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1. 发明授权

US5547849A Apparatus and method for volumetric capillary cytometry 失效
标题翻译：用于体积毛细血管细胞计数的装置和方法
公开(公告)号：US5547849A
公开(公告)日：1996-08-20
申请号：US236342
申请日：1994-05-02
申请人： Thomas M. Baer , Louis J. Dietz , Robert S. Dubrow , Paul G. Hayter , Michael Hodges , Bala S. Manian , Robert J. Shartle
发明人： Thomas M. Baer , Louis J. Dietz , Robert S. Dubrow , Paul G. Hayter , Michael Hodges , Bala S. Manian , Robert J. Shartle
IPC分类号： G01N33/49 , G01N15/14 , G01N21/78 , G01N33/543 , G01N33/554 , G06K9/00 , G01N33/536
CPC分类号： G06K9/00127 , G01N15/1468
摘要： The apparatus and method of the present invention disclose a scanning imaging cytometer wherein an unprocessed biological fluid sample is reacted with a fluorescently-labeled binding agent. The reacted sample undergoes minimal processing before it is placed into a capillary tube. The sample is optically scanned and fluorescence excitation is recorded from a plurality of columnar regions of the capillary tube, each columnar region generally defined by the spot size of the excitation beam and the depth dimension of the capillary tube. A spatial filter of a sufficient pinhole diameter is selected to allow simultaneous volumetric detection of all fluorescent targets in each columnar region.
摘要翻译：本发明的装置和方法公开了一种扫描成像细胞仪，其中未处理的生物流体样品与荧光标记的结合剂反应。反应的样品在放入毛细管之前经历最少的处理。样品被光学扫描，并且从毛细管的多个柱状区域记录荧光激发，每个柱状区域通常由激发光束的光斑尺寸和毛细管的深度尺寸限定。选择足够的针孔直径的空间滤波器以允许对每个柱状区域中的所有荧光目标的同时体积检测。

2. 发明授权

US5689110A Calibration method and apparatus for optical scanner 失效
标题翻译：光学扫描仪的校准方法和装置
公开(公告)号：US5689110A
公开(公告)日：1997-11-18
申请号：US670540
申请日：1996-06-27
申请人： Louis J. Dietz , Thomas M. Baer
发明人： Louis J. Dietz , Thomas M. Baer
IPC分类号： G01N21/64 , G01J3/28 , G01N15/10 , G01N21/27 , G01J3/443
CPC分类号： G01N15/1012 , G01N21/274 , G01J2003/2866
摘要： A calibration method and device for a fluorescence spectrometer which uses fluorescence from a homogeneous solid state standard as the source of calibration fluorescence and wherein the solid state standard may be built into the optical scanner and the calibration may be automatically performed as a routine step when using the optical scanner. A gold standard establishes fluorescent units, and the fluorescence spectrometer is calibrated by reference to calibration standards, such as calibration rubies, which are themselves rated against the gold standard and built into the fluorescence spectrometer to provide an unchanging reference to the gold standard and by which simultaneous calibration of two or more channels of a multi-channel fluorescence spectrometer may be accomplished, including automatically calibrating a multi-channel optical scanner when it is turned on to achieve an acceptable level of sensitivity in each channel and to adjust for any relative shift in sensitivity between the channels.
摘要翻译：用于荧光光谱仪的校准方法和装置，其使用来自均匀固态标准的荧光作为校准荧光源，并且其中固态标准可内置在光学扫描仪中，并且可以在使用时自动执行校准作为常规步骤光学扫描仪。黄金标准建立荧光单位，并且通过参考校准标准校准红宝石来校准荧光光谱仪，例如校准红宝石，其自身被评定为黄金标准，并被内置于荧光光谱仪中以提供对黄金标准的不变参考，并且由此可以实现多通道荧光光谱仪的两个或更多个通道的同时校准，包括当其打开时自动校准多通道光学扫描仪以在每个通道中实现可接受的灵敏度水平并且调整任何相对偏移通道之间的灵敏度。

