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1. 发明申请

US20090001633A1 Method Of Manufacturing A Stent From A Polymer Tube 有权
标题翻译：从聚合物管制造支架的方法
公开(公告)号：US20090001633A1
公开(公告)日：2009-01-01
申请号：US11771967
申请日：2007-06-29
申请人： Timothy A. Limon , Daniel A. Castro , David C. Gale
发明人： Timothy A. Limon , Daniel A. Castro , David C. Gale
IPC分类号： B29C35/06
CPC分类号： B29B13/024 , A61F2/91 , B29C35/041 , B29C49/68 , B29C2049/0089 , B29K2105/258 , B29L2031/7532 , B29L2031/7542
摘要： A blow molding apparatus for expanding a polymer tube and a method for fabricating a stent using the apparatus is disclosed. The polymer tube is disposed within a tubular mold, over which a heated ring is made of a material having thermal conductivity greater than the tubular mold is translated. The ring is heated with heated fluid streams applied directly onto an outer surface of the ring, or heated fluid circulated within the ring, or an electrically resistive coil within the ring, or combinations thereof. The heated ring uniformly heats a circumference of the tubular mold that, in turn, uniformly heats a circumferential band of the polymer tube. The heated polymer tube is progressively expanded radially and axially while the ring is translated longitudinally over the polymer tube. The expanded polymer tube can be heat set and cooled prior to removal from the tubular mold.
摘要翻译：公开了一种用于膨胀聚合物管的吹塑设备和使用该设备制造支架的方法。聚合物管设置在管状模具内，加热的环由热导率大于管状模具的材料制成。环被加热的流体流直接施加到环的外表面上，或在环内循环的加热流体，或环内的电阻线圈或其组合。加热环均匀地加热管状模具的圆周，这又使得聚合物管的周向带均匀地加热。加热的聚合物管在径向和轴向上逐渐扩大，同时环在聚合物管上纵向平移。膨胀聚合物管可以在从管状模具移除之前进行热定形和冷却。

2. 发明授权

US07666342B2 Method of manufacturing a stent from a polymer tube 有权
标题翻译：从聚合物管制造支架的方法
公开(公告)号：US07666342B2
公开(公告)日：2010-02-23
申请号：US11771967
申请日：2007-06-29
申请人： Timothy A. Limon , Daniel A. Castro , David C. Gale
发明人： Timothy A. Limon , Daniel A. Castro , David C. Gale
IPC分类号： B29C35/06
CPC分类号： B29B13/024 , A61F2/91 , B29C35/041 , B29C49/68 , B29C2049/0089 , B29K2105/258 , B29L2031/7532 , B29L2031/7542
摘要： A blow molding apparatus for expanding a polymer tube and a method for fabricating a stent using the apparatus is disclosed. The polymer tube is disposed within a tubular mold, over which a heated ring is made of a material having thermal conductivity greater than the tubular mold is translated. The ring is heated with heated fluid streams applied directly onto an outer surface of the ring, or heated fluid circulated within the ring, or an electrically resistive coil within the ring, or combinations thereof. The heated ring uniformly heats a circumference of the tubular mold that, in turn, uniformly heats a circumferential band of the polymer tube. The heated polymer tube is progressively expanded radially and axially while the ring is translated longitudinally over the polymer tube. The expanded polymer tube can be heat set and cooled prior to removal from the tubular mold.
摘要翻译：公开了一种用于膨胀聚合物管的吹塑设备和使用该设备制造支架的方法。聚合物管设置在管状模具内，加热的环由热导率大于管状模具的材料制成。环被加热的流体流直接施加到环的外表面上，或在环内循环的加热流体，或环内的电阻线圈或其组合。加热环均匀地加热管状模具的圆周，这又使得聚合物管的周向带均匀地加热。加热的聚合物管在径向和轴向上逐渐扩大，同时环在聚合物管上纵向平移。膨胀聚合物管可以在从管状模具移除之前进行热定形和冷却。

