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1. 发明授权

US08907067B2 Nucleotide and amino acid sequences relating to respiratory diseases and obesity 有权
标题翻译：与呼吸系统疾病和肥胖相关的核苷酸和氨基酸序列
公开(公告)号：US08907067B2
公开(公告)日：2014-12-09
申请号：US13341457
申请日：2011-12-30
申请人： Tim Keith , Randall D. Little , Paul Van Eerdewegh , Josée Dupuis , Richard G. Del Mastro , Jason Simon , Kristina Allen , Sunil D. Pandit
发明人： Tim Keith , Randall D. Little , Paul Van Eerdewegh , Josée Dupuis , Richard G. Del Mastro , Jason Simon , Kristina Allen , Sunil D. Pandit
IPC分类号： C07K16/26
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/47 , C07K2317/24
摘要： This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.
摘要翻译：本发明涉及从人染色体12q23-qter鉴定的与各种疾病（包括哮喘）相关的基因。本发明还涉及这些基因的核苷酸序列，包含这些核苷酸序列的分离的核酸，以及由此编码的分离的多肽或肽。本发明还涉及包含所公开的核苷酸序列或其片段的载体和宿主细胞，以及结合编码的多肽或肽的抗体。还涉及调节所公开的基因或基因产物的活性的配体。此外，本发明涉及使用所公开的核酸，多肽或肽，抗体和/或配体用于诊断和治疗哮喘和其他疾病的方法和组合物。

2. 发明申请

US20120100146A1 NUCLEOTIDE AND AMINO ACID SEQUENCES RELATING TO RESPIRATORY DISEASES AND OBESITY 有权
标题翻译：与呼吸道疾病和肥胖相关的核酸和氨基酸序列
公开(公告)号：US20120100146A1
公开(公告)日：2012-04-26
申请号：US13341457
申请日：2011-12-30
申请人： Tim Keith , Randall D. Little , Paul Van Eerdewegh , Josée Dupuis , Richard G. Del Mastro , Jason Simon , Kristina Allen , Sunil D. Pandit
发明人： Tim Keith , Randall D. Little , Paul Van Eerdewegh , Josée Dupuis , Richard G. Del Mastro , Jason Simon , Kristina Allen , Sunil D. Pandit
IPC分类号： A61K39/395 , A61P11/06 , C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/47 , C07K2317/24
摘要： This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.
摘要翻译：本发明涉及从人染色体12q23-qter鉴定的与各种疾病（包括哮喘）相关的基因。本发明还涉及这些基因的核苷酸序列，包含这些核苷酸序列的分离的核酸，以及由此编码的分离的多肽或肽。本发明还涉及包含所公开的核苷酸序列或其片段的载体和宿主细胞，以及结合编码的多肽或肽的抗体。还涉及调节所公开的基因或基因产物的活性的配体。此外，本发明涉及使用所公开的核酸，多肽或肽，抗体和/或配体用于诊断和治疗哮喘和其他疾病的方法和组合物。

3. 发明授权

US08105826B2 Nucleotide and amino acid sequences relating to respiratory diseases and obesity 失效
标题翻译：与呼吸系统疾病和肥胖相关的核苷酸和氨基酸序列
公开(公告)号：US08105826B2
公开(公告)日：2012-01-31
申请号：US11690650
申请日：2007-03-23
申请人： Tim Keith , Randall D. Little , Paul Van Eerdewegh , Josée Dupuis , Richard G. Del Mastro , Jason Simon , Kristina Allen , Sunil D. Pandit
发明人： Tim Keith , Randall D. Little , Paul Van Eerdewegh , Josée Dupuis , Richard G. Del Mastro , Jason Simon , Kristina Allen , Sunil D. Pandit
IPC分类号： C12N5/10
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/47 , C07K2317/24
摘要： This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.
摘要翻译：本发明涉及从人染色体12q23-qter鉴定的与各种疾病（包括哮喘）相关的基因。本发明还涉及这些基因的核苷酸序列，包含这些核苷酸序列的分离的核酸，以及由此编码的分离的多肽或肽。本发明还涉及包含所公开的核苷酸序列或其片段的载体和宿主细胞，以及结合编码的多肽或肽的抗体。还涉及调节所公开的基因或基因产物的活性的配体。此外，本发明涉及使用所公开的核酸，多肽或肽，抗体和/或配体用于诊断和治疗哮喘和其他疾病的方法和组合物。

