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1. 发明授权

US07928205B2 Methods for refolding of recombinant antibodies 有权
标题翻译：重组抗体重折叠方法
公开(公告)号：US07928205B2
公开(公告)日：2011-04-19
申请号：US11255528
申请日：2005-10-21
申请人： Thomas M. Dillon , Douglas Rehder , Pavel Bondarenko , Margaret Ricci , Himanshu S. Gadgil , Douglas D. Banks , Joe Zhou , Yuefeng Lu , Andrew Goetze , Yuling Zhang
发明人： Thomas M. Dillon , Douglas Rehder , Pavel Bondarenko , Margaret Ricci , Himanshu S. Gadgil , Douglas D. Banks , Joe Zhou , Yuefeng Lu , Andrew Goetze , Yuling Zhang
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/244 , A61K39/39525 , C07K16/00 , C07K16/2866 , C07K2317/21 , C07K2317/52 , C07K2317/55
摘要： The present invention is generally directed to methods of producing an increase in the enrichment or recovery of preferred forms of IgG proteins. More particularly, the invention relates to subjecting preparations of such recombinant IgG proteins with a reduction/oxidation coupling reagent and optionally a chaotropic agent.
摘要翻译：本发明一般涉及产生IgG蛋白的优选形式的富集或回收增加的方法。更具体地说，本发明涉及使用还原/氧化偶联剂和任选的离液剂对这些重组IgG蛋白的制备物进行处理。

2. 发明申请

US20060194280A1 Methods for refolding of recombinant antibodies 有权
标题翻译：重组抗体重折叠方法
公开(公告)号：US20060194280A1
公开(公告)日：2006-08-31
申请号：US11255528
申请日：2005-10-21
申请人： Thomas Dillon , Douglas Rehder , Pavel Bondarenko , Margaret Ricci , Himanshu Gadgil , Douglas Banks , Joe Zhou , Yuefeng Lu
发明人： Thomas Dillon , Douglas Rehder , Pavel Bondarenko , Margaret Ricci , Himanshu Gadgil , Douglas Banks , Joe Zhou , Yuefeng Lu
IPC分类号： C12P21/06 , C07H21/04 , C07K16/18
CPC分类号： C07K16/244 , A61K39/39525 , C07K16/00 , C07K16/2866 , C07K2317/21 , C07K2317/52 , C07K2317/55
摘要： The present invention is generally directed to methods of producing an increase in the enrichment or recovery of preferred forms of IgG proteins. More particularly, the invention relates to subjecting preparations of such recombinant IgG proteins with a reduction/oxidation coupling reagent and optionally a chaotropic agent.
摘要翻译：本发明一般涉及产生IgG蛋白的优选形式的富集或回收增加的方法。更具体地说，本发明涉及使用还原/氧化偶联剂和任选的离液剂对这些重组IgG蛋白的制备物进行处理。

3. 发明授权

US07329353B2 LC/MS method of analyzing high molecular weight proteins 失效
标题翻译：分析高分子量蛋白质的LC / MS方法
公开(公告)号：US07329353B2
公开(公告)日：2008-02-12
申请号：US11040659
申请日：2005-01-21
申请人： Thomas Dillon , Pavel Bondarenko , Gary Pipes , Margaret Ricci , Douglas Rehder , Gerd Kleemann
发明人： Thomas Dillon , Pavel Bondarenko , Gary Pipes , Margaret Ricci , Douglas Rehder , Gerd Kleemann
IPC分类号： B01D15/08
CPC分类号： G01N30/7266 , C07K1/023 , C07K1/047 , G01N30/02 , G01N30/30 , G01N30/34 , G01N30/54 , G01N2030/3007 , G01N2030/3076 , G01N2030/8813 , B01D15/325
摘要： The present invention is directed to a novel method of analysis of high molecular weight proteins. More specifically, it is directed to a novel reversed-phase LC/MS method of analysis of high molecular weight proteins including antibodies.
摘要翻译：本发明涉及一种分析高分子量蛋白质的新方法。更具体地，涉及一种新型的反相LC / MS分析高分子量蛋白质（包括抗体）的方法。

4. 发明申请

US20050161399A1 LC/MS method of analyzing high molecular weight proteins 失效
标题翻译：分析高分子量蛋白质的LC / MS方法
公开(公告)号：US20050161399A1
公开(公告)日：2005-07-28
申请号：US11040659
申请日：2005-01-21
申请人： Thomas Dillon , Pavel Bondarenko , Gary Pipes , Margaret Ricci , Douglas Rehder , Gerd Kleemann
发明人： Thomas Dillon , Pavel Bondarenko , Gary Pipes , Margaret Ricci , Douglas Rehder , Gerd Kleemann
IPC分类号： B01D15/08 , C07K1/02 , C07K1/04 , C07K1/20 , C07K16/06 , C12N15/10 , G01N30/02 , G01N30/30 , G01N30/34 , G01N30/46 , G01N30/54 , G01N30/72 , G01N30/88 , G01N33/558 , H01J49/04
CPC分类号： G01N30/7266 , C07K1/023 , C07K1/047 , G01N30/02 , G01N30/30 , G01N30/34 , G01N30/54 , G01N2030/3007 , G01N2030/3076 , G01N2030/8813 , B01D15/325
摘要： The present invention is directed to a novel method of analysis of high molecular weight proteins. More specifically, it is directed to a novel reversed-phase LC/MS method of analysis of high molecular weight proteins including antibodies.
摘要翻译：本发明涉及一种分析高分子量蛋白质的新方法。更具体地，涉及一种新型的反相LC / MS分析高分子量蛋白质（包括抗体）的方法。

