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1. 发明授权

US07074622B2 Method and system for sorting and separating particles 失效
标题翻译：颗粒分选和分离方法和系统
公开(公告)号：US07074622B2
公开(公告)日：2006-07-11
申请号：US10988920
申请日：2004-11-15
申请人： Tiecheng A. Qiao , Yun C. Chang , Eric R. Schmittou , Thomas I. Penner
发明人： Tiecheng A. Qiao , Yun C. Chang , Eric R. Schmittou , Thomas I. Penner
IPC分类号： G01N33/543 , G01N33/532 , G01N33/53 , C07C39/04 , C09D189/00
CPC分类号： G01N33/544 , C12Q1/28 , G01N33/569 , Y10S436/824 , Y10S530/812
摘要： The present invention relates to a method of particle separation comprising preparing a suspension of particles containing at least one recognizable target particle in a suspending solution, labeling the target particle with a conjugate marker, wherein the conjugate marker comprises at least one recognition unit for the recognizable target particle and at least one peroxidase enzyme, contacting a gelatin surface with the suspending solution, adding developer to the suspending solution in contact with the gelatin surface and in the presence of phenol to attach the target particle to the gelatin surface, and washing the gelatin surface to remove unattached particles. The method may also include detecting the presence of the target particle on the gelatin surface as well as detaching and recovering the attached particles after removal of the non-target particles.
摘要翻译：本发明涉及一种颗粒分离方法，包括在悬浮液中制备含有至少一种可识别目标颗粒的颗粒的悬浮液，用共轭标记物标记目标颗粒，其中该共轭标记包括用于可识别的至少一个识别单元目标颗粒和至少一种过氧化物酶，使明胶表面与悬浮液接触，将显影剂加入到与明胶表面接触的悬浮液中，并在苯酚存在下将目标颗粒附着到明胶表面，并洗涤明胶表面去除未附着的颗粒。该方法还可以包括在明胶表面上检测目标颗粒的存在以及在去除非目标颗粒之后分离和回收附着的颗粒。

2. 发明授权

US07183119B2 Method for sensitive detection of multiple biological analytes 失效
标题翻译：多种生物分析物敏感检测方法
公开(公告)号：US07183119B2
公开(公告)日：2007-02-27
申请号：US10989072
申请日：2004-11-15
申请人： Tiecheng A. Qiao , Brian J. Kelley
发明人： Tiecheng A. Qiao , Brian J. Kelley
IPC分类号： G01N33/53 , G01N33/532 , G01N33/543 , C07C39/04 , C09D189/00
CPC分类号： G01N33/569 , C12Q1/28 , C12Q1/6834 , G01N33/544 , Y10S436/824 , Y10S530/812 , C12Q2563/149 , C12Q2563/125 , C12Q2537/125 , C12Q2527/125
摘要： The present invention relates to a method of detecting biological analytes comprising suspending a target analyte in a suspending solution containing polymeric particles marked with a probe, wherein the probe has an affinity for said target analyte; adding recognition unit-peroxidase conjugate marker to the suspending solution; forming a complex of the target analyte, the polymeric particles marked with a probe, and the recognition unit-peroxidase conjugate marker; contacting a gelatin surface with the suspending solution; adding developer to the suspending solution in contact with the gelatin surface in the presence of phenol to attach the complex to the gelatin surface; washing the gelatin surface; and detecting the complex attached to the gelatin surface.
摘要翻译：本发明涉及一种检测生物分析物的方法，包括将目标分析物悬浮在含有用探针标记的聚合物颗粒的悬浮液中，其中探针对所述目标分析物具有亲和力; 将识别单位 - 过氧化物酶缀合物标记物添加到悬浮液中; 形成目标分析物的复合物，用探针标记的聚合物颗粒和识别单元 - 过氧化物酶缀合物标记; 使明胶表面与悬浮液接触; 在苯酚存在下将显色剂加入到与明胶表面接触的悬浮溶液中，以将复合物附着到明胶表面; 清洗明胶表面; 并检测附着于明胶表面的复合物。