4. 发明授权

US07205146B1 Nucleotide and amino acid sequences relating to respiratory diseases and obesity 失效
标题翻译：与呼吸系统疾病和肥胖相关的核苷酸和氨基酸序列
公开(公告)号：US07205146B1
公开(公告)日：2007-04-17
申请号：US10021698
申请日：2001-10-22
申请人： Tim Keith , Randall D. Little , Paul Van Eerdewegh , Josée Dupuis , Richard G. Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
发明人： Tim Keith , Randall D. Little , Paul Van Eerdewegh , Josée Dupuis , Richard G. Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
IPC分类号： C12N5/10 , C12N15/70 , C12N1/20 , C12N1/00 , C07H21/04
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/47 , C07K2317/24
摘要： This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.
摘要翻译：本发明涉及从人染色体12q23-qter鉴定的与各种疾病（包括哮喘）相关的基因。本发明还涉及这些基因的核苷酸序列，包含这些核苷酸序列的分离的核酸，以及由此编码的分离的多肽或肽。本发明还涉及包含所公开的核苷酸序列或其片段的载体和宿主细胞，以及结合编码的多肽或肽的抗体。还涉及调节所公开的基因或基因产物的活性的配体。此外，本发明涉及使用所公开的核酸，多肽或肽，抗体和/或配体用于诊断和治疗哮喘和其他疾病的方法和组合物。

5. 发明申请

US20090292002A1 NUCLEOTIDE AND AMINO ACID SEQUENCES RELATING TO RESPIRATORY DISEASES AND OBESITY 失效
标题翻译：与呼吸道疾病和肥胖相关的核酸和氨基酸序列
公开(公告)号：US20090292002A1
公开(公告)日：2009-11-26
申请号：US11690650
申请日：2007-03-23
申请人： TIM KEITH , Randall D. Little , Paul Van Eerdewegh , Josee Dupuis , Richard G. Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
发明人： TIM KEITH , Randall D. Little , Paul Van Eerdewegh , Josee Dupuis , Richard G. Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
IPC分类号： A61K31/70 , A61P43/00 , C07H21/00 , C07H21/04 , C12N1/00 , C12N1/20 , C12N15/00 , C12N5/00 , C12N5/02 , C12Q1/68 , A61K48/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/47 , C07K2317/24
摘要： This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.
摘要翻译：本发明涉及从人染色体12q23-qter鉴定的与各种疾病（包括哮喘）相关的基因。本发明还涉及这些基因的核苷酸序列，包含这些核苷酸序列的分离的核酸，以及由此编码的分离的多肽或肽。本发明还涉及包含所公开的核苷酸序列或其片段的载体和宿主细胞，以及结合编码的多肽或肽的抗体。还涉及调节所公开的基因或基因产物的活性的配体。此外，本发明涉及使用所公开的核酸，多肽或肽，抗体和/或配体用于诊断和治疗哮喘和其他疾病的方法和组合物。

6. 发明申请

US20100167285A1 METHODS AND AGENTS FOR EVALUATING INFLAMMATORY BOWEL DISEASE, AND TARGETS FOR TREATMENT 审中-公开
标题翻译：用于评估炎症性皮肤病的方法和试剂以及治疗目标
公开(公告)号：US20100167285A1
公开(公告)日：2010-07-01
申请号：US12450478
申请日：2008-03-26
申请人： Stefan Schreiber , Philip Rosenstiel , Andreas Ruether , Andre Franke , John Raelson , Randall D. Little , Tim Keith , Helene Fournier
发明人： Stefan Schreiber , Philip Rosenstiel , Andreas Ruether , Andre Franke , John Raelson , Randall D. Little , Tim Keith , Helene Fournier
IPC分类号： C12Q1/68 , C07K2/00 , C12N5/10 , C07K16/00
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156
摘要： The invention provides methods for evaluating irritable bowel disease (IBD), including Crohn Disease and Ulcerative Colitis, methods for determining a patient's susceptibility to developing an IBD, and methods for determining a patient's IBD genotype. The invention includes methods, polynucleotides, polypeptides, and antibodies relating to disclosed variants of, and polymorphisms in, the nel-like 1 precursor (NELL1), as well as the 5p13.1 locus, and other genes disclosed herein to be associated with IBD. Thus, the invention provides diagnostic and/or therapeutic targets for IBD, as well as diagnostic and therapeutic agents for IBD.
摘要翻译：本发明提供了用于评估肠易激综合征（IBD）的方法，包括克罗恩病和溃疡性结肠炎，用于确定患者对发展IBD的易感性的方法以及确定患者IBD基因型的方法。本发明包括与nel样1前体（NELL1）的公开变体和多态性相关的方法，多核苷酸，多肽和抗体，以及5p13.1基因座以及本文公开的与IBD相关的其他基因。因此，本发明提供了用于IBD的诊断和/或治疗靶标，以及用于IBD的诊断和治疗剂。

