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1. 发明授权

US08252345B2 Methods for modulating eicosanoid metabolism 有权
标题翻译：调节类花生酸代谢的方法
公开(公告)号：US08252345B2
公开(公告)日：2012-08-28
申请号：US12318389
申请日：2008-12-29
申请人： Thomas Newmark , Paul Schulick , Robert Newman , Bharat Aggarwal
发明人： Thomas Newmark , Paul Schulick , Robert Newman , Bharat Aggarwal
IPC分类号： A61K36/00 , A61K36/82 , A61K36/53 , A61K36/906
CPC分类号： A61K36/9066 , A61K36/29 , A61K36/53 , A61K36/539 , A61K36/704 , A61K36/718 , A61K36/82 , A61K36/9068 , A61K2300/00
摘要： The inventive subject matter relates to methods for modulating an eicosanoid metabolic process in cells of an animal in need thereof, which comprises administering to the animal an amount of the inventive compositions effective for regulating the activity of an eicosanoid oxygenase. In particular, the inventive subject matter relates to methods for modulating arachidonic acid metabolism by administering an amount of the inventive compositions effective for regulating the activity of lipoxygenases and cyclooxygenases.
摘要翻译：本发明主题涉及在有需要的动物的细胞中调节类花生酸代谢过程的方法，其包括向动物施用一定量的有效调节类二烷酸加氧酶活性的本发明组合物。特别地，本发明主题涉及通过施用一定量的有效调节脂氧合酶和环氧合酶的活性的本发明组合物来调节花生四烯酸代谢的方法。

2. 发明授权

US08114446B2 Methods for modulating eicosanoid metabolism 有权
标题翻译：调节类花生酸代谢的方法
公开(公告)号：US08114446B2
公开(公告)日：2012-02-14
申请号：US12826289
申请日：2010-06-29
申请人： Thomas Newmark , Paul Schulick , Robert Newman , Bharat Aggarwal
发明人： Thomas Newmark , Paul Schulick , Robert Newman , Bharat Aggarwal
IPC分类号： A61K36/82 , A61K36/53 , A61K36/906 , A61K36/00
CPC分类号： A61K36/9066 , A61K36/29 , A61K36/53 , A61K36/539 , A61K36/704 , A61K36/718 , A61K36/82 , A61K36/9068 , A61K2300/00
摘要： The inventive subject matter relates to methods for modulating an eicosanoid metabolic process in cells of an animal in need thereof, which comprises administering to the animal an amount of the inventive compositions effective for regulating the activity of an eicosanoid oxygenase. In particular, the inventive subject matter relates to methods for modulating arachadonic acid metabolism by administering an amount of the inventive compositions effective for regulating the activity of lipoxygenases and cyclooxygenases.
摘要翻译：本发明主题涉及在有需要的动物的细胞中调节类花生酸代谢过程的方法，其包括向动物施用一定量的有效调节类二烷酸加氧酶活性的本发明组合物。具体地，本发明主题涉及通过施用一定量的有效调节脂氧合酶和环加氧酶的活性的本发明组合物来调节花生四烯酸代谢的方法。

3. 发明授权

US07563462B2 Methods for modulating eicosanoid metabolism 有权
标题翻译：调节类花生酸代谢的方法
公开(公告)号：US07563462B2
公开(公告)日：2009-07-21
申请号：US11452246
申请日：2006-06-14
申请人： Thomas Newmark , Paul Schulick , Robert Newman , Bharat Aggarwal
发明人： Thomas Newmark , Paul Schulick , Robert Newman , Bharat Aggarwal
IPC分类号： A61K36/00 , A61K36/82 , A61K36/53 , A61K36/906
CPC分类号： A61K36/9066 , A61K36/29 , A61K36/53 , A61K36/539 , A61K36/704 , A61K36/718 , A61K36/82 , A61K36/9068 , A61K2300/00
摘要： The inventive subject matter relates to methods for modulating an eicosanoid metabolic process in cells of an animal in need thereof, which comprises administering to the animal an amount of the inventive compositions effective for regulating the activity of an eicosanoid oxygenase. In particular, the inventive subject matter relates to methods for modulating arachadonic acid metabolism by administering an amount of the inventive compositions effective for regulating the activity of lipoxygenases and cyclooxygenases.
摘要翻译：本发明主题涉及在有需要的动物的细胞中调节类花生酸代谢过程的方法，其包括向动物施用一定量的有效调节类二烷酸加氧酶活性的本发明组合物。具体地，本发明主题涉及通过施用一定量的有效调节脂氧合酶和环加氧酶的活性的本发明组合物来调节花生四烯酸代谢的方法。

