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1. 发明授权

US08696760B2 Scaffolds for organ reconstruction and augmentation 失效
标题翻译：器官重建和扩充支架
公开(公告)号：US08696760B2
公开(公告)日：2014-04-15
申请号：US13037559
申请日：2011-03-01
申请人： Timothy A. Bertram , Andrew Bruce , Deepak Jain , Manuel J. Jayo , John W. Ludlow , Darell McCoy , Richard Payne , Namrata D. Sangha , Oluwatoyin A. Knight
发明人： Timothy A. Bertram , Andrew Bruce , Deepak Jain , Manuel J. Jayo , John W. Ludlow , Darell McCoy , Richard Payne , Namrata D. Sangha , Oluwatoyin A. Knight
IPC分类号： A61F2/04
CPC分类号： A61F2/02 , A61F2/042 , A61F2002/047 , A61F2002/048 , A61L27/3813 , A61L27/3826 , A61L27/383 , A61L27/3882 , A61L27/3891 , C12N5/0697 , C12N2502/1347 , C12N2502/253 , C12N2533/40
摘要： Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.
摘要翻译：生物相容的合成或天然支架用于需要这种治疗的患者中的器官或组织结构的重建，修复，增加或替换。支架被成形为符合器官或组织结构的至少一部分，并且可以用一个或多个细胞群体接种。还提供了插入物，容器和端口用于将管状容器附接到新器官支架。将种子支架植入需要治疗的部位的患者中以形成有组织的器官或组织结构。支架可用于形成器官或组织，例如膀胱，尿道，瓣膜和血管。

2. 发明授权

US07918897B2 Scaffolds for organ reconstruction and augmentation 有权
标题翻译：器官重建和扩充支架
公开(公告)号：US07918897B2
公开(公告)日：2011-04-05
申请号：US11706081
申请日：2007-02-12
申请人： Timothy A. Bertram , Andrew Bruce , Deepak Jain , Manuel J. Jayo , John W. Ludlow , Darell McCoy , Richard Payne , Namrata D. Sangha
发明人： Timothy A. Bertram , Andrew Bruce , Deepak Jain , Manuel J. Jayo , John W. Ludlow , Darell McCoy , Richard Payne , Namrata D. Sangha
IPC分类号： A61F2/04
CPC分类号： A61F2/02 , A61F2/042 , A61F2002/047 , A61F2002/048 , A61L27/3813 , A61L27/3826 , A61L27/383 , A61L27/3882 , A61L27/3891 , C12N5/0697 , C12N2502/1347 , C12N2502/253 , C12N2533/40
摘要： Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.
摘要翻译：生物相容的合成或天然支架用于需要这种治疗的患者中的器官或组织结构的重建，修复，增加或替换。支架被成形为符合器官或组织结构的至少一部分，并且可以用一个或多个细胞群体接种。还提供了插入物，容器和端口用于将管状容器附接到新器官支架。将种子支架植入需要治疗的部位的患者中以形成有组织的器官或组织结构。支架可用于形成器官或组织，例如膀胱，尿道，瓣膜和血管。

3. 发明申请

US20110257726A1 SCAFFOLDS FOR ORGAN RECONSTRUCTION AND AUGMENTATION 失效
标题翻译：组织机构重组和补充
公开(公告)号：US20110257726A1
公开(公告)日：2011-10-20
申请号：US13037559
申请日：2011-03-01
申请人： Timothy A. Bertram , Andrew Bruce , Deepak Jain , Manuel J. Jayo , John W. Ludlow , Darell McCoy , Richard Payne , Namrata D. Sangha
发明人： Timothy A. Bertram , Andrew Bruce , Deepak Jain , Manuel J. Jayo , John W. Ludlow , Darell McCoy , Richard Payne , Namrata D. Sangha
IPC分类号： A61F2/82 , A61K35/12 , A61P13/10 , A61K9/00
CPC分类号： A61F2/02 , A61F2/042 , A61F2002/047 , A61F2002/048 , A61L27/3813 , A61L27/3826 , A61L27/383 , A61L27/3882 , A61L27/3891 , C12N5/0697 , C12N2502/1347 , C12N2502/253 , C12N2533/40
摘要： Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.
摘要翻译：生物相容的合成或天然支架用于需要这种治疗的患者中的器官或组织结构的重建，修复，增加或替换。支架被成形为符合器官或组织结构的至少一部分，并且可以用一个或多个细胞群体接种。还提供了插入物，容器和端口用于将管状容器附接到新器官支架。将种子支架植入需要治疗的部位的患者中以形成有组织的器官或组织结构。支架可用于形成器官或组织，例如膀胱，尿道，瓣膜和血管。