3. 发明授权

US07163998B2 Stabilized polymer beads and method of preparation 有权
标题翻译：稳定聚合物珠粒及其制备方法
公开(公告)号：US07163998B2
公开(公告)日：2007-01-16
申请号：US10658009
申请日：2003-09-09
申请人： Jeffrey W. Leon , Tiecheng A. Qiao
发明人： Jeffrey W. Leon , Tiecheng A. Qiao
IPC分类号： C08G75/00 , C08C9/00 , C08F283/00 , C08L81/00
CPC分类号： C08F265/04 , C08F257/02 , C08F2800/20 , C08F2810/30 , C08L51/003 , C08L2666/02
摘要： The present invention relates to a polymer particles comprising a polymer bead stabilized by vinylsulfonyl-functionalized polymers grafted to the surface of the bead, as well as a particle composition comprising monodisperse polymer beads stabilized by vinylsulfonyl-functionalized polymers, wherein the vinylsulfonyl-functionalized polymers are grafted to the surfaces of the beads. The invention also includes a method of preparing monodisperse polymer particles comprising preparing a homogeneous solution of an ethylenically unsaturated polymerizable monomer, an initiator, and a polymeric stabilizer, wherein the polymeric stabilizer consists of repetitive units, wherein the repetitive units comprise latent vinylsulfonyl moiety, polymerizing the homogeneous solution, and converting the latent vinylsulfonyl moiety to vinylsulfonyl moieties.
摘要翻译：本发明涉及包含由接枝到珠粒表面的乙烯基磺酰基官能化聚合物稳定的聚合物珠粒的聚合物颗粒，以及包含由乙烯基磺酰基官能化聚合物稳定的单分散聚合物珠粒的颗粒组合物，其中乙烯基磺酰基官能化聚合物是接枝到珠的表面。本发明还包括制备单分散聚合物颗粒的方法，其包括制备烯属不饱和可聚合单体，引发剂和聚合物稳定剂的均匀溶液，其中聚合物稳定剂由重复单元组成，其中重复单元包括潜在的乙烯基磺酰基部分，聚合均匀溶液，并将潜在的乙烯基磺酰基部分转化为乙烯基磺酰基部分。

4. 发明授权

US06479222B1 Protective overcoat for photographic elements 失效
标题翻译：摄影元素保护罩
公开(公告)号：US06479222B1
公开(公告)日：2002-11-12
申请号：US09621267
申请日：2000-07-21
申请人： Tamara K. Jones , Lloyd A. Lobo , Mridula Nair , Kevin M. O'connor , Tiecheng A. Qiao , Yongcai Wang , Thomas H. Whitesides , Hwei-Ling Yau
发明人： Tamara K. Jones , Lloyd A. Lobo , Mridula Nair , Kevin M. O'connor , Tiecheng A. Qiao , Yongcai Wang , Thomas H. Whitesides , Hwei-Ling Yau
IPC分类号： G03C176
CPC分类号： G03C1/7614 , G03C2001/7635 , Y10S430/162
摘要： The present invention is a photographic element which includes a support, at least one silver halide emulsion layer superposed on the support and a processing-solution-permeable protective overcoat overlying the silver halide emulsion layer that becomes water-resistant in the final product without lamination or fusing. The present invention is also directed to a method of making a photographic print involving developing the photographic element.
摘要翻译：本发明是一种照相材料，它包括一个载体，至少一个叠加在载体上的卤化银乳剂层和覆盖卤化银乳剂层的加工溶液渗透性保护外涂层，在最终产品中不会层压而成为防水的，融合本发明还涉及一种制造涉及显影照相元件的照相印相的方法。

5. 发明授权

US06428948B2 Imaged element with improved wet abrasion resistance 失效
公开(公告)号：US06428948B2
公开(公告)日：2002-08-06
申请号：US09805335
申请日：2001-03-13
申请人： Tiecheng A. Qiao , Joseph S. Sedita , Mridula Nair , Brian J. Kelley , Yongcai Wang
发明人： Tiecheng A. Qiao , Joseph S. Sedita , Mridula Nair , Brian J. Kelley , Yongcai Wang
IPC分类号： G03C185
CPC分类号： G03C1/7614 , G03C1/30
摘要： The present invention relates to photographic elements, including photographic prints, having a protective overcoat that resists fingerprints, common stains, and spills. More particularly, the present invention provides a processing-solution-permeable protective overcoat that is water resistant in the final processed product and which, at the same time, provides improved wet-abrasion resistance.

