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1. 发明授权

US08030305B2 Triazolopyridazines as kinase modulators 有权
标题翻译：三唑并嘧啶作为激酶调节剂
公开(公告)号：US08030305B2
公开(公告)日：2011-10-04
申请号：US11612020
申请日：2006-12-18
申请人： Tianbao Lu , Richard Alexander , Richard W. Connors , Maxwell D. Cummings , Robert A. Galemmo , Heather Rae Hufnagel , Dana L. Johnson , Ehab Khalil , Kristi A. Leonard , Thomas P. Markotan , Anna C. Maroney , Jan L. Sechler , Jeremy M. Travins , Robert W. Tuman
发明人： Tianbao Lu , Richard Alexander , Richard W. Connors , Maxwell D. Cummings , Robert A. Galemmo , Heather Rae Hufnagel , Dana L. Johnson , Ehab Khalil , Kristi A. Leonard , Thomas P. Markotan , Anna C. Maroney , Jan L. Sechler , Jeremy M. Travins , Robert W. Tuman
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention is directed to triazolopyridazine compounds of Formula I: where R1, R5, R6, R7, R8, and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
摘要翻译：本发明涉及式I的三唑并哒嗪化合物：其中R 1，R 5，R 6，R 7，R 8和A如本文所定义，使用这些化合物作为蛋白质酪氨酸激酶调节剂，特别是c-Met的抑制剂，以及使用的这样的化合物以减少或抑制细胞或受试者中c-Met的激酶活性，并调节细胞或受试者中的c-Met表达，以及这些化合物在受试者中用于预防或治疗细胞增殖性病症和 /或与c-Met有关的障碍。本发明进一步涉及包含本发明化合物的药物组合物和治疗诸如癌症和其它细胞增殖性疾病的病症的方法。

2. 发明申请

US20090098181A1 TRIAZOLOPYRIDAZINES AS KINASE MODULATORS 有权
标题翻译：三唑吡啶作为激酶调节剂
公开(公告)号：US20090098181A1
公开(公告)日：2009-04-16
申请号：US12187524
申请日：2008-08-07
申请人： Tianbao Lu , Richard Alexander , Richard W. Connors , Maxwell D. Cummings , Robert A. Galemmo , Heather Rae Hufnagel , Dana L. Johnson , Ehab Khalil , Kristi A. Leonard , Thomas P. Markotan , Anna C. Maroney , Jan L. Sechler , Jeremy M. Travins , Robert W. Tuman
发明人： Tianbao Lu , Richard Alexander , Richard W. Connors , Maxwell D. Cummings , Robert A. Galemmo , Heather Rae Hufnagel , Dana L. Johnson , Ehab Khalil , Kristi A. Leonard , Thomas P. Markotan , Anna C. Maroney , Jan L. Sechler , Jeremy M. Travins , Robert W. Tuman
IPC分类号： A61F2/04 , C07D487/04 , A61K31/5025 , C12N9/99 , A61K31/541
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention is directed to triazolopyridazine compounds of Formula I: where R1, R5, R6, R7, R8, and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
摘要翻译：本发明涉及式I的三唑并哒嗪化合物：其中R 1，R 5，R 6，R 7，R 8和A如本文所定义，使用这些化合物作为蛋白质酪氨酸激酶调节剂，特别是c-Met的抑制剂，以及使用的这样的化合物以减少或抑制细胞或受试者中c-Met的激酶活性，并调节细胞或受试者中的c-Met表达，以及这些化合物在受试者中预防或治疗细胞增殖性病症和 /或与c-Met有关的障碍。本发明进一步涉及包含本发明化合物的药物组合物和治疗诸如癌症和其它细胞增殖性疾病的病症的方法。

