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1. 发明授权

US09046528B2 Cross-reactive determinants and methods for their identification 有权
标题翻译：交叉反应决定因素及其鉴定方法
公开(公告)号：US09046528B2
公开(公告)日：2015-06-02
申请号：US12934654
申请日：2009-03-20
申请人： Thomas Plocher , Manuel Campos , Richard Harland , Todd Johnson , Trent Harbison , Dan Keil
发明人： Thomas Plocher , Manuel Campos , Richard Harland , Todd Johnson , Trent Harbison , Dan Keil
IPC分类号： A61K39/00 , A61K39/02 , A61K39/102 , G01N33/68 , G01N33/50
CPC分类号： G01N33/6854 , A61K39/102 , A61K2039/552 , G01N33/5052 , G01N33/6878 , G01N2333/285
摘要： Compositions and methods for determining immunologically cross-reactive molecules comprising a cross-reactive antigenic determinant are provided, in particular for determining proteins comprising cross-reactive antigenic determinants, in particular for determining proteins that are cross-reactive based on serological screens using sequential immunological challenges to an animal, including determining cross-reactive H. parasuis proteins. Also provided are compositions, vaccines, and kits using the molecules for diagnostics and methods for preventing or treating a disease, disorder, condition, or symptoms thereof associated with infectious agents, in particular infectious microorganisms, in particular for preventing or treating a disease, disorder, condition, or symptom thereof associated with H. parasuis infection.
摘要翻译：提供了用于确定包含交叉反应性抗原决定簇的免疫交叉反应性分子的组合物和方法，特别是用于确定包含交叉反应性抗原决定簇的蛋白质，特别是用于基于血清学筛选使用顺序免疫挑战来测定交叉反应的蛋白质包括确定交叉反应性副猪嗜血菌蛋白。还提供了使用分子进行诊断的组合物，疫苗和试剂盒，以及用于预防或治疗与感染因子，特别是感染性微生物相关的疾病，病症，状况或症状的方法，特别是用于预防或治疗疾病，病症，病症或与副猪嗜血菌感染相关的症状。

2. 发明申请

US20150293118A1 CROSS-REACTIVE DETERMINANTS AND METHODS FOR THEIR IDENTIFICATION 审中-公开
标题翻译：交叉反应性决定因素及其鉴定方法
公开(公告)号：US20150293118A1
公开(公告)日：2015-10-15
申请号：US14696904
申请日：2015-04-27
申请人： Thomas Plocher , Manuel Campos , Richard Harland , Todd Johnson , Trent Harbison , Dan Keil
发明人： Thomas Plocher , Manuel Campos , Richard Harland , Todd Johnson , Trent Harbison , Dan Keil
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , A61K39/102 , A61K2039/552 , G01N33/5052 , G01N33/6878 , G01N2333/285
摘要： Compositions and methods for determining immunologically cross-reactive molecules comprising a cross-reactive antigenic determinant are provided, in particular for determining proteins comprising cross-reactive antigenic determinants, in particular for determining proteins that are cross-reactive based on serological screens using sequential immunological challenges to an animal, including determining cross-reactive H. parasuis proteins. Also provided are compositions, vaccines, and kits using the molecules for diagnostics and methods for preventing or treating a disease, disorder, condition, or symptoms thereof associated with infectious agents, in particular infectious microorganisms, in particular for preventing or treating a disease, disorder, condition, or symptom thereof associated with H. parasuis infection.
摘要翻译：提供了用于确定包含交叉反应性抗原决定簇的免疫交叉反应性分子的组合物和方法，特别是用于确定包含交叉反应性抗原决定簇的蛋白质，特别是用于基于血清学筛选使用顺序免疫挑战来测定交叉反应的蛋白质包括确定交叉反应性副猪嗜血菌蛋白。还提供了使用分子进行诊断的组合物，疫苗和试剂盒，以及用于预防或治疗与感染因子，特别是感染性微生物相关的疾病，病症，状况或症状的方法，特别是用于预防或治疗疾病，病症，病症或与副猪嗜血菌感染相关的症状。

