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1. 发明申请

US20110020434A1 NANOPARTICLE ARSENIC-PLATINUM COMPOSITIONS 审中-公开
标题翻译：纳米二氧化钛 - 铂族组合物
公开(公告)号：US20110020434A1
公开(公告)日：2011-01-27
申请号：US12877414
申请日：2010-09-08
申请人： Thomas V. O'Halloran , Haimei Chen , Andrew Mazar
发明人： Thomas V. O'Halloran , Haimei Chen , Andrew Mazar
IPC分类号： A61K9/127 , A61K33/36 , A61K31/285 , A61K31/282 , A61K33/24 , A61K38/19 , A61K39/395 , A61P35/00
CPC分类号： A61K9/127 , A61K9/1271 , A61K31/282 , A61K33/24 , A61K33/36 , A61K38/193 , A61K38/40 , A61K45/06 , A61K47/6913 , C07F9/72 , C07F15/0093 , C07K16/2887 , C07K2317/24 , A61K2300/00
摘要： The present invention relates to nanoparticle encapsulated arsenic and platinum compositions and methods of use thereof. In particular, the present invention provides co-encapsulation of active forms of arsenic and platinum drugs into liposomes, and methods of using such compositions for the diagnosis and treatment of cancer.
摘要翻译：本发明涉及纳米颗粒包封的砷和铂组合物及其使用方法。特别地，本发明提供了活性形式的砷和铂药物到脂质体中的共包封，以及使用这些组合物来诊断和治疗癌症的方法。

2. 发明授权

US5534542A Methods and materials relating to a bi-metallic cross-linking species 失效
标题翻译：与双金属交联物种有关的方法和材料
公开(公告)号：US5534542A
公开(公告)日：1996-07-09
申请号：US187389
申请日：1994-01-24
申请人： Thomas V. O'Halloran , Stephen P. Watton
发明人： Thomas V. O'Halloran , Stephen P. Watton
IPC分类号： C07F15/00 , A61K31/28 , C07F3/10 , C07F19/00
CPC分类号： C07F15/0093
摘要： Disclosed herein is a bi-metallic cross-linking reagent according to the following formula: ##STR1## where M.sub.1 is a metal ion species capable of forming a complex of coordination number four or coordination number six; wherein L.sub.1, L.sub.2, L.sub.3, and L.sub.4 are each independently a halide, ammonia, dimethyl sulfoxide, carboxylate, thiolate, imidazole, a nucleobase, or an empty coordination site, provided that no more than two of L.sub.1, L.sub.2, L.sub.3, and L.sub.4 are empty coordination sites; wherein M.sub.2 is a metal ion species capable of forming a complex of coordination number two with a first ligand that is a hydrocarbon moiety and a second ligand that is kinetically lablie; and wherein n is an integer from two to nine. Also disclosed are cross-linked species, methods of preparing the crosslinking reagents of the invention, and methods for their use in tissue-specific targeting of anti-tumor agents.
摘要翻译：本文公开了根据下式的双金属交联剂：其中M1是能够形成配位数4或配位数6的络合物的金属离子种类; 其中L1，L2，L3和L4各自独立地为卤素，氨，二甲基亚砜，羧酸酯，硫醇盐，咪唑，核碱基或空配位部位，条件是不超过L1，L2，L3和L4 是空协调网站; 其中M2是能够与第一配位体形成配位体2的复合物的金属离子物质，所述第一配体是烃部分和动力学上第二配位体; 并且其中n是2至9的整数。还公开了交联物质，制备本发明的交联试剂的方法及其用于组织特异性靶向抗肿瘤剂的方法。

3. 发明申请

US20210096076A1 ZINC-RESPONSIVE FLUOROPHORES 有权
公开(公告)号：US20210096076A1
公开(公告)日：2021-04-01
申请号：US17033029
申请日：2020-09-25
申请人： Seth A. Garwin , Emily L. Que , Thomas V. O'Halloran , Teresa K. Woodruff
发明人： Seth A. Garwin , Emily L. Que , Thomas V. O'Halloran , Teresa K. Woodruff
IPC分类号： G01N21/64 , C07F5/02 , C09K11/06
摘要： Provided herein is a class of zinc-responsive probes with tunable photophysical properties that can be modified for coupling to a solid support or other chemical moieties. In particular, modifications to the 5-position of the BODIPY core allows for alteration of probe properties and functionalities.

