专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06537506B1 Miniaturized reaction apparatus 失效
标题翻译：小型化反应装置
公开(公告)号：US06537506B1
公开(公告)日：2003-03-25
申请号：US09496999
申请日：2000-02-03
申请人： Thomas Schwalbe , Klaus Golbig , Michael Hohmann , Petra Georg , Andreas Oberbeck , Bernd Dittmann , Jiri Stastna , Sebastian Oberbeck
发明人： Thomas Schwalbe , Klaus Golbig , Michael Hohmann , Petra Georg , Andreas Oberbeck , Bernd Dittmann , Jiri Stastna , Sebastian Oberbeck
IPC分类号： B01J1900
CPC分类号： B01F13/0066 , B01F5/0604 , B01F13/0059 , B01F13/0064 , B01F13/0093 , B01F13/0094 , B01F13/1013 , B01F13/1022 , B01F15/06 , B01J19/0093 , B01J19/249 , B01J2219/00783 , B01J2219/00873 , B01J2219/00889 , B01J2219/00961 , B01J2219/2453 , B01J2219/2456 , B01J2219/246 , B01J2219/2462 , B01J2219/2464 , B01J2219/247 , B01J2219/2485 , B01J2219/2486 , B01J2219/2487 , B01J2219/2488 , B01J2219/249 , B01J2219/2493 , B01J2219/2495 , B01J2219/2496 , B01J2219/2497 , F28D9/0093 , F28F2260/02
摘要： A stacked plate chemical reactor in which simple plates, each incorporating no surface features other that an opening, are stacked together. When openings in adjacent plates are properly aligned, a fluid pathway is defined between inlet ports for each chemical reactant and an outlet port for a chemical product. In one embodiment of the invention, sixteen simple plates are stacked to provide a reactor incorporating three heat transfer fluid pathways, two reactant fluid pathways, one product fluid pathway, multiple mixing chambers, multiple reaction chambers, two reactant pretreatment heat exchangers, two reaction chamber heat exchangers, and multiple temperature sensor pathways. Precise dimensional control of the reactant fluid pathway height enables stacked laminar flow paths for the reactants to be achieved, allowing efficient and rapid diffusion mixing to occur. Because the simple plates incorporate no features other than openings, fabrication of such plates is easily achieved. Different reactor designs, having additional reactant pathways, more or fewer heat transfer fluid pathways, more or fewer heat exchangers, more or fewer mixing chambers, more of fewer reaction chambers, and more or fewer sensor pathways can readily be achieved by adding or removing plates from the stack, and or by changing the pattern and number of openings in the simple plates that are used. The simple plates can be field in the stack during use of the chemical reactor using pressure exerted on opposite outer simple plates of the stack, or can be permanently joined. A preferred material for the fabrication of the plates is stainless steel, although other materials such as glass, plastic, and other metals can alternatively be used, which are compatible with the selected reactants and the desired product.
摘要翻译：堆叠板式化学反应器，其中每个不具有开口的表面特征的简单板堆叠在一起。当相邻板中的开口正确对准时，在每个化学反应物的入口和用于化学产品的出口之间限定流体通道。在本发明的一个实施方案中，堆叠十六个简单的板以提供一个结合有三个传热流体路径，两个反应物流体路径，一个产物流体路径，多个混合室，多个反应室，两个反应物预处理热交换器，两个反应室热交换器和多个温度传感器通路。反应物流体通道高度的精确尺寸控制能够实现用于反应物的堆叠层流路径，从而允许发生高效和快速的扩散混合。由于简单的板不包含开口以外的特征，所以容易实现这种板的制造。不同的反应器设计，具有额外的反应物途径，更多或更少的传热流体途径，更多或更少的热交换器，更多或更少的混合室，更多的更少的反应室和更多或更少的传感器通路可以容易地通过添加或去除板并且或通过改变所使用的简单板中的开口的图案和数量。在使用化学反应器的过程中，简单的板可以使用施加在堆叠的相对的外部简单板上的压力，或者可以永久地连接在堆叠中。用于制造板的优选材料是不锈钢，尽管可以替代地使用其它材料如玻璃，塑料和其它金属，其与选择的反应物和所需产物相容。