4. 发明申请

US20110117162A1 Isolated Renal Cells and Uses Thereof 有权
标题翻译：孤立的肾细胞及其用途
公开(公告)号：US20110117162A1
公开(公告)日：2011-05-19
申请号：US12617721
申请日：2009-11-12
申请人： Sharon C. Presnell , Andrew Bruce , Shay M. Wallace , Sumana Choudhury , Russell W. Kelley , Manuel J. Jayo , Jessica J. Reinsch , Patricia D. Tatsumi , Timothy A. Bertram , Eric S. Werdin , Oluwatoyin A. Knight , H. Scott Rapoport , Roger M. Ilagan
发明人： Sharon C. Presnell , Andrew Bruce , Shay M. Wallace , Sumana Choudhury , Russell W. Kelley , Manuel J. Jayo , Jessica J. Reinsch , Patricia D. Tatsumi , Timothy A. Bertram , Eric S. Werdin , Oluwatoyin A. Knight , H. Scott Rapoport , Roger M. Ilagan
IPC分类号： A61K9/00 , C12N5/071 , A61K35/12 , A61P13/12 , A61P5/00 , A61P13/00 , A61P7/06
CPC分类号： A61K35/22 , A61K35/12 , C12N5/0686 , C12N2500/02
摘要： The invention is directed to isolated renal cells, including tubular and erythropoietin (EPO)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.
摘要翻译：本发明涉及分离的肾细胞，包括产生肾细胞群的管状和促红细胞生成素（EPO），以及分离和培养肾细胞群的方法，以及用细胞群治疗需要的受试者的方法。

5. 发明授权

US08318484B2 Isolated renal cells and uses thereof 有权
标题翻译：分离的肾细胞及其用途
公开(公告)号：US08318484B2
公开(公告)日：2012-11-27
申请号：US12617721
申请日：2009-11-12
申请人： Sharon C. Presnell , Andrew Bruce , Shay M. Wallace , Sumana Choudhury , Russell W. Kelley , Manuel J. Jayo , Jessica J. Reinsch , Patricia D. Tatsumi , Timothy A. Bertram , Eric S. Werdin , Oluwatoyin A. Knight , H. Scott Rapoport , Roger M. Ilagan
发明人： Sharon C. Presnell , Andrew Bruce , Shay M. Wallace , Sumana Choudhury , Russell W. Kelley , Manuel J. Jayo , Jessica J. Reinsch , Patricia D. Tatsumi , Timothy A. Bertram , Eric S. Werdin , Oluwatoyin A. Knight , H. Scott Rapoport , Roger M. Ilagan
IPC分类号： C12N5/00
CPC分类号： A61K35/22 , A61K35/12 , C12N5/0686 , C12N2500/02
摘要： The invention is directed to isolated renal cells, including tubular and erythropoietin (EPO)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.
摘要翻译：本发明涉及分离的肾细胞，包括产生肾细胞群的管状和促红细胞生成素（EPO），以及分离和培养肾细胞群的方法，以及用细胞群治疗需要的受试者的方法。