3. 发明授权

US08173654B2 Triazolopyridazine compounds 有权
标题翻译：三唑并哒嗪化合物
公开(公告)号：US08173654B2
公开(公告)日：2012-05-08
申请号：US12187524
申请日：2008-08-07
申请人： Tianbao Lu , Richard Alexander , Richard W. Connors , Maxwell D. Cummings , Robert A. Galemmo , Heather Rae Hufnagel , Dana L. Johnson , Ehab Khalil , Kristi A. Leonard , Thomas P. Markotan , Anna C. Maroney , Jan L. Sechler , Jeremy M. Travins , Robert W. Tuman
发明人： Tianbao Lu , Richard Alexander , Richard W. Connors , Maxwell D. Cummings , Robert A. Galemmo , Heather Rae Hufnagel , Dana L. Johnson , Ehab Khalil , Kristi A. Leonard , Thomas P. Markotan , Anna C. Maroney , Jan L. Sechler , Jeremy M. Travins , Robert W. Tuman
IPC分类号： A61K31/4985 , C07D487/04 , A61P3/10 , A61P17/06 , A61P25/18 , A61P19/02 , A61P9/10 , A61P9/00 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention is directed to triazolopyridazine compounds of Formula I: where R1, R5, R6, R7, R8, and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
摘要翻译：本发明涉及式I的三唑并哒嗪化合物：其中R 1，R 5，R 6，R 7，R 8和A如本文所定义，使用这些化合物作为蛋白质酪氨酸激酶调节剂，特别是c-Met的抑制剂，以及使用的这样的化合物以减少或抑制细胞或受试者中c-Met的激酶活性，并调节细胞或受试者中的c-Met表达，以及这些化合物在受试者中预防或治疗细胞增殖性病症和 /或与c-Met有关的障碍。本发明进一步涉及包含本发明化合物的药物组合物和治疗诸如癌症和其它细胞增殖性疾病的病症的方法。

4. 发明申请

US20070203136A1 TRIAZOLOPYRIDAZINES AS KINASE MODULATORS 有权
标题翻译：三唑吡啶作为激酶调节剂
公开(公告)号：US20070203136A1
公开(公告)日：2007-08-30
申请号：US11612020
申请日：2006-12-18
申请人： Tianbao Lu , Richard Alexander , Richard Connors , Maxwell Cummings , Robert Galemmo , Heather Rae Hufnagel , Dana Johnson , Ehab Khalil , Kristi Leonard , Thomas Markotan , Anna Maroney , Jan Sechler , Jeremy Travins , Robert Tuman
发明人： Tianbao Lu , Richard Alexander , Richard Connors , Maxwell Cummings , Robert Galemmo , Heather Rae Hufnagel , Dana Johnson , Ehab Khalil , Kristi Leonard , Thomas Markotan , Anna Maroney , Jan Sechler , Jeremy Travins , Robert Tuman
IPC分类号： A61K31/503 , A61K31/5377 , C07D487/04
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention is directed to triazolopyridazine compounds of Formula I: where R1, R5, R6, R7, R8, and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
摘要翻译：本发明涉及式I的三唑并哒嗪化合物：其中R 1，R 5，R 6，R 7， >，R 8和A如本文所定义，使用这些化合物作为蛋白质酪氨酸激酶调节剂，特别是c-Met的抑制剂，以及这些化合物用于降低或抑制激酶活性的用途 c-Met在细胞或受试者中的调节，并调节细胞或受试者中的c-Met表达，以及这些化合物在受试者中预防或治疗细胞增殖性疾病和/或与c-Met有关的障碍的用途。本发明进一步涉及包含本发明化合物的药物组合物和治疗诸如癌症和其它细胞增殖性疾病的病症的方法。

5. 发明申请

US20070066610A1 Acylhydrazones as kinase modulators 有权
标题翻译：酰腙作为激酶调节剂
公开(公告)号：US20070066610A1
公开(公告)日：2007-03-22
申请号：US11377077
申请日：2006-03-16
申请人： Kristi Leonard , Tianbao Lu , Robert Tuman , Dana Johnson , Anna Maroney , Jan Sechler , Richard Connors , Richard Alexander , Maxwell Cummings , Robert Galemmo , Thomas Markotan
发明人： Kristi Leonard , Tianbao Lu , Robert Tuman , Dana Johnson , Anna Maroney , Jan Sechler , Richard Connors , Richard Alexander , Maxwell Cummings , Robert Galemmo , Thomas Markotan
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/404 , C07D413/14 , C07D405/14
CPC分类号： C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12
摘要： The invention is directed to acylhydrazones compounds of Formula I: where R1, R2 and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
摘要翻译：本发明涉及式I的酰腙化合物：其中R 1，R 2和A如本文所定义，使用这些化合物作为蛋白质酪氨酸激酶调节剂，特别是 c-Met的抑制剂以及这些化合物在细胞或受试者中降低或抑制c-Met的激酶活性并调节细胞或受试者中的c-Met表达的用途，以及这些化合物用于预防或在受试者中治疗与c-Met相关的细胞增殖性疾病和/或障碍。本发明进一步涉及包含本发明化合物的药物组合物和治疗诸如癌症和其它细胞增殖性疾病的病症的方法。

