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1. 发明申请

US20090137557A1 Calcilytic Compounds 审中-公开
标题翻译：钙化合物
公开(公告)号：US20090137557A1
公开(公告)日：2009-05-28
申请号：US12094665
申请日：2006-11-21
申请人： Thomas Wen Fu Ku , Hong Lin , Juan I. Luengo , Robert W. Marquis Jr. , Joshi M. Ramanjulu , Robert Trout , Dennis S. Yamashita
发明人： Thomas Wen Fu Ku , Hong Lin , Juan I. Luengo , Robert W. Marquis Jr. , Joshi M. Ramanjulu , Robert Trout , Dennis S. Yamashita
IPC分类号： A61K31/513 , C07D239/22 , C07D413/04 , A61K31/55 , A61P19/10 , A61K31/5377 , C07D487/04
CPC分类号： C07D239/36 , C07D239/40 , C07D239/47 , C07D239/72 , C07D239/91 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07D491/044
摘要： Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.
摘要翻译：提供了新的钙化合物，药物组合物，合成方法和使用它们的方法。

2. 发明授权

US08410095B2 Thiazolopyrimidinone derivatives as PI3 kinase inhibitors 有权
标题翻译：噻唑并嘧啶酮衍生物作为PI3激酶抑制剂
公开(公告)号：US08410095B2
公开(公告)日：2013-04-02
申请号：US13319375
申请日：2010-05-20
申请人： Hong Lin , Juan I. Luengo , Ralph A. Rivero , Mark James Schulz , Ren Xie , Jin Zeng
发明人： Hong Lin , Juan I. Luengo , Ralph A. Rivero , Mark James Schulz , Ren Xie , Jin Zeng
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： C07D513/04
摘要： This invention relates to novel compounds of formula (I): and derivatives thereof useful for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3′ OH kinase family (hereinafter PI3 kinases), suitably, PI3Kα, PI3Kδ, PI3Kβ, and/or PI3Kγ.
摘要翻译：本发明涉及新的式（I）化合物及其衍生物，其用于调节，特别是抑制磷酸肌醇3'OH激酶家族（以下称为PI3激酶）的活性或功能，合适地是PI3Kα，PI3Kδ，PI3K＆bgr; ，和/或PI3Kγ。

3. 发明授权

US07241783B2 Thrombopoietin mimetics 失效
标题翻译：血小板生成素模拟物
公开(公告)号：US07241783B2
公开(公告)日：2007-07-10
申请号：US10451300
申请日：2001-12-19
申请人： Kevin J. Duffy , Juan I. Luengo , Stephen G. Miller , Julian Jenkins , Alan T. Price , Antony N. Shaw
发明人： Kevin J. Duffy , Juan I. Luengo , Stephen G. Miller , Julian Jenkins , Alan T. Price , Antony N. Shaw
IPC分类号： A61K31/427 , A61K31/4709 , A61K31/4152
CPC分类号： A61K31/275 , A61K31/04 , A61K31/045 , A61K31/05 , A61K31/13 , A61K31/131 , A61K31/175 , A61K31/325 , A61K31/415
摘要： Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected substituted thiosemicarbazone derivative.
摘要翻译：发明的是非肽TPO模拟物。还发明了一种在有需要的哺乳动物（包括人）中治疗血小板减少症的方法，其包括向所述哺乳动物施用有效量的选定的取代的缩氨基硫脲衍生物。

4. 发明授权

US06552008B1 Thrombopoietin mimetics 失效
标题翻译：血小板生成素模拟物
公开(公告)号：US06552008B1
公开(公告)日：2003-04-22
申请号：US10110287
申请日：2002-03-22
申请人： Kevin J. Duffy , Nannan Liu , Juan I. Luengo
发明人： Kevin J. Duffy , Nannan Liu , Juan I. Luengo
IPC分类号： A61K31655
CPC分类号： C07D401/14 , C07D231/48
摘要： Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected azo-pyrazole derivative.
摘要翻译：发明的是非肽TPO模拟物。还发明了一种在有需要的哺乳动物（包括人）中治疗血小板减少症的方法，其包括向所述哺乳动物施用有效量的选择的偶氮 - 吡唑衍生物。

5. 发明授权

US07648971B2 Thrombopoietin mimetics 有权
公开(公告)号：US07648971B2
公开(公告)日：2010-01-19
申请号：US12141422
申请日：2008-06-18
申请人： Kevin J. Duffy , Connie Erickson-Miller , Julian Jenkins , Juan I. Luengo , Sophie Visonneau
发明人： Kevin J. Duffy , Connie Erickson-Miller , Julian Jenkins , Juan I. Luengo , Sophie Visonneau
IPC分类号： A61K31/655 , A61K31/4152 , C07C245/10 , C07D231/46
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

