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1. 发明申请

US20060165606A1 Pulmonary delivery particles comprising water insoluble or crystalline active agents 审中-公开
标题翻译：包含水不溶性或结晶活性剂的肺递送颗粒
公开(公告)号：US20060165606A1
公开(公告)日：2006-07-27
申请号：US11317839
申请日：2005-12-22
申请人： Thomas Tarara , Jeffrey Weers , Alexey Kabalnov , Ernest Schutt , Luis Dellamary
发明人： Thomas Tarara , Jeffrey Weers , Alexey Kabalnov , Ernest Schutt , Luis Dellamary
IPC分类号： A61K9/14 , A61L9/04
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： A pulmonary delivery medicament comprises a plurality of particulates, the particulates comprising a structural matrix and a water insoluble and/or crystalline active agent. The particulates have a geometric diameter of 0.5 to 50 μm. The water insoluble active agent can be a fungicide, antibiotic, budesonide. A method of making the medicament comprises forming a liquid feedstock, and forming a feedstock suspension by suspending in the liquid feedstock, the active agent and an excipient capable of forming a structural matrix, such as a phospholipid. The feedstock suspension is spray dried to produce the particulates.
摘要翻译：肺递送药物包括多个颗粒，所述颗粒包含结构基质和水不溶性和/或结晶活性剂。颗粒的几何直径为0.5至50um。水不溶性活性剂可以是杀真菌剂，抗生素，布地奈德。制备药物的方法包括形成液体原料，并通过悬浮在液体原料，活性剂和能够形成结构基质如磷脂的赋形剂中形成原料悬浮液。将原料悬浮液喷雾干燥以产生颗粒。

2. 发明申请

US20070212405A1 DISPERSION FOR PULMONARY DELIVERY OF A BIOACTIVE AGENT 失效
标题翻译：用于脉冲递送生物剂的分散体
公开(公告)号：US20070212405A1
公开(公告)日：2007-09-13
申请号：US11675073
申请日：2007-02-14
申请人： Luis Dellamary , Thomas Tarara , Alexey Kabalnov , Jeffry Weers , Ernest Schutt
发明人： Luis Dellamary , Thomas Tarara , Alexey Kabalnov , Jeffry Weers , Ernest Schutt
IPC分类号： A61K9/16 , A61K9/127
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a liquid fluorochemical. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as by settling or flocculation. In particularly preferred embodiments the stabilized dispersions may be directly administered to the lung of a patient using an endotracheal tube or bronchoscope.
摘要翻译：提供稳定的分散体用于递送生物活性剂。分散体优选包括分散在通常包含液体含氟化合物的悬浮介质中的多个穿孔微结构。随着悬浮颗粒和悬浮介质之间的密度变化被最小化，微结构之间的吸引力减弱，所公开的分散体特别地耐降解，例如通过沉降或絮凝。在特别优选的实施方案中，稳定的分散体可以使用气管内导管或支气管镜直接施用于患者的肺。

3. 发明申请

US20060159629A1 Pulmonary delivery particles with phospholipid structural matrix 审中-公开
标题翻译：肺输送颗粒与磷脂结构基质
公开(公告)号：US20060159629A1
公开(公告)日：2006-07-20
申请号：US11317523
申请日：2005-12-22
申请人： Thomas Tarara , Jeffry Weers , Alexey Kabalnov , Ernest Schutt , Luis Dellamary
发明人： Thomas Tarara , Jeffry Weers , Alexey Kabalnov , Ernest Schutt , Luis Dellamary
IPC分类号： A61K9/14 , A61K31/685 , A61L9/04
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y02A50/41 , Y02A50/466 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： A pulmonary delivery medicament comprises a plurality of particulates, each particulate having a perforated microstructure comprising a phospholipid structural matrix and active agent, the phospholipid structural matrix comprising greater than about 50% w/w phospholipid, and the particulates having a geometric diameter of from 0.5 to 50 μm. The medicament can be made from a liquid feedstock having greater than about 20% w/w phospholipid with an added active agent, which is spray dried to produce the particulates.
摘要翻译：肺递送药物包括多个颗粒，每个颗粒具有包含磷脂结构基质和活性剂的穿孔微结构，所述磷脂结构基质包含大于约50％w / w磷脂，并且所述颗粒的几何直径为0.5 到50个妈妈药物可以由具有大于约20％w / w磷脂的液体原料与添加的活性剂制成，其被喷雾干燥以产生颗粒。