2. 发明授权

US07056477B1 Modular chemical production system incorporating a microreactor 失效
标题翻译：包含微反应器的模块化化学生产系统
公开(公告)号：US07056477B1
公开(公告)日：2006-06-06
申请号：US09578224
申请日：2000-05-24
申请人： Thomas Schwalbe , Sebastian Oberbeck , Klaus Golbig , Michael Hohmann , Andreas Oberbeck
发明人： Thomas Schwalbe , Sebastian Oberbeck , Klaus Golbig , Michael Hohmann , Andreas Oberbeck
IPC分类号： B01J19/24 , B01J19/00 , B01J8/00
CPC分类号： B01J19/0093 , B01J2219/0081 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00867 , B01J2219/00869 , B01J2219/00871 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0095 , B01J2219/00984 , B01J2219/0099
摘要： A modular chemical production system that preferably includes a microreactor for producing a product by reacting two or more reactants. Modularization enables components such as controllers, pumps, valves, microreactors, and processing modules to be added or removed from the system as required to produce a desired product. A minimum system includes a control module and a reaction module, which has a mixing volume and a reaction volume. Various pumping modules and residence time modules may also be included in the system. Modules can be changed if malfunctioning, or for producing a different product, or to change a quantity of the chemical produced. The control module preferably accesses a database in which data define parameters for a plurality of different reactions that are optimized for the production of different chemical products. The user selects the product desired and the amount of the product, provides the reactants, solvents, and heat transfer media supplies, and the control module operates the system to automatically produce the product until the desired amount is obtained. The reaction module preferably includes a microreactor, which can be replaced with a microreactor of a different configuration to produce a different product. Connections between modules are designed to enable quick connection and disconnection of modules, and fluid lines are self sealing to prevent leakage of fluids when changing modules.
摘要翻译：模块化化学生产系统，其优选包括用于通过使两种或更多种反应物反应来生产产物的微反应器。模块化使控制器，泵，阀，微反应器和处理模块等组件可根据需要从系统中添加或移除，以产生所需产品。最小系统包括具有混合体积和反应体积的控制模块和反应模块。系统中还可以包括各种泵送模块和停留时间模块。如果发生故障或生产不同的产品，或者改变生产的化学品的数量，可以改变模块。控制模块优选地访问数据库，其中数据定义为针对不同化学产品的生产而优化的多个不同反应的参数。用户选择所需的产品和产品的量，提供反应物，溶剂和传热介质供应，并且控制模块操作系统以自动生产产品，直到获得所需的量。反应模块优选地包括微反应器，其可以用不同构型的微反应器代替以产生不同的产物。模块之间的连接被设计成能够快速连接和断开模块，并且流体管线是自密封的，以防止在更换模块时泄漏流体。

3. 发明授权

US06436720B1 Residence time providing module/apparatus 失效
标题翻译：停留时间提供模块/设备
公开(公告)号：US06436720B1
公开(公告)日：2002-08-20
申请号：US09662678
申请日：2000-09-15
申请人： Sebastian Oberbeck , Andreas Oberbeck , Klaus Golbig , Michael Hohmann
发明人： Sebastian Oberbeck , Andreas Oberbeck , Klaus Golbig , Michael Hohmann
IPC分类号： G01N110
CPC分类号： B01J19/2415 , B01J19/0093 , B01J2219/00835 , B01J2219/00869 , B01J2219/00871 , B01J2219/00873 , B01J2219/00891 , B01J2219/00934 , B01J2219/0095 , B01J2219/00952 , B01J2219/00984 , Y10T137/0318 , Y10T137/86187 , Y10T137/86196 , Y10T436/2575
摘要： A variable residence time chamber module that provides an additional residence time for a reaction of mixed reactants to reach completion. The module includes a thermally insulated housing in which are disposed a plurality of residence time chambers. A rotary inlet valve and rotary outlet valve select among the plurality of chambers, coupling them respectively to an inlet port through which the mixed but incompletely reacted reactants are supplied and an outlet port through which a desired product of the reaction is withdrawn. A heat transfer media is preferably used to control the temperature of the residence time chambers, so that an optimal reaction temperature is provided. The mixed reactants pass through the inlet valve into a selected one of the plurality of residence time chambers. Once the selected residence time chamber is full, the inlet valve is actuated to supply the mixed reactants to a successive residence time chamber. After the reactants in a filled residence time chamber have completely reacted to form the desired product, the outlet valve is actuated to withdraw the desired product. Because a plurality of different residence time chambers are provided, it is possible for the module to be used with a chemical processing system that produces different products in sequence. Each of the residence time chambers can be filled with a different mixture of reactants. It is then preferable that the valves and empty residence time chambers be flushed with solvent to ensure that no cross-reactions and no contamination occurs among different reactants/products.
摘要翻译：可变停留时间室模块，为混合反应物的反应达到完成提供额外的停留时间。该模块包括隔热壳体，其中设置有多个停留时间室。在多个室中选择旋转入口阀和旋转出口阀，将它们分别连接到供应混合但不完全反应的反应物的入口和出口，通过该出口排出反应的期望产物。优选使用传热介质来控制停留时间室的温度，从而提供最佳的反应温度。混合的反应物通过入口阀进入多个停留时间室中的选定的一个。一旦选定的停留时间室满了，启动入口阀，将混合的反应物供应到连续的停留时间室。在填充的停留时间室中的反应物已经完全反应以形成所需产物之后，启动出口阀以抽出所需的产物。由于提供了多个不同的停留时间室，所以可以将模块与依次产生不同产品的化学处理系统一起使用。每个停留时间室可以填充不同的反应物混合物。然后优选的是用溶剂冲洗阀和空的停留时间室，以确保不同反应物/产物之间不发生交叉反应和不发生污染。