6. 发明申请

US20060041398A1 Increased precision position sensors 有权
标题翻译：增加精密位置传感器
公开(公告)号：US20060041398A1
公开(公告)日：2006-02-23
申请号：US10523396
申请日：2004-11-04
申请人： Richard Alexander , Richard Manley , Carol Walker
发明人： Richard Alexander , Richard Manley , Carol Walker
IPC分类号： G06F15/00
CPC分类号： G01D5/145
摘要： An increased precision position sensor comprises a first magnetic field sensing device; a second magnetic field sensing device; and a processor, the processor further comprising a calibrator; a mathematical model to predict the magnetic field at a given position relative to the object; and an estimator algorithm to compare the measured magnetic field within the predicted magnetic field, thereby calculating the most likely position of the position sensor relative to the magnetic object. A position sensor in accordance with the invention is capable of locating the axis of a cylindrical magnetic object to within ±0.5 mm through 70 mm thick aluminium, and is expected to find application, in the aerospace industry, or other industries where high precision during manufacture is required. The invention may be conveniently embodied in a portable, handheld device.
摘要翻译：增加的精密位置传感器包括第一磁场感测装置; 第二磁场感测装置; 和处理器，所述处理器还包括校准器; 用于预测相对于物体的给定位置处的磁场的数学模型; 以及用于比较预测磁场内的测量磁场的估计器算法，由此计算位置传感器相对于磁性物体的最可能的位置。根据本发明的位置传感器能够将圆柱形磁性物体的轴线定位在±0.5mm至70mm厚的铝之间，并且预期在航空航天工业或其他制造中具有高精度的其它工业中应用是必须的。本发明可以方便地实现在便携式手持设备中。

7. 发明授权

US4749934A Intrinsically safe battery circuit 失效
标题翻译：本质安全电池电路
公开(公告)号：US4749934A
公开(公告)日：1988-06-07
申请号：US926201
申请日：1986-11-07
申请人： Richard Alexander , Dennis Kindschuh
发明人： Richard Alexander , Dennis Kindschuh
IPC分类号： H02J7/00 , H02H9/02
CPC分类号： H02J7/0031 , Y10S320/22
摘要： An intrinsically safe battery circuit for connection between a battery and a load, such as a hand held transceiver, referred to as "HT's". The circuit includes a minor current path through a switching transistor and a major current path through a SCR. The circuit is a hybrid circuit which includes an integrated circuit timer which provides a delay in establishing the major current path subsequent to the minor current path being established, and mounts on a small printed circuit board.
摘要翻译：用于电池和负载之间的连接的本质上安全的电池电路，例如被称为“HT”的手持收发器。该电路包括通过开关晶体管的次要电流路径和通过SCR的主要电流路径。电路是一种混合电路，其包括集成电路定时器，其在建立次要电流路径之后提供延迟建立主电流路径，并且安装在小型印刷电路板上。

8. 发明授权

US06618633B1 Method and apparatus for calibrating a first co-ordinate frame of an indexing means in a second frame of reference of a sensing means 失效
标题翻译：用于在感测装置的第二参考系中校准索引装置的第一坐标系的方法和装置
公开(公告)号：US06618633B1
公开(公告)日：2003-09-09
申请号：US09647545
申请日：2000-10-02
申请人： Richard M Gooch , Richard Alexander
发明人： Richard M Gooch , Richard Alexander
IPC分类号： G05B1918
CPC分类号： G01B21/042 , B25J9/1692 , G05B2219/39024 , G05B2219/39057
摘要： A method for calibrating a first co-ordinate frame of a robot and effector in a second frame of reference of a sensor when the sensor is substantially rigidly attached to the robot and effector, including the steps of measuring first positions of a plurality of first light sources relative to the sensor, with the first positions corresponding to a first absolute position of the robot and effector, moving the robot and effector, measuring second positions of the plurality of first light sources, which second positions correspond to the desired second absolute position of the robot and effector and the sensor, repeating the measurement of and movement from the first to second positions so as to provide at least two sets of measurements of first and second positions corresponding to at least two movements, each of which at least two movements is a known, unique transform, combining the at least two sets of measurements of first and second positions so as to calibrate the first co-ordinate frame in the second frame of reference.
摘要翻译：一种用于当传感器基本上刚性地附接到机器人和效应器时，在传感器的第二参考系中校准机器人和效应器的第一坐标系的方法，包括以下步骤：测量多个第一光的第一位置来源相对于传感器，其中第一位置对应于机器人和效应器的第一绝对位置，移动机器人和效应器，测量多个第一光源的第二位置，该第二位置对应于期望的第二绝对位置机器人和效应器和传感器，重复从第一位置到第二位置的测量和移动，以便提供至少两组对应于至少两个运动的第一和第二位置的测量结果，其中至少两个运动是至少两个运动一种已知的唯一变换，组合第一和第二位置的至少两组测量，以便校准第一坐标框架在第二个参考框架。