4. 发明申请

US20050074498A1 Engineered particles and methods of use 审中-公开
标题翻译：工程粒子和使用方法
公开(公告)号：US20050074498A1
公开(公告)日：2005-04-07
申请号：US10612393
申请日：2003-07-03
申请人： Thomas Tarara , Jeffry Weers , Alexey Kabalnov , Ernest Schutt , Luis Dellamary
发明人： Thomas Tarara , Jeffry Weers , Alexey Kabalnov , Ernest Schutt , Luis Dellamary
IPC分类号： A61K9/00 , A61K9/12 , A61K9/16 , A61K9/22 , A61K9/51 , A61K9/72 , A61K45/00 , A61K47/24 , A61K49/04 , A61P11/00 , A61P39/00 , A61K9/14 , A61K9/50
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y02A50/41 , Y02A50/466 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： Engineered particles are provided may be used for the delivery of a bioactive agent to the respiratory tract of a patient. The particles may be used in the form of dry powders or in the form of stabilized dispersions comprising a nonaqueous continuous phase. In particularly preferred embodiments the particles may be used in conjunction with an inhalation device such as a dry powder inhaler, metered dose inhaler or a nebulizer.
摘要翻译：提供的工程颗粒可用于将生物活性剂递送到患者的呼吸道。颗粒可以以干粉形式或以包含非水连续相的稳定分散体的形式使用。在特别优选的实施方案中，颗粒可以与吸入装置如干粉吸入器，计量剂量吸入器或喷雾器结合使用。

5. 发明申请

US20050207986A1 Stabilized preparations for use in nebulizers 审中-公开
标题翻译：用于雾化器的稳定制剂
公开(公告)号：US20050207986A1
公开(公告)日：2005-09-22
申请号：US11076430
申请日：2005-03-09
申请人： Ernest Schutt , Thomas Tarara , Luis Dellamary , Alexey Kabalnov , Jeffry Weers
发明人： Ernest Schutt , Thomas Tarara , Luis Dellamary , Alexey Kabalnov , Jeffry Weers
IPC分类号： A61F2/00 , A61F13/00 , A61K9/00 , A61K9/14 , A61K9/16 , A61L9/04 , A61M11/00
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/008 , Y02A50/41 , Y02A50/466
摘要： Stabilized dispersions are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The dispersions preferably comprise a stabilized colloidal system which may comprise a fluorochemical component. In particularly preferred embodiments, the stabilized dispersions comprise perforated microstructures dispersed in a fluorochemical suspension medium. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as by settling or flocculation. In particularly preferred embodiments, the stabilized dispersions may be administered to the lung of a patient using a nebulizer.
摘要翻译：提供稳定的分散体用于将生物活性剂递送到患者的呼吸道。分散体优选包含稳定的胶体体系，其可以包含含氟化合物组分。在特别优选的实施方案中，稳定的分散体包含分散在含氟化合物悬浮介质中的穿孔微结构。随着悬浮颗粒和悬浮介质之间的密度变化被最小化，微结构之间的吸引力减弱，所公开的分散体特别地耐降解，例如通过沉降或絮凝。在特别优选的实施方案中，稳定的分散体可以使用喷雾器施用于患者的肺。

6. 发明授权

US07205343B2 Stabilized bioactive preparations and method of use 失效
标题翻译：稳定的生物活性制剂和使用方法
公开(公告)号：US07205343B2
公开(公告)日：2007-04-17
申请号：US09999071
申请日：2001-12-03
申请人： Luis A. Dellamary , Thomas Tarara , Alexey Kabalnov , Jeffry Weers , Ernest Schutt
发明人： Luis A. Dellamary , Thomas Tarara , Alexey Kabalnov , Jeffry Weers , Ernest Schutt
IPC分类号： C08K7/22
CPC分类号： A61K9/008 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/1694 , A61K31/685 , Y10S514/937 , Y10S977/904 , Y10S977/906 , Y10S977/926
摘要： Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a liquid fluorochemical. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as by settling or flocculation. In particularly preferred embodiments the stabilized dispersions may be directly administered to the lung of a patient using an endotracheal tube or bronchoscope.
摘要翻译：提供稳定的分散体用于递送生物活性剂。分散体优选包括分散在通常包含液体含氟化合物的悬浮介质中的多个穿孔微结构。随着悬浮颗粒和悬浮介质之间的密度变化被最小化，微结构之间的吸引力减弱，所公开的分散体特别地耐降解，例如通过沉降或絮凝。在特别优选的实施方案中，稳定的分散体可以使用气管内导管或支气管镜直接施用于患者的肺。