6. 发明申请

US20070276507A1 Scaffolds for organ reconstruction and augmentation 有权
标题翻译：器官重建和扩充支架
公开(公告)号：US20070276507A1
公开(公告)日：2007-11-29
申请号：US11706081
申请日：2007-02-12
申请人： Timothy Bertram , Andrew Bruce , Deepak Jain , Manuel Jayo , John Ludlow , Darrell McCoy , Richard Payne , Namrata Sangha
发明人： Timothy Bertram , Andrew Bruce , Deepak Jain , Manuel Jayo , John Ludlow , Darrell McCoy , Richard Payne , Namrata Sangha
IPC分类号： A61F2/02
CPC分类号： A61F2/02 , A61F2/042 , A61F2002/047 , A61F2002/048 , A61L27/3813 , A61L27/3826 , A61L27/383 , A61L27/3882 , A61L27/3891 , C12N5/0697 , C12N2502/1347 , C12N2502/253 , C12N2533/40
摘要： Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.
摘要翻译：生物相容的合成或天然支架用于需要这种治疗的患者中的器官或组织结构的重建，修复，增加或替换。支架被成形为符合器官或组织结构的至少一部分，并且可以用一个或多个细胞群体接种。还提供了插入物，容器和端口用于将管状容器附接到新器官支架。将种子支架植入需要治疗的部位的患者中以形成有组织的器官或组织结构。支架可用于形成器官或组织，例如膀胱，尿道，瓣膜和血管。

7. 发明申请

US20110123455A1 RATIONAL DESIGN OF REGENERATIVE MEDICINE PRODUCTS 审中-公开
标题翻译：再生医学产品的设计
公开(公告)号：US20110123455A1
公开(公告)日：2011-05-26
申请号：US12945436
申请日：2010-11-12
申请人： Sharon C. Presnell , Thomas Spencer , Belinda J. Wagner , Manuel J. Jayo , Timothy Bertram , Roger M. Ilagan , Russell W. Kelly , H. Scott Rapoport , Andrew Bruce
发明人： Sharon C. Presnell , Thomas Spencer , Belinda J. Wagner , Manuel J. Jayo , Timothy Bertram , Roger M. Ilagan , Russell W. Kelly , H. Scott Rapoport , Andrew Bruce
IPC分类号： A61K49/00 , C12Q1/02
CPC分类号： G01N33/5088 , G01N2333/475 , G01N2333/52 , G01N2800/347
摘要： The present invention concerns a non-biased, combinatorial approach to the identification of components that modulate a regenerative response in a target tissue, thereby restoring or partially restoring homeostasis to the target tissue. The methods of the present invention are based on in vivo testing, with or without prior in vitro predictive functional testing or combinatorial testing.
摘要翻译：本发明涉及用于鉴定调节靶组织中的再生应答的组分的非偏置组合方法，从而恢复或部分恢复到目标组织的体内平衡。本发明的方法基于体内测试，具有或不具有先前的体外预测功能测试或组合测试。

8. 发明申请

US20070275363A1 Bioreactor for organ reconstruction and augmentation 审中-公开
标题翻译：用于器官重建和增生的生物反应器
公开(公告)号：US20070275363A1
公开(公告)日：2007-11-29
申请号：US11706173
申请日：2007-02-12
申请人： Timothy Bertram , Andrew Bruce , Deepak Jain , John Ludlow , Darrell McCoy , Namrata Sangha
发明人： Timothy Bertram , Andrew Bruce , Deepak Jain , John Ludlow , Darrell McCoy , Namrata Sangha
IPC分类号： A01N1/00 , C12M1/12
CPC分类号： C12M37/04 , A01N1/02 , A01N1/0231 , A01N1/0247 , C12M21/08 , C12M25/14 , C12M27/14
摘要： Bioreactors are used in neo-organ production to allow for an appropriate environment for the maintenance of healthy culturing conditions from pre-wetting to shipment of the neo-organ. The closed system “all-in-one bioreactor” is designed to allow for minimal exposure of the scaffold to the open air in order to maintain sterility. The design allows for the same container to be utilized for sterilization, pre-wetting, cell seeding, medium exchange, and shipment. The “all-in-one” bioreactor also remains completely closed after the urothelial cell seeding step to the implantation at the clinical site. This allows for sufficient time for release testing to occur so the neo-organ can be implanted into the patient.
摘要翻译：生物反应器用于新器官生产，以允许适当的环境来维持健康的培养条件，从预润湿到新器官的运输。封闭系统“一体化生物反应器”被设计成允许脚手架暴露于露天以保持无菌性。该设计允许将相同的容器用于灭菌，预润湿，细胞播种，培养基更换和运输。 “一体化”生物反应器在尿路上皮细胞接种步骤到临床部位植入后也保持完全闭合。这允许足够的时间进行释放测试，从而可以将新器官植入患者体内。