4. 发明授权

US08821922B2 Compositions and methods for polymer-caged liposomes 有权
标题翻译：聚合物笼状脂质体的组成和方法
公开(公告)号：US08821922B2
公开(公告)日：2014-09-02
申请号：US12135828
申请日：2008-06-09
申请人： Sang-Min Lee , SonBinh Nguyen , Thomas V. O'Halloran
发明人： Sang-Min Lee , SonBinh Nguyen , Thomas V. O'Halloran
IPC分类号： A61K9/127
CPC分类号： A61K31/704 , A61K9/1271 , A61K9/1273 , A61K31/12
摘要： The present invention provides liposomal compositions and methods of using such compositions in vitro and in vivo. In particular, the present invention provides stable, polymer-caged liposomes comprising a pH responsive delivery mechanism for delivery of nucleic acids, peptides, small molecules, drugs, etc. in vitro and in vivo.
摘要翻译：本发明提供在体外和体内使用这些组合物的脂质体组合物和方法。特别地，本发明提供了稳定的聚合物封闭的脂质体，其包含用于在体外和体内递送核酸，肽，小分子，药物等的pH响应递送机制。

5. 发明授权

US07262301B1 Zinc-chelating ratiometric fluorescent probes and related methods 有权
标题翻译：锌螯合比例荧光探针及相关方法
公开(公告)号：US07262301B1
公开(公告)日：2007-08-28
申请号：US11519367
申请日：2006-09-12
申请人： Thomas V. O'Halloran , Masayasu Taki
发明人： Thomas V. O'Halloran , Masayasu Taki
IPC分类号： C07D413/04
CPC分类号： G01N33/84 , C07D263/57 , C07D413/12 , C07D413/14
摘要： Benzoxazole fluorescent sensor compounds and related ratiometric imaging methods for zinc metal ion.
摘要翻译：苯并恶唑荧光传感器化合物和锌金属离子的相关比例成像方法。

6. 发明申请

US20120271100A1 COMPOSITIONS AND METHODS FOR THE DETECTION OF ZINC 审中-公开
标题翻译：用于检测ZINC的组合物和方法
公开(公告)号：US20120271100A1
公开(公告)日：2012-10-25
申请号：US13442453
申请日：2012-04-09
申请人： Teresa K. Woodruff , Thomas V. O'Halloran , Alison M. Kim , Emily Que , Betty Kong , Miranda Bernhardt
发明人： Teresa K. Woodruff , Thomas V. O'Halloran , Alison M. Kim , Emily Que , Betty Kong , Miranda Bernhardt
IPC分类号： C07F5/02 , A61B17/425 , G01N21/64
CPC分类号： G01N33/5091 , A61B17/435 , A61D19/04 , G01N21/6428 , G01N21/643
摘要： The invention relates generally to compositions and methods for the detection of zinc. In particular, compositions and methods are provided to detect changes in cellular zinc concentration and to correlate them to cellular phenomena.
摘要翻译：本发明一般涉及用于检测锌的组合物和方法。特别地，提供组合物和方法以检测细胞锌浓度的变化并将其与细胞现象相关联。

7. 发明申请

US20090075836A1 SCREENING FOR MODULATORS OF METALATION PATHWAYS FOR METALLOPROTEINS 审中-公开
标题翻译：金属化学金属化路径调制器的筛选
公开(公告)号：US20090075836A1
公开(公告)日：2009-03-19
申请号：US12090764
申请日：2006-10-20
申请人： Herbert H. Thorp , Thomas V. O'Halloran
发明人： Herbert H. Thorp , Thomas V. O'Halloran
IPC分类号： C40B30/06 , C12Q1/02 , C40B30/08 , C07K1/00
CPC分类号： G01N33/68 , G01N33/5008 , G01N33/502 , G01N33/6842 , G01N33/6845 , G01N33/6848 , G01N2500/02
摘要： The present invention is directed to compositions and methods for screening of metalation pathways for the metalation of metalloproteins.
摘要翻译：本发明涉及筛选金属蛋白金属化的金属化途径的组合物和方法。