4. 发明申请

US20070042059A1 Methods for modulating eicosanoid metabolism 有权
标题翻译：调节类花生酸代谢的方法
公开(公告)号：US20070042059A1
公开(公告)日：2007-02-22
申请号：US11452246
申请日：2006-06-14
申请人： Thomas Newmark , Paul Schulick , Robert Newman , Bharat Aggarwal
发明人： Thomas Newmark , Paul Schulick , Robert Newman , Bharat Aggarwal
IPC分类号： A61K36/539 , A61K36/53 , A61K36/906
CPC分类号： A61K36/9066 , A61K36/29 , A61K36/53 , A61K36/539 , A61K36/704 , A61K36/718 , A61K36/82 , A61K36/9068 , A61K2300/00
摘要： The inventive subject matter relates to methods for modulating an eicosanoid metabolic process in cells of an animal in need thereof, which comprises administering to the animal an amount of the inventive compositions effective for regulating the activity of an eicosanoid oxygenase. In particular, the inventive subject matter relates to methods for modulating arachadonic acid metabolism by administering an amount of the inventive compositions effective for regulating the activity of lipoxygenases and cyclooxygenases.
摘要翻译：本发明主题涉及在有需要的动物的细胞中调节类花生酸代谢过程的方法，其包括向动物施用一定量的有效调节类二烷酸加氧酶活性的本发明组合物。具体地，本发明主题涉及通过施用一定量的有效调节脂氧合酶和环加氧酶的活性的本发明组合物来调节花生四烯酸代谢的方法。

5. 发明申请

US20100278947A1 Methods for modulating Eicosanoid metabolism 有权
标题翻译：调节类花生酸代谢的方法
公开(公告)号：US20100278947A1
公开(公告)日：2010-11-04
申请号：US12318389
申请日：2008-12-29
申请人： Thomas Newmark , Paul Schulick , Robert Newman , Bharat Aggarwal
发明人： Thomas Newmark , Paul Schulick , Robert Newman , Bharat Aggarwal
IPC分类号： A61K36/539 , A61P35/00 , A61P35/04
CPC分类号： A61K36/9066 , A61K36/29 , A61K36/53 , A61K36/539 , A61K36/704 , A61K36/718 , A61K36/82 , A61K36/9068 , A61K2300/00
摘要： The inventive subject matter relates to methods for modulating an eicosanoid metabolic process in cells of an animal in need thereof, which comprises administering to the animal an amount of the inventive compositions effective for regulating the activity of an eicosanoid oxygenase. In particular, the inventive subject matter relates to methods for modulating arachadonic acid metabolism by administering an amount of the inventive compositions effective for regulating the activity of lipoxygenases and cyclooxygenases.
摘要翻译：本发明主题涉及在有需要的动物的细胞中调节类花生酸代谢过程的方法，其包括向动物施用一定量的有效调节类二烷酸加氧酶活性的本发明组合物。具体地，本发明主题涉及通过施用一定量的有效调节脂氧合酶和环加氧酶的活性的本发明组合物来调节花生四烯酸代谢的方法。

6. 发明申请

US20050201976A1 Selective inhibitors of nuclear factor-kappaB activation and uses thereof 失效
标题翻译：核因子κB激活的选择性抑制剂及其用途
公开(公告)号：US20050201976A1
公开(公告)日：2005-09-15
申请号：US10981082
申请日：2004-11-04
申请人： Bharat Aggarwal , Sujay Singh
发明人： Bharat Aggarwal , Sujay Singh
IPC分类号： A61K31/704 , A61K33/24 , A61K38/00 , A61K38/19 , C07H21/04 , C07K14/47 , C07K14/52
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides cell permeable NF-κB inhibitors consist of a polypeptide derived from the p65 subunit of NF-κB and a protein transduction domain derived from antennapedia third helix sequence. The inhibitor suppressed NF-κB activation induced by TNF, LPS, IL-1, okadaic acid, PMA, H2O2 and cigarette smoke condensate. NF-κB-regulated reporter gene expression induced by TNF, TNFR1, TRADD, TRAF2, NIK, IKK and p65 was suppressed by the inhibitor. The inhibitor enhanced TNF- and chemotherapeutic agent-induced apoptosis. Overall these results demonstrate a NF-κB inhibitor that can selectively inhibit NF-κB activation induced by various inflammatory stimuli, downregulate NF-κB mediated gene expression and upregulate apoptosis.
摘要翻译：本发明提供由NF-κB的p65亚基衍生的多肽和来自触角二极体第三螺旋序列的蛋白质转导结构域的细胞渗透性NF-κB抑制剂。抑制剂抑制由TNF，LPS，IL-1，冈田酸，PMA，H 2 O 2 O 2和香烟烟雾冷凝物诱导的NF-κB活化。由TNF，TNFR1，TRADD，TRAF2，NIK，IKK和p65诱导的NF-κB调节的报告基因表达被抑制剂抑制。该抑制剂增强了TNF-和化学治疗剂诱导的细胞凋亡。总体上，这些结果表明可以选择性地抑制由各种炎性刺激诱导的NF-κB活化，下调NF-κB介导的基因表达和上调细胞凋亡的NF-κB抑制剂。