3. 发明授权

US08715955B2 Laser microdissection apparatus and method 有权
标题翻译：激光显微解剖设备及方法
公开(公告)号：US08715955B2
公开(公告)日：2014-05-06
申请号：US11222281
申请日：2005-09-08
申请人： Brian W. Donovan , Thomas M. Baer
发明人： Brian W. Donovan , Thomas M. Baer
IPC分类号： G01N1/28
CPC分类号： G01N1/28 , G01N1/2813 , G01N1/286 , G01N1/30 , G01N1/44 , G01N2001/2826 , G01N2001/2833 , G01N2001/284 , G01N2001/2886 , Y10T156/10 , Y10T156/1054
摘要： Systems and methods for automated laser microdissection are disclosed. In one variation, targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition to the location of an interior of a cut path. In another variation, a sample of biological material is mounted onto a polymer membrane which is then placed onto a substrate. Targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition with the targeted biological material on the side of the biological material. In yet another variation, a sample of biological material is mounted onto a polymer membrane which is then inverted onto a substrate. Targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition with the targeted biological material on the side of the polymer membrane. Then, an UV laser cuts along a cut path around the targeted portions of biological material in a closed cut path or a substantially closed cut path defining an interior and an exterior portion of the tissue sample. In a substantially closed cut path, bridges are left spanning the interior of the cut path and the exterior of the cut path. An IR laser activates at least a portion of the transfer film such that the transfer film in the vicinity of targeted portion adheres to the biological material interior to the cut path. The transfer film is then removed separating the targeted portions of biological material which are adhered to the transfer film from the remaining portion of the tissue sample.
摘要翻译：公开了用于自动激光显微切割的系统和方法。在一个变型中，手动或自动选择目标生物材料，并且将转移膜并排放置在切割路径的内部的位置。在另一个变体中，将生物材料样品安装在聚合物膜上，然后将其放置在基底上。手动或自动选择靶向生物材料，并将转移膜与生物材料侧面上的靶向生物材料并置放置。在另一个变体中，将生物材料样品安装在聚合物膜上，然后将其反转到基底上。手动或自动选择目标生物材料，并将转移膜与聚合物膜侧面上的目标生物材料并置放置。然后，UV激光沿着围绕生物材料的目标部分的切割路径沿封闭的切割路径或限定组织样本的内部和外部部分的基本封闭的切割路径切割。在基本封闭的切割路径中，跨越切割路径的内部和切割路径的外部。红外激光激活转印膜的至少一部分，使得目标部分附近的转印膜附着在生物材料内部至切割路径。然后除去转移膜，从生物材料的目标部分分离出粘附到转移膜上的剩余部分的组织样品。

4. 发明授权

US08337387B2 Imaging and evaluating embryos, oocytes, and stem cells 有权
标题翻译：成像和评估胚胎，卵母细胞和干细胞
公开(公告)号：US08337387B2
公开(公告)日：2012-12-25
申请号：US13302914
申请日：2011-11-22
申请人： Connie C. Wong , Kevin E. Loewke , Thomas M. Baer , Renee A. Reijo-Pera , Barry Behr
发明人： Connie C. Wong , Kevin E. Loewke , Thomas M. Baer , Renee A. Reijo-Pera , Barry Behr
IPC分类号： A61D19/00
CPC分类号： G01N15/10 , A61B17/435 , C12M21/06 , C12M41/36 , C12M41/46 , C12M41/48 , C12N5/0604 , C12Q1/02 , C12Q1/6881 , C12Q2600/158 , G01N15/1475 , G01N33/5005 , G01N2015/1087 , G01N2015/1093 , G01N2015/1493 , G01N2015/1497 , G02B21/0004 , G06F19/26 , G06K9/00147 , G06T7/0012 , G06T2207/10004 , G06T2207/10056 , G06T2207/30044
摘要： Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.
摘要翻译：提供了用于确定一个或多个胚胎或多能细胞的发育潜力和/或在一个或多个胚胎或多能细胞中存在染色体异常的方法，组合物和试剂盒。这些方法，组合物和试剂盒可用于鉴定体外最有用的治疗人类不育症的胚胎和卵母细胞。