5. 发明申请

US20100158908A1 Stable Polypeptide Formulations 有权
标题翻译：稳定的多肽配方
公开(公告)号：US20100158908A1
公开(公告)日：2010-06-24
申请号：US12718898
申请日：2010-03-05
申请人： Douglas Rehder , Pavel Bondarenko , Dirk Chelius , Arnold Mcauley , Masazumi Matsumura
发明人： Douglas Rehder , Pavel Bondarenko , Dirk Chelius , Arnold Mcauley , Masazumi Matsumura
IPC分类号： A61K39/395 , A61P37/00
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/19 , A61K39/39591 , A61K47/02 , C07K16/2863 , C07K2317/21 , C07K2317/565
摘要： The invention provides a formulation including a buffer having a pH less than 6.0, a divalent cation between about 5-200 mM, an excipient comprising a sugar or polyol and an effective amount of a therapeutic polypeptide. Also provided is a method of stabilizing a polypeptide. The method includes contacting a therapeutic polypeptide with a concentration of divalent cation between about 5-150 150 mM in a buffer having a pH less than 6.0 and an excipient comprising a sugar or polyol.
摘要翻译：本发明提供了包含pH小于6.0的缓冲液，约5-200mM的二价阳离子，包含糖或多元醇的赋形剂和有效量的治疗性多肽的制剂。还提供了稳定多肽的方法。该方法包括在pH小于6.0的缓冲液和包含糖或多元醇的赋形剂之间使治疗性多肽与浓度为约5-150 150mM的二价阳离子接触。

6. 发明授权

US08241632B2 Stable polypeptide formulations 有权
标题翻译：稳定的多肽制剂
公开(公告)号：US08241632B2
公开(公告)日：2012-08-14
申请号：US12718898
申请日：2010-03-05
申请人： Douglas Rehder , Pavel Bondarenko , Dirk Chelius , Arnold McAuley , Masazumi Matsumura
发明人： Douglas Rehder , Pavel Bondarenko , Dirk Chelius , Arnold McAuley , Masazumi Matsumura
IPC分类号： A61K39/395 , C07K16/00 , C12P21/08
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/19 , A61K39/39591 , A61K47/02 , C07K16/2863 , C07K2317/21 , C07K2317/565
摘要： The invention provides a formulation including a buffer having a pH less than 6.0, a divalent cation between about 5-200 mM, an excipient comprising a sugar or polyol and an effective amount of a therapeutic polypeptide. Also provided is a method of stabilizing a polypeptide. The method includes contacting a therapeutic polypeptide with a concentration of divalent cation between about 5-150 150 mM in a buffer having a pH less than 6.0 and an excipient comprising a sugar or polyol.
摘要翻译：本发明提供了包含pH小于6.0的缓冲液，约5-200mM的二价阳离子，包含糖或多元醇的赋形剂和有效量的治疗性多肽的制剂。还提供了稳定多肽的方法。该方法包括在pH小于6.0的缓冲液和包含糖或多元醇的赋形剂之间使治疗性多肽与浓度为约5-150 150mM的二价阳离子接触。

7. 发明授权

US07705132B2 Stable polypeptide formulations 有权
标题翻译：稳定的多肽制剂
公开(公告)号：US07705132B2
公开(公告)日：2010-04-27
申请号：US11973051
申请日：2007-10-05
申请人： Douglas Rehder , Pavel Bondarenko , Dirk Chelius , Arnold McAuley , Masazumi Matsumura
发明人： Douglas Rehder , Pavel Bondarenko , Dirk Chelius , Arnold McAuley , Masazumi Matsumura
IPC分类号： C07K16/00 , C12P21/08 , A61K39/00 , A61K39/395
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/19 , A61K39/39591 , A61K47/02 , C07K16/2863 , C07K2317/21 , C07K2317/565
摘要： The invention provides a formulation including a buffer having a pH less than 6.0, a divalent cation between about 5-200 mM, an excipient comprising a sugar or polyol and an effective amount of a therapeutic polypeptide. Also provided is a method of stabilizing a polypeptide. The method includes contacting a therapeutic polypeptide with a concentration of divalent cation between about 5-150 150 mM in a buffer having a pH less than 6.0 and an excipient comprising a sugar or polyol.
摘要翻译：本发明提供了包含pH小于6.0的缓冲液，约5-200mM的二价阳离子，包含糖或多元醇的赋形剂和有效量的治疗性多肽的制剂。还提供了稳定多肽的方法。该方法包括在pH小于6.0的缓冲液和包含糖或多元醇的赋形剂之间使治疗性多肽与浓度为约5-150 150mM的二价阳离子接触。