7. 发明授权

US07196105B2 Treatment of human multiple myeloma by curcumin 失效
标题翻译：姜黄素治疗人多发性骨髓瘤
公开(公告)号：US07196105B2
公开(公告)日：2007-03-27
申请号：US10602303
申请日：2003-06-24
申请人： Bharat Aggarwal
发明人： Bharat Aggarwal
IPC分类号： A01N43/40 , A61K31/44
CPC分类号： A61K31/12 , A61K31/175 , A61K31/195 , A61K31/44 , A61K31/56 , A61K31/66 , A61K31/70 , A61K45/06 , A61K2300/00
摘要： All multiple myeloma cell lines examined showed constitutively active IκB kinase (IKK), IκBα phosphorylation and constitutively active NF-κB. Curcumin, a chemopreventive agent, suppressed constitutive IκBα phosphorylation through inhibition of IKK activity and downregulated NF-κB. Curcumin also downregulated expression of NF-κB-regulated gene products such as IκBα, Bcl-2, Bcl-xL, cyclin D1 and interleukin-6. Consequently, curcumin suppressed multiple myeloma cell proliferation and arrested cells at the G1/S phase of the cell cycle. Curcumin also induced apoptosis and chemosensitivity to vincristine. Overall, results presented herein provide a molecular basis for the treatment of multiple myeloma patients with this pharmacologically safe agent.
摘要翻译：检查的所有多发性骨髓瘤细胞系显示组成型活性IkappaB激酶（IKK），IkappaBalpha磷酸化和组成型活性NF-κB。姜黄素是化学预防药物，通过抑制IKK活性和下调NF-κB来抑制组成型IkappaBalpha磷酸化。姜黄素也下调NF-κB调节的基因产物如IkappaBalpha，Bcl-2，Bcl-xL细胞周期蛋白D1和白细胞介素-6的表达。因此，姜黄素在细胞周期的G1 / S期抑制多发性骨髓瘤细胞增殖和阻滞细胞。姜黄素还诱导长春新碱的凋亡和化学敏感性。总体而言，本文提供的结果提供了用该药物安全剂治疗多发性骨髓瘤患者的分子基础。

8. 发明申请

US20050049299A1 Selective inhibitors of stat-3 activation and uses thereof 审中-公开
标题翻译： stat-3激活的选择性抑制剂及其用途
公开(公告)号：US20050049299A1
公开(公告)日：2005-03-03
申请号：US10925814
申请日：2004-08-25
申请人： Bharat Aggarwal
发明人： Bharat Aggarwal
IPC分类号： A61K31/12 , A61K45/06
CPC分类号： A61K31/12 , A61K45/06
摘要： The present invention provides a method of treating a cancerous or pre-cancerous state in an individual in need of such treatment, comprising the step of administering a pharmacologically effective dose of a curcuminoid to the individual.
摘要翻译：本发明提供了治疗需要这种治疗的个体中的癌性或癌前状态的方法，其包括向个体施用药理学有效剂量的姜黄素类药物的步骤。

9. 发明授权

US06998383B2 Inhibitors of receptor activator of NF-κB and uses thereof 失效
公开(公告)号：US06998383B2
公开(公告)日：2006-02-14
申请号：US10143293
申请日：2002-05-10
申请人： Bharat Aggarwal , Bryant G. Darnay , Sujay Singh
发明人： Bharat Aggarwal , Bryant G. Darnay , Sujay Singh
IPC分类号： A61K38/18 , C07K14/475 , C07K19/00 , C12N5/02
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/70578 , C07K2319/00 , C07K2319/10 , C12N9/1205
摘要： The present invention provides a RANK (receptor activator of NF-κB) inhibitor consisted of a TRAF-6 (TNF receptor-associated factor-6) binding domain attached to a leader sequence. The peptide inhibitor inhibits RANKL (RANK ligand)-mediated osteoclast differentiation, thus indicating that targeted disruption of interaction between RANK and TRAF6 may prove useful as a therapeutic for metabolic bone disorders, leukemia, arthritis, and metastatic cancer of the bone.

10. 发明申请

US20050181036A1 Aerosol delivery of curcumin 审中-公开
标题翻译：气溶胶递送姜黄素
公开(公告)号：US20050181036A1
公开(公告)日：2005-08-18
申请号：US10925731
申请日：2004-08-25
申请人： Bharat Aggarwal , Jack Knight
发明人： Bharat Aggarwal , Jack Knight
IPC分类号： A61K9/00 , A61K9/127 , A61K31/12 , A61K36/9066
CPC分类号： A61K31/12 , A61K9/0078 , A61K9/127 , A61K36/9066 , A61K2300/00
摘要： Pharmaceutical compositions suitable for aerosol delivery to a subject that include curcumin dispersed in a lipid vehicle, wherein the lipid has a transition temperature of less than about 15° C., are disclosed. In addition, methods of treating a pathological condition in a subject that include providing one of the claimed pharmaceutical compositions and administering the composition to the subject are disclosed. For example, the pathological condition can be a hyperproliferative disease, such as cancer, an inflammatory disease, or a pulmonary disease.
摘要翻译：公开了适用于向包括分散在脂质载体中的姜黄素的受试者的气溶胶递送的药物组合物，其中所述脂质具有小于约15℃的转变温度。此外，公开了治疗受试者的病理状况的方法，其包括提供所要求保护的药物组合物之一并将所述组合物给予所述受试者。例如，病理状况可以是过度增生性疾病，例如癌症，炎性疾病或肺部疾病。

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