3. 发明申请

US20110014225A1 CROSS-REACTIVE DETERMINANTS AND METHODS FOR THEIR IDENTIFICATION 有权
标题翻译：交叉反应性决定因素及其鉴定方法
公开(公告)号：US20110014225A1
公开(公告)日：2011-01-20
申请号：US12934654
申请日：2009-03-20
申请人： Thomas Plocher , Manuel Campos , Richard Harland , Todd Johnson , Trent Harbison , Dan Kiel
发明人： Thomas Plocher , Manuel Campos , Richard Harland , Todd Johnson , Trent Harbison , Dan Kiel
IPC分类号： A61K39/02 , G01N33/53 , C07K7/06 , C07K7/08 , A61P31/04
CPC分类号： G01N33/6854 , A61K39/102 , A61K2039/552 , G01N33/5052 , G01N33/6878 , G01N2333/285
摘要： Compositions and methods for determining immunologically cross-reactive molecules comprising a cross-reactive antigenic determinant are provided, in particular for determining proteins comprising cross-reactive antigenic determinants, in particular for determining proteins that are cross-reactive based on serological screens using sequential immunological challenges to an animal, including determining cross-reactive H. parasuis proteins. Also provided are compositions, vaccines, and kits using the molecules for diagnostics and methods for preventing or treating a disease, disorder, condition, or symptoms thereof associated with infectious agents, in particular infectious microorganisms, in particular for preventing or treating a disease, disorder, condition, or symptom thereof associated with H. parasuis infection.
摘要翻译：提供了用于确定包含交叉反应性抗原决定簇的免疫交叉反应性分子的组合物和方法，特别是用于确定包含交叉反应性抗原决定簇的蛋白质，特别是用于基于血清学筛选使用顺序免疫挑战来测定交叉反应的蛋白质包括确定交叉反应性副猪嗜血菌蛋白。还提供了使用分子进行诊断的组合物，疫苗和试剂盒，以及用于预防或治疗与感染因子，特别是感染性微生物相关的疾病，病症，状况或症状的方法，特别是用于预防或治疗疾病，病症，病症或与副猪嗜血菌感染相关的症状。

4. 发明授权

US06911206B1 Fusion proteins comprising carriers that can induce a dual immune response 失效
标题翻译：融合蛋白包含可诱导双重免疫应答的载体
公开(公告)号：US06911206B1
公开(公告)日：2005-06-28
申请号：US09506078
申请日：2000-02-16
申请人： Manuel Campos , Terecita D. Yule , Serge Martinod , Becky A. Durtschi
发明人： Manuel Campos , Terecita D. Yule , Serge Martinod , Becky A. Durtschi
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/21 , A61K39/245 , A61K39/385 , A61P31/22 , C07K7/23 , C07K14/03 , C07K16/26 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/62 , C12N15/70 , C12N15/79 , G01N33/566 , A61K38/24 , A61K39/12 , C07K17/00 , C07K38/27
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/0006 , C07K7/23 , C07K16/26 , C07K19/00 , C07K2319/00 , C12N2710/16722
摘要： The subject invention provides a fusion protein for producing a dual immune response in a vertebrate, which fusion protein comprises: (a) a first proteinaceous portion analogous to all or part of a peptide endogenously synthesized within the vertebrate, the activity of which peptide is to be inhibited within the vertebrate, and which proteinaceous portion by itself is incapable of eliciting an effective immunoinhibitory response in said vertebrate; connected to (b) a second proteinaceous portion analogous to all or part of an immunogen from a pathogen, which pathogen is capable of pathogenically infecting the vertebrate; the portion (b) causing the vertebrate's immune system to recognize the portion (a) and produce a response that: (i) inhibits the activity of the peptide endogenously synthesized within the vertebrate; and (ii) protects the vertebrate from infection by the pathogen, when the vertebrate is vaccinated with an effective amount of the fusion protein. The subject invention also provides fusion proteins which comprise a proteinaceous portion (b) that is a carrier that is analogous to all or part of a BHV-1 antigen, which fusion proteins induce in a vertebrate vaccinated with an effective amount of such fusion protein an immune response that inhibits the activity of a peptide as recited in (a), above.
摘要翻译：本发明提供了用于在脊椎动物中产生双重免疫应答的融合蛋白，所述融合蛋白包含：（a）与在脊椎动物内部合成的全部或部分肽全部或部分类似的第一蛋白质部分，其肽的活性在脊椎动物内被抑制，哪个蛋白质部分本身不能在所述脊椎动物中引发有效的免疫抑制反应; 与（b）类似于来自病原体的全部或部分免疫原的第二蛋白质部分，该病原体能够病原体感染脊椎动物; 所述部分（b）使脊椎动物的免疫系统识别部分（a）并产生以下响应：（i）抑制在脊椎动物内内生的合成的肽的活性; 和（ii）当脊椎动物接种有效量的融合蛋白时，保护脊椎动物免受病原体的感染。本发明还提供了融合蛋白，其包含蛋白质部分（b），其是与所有或部分BHV-1抗原类似的载体，所述融合蛋白在用有效量的这种融合蛋白接种的脊椎动物中诱导，如上文（a）所述抑制肽的活性的免疫应答。