3. 发明授权

US08709071B1 Stent with preferential coating 失效
标题翻译：支架优先涂层
公开(公告)号：US08709071B1
公开(公告)日：2014-04-29
申请号：US11864472
申请日：2007-09-28
申请人： Bin Huang , David C. Gale , Daniel A. Castro , Vincent J. Gueriguian
发明人： Bin Huang , David C. Gale , Daniel A. Castro , Vincent J. Gueriguian
IPC分类号： A61F2/06
CPC分类号： A61L31/10 , A61F2/86 , A61F2240/001 , A61F2250/0051 , A61F2250/0067 , A61K31/436 , A61L31/022 , A61L31/06 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2420/02 , A61L2420/08 , B05D1/02 , B05D1/18 , B05D1/32
摘要： This invention relates to stents, a type of implantable medical device, with an antiproliferative coating and a prohealing luminal coating and methods of fabricating stents with an antiproliferative coating and a prohealing luminal coating.
摘要翻译：本发明涉及支架，一种可植入医疗装置，其具有抗增殖性涂层和预呼流道腔涂层，以及制造具有抗增殖性涂层和预呼流道涂层的支架的方法。

4. 发明申请

US20110305819A1 METHOD OF COATING STENTS 审中-公开
标题翻译：涂层方法
公开(公告)号：US20110305819A1
公开(公告)日：2011-12-15
申请号：US13215087
申请日：2011-08-22
申请人： Kevin Jow , Daniel A. Castro
发明人： Kevin Jow , Daniel A. Castro
IPC分类号： B05D1/02 , B05D3/00
CPC分类号： B05B12/084 , B23K2103/42 , B23K2103/50
摘要： A method of coating a stent involves modifying a spray coating parameter until a target mass per coating layer is achieved. A method for coating involves spraying a batch of stents according to spraying parameters that were previously determined to provide a target mass per coating layer.
摘要翻译：涂覆支架的方法包括改变喷涂参数，直到达到每个涂层的目标质量。涂覆方法包括根据先前确定的每个涂层提供靶质量的喷雾参数喷涂一批支架。

5. 发明授权

US07998524B2 Methods to improve adhesion of polymer coatings over stents 有权
标题翻译：改善聚合物涂层在支架上的附着力的方法
公开(公告)号：US07998524B2
公开(公告)日：2011-08-16
申请号：US11953657
申请日：2007-12-10
申请人： Yunbing Wang , Daniel A. Castro , Stephen D. Pacetti
发明人： Yunbing Wang , Daniel A. Castro , Stephen D. Pacetti
IPC分类号： A61L33/00
CPC分类号： A61F2/82 , A61F2/06 , A61F2210/0004 , A61F2210/0076 , A61F2250/0067 , A61L31/04 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/00 , A61L2420/08 , A61M29/00 , B32B17/06 , B32B27/38 , Y10T428/31511 , C08L67/04
摘要： Methods are disclosed to improved adhesion of polymer coatings over polymer surfaces of stents which include plasma treatment, applying an adhesion promoting layer, surface treatments with solvents, and mechanical roughening techniques.
摘要翻译：公开了改进聚合物涂层在支架聚合物表面上的附着力的方法，包括等离子体处理，施加粘合促进层，用溶剂进行表面处理和机械粗糙化技术。

6. 发明申请

US20100102046A1 Laser Machining Medical Devices With Localized Cooling 审中-公开
标题翻译：激光加工具有局部冷却的医疗设备
公开(公告)号：US20100102046A1
公开(公告)日：2010-04-29
申请号：US12259118
申请日：2008-10-27
申请人： Bin Huang , Daniel A. Castro , Arzu M. Ozkan
发明人： Bin Huang , Daniel A. Castro , Arzu M. Ozkan
IPC分类号： B23K26/00
CPC分类号： B23K26/146 , A61F2/82 , A61F2240/001 , B23K26/0624 , B23K2103/42 , B23K2103/50
摘要： Laser machining a tubular construct comprising a polymer layer to form a stent pattern in the construct with localized cooling of the machined surface to reduce or prevent heat transfer to uncut polymer of the polymer layer is disclosed.
摘要翻译：激光加工包含聚合物层的管状结构，以在构造体中形成支架图案，其中加工表面的局部冷却以减少或防止热传递到未切割聚合物层的聚合物层。