4. 发明申请

US20050025677A1 Microreactor system 失效
标题翻译：微反应器系统
公开(公告)号：US20050025677A1
公开(公告)日：2005-02-03
申请号：US10494725
申请日：2002-10-21
申请人： Sebastian Oberbeck , Volker Autze , Klaus Golbig
发明人： Sebastian Oberbeck , Volker Autze , Klaus Golbig
IPC分类号： B81B1/00 , B01J19/00 , B01L3/00 , B01L9/00 , B01L99/00
CPC分类号： B01L3/5027 , B01J19/0093 , B01J2219/0081 , B01L9/527 , B01L2200/028
摘要： The invention related to a microreactor system for the continuous synthesis, which provides defined reaction chambers and conditions for said synthesis, as well as to the uses of said microreactor in carrying out a chemical reaction. According to said invention, (a) said mircoreactor system (11) is of modular design, (b) a processing unit (10) is made up of processing modules which are connected to each other by frictional engagement and (c) the fluid connections in said processing unit (10) can be obtained by the frictional connection of said processing modules.
摘要翻译：本发明涉及用于连续合成的微反应器系统，其提供用于所述合成的限定的反应室和条件，以及所述微反应器在进行化学反应中的用途。根据所述发明，（a）所述微电机系统（11）具有模块化设计，（b）处理单元（10）由处理模块组成，所述处理模块通过摩擦接合彼此连接，（c）流体连接在所述处理单元（10）中可以通过所述处理模块的摩擦连接获得。

5. 发明授权

US07468165B2 Microreactor system 失效
标题翻译：微反应器系统
公开(公告)号：US07468165B2
公开(公告)日：2008-12-23
申请号：US10494725
申请日：2002-10-21
申请人： Sebastian Oberbeck , Volker Autze , Klaus Golbig
发明人： Sebastian Oberbeck , Volker Autze , Klaus Golbig
IPC分类号： B01J19/00 , B01L11/00 , G01N31/00
CPC分类号： B01L3/5027 , B01J19/0093 , B01J2219/0081 , B01L9/527 , B01L2200/028
摘要： The invention related to a microreactor system for the continuous synthesis, which provides defined reaction chambers and conditions for said synthesis, as well as to the uses of said microreactor in carrying out a chemical reaction. According to said invention, (a) said mircoreactor system (11) is of modular design, (b) a processing unit (10) is made up of processing modules which are connected to each other by frictional engagement and (c) the fluid connections in said processing unit (10) can be obtained by the frictional connection of said processing modules.
摘要翻译：本发明涉及用于连续合成的微反应器系统，其提供用于所述合成的限定的反应室和条件，以及所述微反应器在进行化学反应中的用途。根据所述发明，（a）所述微电机系统（11）具有模块化设计，（b）处理单元（10）由处理模块组成，所述处理模块通过摩擦接合彼此连接，（c）流体连接在所述处理单元（10）中可以通过所述处理模块的摩擦连接获得。