5. 发明申请

US20050095258A1 Fusion proteins comprising carriers that can induce a dual immune response 审中-公开
公开(公告)号：US20050095258A1
公开(公告)日：2005-05-05
申请号：US10999363
申请日：2004-11-29
申请人： Manuel Campos , Terecita Yule , Serge Martinod , Becky Durtschi
发明人： Manuel Campos , Terecita Yule , Serge Martinod , Becky Durtschi
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/21 , A61K39/245 , A61K39/385 , A61P31/22 , C07K7/23 , C07K14/03 , C07K16/26 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/62 , C12N15/70 , C12N15/79 , G01N33/566 , C07H21/04 , C07K14/47 , C12P21/04
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K39/0006 , C07K7/23 , C07K16/26 , C07K19/00 , C07K2319/00 , C12N2710/16722
摘要： The subject invention provides a fusion protein for producing a dual immune response in a vertebrate, which fusion protein comprises: (a) a first proteinaceous portion analogous to all or part of a peptide endogenously synthesized within the vertebrate, the activity of which peptide is to be inhibited within the vertebrate, and which proteinaceous portion by itself is incapable of eliciting an effective immunoinhibitory response in said vertebrate; connected to (b) a second proteinaceous portion analogous to all or part of an immunogen from a pathogen, which pathogen is capable of pathogenically infecting the vertebrate; the portion (b) causing the vertebrate's immune system to recognize the portion (a) and produce a response that: (i) inhibits the activity of the peptide endogenously synthesized within the vertebrate; and (ii) protects the vertebrate from infection by the pathogen, when the vertebrate is vaccinated with an effective amount of the fusion protein. The subject invention also provides fusion proteins which comprise a proteinaceous portion (b) that is a carrier that is analogous to all or part of a BHV-1 antigen, which fusion proteins induce in a vertebrate vaccinated with an effective amount of such fusion protein an immune response that inhibits the activity of a peptide as recited in (a), above.

6. 发明授权

US06787146B2 Neospora vaccine 失效
公开(公告)号：US06787146B2
公开(公告)日：2004-09-07
申请号：US10036351
申请日：2001-11-09
申请人： David A. Brake , Manuel Campos
发明人： David A. Brake , Manuel Campos
IPC分类号： A61K39002
CPC分类号： A61K39/002 , C07K16/20 , Y02A50/489
摘要： The present invention provides an homogenate prepared from cells of Neospora, and vaccines against neosporosis prepared therefrom which are useful in the prevention of clinical disease and abortion in mammals.

7. 发明授权

US6096320A Vaccines with chimeric protein comprising gamma-interferon and leukotoxin derived from pasteurella haemolytica 失效
标题翻译：含有衍生自溶血性巴斯德氏菌的γ-干扰素和白细胞毒素的嵌合蛋白的疫苗
公开(公告)号：US6096320A
公开(公告)日：2000-08-01
申请号：US954418
申请日：1997-10-20
申请人： Andrew Potter , Manuel Campos , Huw P. A. Hughes
发明人： Andrew Potter , Manuel Campos , Huw P. A. Hughes
IPC分类号： A61K39/00 , A61P11/00 , C07K14/285 , C07K14/55 , C07K14/57 , C12N15/23 , A61K39/102
CPC分类号： C07K14/285 , C07K14/55 , C07K14/57 , A61K39/00 , C07K2319/00 , C07K2319/55 , C07K2319/61 , C07K2319/75 , Y10S530/825
摘要： New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The chimeric proteins include at least one epitope of an RTX cytotoxin fused to an active fragment of a cytokine. The chimeric proteins can be used in a vaccine composition. Also disclosed are methods of vaccination as well as methods of making the proteins employed in the vaccines.
摘要翻译：公开了新的嵌合蛋白质，编码相同的DNA，以及这些蛋白质在刺激抗呼吸系统疾病如肺炎的免疫力（包括运送发热性肺炎）中的用途。嵌合蛋白包括与细胞因子的活性片段融合的RTX细胞毒素的至少一个表位。嵌合蛋白可用于疫苗组合物。还公开了接种疫苗的方法以及制备疫苗中使用的蛋白质的方法。