7. 发明申请

US20050244338A1 Ultrasonic imaging system utilizing a long-persistence contrast agent 审中-公开
标题翻译：超声波成像系统利用长持续造影剂
公开(公告)号：US20050244338A1
公开(公告)日：2005-11-03
申请号：US11110416
申请日：2005-07-13
申请人： Ernest Schutt
发明人： Ernest Schutt
IPC分类号： A61K49/00 , A61B8/00 , A61K49/22 , B01J13/02 , F21V8/00
CPC分类号： A61K49/227 , A61K49/223 , G02B6/0006
摘要： An ultrasound contrast agent precursor composition comprising: a plurality of void containing polymeric structures; a fluorocarbon gas osmotic agent having a water solubility of not more than about 0.5 mM at 25° C. and one atmosphere; and a phospholipid associated with said structures, wherein said structures, said gas and said phospholipid are together adapted to form microbubbles upon addition of said microbubble precursor composition to an aqueous medium. An ultrasound contrast agent precursor composition comprising: lyophilized void containing structures; a perfluorocarbon gas osmotic agent, said gas osmotic agent dispersed in said voids; and a phospholipid associated with said structures, wherein said structures, said gas and said phospholipid are together adapted to form an ultrasound contrast agent upon addition of an aqueous liquid. An ultrasound contrast agent precursor composition comprising: spray dryed void containing structures; a perfluorocarbon gas osmotic agent, said gas osmotic agent dispersed in said voids; and a phospholipid associated with said structures, wherein said structures, said gas and said phospholipid are together adapted to form an ultrasound contrast agent upon addition of an aqueous liquid. An ultrasound contrast agent comprising a plurality of microbubbles comprising a phospholipid further comprising a perfluorocarbon gas osmotic agent.
摘要翻译：一种超声造影剂前体组合物，其包含：多个含有聚合物结构的空隙; 在25℃和一个大气压下水溶解度不大于约0.5mM的氟烃气体渗透剂; 和与所述结构相关的磷脂，其中所述结构，所述气体和所述磷脂一起适于在将所述微泡前体组合物加入到水性介质中时形成微泡。一种超声造影剂前体组合物，其包含：含冻结空隙的结构; 全氟化碳气体渗透剂，所述气体渗透剂分散在所述空隙中; 和与所述结构相关联的磷脂，其中所述结构，所述气体和所述磷脂一起适于在加入水性液体时形成超声造影剂。一种超声造影剂前体组合物，其包含：含有喷雾干燥空隙的结构物; 全氟化碳气体渗透剂，所述气体渗透剂分散在所述空隙中; 和与所述结构相关联的磷脂，其中所述结构，所述气体和所述磷脂一起适于在加入水性液体时形成超声造影剂。一种包含多个微泡的超声造影剂，其包含还包含全氟化碳气体渗透剂的磷脂。

8. 发明申请

US20050049484A1 Methods and apparatus for monitoring and quantifying the movement of fluid 失效
标题翻译：用于监测和量化流体运动的方法和装置
公开(公告)号：US20050049484A1
公开(公告)日：2005-03-03
申请号：US10962958
申请日：2004-10-12
申请人： Ernest Schutt
发明人： Ernest Schutt
IPC分类号： A61B6/00 , A61B8/00 , A61B8/06 , A61B8/14 , A61K41/00 , A61K49/22 , B65D63/10 , F16L3/137 , F16L3/233 , G09F3/03 , A61B5/05
CPC分类号： A61B8/481 , A61B5/055 , A61B6/00 , A61B6/507 , A61B8/06 , A61B8/14 , A61K41/0028 , A61K49/223
摘要： Methods, systems and devices are provided for monitoring and quantifying the movement of fluid in a target region. Generally, an imaging agent is introduced into a target region through fluid flow. The imaging agent in the target region is then disrupted using appropriate methods such as the application of ultrasonic energy. As fluid flow brings undisrupted imaging agent into the target region, the rate of accumulation is monitored and quantified thereby providing the exchange rate and flow rate of the fluid in the target region. The disclosed invention is particularly useful for medical applications such as determining the flow rate of blood in an organ or tissue.
摘要翻译：提供了用于监测和量化目标区域中流体运动的方法，系统和装置。通常，通过流体流将成像剂引入目标区域。然后使用适当的方法（例如施加超声波能量）来破坏目标区域中的成像剂。当流体流动将不间断的成像剂引入目标区域时，监测和定量积累速率，从而提供目标区域中的流体的交换速率和流速。所公开的发明特别适用于医疗应用，例如确定器官或组织中血液的流速。

9. 发明申请

US20050281747A1 Mixed gas microbubble compositions 审中-公开
标题翻译：混合气体微泡组合物
公开(公告)号：US20050281747A1
公开(公告)日：2005-12-22
申请号：US11181661
申请日：2005-07-14
申请人： Ernest Schutt , David Evitts , Rene Kinner , Charles Anderson , Jeffry Weers
发明人： Ernest Schutt , David Evitts , Rene Kinner , Charles Anderson , Jeffry Weers
IPC分类号： A61K49/00 , A61B8/00 , A61K49/22 , B01J13/02 , F21V8/00
CPC分类号： A61K49/227 , A61K49/223 , G02B6/0006
摘要： A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760-x) mm Hg at 37 C., where x is the vapor pressure of the second gas at 37 C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37 C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; kits for preparing microbubbles; and methods for using such microbubbles as ultrasound contrast agents
摘要翻译：一种由多个微泡形成的微泡制品，包括第一气体和被诸如表面活性剂的膜包围的第二气体，其中第一气体和第二气体以约1:100至约1000:1的摩尔比存在。 1，并且其中第一气体在37℃下具有至少约（760-x）mm Hg的蒸汽压，其中x是第二气体在37℃的蒸汽压，并且其中每个第一和第二气体在37℃下大于约75mm Hg。还公开了制备微泡组合物的方法，包括从第一平均直径快速收缩至小于第一平均直径的约75％的第二平均直径的组合物，并且稳定在第二平均直径; 用于制备微泡的试剂盒以及使用这种微泡作为超声造影剂的方法

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