6. 发明申请

US20060234381A1 SYSTEM AND METHOD FOR DETERMINING OPTIMAL REACTION PARAMETERS USING CONTINUOUSLY RUNNING PROCESS 审中-公开
标题翻译：使用连续运行过程确定最佳反应参数的系统和方法
公开(公告)号：US20060234381A1
公开(公告)日：2006-10-19
申请号：US11425895
申请日：2006-06-22
申请人： Thomas Schwalbe , Volker Autze , Sebastian Oberbeck , Ansgar Kursawe , Kemal Sahin
发明人： Thomas Schwalbe , Volker Autze , Sebastian Oberbeck , Ansgar Kursawe , Kemal Sahin
IPC分类号： G01N31/10
CPC分类号： B01J19/0093 , B01J19/0033 , B01J2219/00166 , B01J2219/00186 , B01J2219/0059 , B01J2219/00698 , B01J2219/00702 , B01J2219/00867 , B01J2219/00873 , B01J2219/00889 , B01J2219/00909 , B01J2219/00961 , B01J2219/00963 , B01J2219/00977 , B01J2219/00984 , B01J2219/00986 , G05B13/024 , Y10T436/11 , Y10T436/12
摘要： A reaction system enables a plurality of optimization experiments for a reaction to be performed continuously, to enable optimal reaction parameters to be determined. Dilution pumps are included to automatically vary the solvent mixed with reactants so a concentration of each reactant can be selectively varied. The reactants are introduced into a reaction module selectively coupled to residence time chambers or directly to an analytical unit. The analytical unit determines the yield and/or quality for each optimization experiment, enabling optimal parameters to be determined. Residence time chambers can be employed sequentially to enable total residence time to be varied. The controller performs as many experiments as required to enable each parameter to be varied according to a predefined testing program and can redefine a testing program based on the results from previous experiments. At least two reaction parameters can be varied according to periodic functions to further enhance analytical efficiency.
摘要翻译：反应系统能够进行连续执行反应的多个优化实验，以确定最佳反应参数。包括稀释泵以自动改变与反应物混合的溶剂，从而可以选择性地改变每种反应物的浓度。将反应物引入选择性地连接到停留时间室的反应模块中，或直接引入分析单元。分析单元确定每个优化实验的产量和/或质量，从而确定最佳参数。可以顺序使用停留时间室，以使总停留时间变化。控制器根据需要执行尽可能多的实验，以使每个参数根据预定义的测试程序而变化，并可以基于先前实验的结果重新定义测试程序。至少两个反应参数可以根据周期功能而变化，以进一步提高分析效率。

7. 发明授权

US07435392B2 Scalable continuous production system 失效
标题翻译：可扩展连续生产系统
公开(公告)号：US07435392B2
公开(公告)日：2008-10-14
申请号：US10456162
申请日：2003-06-06
申请人： Sebastian Oberbeck , Thomas Schwalbe , Volker Autze , Klaus Poelderl
发明人： Sebastian Oberbeck , Thomas Schwalbe , Volker Autze , Klaus Poelderl
IPC分类号： B01J19/00
CPC分类号： B01F13/0066 , B01F5/0604 , B01F13/0059 , B01F13/0064 , B01F13/0093 , B01F13/0094 , B01F13/1013 , B01F13/1022 , B01F15/06 , B01J19/0033 , B01J19/0093 , B01J19/249 , B01J2219/00783 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/00869 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00961 , B01J2219/00986 , B01J2219/0099 , B01J2219/2453 , B01J2219/2456 , B01J2219/246 , B01J2219/2462 , B01J2219/2464 , B01J2219/247 , B01J2219/2485 , B01J2219/2486 , B01J2219/2487 , B01J2219/2488 , B01J2219/249 , B01J2219/2493 , B01J2219/2495 , B01J2219/2496 , B01J2219/2497 , F28D9/0075 , F28D9/0093 , F28F9/26 , F28F2260/02
摘要： A parallel chemical production system producing a desired product by operating a plurality of reactors in parallel. The fluidic properties of each of the reactors are identical to the properties of a test reactor employed to determine conditions for producing the product, to facilitate scaling up production. In one embodiment, the production system is configured such that at least one reactor is always offline for cleaning, servicing, and use as a backup. If sensors detect less than optimal conditions in any reactor, the reactor is taken offline and serviced, while a previously designated backup reactor is placed online to maintain continuous production. Another aspect involves arranging the reactors in a concentric configuration to facilitate equal fluid distribution.
摘要翻译：并联化学生产系统，其通过并行操作多个反应器来生产所需产物。每个反应器的流体性质与用于确定生产产品的条件的试验反应器的性质相同，以便于扩大生产。在一个实施例中，生产系统被配置为使得至少一个反应器总是脱机以进行清洁，维修和用作备份。如果传感器在任何反应堆中检测到不到最佳条件，则将反应器脱机并维修，同时将先前指定的备用反应器放置在线以保持连续生产。另一方面涉及将反应器布置成同心配置以促进相等的流体分配。