7. 发明授权

US09061091B2 Methods to improve adhesion of polymer coatings over stents 有权
公开(公告)号：US09061091B2
公开(公告)日：2015-06-23
申请号：US13175684
申请日：2011-07-01
申请人： Yunbing Wang , Daniel A. Castro , Stephen D. Pacetti
发明人： Yunbing Wang , Daniel A. Castro , Stephen D. Pacetti
IPC分类号： A61L33/00 , A61L31/14 , A61L31/10 , B32B27/38 , A61F2/06 , B32B17/06 , A61M29/00
CPC分类号： A61F2/82 , A61F2/06 , A61F2210/0004 , A61F2210/0076 , A61F2250/0067 , A61L31/04 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/00 , A61L2420/08 , A61M29/00 , B32B17/06 , B32B27/38 , Y10T428/31511 , C08L67/04
摘要： Methods are disclosed to improved adhesion of polymer coatings over polymer surfaces of stents which include plasma treatment, applying an adhesion promoting layer, surface treatments with solvents, and mechanical roughening techniques.

8. 发明授权

US08936826B2 Method of coating stents 有权
标题翻译：涂层支架方法
公开(公告)号：US08936826B2
公开(公告)日：2015-01-20
申请号：US13215087
申请日：2011-08-22
申请人： Kevin Jow , Daniel A. Castro
发明人： Kevin Jow , Daniel A. Castro
IPC分类号： A61L33/00 , B05B12/08 , B23K26/40
CPC分类号： B05B12/084 , B23K2103/42 , B23K2103/50
摘要： A method of coating a stent involves modifying a spray coating parameter until a target mass per coating layer is achieved. A method for coating involves spraying a batch of stents according to spraying parameters that were previously determined to provide a target mass per coating layer.
摘要翻译：涂覆支架的方法包括改变喷涂参数，直到达到每个涂层的目标质量。涂覆方法包括根据先前确定的每个涂层提供靶质量的喷雾参数喷涂一批支架。

9. 发明授权

US08486482B2 Methods to improve adhesion of polymer coatings over stents 有权
公开(公告)号：US08486482B2
公开(公告)日：2013-07-16
申请号：US13175689
申请日：2011-07-01
申请人： Yunbing Wang , Daniel A. Castro , Stephen D. Pacetti
发明人： Yunbing Wang , Daniel A. Castro , Stephen D. Pacetti
IPC分类号： A61L33/00
CPC分类号： A61F2/82 , A61F2/06 , A61F2210/0004 , A61F2210/0076 , A61F2250/0067 , A61L31/04 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/00 , A61L2420/08 , A61M29/00 , B32B17/06 , B32B27/38 , Y10T428/31511 , C08L67/04
摘要： Methods are disclosed to improved adhesion of polymer coatings over polymer surfaces of stents which include plasma treatment, applying an adhesion promoting layer, surface treatments with solvents, and mechanical roughening techniques.

10. 发明授权

US08003158B2 Spray coating stents with fixed No. of layers 有权
标题翻译：具有固定层数的喷涂支架
公开(公告)号：US08003158B2
公开(公告)日：2011-08-23
申请号：US11864236
申请日：2007-09-28
申请人： Kevin Jow , Daniel A. Castro
发明人： Kevin Jow , Daniel A. Castro
IPC分类号： A61L33/00
CPC分类号： B05B12/084 , B23K2103/42 , B23K2103/50
摘要： Various embodiments of methods for coating stents are described herein. One method is directed to a stent spraying apparatus calibration procedure. Another method is directed to obtaining a batch of stents where each stent has the same number of layers of coatings, and the same total amount of coating material.
摘要翻译：本文描述了用于涂覆支架的方法的各种实施例。一种方法涉及支架喷射装置校准程序。另一种方法是获得一批支架，其中每个支架具有相同数量的涂层层数，以及相同的涂层材料总量。

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