6. 发明授权

US07011945B2 Random array of micro-spheres for the analysis of nucleic acids 失效
公开(公告)号：US07011945B2
公开(公告)日：2006-03-14
申请号：US10036828
申请日：2001-12-21
申请人： Tiecheng A. Qiao , Krishnan Chari , Douglas L. Vizard
发明人： Tiecheng A. Qiao , Krishnan Chari , Douglas L. Vizard
IPC分类号： C12Q1/68 , C12M1/36 , C07H21/04
CPC分类号： B01J19/0046 , B01J2219/00466 , B01J2219/00529 , B01J2219/00545 , B01J2219/00547 , B01J2219/00576 , B01J2219/00648 , B01J2219/00702 , G06F19/20
摘要： A method of identifying nucleic acid samples comprising: providing a mircoarray including a substrate coated with a composition including a population of micro-spheres dispersed in a fluid containing a gelling agent or a precursor to a gelling agent and immobilized at random positions on the substrate, at least one sub-population of said population micro-spheres containing an optical barcode generated from at least one colorant associated with the micro-spheres and including a nucleic acid probe sequence; contacting said array with a target nucleic acid sequence; and detecting the color barcode of said sub-population of micro-spheres due to the interaction of said probe nucleic acid sequence and said target nucleic acid sequence.

7. 发明授权

US06916620B2 Random array of micro-spheres for the analysis of nucleic acid using enzyme digestion 失效
标题翻译：随机阵列的微球用于分析核酸酶消化
公开(公告)号：US06916620B2
公开(公告)日：2005-07-12
申请号：US10098642
申请日：2002-03-15
申请人： Tiecheng A. Qiao , Krishnan Chari , Douglas L. Vizard
发明人： Tiecheng A. Qiao , Krishnan Chari , Douglas L. Vizard
IPC分类号： G01N33/53 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/06 , C40B70/00 , G01N37/00 , C07H21/04 , C12M1/36 , C12N11/16 , G01N15/06
CPC分类号： C12Q1/6837 , B01J2219/00466 , B01J2219/00545 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , C40B40/06 , C40B70/00 , C12Q2565/513 , C12Q2565/102 , C12Q2563/149
摘要： A method of identifying nucleic acid samples comprising: providing a mircoarray including a substrate coated with a composition including a population of nucleic acid probe modified micro-spheres immobilized in a coating containing a gelling agent or a precursor to a gelling agent, wherein a first portion of the micro-spheres is submerged in the gelatin coating and a second portion is exposed above the gelatin coating and is substantially free of gelatin, at least one sub-population of the population micro-spheres containing an optical barcode generated from at least one colorant associated with the micro-spheres and including a nucleic acid probe sequence; contacting the array with a target nucleic acid sequence; and detecting the color barcode of the sub-population of micro-spheres due to the interaction of the probe nucleic acid sequence and the fluorescently/chemiluminescently labeled nucleic acid sample target nucleic acid sequence.
摘要翻译：一种鉴定核酸样品的方法，包括：提供包含底物的微阵列，所述底物涂覆有组合物，所述组合物包含固定在包含胶凝剂或胶凝剂前体的涂层中的核酸探针修饰微球体群体，其中第一部分的微球浸没在明胶涂层中，第二部分暴露在明胶涂层上方并且基本上不含明胶，至少一个群体微球的亚群包含由至少一种着色剂产生的光学条形码与微球相关并包括核酸探针序列; 使阵列与靶核酸序列接触; 并且由于探针核酸序列和荧光/化学发光标记的核酸样品靶核酸序列的相互作用，检测微球子群体的颜色条形码。