7. 发明授权

US06780609B1 High bone mass gene of 1.1q13.3 失效
标题翻译：高骨质量基因为1.1q13.3
公开(公告)号：US06780609B1
公开(公告)日：2004-08-24
申请号：US09543771
申请日：2000-04-05
申请人： John P. Carulli , Randall D. Little , Robert R. Recker , Mark L. Johnson
发明人： John P. Carulli , Randall D. Little , Robert R. Recker , Mark L. Johnson
IPC分类号： C12P2106
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/705 , C07K14/775
摘要： The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.
摘要翻译：本发明涉及用于分离和检测高骨量基因和相应野生型基因的方法和材料及其突变体。本发明还涉及高骨量基因，相应的野生型基因及其突变体。在本发明中鉴定的基因涉及骨发育。本发明还提供核酸，包括编码序列，寡核苷酸引物和探针，蛋白质，克隆载体，表达载体，转化的宿主，开发药物组合物的方法，鉴定涉及骨发育的分子的方法，以及诊断和治疗涉及的疾病的方法在骨发育。在优选的实施方案中，本发明涉及治疗，诊断和预防骨质疏松症的方法。

8. 发明授权

US07151161B1 Human genes of chromosome 11q13.3 失效
标题翻译：染色体11q13.3的人类基因
公开(公告)号：US07151161B1
公开(公告)日：2006-12-19
申请号：US10185047
申请日：2002-07-01
申请人： John P. Carulli , Randall D. Little , Richard Del Mastro , Mark Osborne
发明人： John P. Carulli , Randall D. Little , Richard Del Mastro , Mark Osborne
IPC分类号： C07K14/00 , C12P21/06 , C12N5/00 , C12N15/00 , C12N15/63
CPC分类号： C07K14/47
摘要： This invention relates to isolated nucleic acids comprising novel genes of a 20 cM region of human chromosome 11q13.3 and the proteins encoded by these genes. Expression vectors and host cells containing these genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.
摘要翻译：本发明涉及分离的核酸，其包含人染色体11q13.3的20cM区域的新基因和由这些基因编码的蛋白质。包含这些基因或其片段的表达载体和宿主细胞以及由这些核酸编码的蛋白质的抗体也包括在本文中。

9. 发明授权

US06770461B1 High bone mass gene of 11q13.3 失效
标题翻译： 11q13.3高骨质量基因
公开(公告)号：US06770461B1
公开(公告)日：2004-08-03
申请号：US09544398
申请日：2000-04-05
申请人： John P. Carulli , Randall D. Little , Robert R. Recker , Mark L. Johnson
发明人： John P. Carulli , Randall D. Little , Robert R. Recker , Mark L. Johnson
IPC分类号： C12P2100
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/705 , C07K14/775
摘要： The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.
摘要翻译：本发明涉及用于分离和检测高骨量基因和相应野生型基因的方法和材料及其突变体。本发明还涉及高骨量基因，相应的野生型基因及其突变体。本发明鉴定的基因涉及骨发育。本发明还提供核酸，包括编码序列，寡核苷酸引物和探针，蛋白质，克隆载体，表达载体，转化的宿主，开发药物组合物的方法，鉴定涉及骨发育的分子的方法，以及诊断和治疗涉及的疾病的方法在骨发育。在优选的实施方案中，本发明涉及治疗，诊断和预防骨质疏松症的方法。

10. 发明授权

US07285400B2 High bone mass gene of 11q13.3 失效
标题翻译： 11q13.3高骨质量基因
公开(公告)号：US07285400B2
公开(公告)日：2007-10-23
申请号：US10731739
申请日：2003-12-10
申请人： John P. Carulli , Randall D. Little , Robert R. Recker , Mark L. Johnson
发明人： John P. Carulli , Randall D. Little , Robert R. Recker , Mark L. Johnson
IPC分类号： C12P21/00 , C12N15/63 , C12N15/11
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/705 , C07K14/775
摘要： The present invention relates to methods and materials used to isolate and detect a high bone mass gene and a corresponding wild-type gene, and mutants thereof. The present invention also relates to the high bone mass gene, the corresponding wild-type gene, and mutants thereof. The genes identified in the present invention are implicated in bone development. The invention also provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.
摘要翻译：本发明涉及用于分离和检测高骨量基因和相应野生型基因的方法和材料及其突变体。本发明还涉及高骨量基因，相应的野生型基因及其突变体。在本发明中鉴定的基因涉及骨发育。本发明还提供核酸，包括编码序列，寡核苷酸引物和探针，蛋白质，克隆载体，表达载体，转化的宿主，开发药物组合物的方法，鉴定涉及骨发育的分子的方法，以及诊断和治疗涉及的疾病的方法在骨发育。在优选的实施方案中，本发明涉及治疗，诊断和预防骨质疏松症的方法。

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