5. 发明授权

US07075640B2 Consumable for laser capture microdissection 失效
标题翻译：可用于激光捕获显微切割
公开(公告)号：US07075640B2
公开(公告)日：2006-07-11
申请号：US08984979
申请日：1997-12-04
申请人： Thomas M. Baer , David F. Head , John Toeppen
发明人： Thomas M. Baer , David F. Head , John Toeppen
IPC分类号： G01N21/01
CPC分类号： G01N1/2813 , G01N2001/028 , G01N2001/2833 , G01N2001/284
摘要： Systems and methods for acquiring laser capture microdissection samples are disclosed. An integral portion of a biological reaction vessel includes a transfer film carrier having a substrate surface; and a laser capture microdissection transfer film coupled to the substrate surface of the transfer film carrier. The systems and methods facilitate quick and accurate laser capture microdissection while simultaneously minimizing contamination.
摘要翻译：公开了用于获取激光捕获显微解剖样品的系统和方法。生物反应容器的整体部分包括具有基底表面的转移膜载体; 以及耦合到转印膜载体的基板表面的激光捕获显微切割转印膜。系统和方法有助于快速准确的激光捕获显微切割，同时最大限度地减少污染。

6. 发明授权

US07027133B2 Automated laser capture microdissection 有权
标题翻译：自动激光捕获显微解剖
公开(公告)号：US07027133B2
公开(公告)日：2006-04-11
申请号：US10989206
申请日：2004-11-15
申请人： Thomas M. Baer , Norbert Hagen , Bruce J. Richardson , David R. Brewer, III , Lisa Reese
发明人： Thomas M. Baer , Norbert Hagen , Bruce J. Richardson , David R. Brewer, III , Lisa Reese
IPC分类号： G01N1/00
CPC分类号： G02B21/0076 , G01N1/2813 , G01N2001/284 , G01N2015/1472 , G02B21/32 , G02B21/36 , Y10T83/141
摘要： Systems and methods for automated laser capture microdissection are disclosed. High throughput microdissection is provided by using cell procurement and multi-imaging tools for pre-selecting cells of interest. Novel methods of computer-controlled cap transfer along with automated multi-slide and multi-cap placements, and automated slide and cap detection are provided. The systems and methods provide the advantages of increased speed and much lower rates of contamination.
摘要翻译：公开了用于自动激光捕获显微切割的系统和方法。通过使用细胞采集和多成像工具来预选择感兴趣的细胞来提供高通量显微解剖。提供了计算机控制盖传输的新方法以及自动多滑动和多盖布置，以及自动滑盖和盖检测。这些系统和方法提供了增加速度和低得多的污染率的优点。

7. 发明授权

US07012676B2 Laser capture microdissection translation stage joystick 有权
公开(公告)号：US07012676B2
公开(公告)日：2006-03-14
申请号：US10635721
申请日：2003-08-05
申请人： Thomas M. Baer , Mark A. Enright , David F. Head , Christopher E. Todd
发明人： Thomas M. Baer , Mark A. Enright , David F. Head , Christopher E. Todd
IPC分类号： G01N1/00
CPC分类号： G01N1/2813 , G01N1/2806 , G01N1/286 , G01N2001/2833 , G01N2001/284 , G02B21/32
摘要： Systems and methods for laser capture microdissection are disclosed. An inverted microscope includes a translation stage joystick subsystem. The systems and methods provide the advantages of increased speed and much lower rates of contamination.