8. 发明授权

US06914106B2 Polymer microspheres containing latent colorants and method of preparation 失效
公开(公告)号：US06914106B2
公开(公告)日：2005-07-05
申请号：US10625684
申请日：2003-07-23
申请人： Jeffrey W. Leon , Tiecheng A. Qiao , Robert E. Mccovick
发明人： Jeffrey W. Leon , Tiecheng A. Qiao , Robert E. Mccovick
IPC分类号： C08J3/00 , C08L89/00 , C09B67/02 , C09B67/28 , C09D157/00 , G03C7/327
CPC分类号： G03C7/3275 , C09B67/0077 , C09B67/0078 , C09B67/0097
摘要： The present invention relates to a polymer microsphere comprising at least one polymer and at least one bound latent colorant, wherein the microsphere is stabilized by at least one stabilizing polymer. The invention also includes a method of preparing polymer microspheres comprising combining latent colorant, ethylenically unsaturated monomer, stabilizing polymer, and an initiator in solvent and initiating polymerization to form a polymeric microsphere stabilized by a stabilizing polymer bound to the surface of the polymeric microsphere.

9. 发明授权

US06797393B2 Method for making biochip substrate 失效
标题翻译：制造生物芯片基板的方法
公开(公告)号：US06797393B2
公开(公告)日：2004-09-28
申请号：US10020747
申请日：2001-11-30
申请人： Tiecheng A. Qiao , Krishnan Chari , Thomas L. Penner , Zhihao Yang
发明人： Tiecheng A. Qiao , Krishnan Chari , Thomas L. Penner , Zhihao Yang
IPC分类号： B32B902
CPC分类号： B82Y30/00 , B01J2219/00274 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00725 , C40B40/10 , G01N33/54353 , Y10T428/31504 , Y10T428/31768
摘要： A gelatin-based substrate for fabricating protein arrays, the substrate containing: gelatin and a trifunctional compound A—L—B; wherein A is a functional group capable of interacting with the gelatin; L is a linking group capable of interacting with A and with B; and B is a functional group capable of interacting with a protein capture agent. A may be the same or different from B.
摘要翻译：用于制造蛋白质阵列的明胶基底物，所述基质含有：明胶和三官能化合物A-L-B; 其中A是能够与明胶相互作用的官能团; L是能够与A和B相互作用的连接基团; 并且B是能够与蛋白质捕获剂相互作用的官能团。 A可能与B相同或不同。

10. 发明授权

US07541017B2 Amine polymer-modified nanoparticulate carriers 失效
标题翻译：胺聚合物改性纳米颗粒载体
公开(公告)号：US07541017B2
公开(公告)日：2009-06-02
申请号：US11036814
申请日：2005-01-14
申请人： Joseph F. Bringley , Tiecheng A. Qiao , John W. Harder , Andrew Wunder , James M. Hewitt
发明人： Joseph F. Bringley , Tiecheng A. Qiao , John W. Harder , Andrew Wunder , James M. Hewitt
IPC分类号： A61K51/00 , B01J13/00 , C09D11/00
CPC分类号： B01J13/02 , B01J13/0008 , B01J13/0086 , B01J13/04 , Y10T428/2998
摘要： The invention relates to a composition comprising a colloid which is stable under physiological pH and ionic strength, said colloid comprising particles having a silica core and a shell: a) wherein said shell comprises a cross-linked poly(ethylene)imine polymer having amine functionalities; b) wherein the particles have a volume-weighted mean particle size diameter of less than 200 nm, and c) wherein greater than 50% of said polymer in the colloid is bound to the core surfaces, wherein the polymer having amine functionalities has an average molecular weight less than 100,000 g/mol, the composition has a H of between 6 and 8; and d) wherein the colloid contains between 300 and 6000 .μmol amine-monomer/g core particles.
摘要翻译：本发明涉及包含在生理pH和离子强度下稳定的胶体的组合物，所述胶体包含具有二氧化硅芯和壳的颗粒：a）其中所述壳包含具有胺官能团的交联聚（亚乙基）亚胺聚合物 ; b）其中所述颗粒具有小于200nm的体积加权平均粒度直径，和c）其中胶体中大于50％的所述聚合物与核表面结合，其中具有胺官能团的聚合物具有平均值分子量小于100,000g / mol，组合物的H为6至8; 和d）其中所述胶体含有300至6000μmol胺单体/ g核心颗粒。

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