8. 发明申请

US20080317840A1 COMPOSITIONS AND METHODS FOR POLYMER-CAGED LIPOSOMES 有权
标题翻译：聚合物脂质体的组合物和方法
公开(公告)号：US20080317840A1
公开(公告)日：2008-12-25
申请号：US12135828
申请日：2008-06-09
申请人： Sang-Min Lee , SonBinh Nguyen , Thomas V. O'Halloran
发明人： Sang-Min Lee , SonBinh Nguyen , Thomas V. O'Halloran
IPC分类号： A61K9/127 , C12N5/02 , C12N15/88 , A61K38/00 , A61K31/7088 , A61K33/00
CPC分类号： A61K31/704 , A61K9/1271 , A61K9/1273 , A61K31/12
摘要： The present invention provides liposomal compositions and methods of using such compositions in vitro and in vivo. In particular, the present invention provides stable, polymer-caged liposomes comprising a pH responsive delivery mechanism for delivery of nucleic acids, peptides, small molecules, drugs, etc. in vitro and in vivo.
摘要翻译：本发明提供在体外和体内使用这些组合物的脂质体组合物和方法。特别地，本发明提供了稳定的聚合物封闭的脂质体，其包含用于在体外和体内递送核酸，肽，小分子，药物等的pH响应递送机制。

9. 发明授权

US07105680B1 Zinc-chelating ratiometric fluorescent probes and related methods 有权
标题翻译：锌螯合比例荧光探针及相关方法
公开(公告)号：US07105680B1
公开(公告)日：2006-09-12
申请号：US10887465
申请日：2004-07-08
申请人： Thomas V. O'Halloran , Masayasu Taki
发明人： Thomas V. O'Halloran , Masayasu Taki
IPC分类号： C07D413/12
CPC分类号： G01N33/84 , C07D263/57 , C07D413/12 , C07D413/14
摘要： Benzoxazole fluorescent sensor compounds and related ratiometric imaging methods for zinc metal ion.
摘要翻译：苯并恶唑荧光传感器化合物和锌金属离子的相关比例成像方法。

10. 发明授权

US08772029B2 Modulation of oocyte meiotic progression and oocyte activation 有权
标题翻译：调节卵母细胞减数分裂进展和卵母细胞活化
公开(公告)号：US08772029B2
公开(公告)日：2014-07-08
申请号：US13548326
申请日：2012-07-13
申请人： Teresa K. Woodruff , Thomas V. O'Halloran , Miranda L. Bernhardt , Betty Y. Kong , Alison M. Kim
发明人： Teresa K. Woodruff , Thomas V. O'Halloran , Miranda L. Bernhardt , Betty Y. Kong , Alison M. Kim
IPC分类号： C12N5/00 , C12N5/02
CPC分类号： C12N5/0609 , A01K2207/05 , C12N15/873 , C12N2500/22 , C12N2501/01 , C12N2501/11 , C12N2501/31 , C12N2517/10
摘要： The present invention provides methods, compositions, and systems for reinitiating meiosis in cells in meiotic arrest and oocyte activation in fertilized, but un-activated, oocytes. In certain embodiments, Zn-binding moieties (e.g., zinc chelators) are used for reinitiating meiosis or oocyte activation.
摘要翻译：本发明提供了在受精的但未激活的卵母细胞中减数分裂停止和卵母细胞活化的细胞中重新起始减数分裂的方法，组合物和系统。在某些实施方案中，Zn结合部分（例如，锌螯合剂）用于重新启动减数分裂或卵母细胞活化。

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