8. 发明申请

US20080124326A1 Stable polypeptide formulations 有权
标题翻译：稳定的多肽制剂
公开(公告)号：US20080124326A1
公开(公告)日：2008-05-29
申请号：US11973051
申请日：2007-10-05
申请人： Douglas Rehder , Pavel Bondarenko , Dirk Chelius , Arnold McAuley , Masazumi Matsumura
发明人： Douglas Rehder , Pavel Bondarenko , Dirk Chelius , Arnold McAuley , Masazumi Matsumura
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/19 , A61K39/39591 , A61K47/02 , C07K16/2863 , C07K2317/21 , C07K2317/565
摘要： The invention provides a formulation including a buffer having a pH less than 6.0, a divalent cation between about 5-200 mM, an excipient comprising a sugar or polyol and an effective amount of a therapeutic polypeptide. Also provided is a method of stabilizing a polypeptide. The method includes contacting a therapeutic polypeptide with a concentration of divalent cation between about 5-150 150 mM in a buffer having a pH less than 6.0 and an excipient comprising a sugar or polyol.
摘要翻译：本发明提供了包含pH小于6.0的缓冲液，约5-200mM的二价阳离子，包含糖或多元醇的赋形剂和有效量的治疗性多肽的制剂。还提供了稳定多肽的方法。该方法包括在pH小于6.0的缓冲液和包含糖或多元醇的赋形剂之间使治疗性多肽与浓度为约5-150 150mM的二价阳离子接触。

9. 发明申请

US20100226925A1 Homogeneous Antibody Populations 审中-公开
标题翻译：均质抗体群体
公开(公告)号：US20100226925A1
公开(公告)日：2010-09-09
申请号：US12678130
申请日：2008-09-11
申请人： Thomas M. Dillon , Pavel Bondarenko , Jette Wypych , Martin J. Allen , Alain Balland , Margaret Speed Ricci , Amy Guo , Wenyan Shen , Jeonghoon Sun , Chris Vezina
发明人： Thomas M. Dillon , Pavel Bondarenko , Jette Wypych , Martin J. Allen , Alain Balland , Margaret Speed Ricci , Amy Guo , Wenyan Shen , Jeonghoon Sun , Chris Vezina
IPC分类号： A61K39/395 , C07K16/18 , C12P21/04 , C07H21/04 , C12N15/74 , C12N5/16 , A61P43/00
CPC分类号： C07K16/245 , C07K16/00 , C07K16/2863 , C07K16/2866 , C07K16/2875 , C07K2317/53 , C07K2317/56
摘要： The present invention is generally directed to methods of producing an increase in the enrichment and/or recovery of preferred forms of monoclonal antibodies. More particularly, the invention relates to methods for eliminating disulfide heterogeneity in the hinge region of recombinant IgG2 antibody proteins.
摘要翻译：本发明一般涉及产生增殖和/或回收优选形式的单克隆抗体的方法。更具体地说，本发明涉及消除重组IgG2抗体蛋白的铰链区中二硫键异质性的方法。

10. 发明申请

US20060141631A1 Quantitation of biological molecules 审中-公开
标题翻译：定量生物分子
公开(公告)号：US20060141631A1
公开(公告)日：2006-06-29
申请号：US10511490
申请日：2003-04-15
申请人： Pavel Bondarenko , Thomas Shaler , Dirk Chelius
发明人： Pavel Bondarenko , Thomas Shaler , Dirk Chelius
IPC分类号： G01N33/48
CPC分类号： G01N33/6848 , G01N33/6842
摘要： Methods and apparatus, including computer program products, for quantifying peptides in a peptide mixture. A peptide mixture containing a plurality of peptides is received. One or more peptides are separated from the peptide mixture over a period of time. One or more of the peptides separated at a particular time are subjected to mass-to-charge analysis and an abundance of one or more of the mass analyzed peptides is calculated. A relative quantity for the one or more mass analyzed peptides is calculated by comparing the calculated abundance of the peptides with an abundance of one or more peptides in a reference sample that is external to the first peptide mixture. The techniques can be applied to arbitrary peptides, without requiring the use of differential mass labeling, and can be applied to other biological molecules, such as nucleic acids and small molecules.
摘要翻译：用于定量肽混合物中的肽的方法和装置，包括计算机程序产品。接收含有多个肽的肽混合物。在一段时间内将一种或多种肽与肽混合物分离。在特定时间分离的一种或多种肽进行质量 - 电荷分析，并计算一种或多种质量分析的肽的丰度。通过将所计算的肽丰度与在第一种肽混合物外部的参考样品中的一种或多种肽的丰度进行比较来计算一种或多种质量分析肽的相对量。这些技术可以应用于任意肽，而不需要使用差别质量标记，并且可以应用于其它生物分子，例如核酸和小分子。

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