8. 发明申请

US20050013738A1 System and method for determining optimal reaction parameters using continuously running process 失效
标题翻译：使用连续运行过程确定最佳反应参数的系统和方法
公开(公告)号：US20050013738A1
公开(公告)日：2005-01-20
申请号：US10824186
申请日：2004-04-14
申请人： Thomas Schwalbe , Volker Autze , Sebastian Oberbeck , Ansgar Kursawe , Kemal Sahin
发明人： Thomas Schwalbe , Volker Autze , Sebastian Oberbeck , Ansgar Kursawe , Kemal Sahin
IPC分类号： B01J19/00 , G01N31/00 , G01N33/00 , G01N35/00 , G01N35/08 , G06F20060101
CPC分类号： B01J19/0093 , B01J19/0033 , B01J2219/00166 , B01J2219/00186 , B01J2219/0059 , B01J2219/00698 , B01J2219/00702 , B01J2219/00867 , B01J2219/00873 , B01J2219/00889 , B01J2219/00909 , B01J2219/00961 , B01J2219/00963 , B01J2219/00977 , B01J2219/00984 , B01J2219/00986 , G05B13/024 , Y10T436/11 , Y10T436/12
摘要： A reaction system enables a plurality of optimization experiments for a reaction to be performed continuously, to enable optimal reaction parameters to be determined. Dilution pumps are included to automatically vary the solvent mixed with reactants so a concentration of each reactant can be selectively varied. The reactants are introduced into a reaction module selectively coupled to residence time chambers or directly to an analytical unit. The analytical unit determines the yield and/or quality for each optimization experiment, enabling optimal parameters to be determined. Residence time chambers can be employed sequentially to enable total residence time to be varied. The controller performs as many experiments as required to enable each parameter to be varied according to a predefined testing program and can redefine a testing program based on the results from previous experiments. At least two reaction parameters can be varied according to periodic functions to further enhance analytical efficiency.
摘要翻译：反应系统能够进行连续执行反应的多个优化实验，以确定最佳反应参数。包括稀释泵以自动改变与反应物混合的溶剂，从而可以选择性地改变每种反应物的浓度。将反应物引入选择性地连接到停留时间室的反应模块中，或直接引入分析单元。分析单元确定每个优化实验的产量和/或质量，使得能够确定最佳参数。可以顺序使用停留时间室，以使总停留时间变化。控制器根据需要执行尽可能多的实验，以使每个参数根据预定义的测试程序而变化，并可以基于先前实验的结果重新定义测试程序。至少两个反应参数可以根据周期功能而变化，以进一步提高分析效率。

9. 发明授权

US07101515B2 System and method for determining optimal reaction parameters using continuously running process 失效
标题翻译：使用连续运行过程确定最佳反应参数的系统和方法
公开(公告)号：US07101515B2
公开(公告)日：2006-09-05
申请号：US10824186
申请日：2004-04-14
申请人： Thomas Jochen Schwalbe , Volker Autze , Sebastian Oberbeck , Ansgar Kursawe , Kemal Hünkar Sahin
发明人： Thomas Jochen Schwalbe , Volker Autze , Sebastian Oberbeck , Ansgar Kursawe , Kemal Hünkar Sahin
IPC分类号： B01J19/00
CPC分类号： B01J19/0093 , B01J19/0033 , B01J2219/00166 , B01J2219/00186 , B01J2219/0059 , B01J2219/00698 , B01J2219/00702 , B01J2219/00867 , B01J2219/00873 , B01J2219/00889 , B01J2219/00909 , B01J2219/00961 , B01J2219/00963 , B01J2219/00977 , B01J2219/00984 , B01J2219/00986 , G05B13/024 , Y10T436/11 , Y10T436/12
摘要： A reaction system enables a plurality of optimization experiments for a reaction to be performed continuously, to enable optimal reaction parameters to be determined. Dilution pumps are included to automatically vary the solvent mixed with reactants so a concentration of each reactant can be selectively varied. The reactants are introduced into a reaction module selectively coupled to residence time chambers or directly to an analytical unit. The analytical unit determines the yield and/or quality for each optimization experiment, enabling optimal parameters to be determined. Residence time chambers can be employed sequentially to enable total residence time to be varied. The controller performs as many experiments as required to enable each parameter to be varied according to a predefined testing program and can redefine a testing program based on the results from previous experiments. At least two reaction parameters can be varied according to periodic functions to further enhance analytical efficiency.
摘要翻译：反应系统能够进行连续执行反应的多个优化实验，以确定最佳反应参数。包括稀释泵以自动改变与反应物混合的溶剂，从而可以选择性地改变每种反应物的浓度。将反应物引入选择性地连接到停留时间室的反应模块中，或直接引入分析单元。分析单元确定每个优化实验的产量和/或质量，从而确定最佳参数。可以顺序使用停留时间室，以使总停留时间变化。控制器根据需要执行尽可能多的实验，以使每个参数根据预定义的测试程序而变化，并可以基于先前实验的结果重新定义测试程序。至少两个反应参数可以根据周期功能而变化，以进一步提高分析效率。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式