6. 发明授权

US07452874B2 Thrombopoietin mimetics 有权
公开(公告)号：US07452874B2
公开(公告)日：2008-11-18
申请号：US11650838
申请日：2007-01-08
申请人： Kevin J. Duffy , Juan I. Luengo , Antony N. Shaw , Kenneth Wiggall
发明人： Kevin J. Duffy , Juan I. Luengo , Antony N. Shaw , Kenneth Wiggall
IPC分类号： C07D231/46 , A61K31/4152 , A61K31/655
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

7. 发明授权

US06413952B1 Agonizing dimeric cell-surface receptors with a receptor binding moiety and chelating metal 失效
标题翻译：用受体结合部分和螯合金属激活二聚体细胞表面受体
公开(公告)号：US06413952B1
公开(公告)日：2002-07-02
申请号：US09301897
申请日：1999-04-29
申请人： Juan I. Luengo , Stephen G. Miller , John G. Gleason
发明人： Juan I. Luengo , Stephen G. Miller , John G. Gleason
IPC分类号： A01N5502
CPC分类号： C07D487/04 , A61K31/315 , A61K31/4439 , A61K31/555 , C07F3/003
摘要： Dimeric cell-surface receptors in a subject are agonized by administering a metal chelated dimeric cell-surface receptor ligand formed by chelating a receptor binding moiety with a metal ion such as zinc, or by co-administering the receptor binding moiety and the metal ion. The binding moiety is a small organic molecule having a molecular weight of from about 100 to about 850, and metal chelation may form a symmetrical multimer such as a dimer of the receptor binding moiety. An example is bis{2,5-bis[2-benzimidazolylimino]-3a,6a-bis(2-pyridyl)-1,2,3,3a,4,5,6,6a-octahydroimidazo[4,5-d]imidazole-N,N′}-zinc(II). Dimeric cell surface receptors include granulocyte colony-stimulating factor, erythropoeitin receptor, macrophage-colony-stimulating factor, growth hormone receptor, thrombopoietin receptor, interferon alpha receptor, interferon beta receptor, tyrosine kinase receptor, insulin receptor and leptin receptor. A pharmaceutical composition containing a carrier and the ligand or the binding moiety and the metal ion separately can be used to enhance leukocyte production and to treat bacterial and fungal infections.
摘要翻译：通过施用通过螯合受体结合部分与金属离子如锌形成的金属螯合的二聚体细胞表面受体配体，或通过共同施用受体结合部分和金属离子来激发受试者中的二聚体细胞表面受体。结合部分是分子量为约100至约850的小有机分子，金属螯合可以形成对称的多聚体，例如受体结合部分的二聚体。一个例子是双{2,5-双[2-苯并咪唑并咪唑啉] -3a，6a-双（2-吡啶基）-1,2,3,3a，4,5,6,6a-八氢咪唑并[4,5-d ]咪唑-N，N' - 锌（II）。二聚体细胞表面受体包括粒细胞集落刺激因子，红细胞生成素受体，巨噬细胞集落刺激因子，生长激素受体，血小板生成素受体，干扰素α受体，干扰素β受体，酪氨酸激酶受体，胰岛素受体和瘦蛋白受体。可以使用含有载体和配体或结合部分和金属离子的药物组合物来增强白细胞产生和治疗细菌和真菌感染。

8. 发明授权

US07790704B2 Thrombopoietin mimetics 有权
公开(公告)号：US07790704B2
公开(公告)日：2010-09-07
申请号：US12141397
申请日：2008-06-18
申请人： Kevin J. Duffy , Connie Erickson-Miller , Julian Jenkins , Juan I. Luengo
发明人： Kevin J. Duffy , Connie Erickson-Miller , Julian Jenkins , Juan I. Luengo
IPC分类号： A61K31/655 , A61P7/00 , C07D231/38
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

9. 发明授权

US07439342B2 Thrombopoietin mimetics 有权
公开(公告)号：US07439342B2
公开(公告)日：2008-10-21
申请号：US11650688
申请日：2007-01-08
申请人： Kevin J. Duffy , Juan I. Luengo
发明人： Kevin J. Duffy , Juan I. Luengo
IPC分类号： C07C245/10 , A61K31/655 , C07D231/46 , A61K31/4152
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

10. 发明授权

US07335649B2 Thrombopoietin mimetics 有权
公开(公告)号：US07335649B2
公开(公告)日：2008-02-26
申请号：US11558071
申请日：2006-11-09
申请人： Kevin J. Duffy , Connie Erickson-Miller , Julian Jenkins , Juan I. Luengo , Sophie Visonneau
发明人： Kevin J. Duffy , Connie Erickson-Miller , Julian Jenkins , Juan I. Luengo , Sophie Visonneau
IPC分类号： C07D231/46 , C07D401/12 , C07D403/12 , A61K31/4152
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

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