9. 发明授权

US06987578B2 Printer priority bidding scheme 失效
公开(公告)号：US06987578B2
公开(公告)日：2006-01-17
申请号：US09814258
申请日：2001-03-21
申请人： Richard Alexander
发明人： Richard Alexander
IPC分类号： G06F15/00
CPC分类号： G06Q40/04 , G06F3/1204 , G06F3/1263 , G06F3/1285 , G06F3/1292
摘要： Printing priority is ascertained according to a bidding process that allows users to submit bids along with their print jobs. The printer orders the print jobs from highest to lowest bid. This allows individual users to determine the importance of each print job. If urgent, the user can submit a higher bid to place the print job at the top of the queue ahead of print jobs deemed less important by the users that submitted them. Prioritizing the print jobs according to user submitted bids allows the printer to better reflect the urgencies and printing needs of all users.

10. 发明授权

US06811027B2 Quick opening garment protector 失效
标题翻译：快开服装保护器
公开(公告)号：US06811027B2
公开(公告)日：2004-11-02
申请号：US09927922
申请日：2001-08-10
申请人： Richard Alexander
发明人： Richard Alexander
IPC分类号： B65D8518
CPC分类号： B65D65/22 , B65D65/10 , B65D85/18
摘要： A polyethylene garment protector, extensively used by garment manufacturers to protect garments in transport to and from various facilities such as, factories, distribution centers, and retail establishments. The garment protector is also commonly used by garment pressers or cleaners for the delivery or storage of pressed or cleaned garments mounted on conventional garment hangers. Furthermore, the polyethylene garment protector can also be used to enclose other textiles or goods that may be stored, shipped and/or sold in hanging form. The polyethylene garment protector is provided with at least one zone of weakness on either the front side, back side or both sides of such garment protectors, along which the garment protector may be severed to facilitate its removal so that the enclosed garment is not wrinkled or mussed. Essentially, the zone of weakness provides tear lines upon which the envelope may be opened to facilitate separating the protector and the enclosed garment. The zone of weakness may include minute perforations, which can vary in size and shape. Furthermore, the material of which the garment protector is made may also be partially but not completely severed along the linear zone of weakness. Alternatively, the zone of weakness may comprise a strip of thinner and less resilient material than the adjacent material from which the envelope is made, which can be easily torn.
摘要翻译：服装制造商广泛使用的聚乙烯服装保护器，用于保护运输到各种设施（如工厂，配送中心和零售店）的服装。服装保护器也通常由服装压力机或清洁器用于运送或储存安装在常规衣架上的压制或清洁的衣服。此外，聚乙烯衣服保护膜也可用于封闭可以以悬挂形式存储，运输和/或出售的其它纺织品或商品。聚乙烯衣服保护器在这种服装保护器的前侧，后侧或两侧设置有至少一个弱点区域，衣服保护器沿着该区域可以被切断以便于其移除，使得封闭的衣服不起皱或闷了本质上，弱化区域提供撕裂线，在其上可以打开信封以便于分离保护器和封闭的衣服。弱点区域可以包括微小的穿孔，其尺寸和形状可以变化。此外，制造服装保护器的材料也可以沿着线性弱化区域部分地但不完全地切断。或者，弱化区可以包括比制造封套的相邻材料更薄且更不易弹性的材料条，其可以容易地撕裂。

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