibodies to platelet VDCC α1 subunit polypeptides, and methods of producing the same, are also disclosed. Platelet VDCC α1 subunit polypeptides have biological activity in calcium transport. Thus, therapeutic and diagnostic methods involving this activity are also disclosed.
摘要翻译：分离和纯化的血小板电压依赖性钙通道（VDCC）α1亚基多肽和编码其的核酸分子。还公开了重组宿主细胞，重组核酸和重组蛋白，以及每种产生的方法。还公开了血小板VDCCα1亚基多肽的分离和纯化的抗体及其制备方法。血小板VDCCα1亚基多肽在钙转运中具有生物活性。因此，还公开了涉及该活性的治疗和诊断方法。

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