8. 发明授权

US06690470B1 Automated laser capture microdissection 有权
标题翻译：自动激光捕获显微解剖
公开(公告)号：US06690470B1
公开(公告)日：2004-02-10
申请号：US09707313
申请日：2000-11-06
申请人： Thomas M. Baer , Norbert Hagen , Bruce J. Richardson , David R. Brewer, III , Lisa Reese
发明人： Thomas M. Baer , Norbert Hagen , Bruce J. Richardson , David R. Brewer, III , Lisa Reese
IPC分类号： G01N2164
CPC分类号： G02B21/0076 , G01N1/2813 , G01N2001/284 , G01N2015/1472 , G02B21/32 , G02B21/36 , Y10T83/141
摘要： Systems and methods for automated laser capture microdissection are disclosed. High throughput microdissection is provided by using cell procurement and multi-imaging tools for pre-selecting cells of interest. Novel methods of computer-controlled cap transfer along with automated multi-slide and multi-cap placements, automated slide and cap detection are provided. The systems and methods provide the advantages of increased speed and much lower rates of contamination.
摘要翻译：公开了用于自动激光捕获显微切割的系统和方法。通过使用细胞采集和多成像工具来预选择感兴趣的细胞来提供高通量显微解剖。提供了计算机控制盖传输的新方法以及自动多滑动和多盖安置，自动滑盖和盖检测。这些系统和方法提供了增加速度和低得多的污染率的优点。

9. 发明授权

US06215550B1 Laser capture microdissection optical system 失效
标题翻译：激光捕获显微解剖光学系统
公开(公告)号：US06215550B1
公开(公告)日：2001-04-10
申请号：US09121635
申请日：1998-07-23
申请人： Thomas M. Baer , Mark A. Enright , David F. Head , Christopher E. Todd
发明人： Thomas M. Baer , Mark A. Enright , David F. Head , Christopher E. Todd
IPC分类号： G01N100
CPC分类号： G01N1/2813 , G01N1/2806 , G01N1/286 , G01N2001/2833 , G01N2001/284 , G02B21/32
摘要： Systems and methods for laser capture microdissection are disclosed. An inverted microscope includes an illumination/laser beam delivery system that is adapted to both illuminate a sample and provide energy for laser capture microdissection of the sample. The systems and methods provide the advantages of increased speed and much lower rates of contamination.
摘要翻译：公开了用于激光捕获显微切割的系统和方法。倒置显微镜包括照明/激光束传送系统，其适于照亮样品并为样品的激光捕获显微切割提供能量。这些系统和方法提供了增加速度和低得多的污染率的优点。

10. 发明授权

US5859699A Laser capture microdissection analysis vessel 失效
标题翻译：激光捕获显微解剖分析容器
公开(公告)号：US5859699A
公开(公告)日：1999-01-12
申请号：US797026
申请日：1997-02-07
申请人： Thomas M. Baer , David F. Head
发明人： Thomas M. Baer , David F. Head
IPC分类号： G01N33/48 , B01L3/00 , B01L3/14 , G01N1/00 , G01N1/02 , G01N1/28 , G02B21/34 , G01N1/10
CPC分类号： B01L3/50853 , B01L3/50825 , G01N1/2813 , G02B21/34 , B01L2300/021 , B01L2300/047 , G01N2001/284
摘要： A laser capture microdissection lift-off substrate comprising a transparent thermoplastic film is incorporated into substrate which may take the form of a cap or other structure associated with an analysis vessel or which may be used with a holder or other element of a LCM tissue sample transfer apparatus. The thermoplastic lift-off substrate film is held in a fixed position on the substrate which may be relative to a feature of a biological analysis vessel. The film may be affixed to a substrate which is a structure which goes into the vessel such that the sample is held in a fixed position relative to an observation port on the vessel.
摘要翻译：将包含透明热塑性薄膜的激光捕获显微切割剥离基底结合到基底中，基底可以采取与分析容器相关联的帽或其它结构的形式，或者可以与LCM组织样品转移的保持器或其他元件一起使用仪器。热塑性剥离基材膜保持在基板上的固定位置，其可以相对于生物分析容器的特征。该膜可以固定到基底上，该基底是进入血管的结构，使得样品相对于血管上的观察孔保持在固定位置。

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