8. 发明授权

US5594107A Chimeric protein comprising an RTX-family cytotoxin and interferon-2 or interferon 失效
标题翻译：包含RTX家族细胞毒素和干扰素-2或干扰素的嵌合蛋白
公开(公告)号：US5594107A
公开(公告)日：1997-01-14
申请号：US170126
申请日：1993-12-20
申请人： Andrew Potter , Manuel Campos , Huw P. A. Hughes
发明人： Andrew Potter , Manuel Campos , Huw P. A. Hughes
IPC分类号： A61K39/00 , A61P11/00 , C07K14/285 , C07K14/55 , C07K14/57 , C12N15/23 , C12N15/19 , A61K39/102
CPC分类号： C07K14/285 , C07K14/55 , C07K14/57 , A61K39/00 , C07K2319/00 , C07K2319/55 , C07K2319/61 , C07K2319/75 , Y10S530/825
摘要： New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The chimeric proteins include at least one epitope of an RTX cytotoxin fused to an active fragment of a cytokine. The chimeric proteins can be used in a vaccine composition. Also disclosed are methods of vaccination as well as methods of making the proteins employed in the vaccines.
摘要翻译：公开了新的嵌合蛋白质，编码相同的DNA，以及这些蛋白质在刺激抗呼吸系统疾病如肺炎的免疫力（包括运送发热性肺炎）中的用途。嵌合蛋白包括与细胞因子的活性片段融合的RTX细胞毒素的至少一个表位。嵌合蛋白可用于疫苗组合物。还公开了接种疫苗的方法以及制备疫苗中使用的蛋白质的方法。

9. 发明授权

US5273889A Gamma-iterferon-leukotoxin gene fusions and uses thereof 失效
标题翻译：伽玛迭代 - 白细胞毒素基因融合及其用途
公开(公告)号：US5273889A
公开(公告)日：1993-12-28
申请号：US777715
申请日：1991-10-16
申请人： Andrew Potter , Manuel Campos , Huw P. A. Hughes
发明人： Andrew Potter , Manuel Campos , Huw P. A. Hughes
IPC分类号： A61K39/00 , C07K14/285 , C07K14/55 , C07K14/57 , C12N15/23 , C07H15/12 , C12N15/19
CPC分类号： C07K14/55 , C07K14/285 , C07K14/57 , A61K39/00 , C07K2319/55 , C07K2319/61 , C07K2319/75 , Y10S435/811
摘要： New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The chimeric proteins include at least one epitope of leukotoxin fused to an active fragment of a cytokine. The chimeric proteins can be used in a vaccine composition. Also disclosed are methods of vaccination as well as methods of making the proteins employed in the vaccines.
摘要翻译：公开了新的嵌合蛋白，编码相同的DNA，以及这些蛋白质在刺激免疫呼吸系统疾病例如肺炎，包括发热性肺炎中的用途。嵌合蛋白包括与细胞因子的活性片段融合的白细胞毒素的至少一个表位。嵌合蛋白可用于疫苗组合物。还公开了接种疫苗的方法以及制备疫苗中使用的蛋白质的方法。

10. 发明授权

US06713071B1 Proteins from actinobacillus pleuropneumoniae 失效
标题翻译：来自胸膜肺炎放线杆菌的蛋白质
公开(公告)号：US06713071B1
公开(公告)日：2004-03-30
申请号：US09418980
申请日：1999-10-14
申请人： Robert G. Ankenbauer , Mary Jo Baarsch , Manuel Campos , Robin Keich , Everett Rosey , Brian Suiter , Lynn Warren-Stewart
发明人： Robert G. Ankenbauer , Mary Jo Baarsch , Manuel Campos , Robin Keich , Everett Rosey , Brian Suiter , Lynn Warren-Stewart
IPC分类号： A61K3902
CPC分类号： C07K14/285 , A61K39/00 , A61K39/102 , A61K2039/52 , G01N33/56911
摘要： The present invention is directed to five novel, low molecular weight proteins from Actinobacillus pleuropneumoniae (APP), which are capable of inducing, or contributing to the induction of, a protective immune response in swine against APP. The present invention is further directed to polynucleotide molecules having nucleotide sequences that encode the proteins, as well as vaccines comprising the proteins or polynucleotide molecules, and methods of making and using the same.
摘要翻译：本发明涉及来自胸膜肺炎放线杆菌（APP）的五种新颖的低分子量蛋白质，其能诱导或有助于诱导针对APP的猪的保护性免疫应答。本发明还涉及具有编码蛋白质的核苷酸序列的多核苷酸分子以及包含蛋白质或多核苷酸分子的疫苗以及制备和使用该蛋白质的方法。

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