9. 发明授权

US07254814B1 Methods and apparatus for managing plug-in services 有权
标题翻译：管理插件服务的方法和设备
公开(公告)号：US07254814B1
公开(公告)日：2007-08-07
申请号：US09967111
申请日：2001-09-28
申请人： Richard Francis Cormier , Andrew Bruce , Svetlana Patsenker
发明人： Richard Francis Cormier , Andrew Bruce , Svetlana Patsenker
IPC分类号： G06F9/46 , G06F9/44
CPC分类号： G06F9/44526 , G06F2209/482
摘要： Methods and apparatus operate in a computer system to manage initiation and operation of plug-in modules providing plug-in services. The plug-in manager obtains identities of a plurality of plug-in modules and retrieves a dependency list indicating respective plug-in services provided by, and required by, each plug-in module identified in the identities of the plug-in modules. The plug-in manager then calculates a plug-in initiation order based upon the dependency list indicating respective plug-in services provided by, and required by, each plug-in module. The plug-in manager then initiates service operation of plug-in modules according to the plug-in initiation order, such that if a first plug-in module provides a service required by a second plug-in module, the first plug-in module is initiated such that the service provided by the first plug-in module is available to the second plug-in module when required by the second plug-in module. In addition, the plug-in manager can operate a wait state operation within plug-in modules that provide services that depend upon each other in order to avoid service deadlocked situations.
摘要翻译：方法和装置在计算机系统中操作以管理提供插件服务的插件模块的启动和操作。该插件管理器获得多个插件模块的标识，并且检索一个依赖列表，该依赖列表指示由插件模块的标识中标识的每个插件模块提供的插件服务，并且由其插件模块所标识的每个插件模块所要求。插件管理器然后基于指示由每个插件模块提供并且由每个插件模块要求的相应插件服务的依赖列表来计算插件启动顺序。插件管理器然后根据插件启动顺序启动插件模块的服务操作，使得如果第一插件模块提供第二插件模块所需的服务，则第一插件模块被启动，使得当第二插件模块需要时，由第一插件模块提供的服务可用于第二插件模块。此外，插件管理器可以在提供依赖于彼此的服务的插件模块中操作等待状态操作，以避免服务死锁的情况。

10. 发明申请

US20070171856A1 Apparatus and method for enriching data records in a telecommunications network 有权
标题翻译：用于丰富电信网络中的数据记录的装置和方法
公开(公告)号：US20070171856A1
公开(公告)日：2007-07-26
申请号：US11490447
申请日：2006-07-20
申请人： Andrew Bruce , Richard Beattie , Cameron Kane , James Galloway
发明人： Andrew Bruce , Richard Beattie , Cameron Kane , James Galloway
IPC分类号： H04Q7/00
CPC分类号： H04W24/08 , H04L43/00 , H04L43/12 , H04L43/18
摘要： An apparatus for enriching data records based on messages monitored on a telecommunications network having an Internet Protocol (IP) portion includes a data record enrichment module for receiving data records from a data record builder. The data records include at least a subscriber identifier field and a handset type identifier field and the data enrichment module stores a table mapping subscriber identifiers with the handset type identifiers. When a received data record includes a subscriber identifier and a handset type identifier, the table is updated appropriately and when the received data record includes the subscriber identifier but does not include the handset type identifier, the data record enrichment module checks the table for the handset type identifier mapped to the subscriber identifier and adds the corresponding handset type identifier, if it is present in the table, to the handset type identifier field in the data record.
摘要翻译：一种用于基于在具有因特网协议（IP）部分的电信网络上监视的消息来丰富数据记录的装置包括用于从数据记录生成器接收数据记录的数据记录增益模块。数据记录至少包括订户标识符字段和手机类型标识符字段，并且数据富集模块存储将用户标识符与手机类型标识符进行映射的表格。当接收到的数据记录包括用户标识符和手机类型标识符时，表被适当地更新，并且当接收的数据记录包括用户标识符但是不包括手机类型标识符时，数据记录增强模块检查手机的表格类型标识符映射到订户标识符，并将相应的手机类型标识符（如果存在于表中）添加到数据记录中的手机类型标识符字段。

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